Selective targeting of tumour neovasculature by a radiohalogenated human antibody fragment specific for the ED-B domain of fibronectin

European Journal of Nuclear Medicine

Volumn 28, Issue 4, 2001, Pages 534-539

  Demartis, Salvatore ^a   Tarli, Lorenzo ^a   Borsi, Laura ^b   Zardi, Luciano ^b   Neri, Dario ^a  

^a ETH ZURICH   (Switzerland)

^b UNIVERSITY OF GENOA   (Italy)

Author keywords

Angiogenesis; Astatine 211; Oncofoetal ED B domain of fibronectin; Radioimmunotherapy; ScFv antibody fragment

Indexed keywords

ASTATINE 211; FIBRONECTIN; IODINE 125; RECOMBINANT ANTIBODY;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTORADIOGRAPHY; CANCER DIAGNOSIS; DRUG DETERMINATION; DRUG DISTRIBUTION; MOUSE; NONHUMAN; RADIOIODINATION; RAT; SARCOMA; TERATOCARCINOMA; TUMOR VASCULARIZATION;

ANIMALS; ASTATINE; BENZOATES; FIBRONECTINS; IMMUNOGLOBULIN FRAGMENTS; IODINE RADIOISOTOPES; MICE; MICE, INBRED BALB C; NEOPLASM TRANSPLANTATION; NEOPLASMS; NEOVASCULARIZATION, PATHOLOGIC; RADIOPHARMACEUTICALS; REGIONAL BLOOD FLOW; TISSUE DISTRIBUTION; TRIMETHYLTIN COMPOUNDS;

EID: 0035096320     PISSN: 03406997     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002590100480     Document Type: Article

References (17)

1. Angiogenesis in cancer, vascular, rheumatoid and other disease
2. Transformed human cells produce a new fibronectin isoform by preferential alternative splicing of a previously unobserved exon
3. The fibronectin isoform containing the ED-B oncofetal domain: A marker of angiogenesis
4. Selective targeting and photocoagulation of ocular angiogenesis mediated by a phage derived human antibody fragment
5. Phage antibodies with pan-species recognition of the oncofoetal angiogenesis marker fibronectin ED-B domain
6. Design and use of a phage display library. Human antibodies with subnanomolar affinity against a marker of angiogenesis eluted from a two-dimensional gel
7. Targeting by affinity-matured recombinant antibody fragments of an angiogenesis associated fibronectin isoform
8. A high-affinity human antibody that targets tumoral blood vessels
9. Increased binding affinity and valence of recombinant antibody fragments lead to improved targeting of tumoral angiogenesis
10. Synthesis of radioiodinated N-succinimidyl iodobenzoate: Optimization for use in antibody labelling
11. Alkaline phosphatase activity in mouse teratoma
12. Partial reversion of the transformed phenotype in HRAS-transfected tumorigenic cells by transfer of a human gene
13. NMR structure of the human oncofoetal fibronectin ED-B domain, a specific marker for angiogenesis
14. 213Bi - An alpha-particle emitter
15. 90Y-labeled CO17-1A Fab' fragments in a human colonic cancer model
16. Radioimmunotherapy with alpha-particle emitting radioimmunoconjugates
17. Targeted delivery of tissue factor to the ED-B domain of fibronectin, a marker of angiogenesis, mediated the infarction of solid tumours in mice