The effect of polyethylene glycol 400 on gastrointestinal transit: Implications for the formulation of poorly-water soluble drugs

Pharmaceutical Research

Volumn 18, Issue 8, 2001, Pages 1146-1150

  Basit, A W ^a   Newton, J M ^a   Short, M D ^b   Waddington, W A ^c   Ell, P J ^c   Lacey, L F ^d  

^a UNIVERSITY OF LONDON   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

^d GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Absorption; Co solvent; Gamma scintigraphy; Gastrointestinal transit; Polyethylene glycol 400; Poorly water soluble drugs

Indexed keywords

EXCIPIENT; INDIUM 111; MACROGOL 400; MICROCRYSTALLINE CELLULOSE; SOLVENT; TECHNETIUM 99M;

ADULT; ARTICLE; CONTROLLED STUDY; DRUG FORMULATION; DRUG SOLUBILITY; GASTROINTESTINAL TRANSIT; HUMAN; HUMAN EXPERIMENT; INTESTINE TRANSIT TIME; ISOTOPE LABELING; MALE; NORMAL HUMAN; PRIORITY JOURNAL; SCINTILLATION CAMERA; SMALL INTESTINE; STOMACH EMPTYING;

ADULT; CAPSULES; CECUM; DIGESTIVE SYSTEM; EXCIPIENTS; GASTRIC EMPTYING; GASTROINTESTINAL TRANSIT; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; INTESTINE, SMALL; ISOTOPE LABELING; MALE; MIDDLE AGED; PHARMACEUTICAL PREPARATIONS; POLYETHYLENE GLYCOLS; SOLUBILITY; STOMACH;

EID: 0034812650     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1010927026837     Document Type: Article

References (20)

1. The influence of formulation on the absorption of orally administered griseofulvin preparations in rabbits
2. Comparative gastrointestinal transit of pellet systems of varying density
3. Techniques and errors in scintigraphic measurements of gastric emptying
4. The description of the gastrointestinal transit of pellets assessed by gamma scintigraphy using statistical moments
5. Gastric emptying of liquids and solids: Roles of proximal and distal stomach
6. The physiology and pathophysiology of gastric emptying in humans
7. The gastric emptying of pellets contained in hard gelatin capsules
8. A migrating electrical complex of the canine small intestine
9. The interdigestive myo-electric compex of the stomach and small bowel of dogs
10. Transit of pharmaceutical dosage forms through the small intestine
11. Measurements of intestinal permeability using low molecular weight polyethylene glycols (PEG 400). I. Chemical analysis and biological properties of PEG 400
12. PEG 400, a hydrophilic molecular probe for measuring intestinal permeability
13. Effect of sodium acid pyrophosphate on ranitidine bioavailability and gastrointestinal transit time
14. The effects of pharmaceutical excipients on small intestinal transit
15. The effect of different concentrations of mannitol in solution on small intestinal transit: Implications for drug absorption
16. Agents affecting gastrointestinal water flux and motility; Emesis and antiemetics; Bile acids and pancreatic enzymes
17. Absorption of polyethylene glycol after administration of a PEG-electrolyte lavage solution