Absorption of lefradafiban from different sites of the gastrointestinal tract

British Journal of Clinical Pharmacology

Volumn 50, Issue 1, 2000, Pages 69-72

  Drewe, Jürgen ^a,b   Narjes, Hans ^b   Heinzel, Günther ^a   Brickl, Rolf Stefan ^b   Rohr, Andrea ^b   Beglinger, Christoph ^b  

^a BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG   (Germany)

^b UNIVERSITY HOSPITAL BASEL   (Switzerland)

Author keywords

Enteral absorption; Fibrinogen receptor antagonist; Fradafiban; Lefradafiban

Indexed keywords

LEFRADAFIBAN;

ADULT; AREA UNDER THE CURVE; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DIARRHEA; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG EXCRETION; HEADACHE; HUMAN; HUMAN EXPERIMENT; ILEUM; INTESTINE ABSORPTION; JEJUNUM; MALE; NORMAL HUMAN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SIGMOID; SLOW RELEASE FORMULATION; URINARY EXCRETION;

ADMINISTRATION, ORAL; ADULT; BIOLOGICAL AVAILABILITY; BIPHENYL COMPOUNDS; CROSS-OVER STUDIES; DIGESTIVE SYSTEM; DRUG ADMINISTRATION ROUTES; HUMANS; INTESTINAL ABSORPTION; INTUBATION, GASTROINTESTINAL; MALE; MIDDLE AGED; PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX; PRODRUGS; PYRROLIDINES;

EID: 0034044708     PISSN: 03065251     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2125.2000.00228.x     Document Type: Article

References (4)

1. 1 Tcheng JE. Glycoprotein IIb/IIIa receptor inhibitors: putting the EPIC, IMPACT II, RESTORE, and EPILOG trials into perspective. Am J Cardiol 1996; 78: 35-40.
2. 2 Simpendorfer C, Kottke-Marchant K, Lowrie M, et al. First chronic platelet glycoprotein IIb/IIIa integrin blockade. A randomized, placebo-controlled pilot study of xemilofiban in unstable angina with percutaneous coronary interventions. Circulation 1997; 96: 76-81.
3. 3 Müller TH, Weisenberger H, Brikl R, Narjes H, Himmelsbach F, Krause J. Profound and sustained inhibition of platelet aggregation by Fradafiban, a nonpeptide platelet glycoprotein IIb/IIIa antagonist, and its orally active prodrug, Lefradafiban, in men. Circulation 1997; 96: 1130-1138.
4. 4 Heinzel G, Woloszczak R, Thomann P. Topfit 2.0. Pharmacokinetic and pharmacodynamic data analysis system for the PC. Gustav Fischer, Stuttgart-Jena-New York, 1993.