Bioavailability and therapeutic activity of alicaforsen (ISIS 2302) administered as a rectal retention enema to subjects with active ulcerative colitis

Alimentary Pharmacology and Therapeutics

Volumn 23, Issue 10, 2006, Pages 1427-1434

  Miner Jr , P B ^a   Geary, R S ^b   Matson, J ^b   Chuang, E ^b   Xia, S ^b   Baker, B F ^b   Wedel, M K ^b  

^a UNIVERSITY OF OKLAHOMA   (United States)

^b ISIS PHARMACEUTICALS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALICAFORSEN; ENEMA; MERCAPTOPURINE; MESALAZINE; PREDNISONE;

ABSENCE OF SIDE EFFECTS; ADULT; AREA UNDER THE CURVE; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; COLON BIOPSY; COLON MUCOSA; COLONOSCOPY; DISEASE ACTIVITY; DISEASE ACTIVITY INDEX; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG EFFICACY; DRUG HALF LIFE; DRUG TISSUE LEVEL; FEMALE; HUMAN; MALE; OPEN STUDY; OUTCOME ASSESSMENT; PRIORITY JOURNAL; REMISSION; ULCERATIVE COLITIS; WOUND HEALING;

ABSORPTION; ADULT; AREA UNDER CURVE; BIOLOGICAL AVAILABILITY; COLITIS, ULCERATIVE; COLON; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; ENEMA; FEMALE; GASTROINTESTINAL AGENTS; HUMANS; INTESTINAL MUCOSA; MALE; MIDDLE AGED; OLIGODEOXYRIBONUCLEOTIDES, ANTISENSE; THIONUCLEOTIDES; TREATMENT OUTCOME;

EID: 33646237136     PISSN: 02692813     EISSN: 13652036     Source Type: Journal    
DOI: 10.1111/j.1365-2036.2006.02909.x     Document Type: Article

References (19)

1. Cohen RD Woseth DM Thisted RA Hanauer SB A meta-analysis and overview of the literature on treatment options for left-sided ulcerative colitis and ulcerative proctitis Am J Gastroenterol 2000 95 1263 76
2. Dustin ML Rothlein R Bhan AK Dinarello CA Springer TA Induction by IL1 and interferon-gamma: tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM-1) J Immunol 1986 137 245 54
3. Oppenheimer-Marks N Davis LS Bogue DT Ramberg J Lipsky PE Differential utilization of ICAM-1 and VCAM-1 during the adhesion and transendothelial migration of human T lymphocytes J Immunol 1991 147 2913 21
4. Marlin SD Springer TA Purified intercellular adhesion molecule-1 (ICAM-1) is a ligand for lymphocyte function-associated antigen 1 (LFA-1) Cell 1987 51 813 9
5. Diamond MS Staunton DE de Fougerolles AR et al. ICAM-1 (CD54): a counter receptor for Mac-1 (CD11b/CD18) J Cell Biol 1990 111 3129 39
6. Vainer B Nielsen OH Changed colonic profile of P-selectin, platelet-endothelial cell adhesion molecule-1 (PECAM-1), intercellular adhesion molecule-1 (ICAM-1), ICAM-2, and ICAM-3 in inflammatory bowel disease Clin Exp Immunol 2000 121 242 7
7. Vainer B Sorensen S Nielsen OH Horn T Subcellular localization of intercellular adhesion molecule-1 in colonic mucosa in ulcerative colitis Ultrastruct Pathol 2002 26 113 21
8. Bennett CF Kornbrust D Henry S et al. An ICAM-1 antisense oligonucleotide prevents and reverses dextran sulfate sodium-induced colitis in mice J Pharmacol Exp Ther 1997 280 988 1000
9. Crooke ST Progress in antisense technology Annu Rev Med 2004 55 61 95
10. van Deventer SJ Tami JA Wedel MK A randomised, controlled, double blind, escalating dose study of alicaforsen enema in active ulcerative colitis Gut 2004 53 1646 51
11. Miner P Wedel M Bane B Bradley J An enema formulation of alicaforsen, an antisense inhibitor of intercellular adhesion molecule-1, in the treatment of chronic, unremitting pouchitis Aliment Pharmacol Ther 2004 19 281 6
12. Hanauer S Schwartz J Robinson M et al. Mesalamine capsules for treatment of active ulcerative colitis: results of a controlled trial. Pentasa Study Group Am J Gastroenterol 1993 88 1188 97
13. Schroeder KW Tremaine WJ Ilstrup DM Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study N Engl J Med 1987 317 1625 9
14. Yu RZ Baker B Chappel A Geary RS Cheung E Levin AA Development of an ultrasensitive noncompetitive hybridization-ligation enzyme-linked immunosorbent assay for the determination of phosphorothioate oligodeoxynucleotide in plasma Anal Biochem 2002 304 19 25
15. Yacyshyn BR Barish C Goff J et al. Dose ranging pharmacokinetic trial of high-dose alicaforsen (intercellular adhesion molecule-1 antisense oligodeoxynucleotide) (ISIS 2302) in active Crohn's disease Aliment Pharmacol Ther 2002 16 1761 70
16. Geary RS Khatsenko O Bunker K et al. Absolute bioavailability of 2′-O-(2-methoxyethyl)-modified antisense oligonucleotides following intraduodenal instillation in rats J Pharmacol Exp Ther 2001 296 898 904
17. Khatsenko O Morgan R Truong L et al. Absorption of antisense oligonucleotides in rat intestine: effect of chemistry and length Antisense Nucleic Acid Drug Dev 2000 10 35 44
18. Nicklin PL Bayley D Giddings J et al. Pulmonary bioavailability of a phosphorothioate oligonucleotide (CGP 64128A): comparison with other delivery routes Pharm Res 1998 15 583 91
19. Frieri G Giacomelli R Pimpo M et al Mucosal 5-aminosalicylic acid concentration inversely correlates with severity of colonic inflammation in patients with ulcerative colitis Gut 2000 47 410 4