Intrinsic and microenvironmental defects are involved in the age-related changes of Lin-c-kit+ hematopoietic progenitor cells

Rejuvenation Research

Volumn 10, Issue 4, 2007, Pages 459-472

  Donnini, Alessia ^a   Re, Francesca ^a   Orlando, Fiorenza ^a   Provinciali, Mauro ^a  

^a INRCA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 4; STEM CELL FACTOR;

AGE; AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL AGING; CELL DIFFERENTIATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; HEMATOPOIETIC STEM CELL; HEMATOPOIETIC STEM CELL TRANSPLANTATION; LYMPHOCYTE; MALE; MICROENVIRONMENT; MOUSE; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE;

AGING; ANIMALS; CELL DIFFERENTIATION; FEMALE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HEMATOPOIETIC STEM CELLS; INTERLEUKIN-4; KILLER CELLS, NATURAL; MALE; MICE; MICE, INBRED BALB C; PROTO-ONCOGENE PROTEINS C-KIT; T-LYMPHOCYTES; THYMUS GLAND;

ANIMALIA; MUS;

EID: 37549051248     PISSN: 15491684     EISSN: None     Source Type: Journal    
DOI: 10.1089/rej.2006.0524     Document Type: Article

References (43)

1. Clark WR. A Means to an End: The Biological Basis of Aging and Death. New York: Oxford University Press, 1999.
2. Chen J. Senescence and functional failure of hematopoietic stem cells. Exp Hematol 2004;32:1025-1032.
3. Van Zant G, Liang Y. The role of stem cells aging. Exp Hematol 2003;27:928-935.
4. Geiger H, Van Zant G. The aging of lympho-hematopoietic stem cells. Nat Immunol 2002;3:329-333.
5. Kamminga LM, Van Os R, Ausema A, Noach EJK, Weersing E, Dontje B, Vellenga E, de Haan G. Impaired hematopoietic stem cell functioning after serial transplantation and during normal aging. Stem Cells 2005;23:82-92.
6. Rando TA. Stem cells, ageing and the quest for immortality. Nature 2006;441:1080-1086.
7. Harrison DE. Normal production of erythrocytes by mouse bone marrow continuous for 73 months. Proc Natl Acad Sci USA 1973;70:3184-3188.
8. Harrison DE, Astle CM, Delaittre JA. Loss of proliferative capacity in immunohemopoietic stem cells caused by serial transplantation rather than aging. J Exp Med 1978;147:1526-1531.
9. Ogden DA, Micklem HS. The fate of serially transplanted bone marrow cell populations from young and old donors. Transplantation 1976;22:287-293.
10. Harrison DE. Long-term erythropoietic repopulating ability of old, young and fetal stem cells. J Exp Med 1983;157:1496-1504.
11. Harrison DE, Astle C, Stone M. Numbers and functions of transplantable primitive immuno-hematopoietic stem cells. Effects of age. J Immunol 1989;142: 3833-3840.
12. Chen J, Astle CM, Harrison DE. Genetic regulation of primitive hematopoietic stem cell senescence. Exp Hematol 2000;28:442-450.
13. de Haan G, Van Zant G. Dynamic changes in mouse hematopoietic stem cell numbers during aging. Blood 1999;93:3294-3301.
14. Sudo K, Ema H, Morita Y Nakauchi H. Age-associated characteristics of murine hematopoietic stem cells. J Exp Med 2000;192:1273-1280.
15. Liang Y, Van Zant G, Szilvassy SJ. Effects of aging on the homing and engraftment of murine hematopoietic stem and progenitor cells. Blood 2005;106: 1479-1487.
16. Morrison SJ, Wandycz AM, Akashi K, Globerson A, Weissman IL. The aging of hematopoietic stem cells. Nat Med 1996;2:1011-1016.
17. Kamminga LM, Akkerman I, Weersing E, Ausema A, Dontje B, Van Zant G, de Haan G. Autonomous behavior of hematopoietic stem cell. Exp Hematol 2000; 28:1451-1459.
18. Van Zant G, Holland BP, Eldridge PW, Chen JJ. Genotype-restricted growth and aging patterns in hematopoietic stem cell populations of allophenic mice. J Exp Med 1990;171:1547-1565.
19. Rossi DJ, Bryder D, Zahn JM, Ahlenius H, Sonu R, Wagers AJ. Cell intrinsic alterations underline hematopoietic stem cell aging. Proc Natl Acad Sci USA 2005;102:9194-9199.
20. Kim M, Moon HB, Spangrude GJ. Major age-related changes of mouse hematopoietic stem/progenitor cells. Ann NY Acad Sci 2003;996:195-208.
21. Gordon MY, Lewis JL, Marley SB, Grand FH, Goldman JM. Stromal cells negatively regulate primitive hematopoietic progenitor cell activation via a phosphatidylinosiotol-anchored cell adhesion/signaling mechanism. Br J Haematol 1997;96:647-653.
22. Hackney JA, Charbord P, Brunk BP, Stoeckert CJ, Lemischka IR, Moore KA. A molecular profile of a hematopoietic stem cell niche. Proc Natl Acad Sci USA 2002;99:13061-13066.
23. Walker L, Lynch M, Silverman S, Fraser J, Boulter J, Weinmaster G, Gasson JC. The Notch/Jagged pathway inhibits proliferation of human hematopoietic progenitors in vitro. Stem Cells 1999;17: 162-171.
24. Wilson JG. Adhesive interactions in hematopoiesis. Acta Haematol 1997;97:6-12.
25. Yoder MC, Williams DA. Matrix molecule interactions with hematopoietic stem cells. Exp Hematol 1995;23:961-967.
26. Sharp A, Zipori D, Toledo J, Tal S, Resnitzky P, Globerson A. Age-related changes in hematopoietic capacity of bone marrow cells. Mech Ageing Dev 1989;48:91-99.
27. - progenitors to maintain primitive function and immunophenotype in vitro. Exp Hematol 1998;26: 612-619.
28. Stephan RP, Reilly CR, Witte PL. Impaired ability of bone marrow stroma cells to support B-lymphopoiesis with age. Blood 1998;91:75-88.
29. Updyke LW, Cocke KS, Wierda D. Age-related changes in production of interleukin-7 (IL-7) by murine long-term bone marrow cultures (LTBMC). Mech Ageing Dev 1993;69:109-117.
30. Basso A, Piantanelli L, Rossolini G, Roth GS. Reduced DNA synthesis in primary cultures of hepatocytes from old mice is restored by thymus grafts. J Gerontol 1998;53A:B111-B116.
31. + naive T cells is inversely correlated with donor age in murine allogeneic haematopoietic stem cell transplantation. Br J Haematol 2000;111:700-707.
32. Yuan R, Astle CM, Chen J, Harrison DE. Genetic regulation of hematopoietic stem cell exhaustion during development and growth. Exp Hematol 2005;33: 243-250.
33. Smith AL, Eleison FM, McCoy JP Jr, Chen J. c-Kit expression and stem cell factor-induced hematopoietic cell proliferation are up-regulated in aged B6D2F1 mice. J Gerontol A Biol Sci Med Sci 2005;60:448-456.
34. Bagnara GP, Bonsi L, Strippoli P, , Bonifazi F, Tonelli R, D'Addato S, Paganelli R, Scala E, Fagiolo U, Monti D, Cossarizza A, Bonafe M, Franceschi C. Hemopoiesis in healthy old people and centenarians: wellmaintained responsiveness of CD34+ cells to hemopoietic growth factors and remodeling of cytokine network. J Gerontol A Biol Sci Med Sci 2000;55: B61-66.
35. + progenitor cells. Biogerontology 2005;6:185-192.
36. Buchanan JP, Peters CA, Rasmussen CJ, Rothstein G. Impaired expression of hematopoietic growth factors: a candidate mechanism for the hematopoietic defect of aging. Exp Gerontol 1996;31:135-144.
37. Provinciali M, Argentati K, Tibaldi A. Efficacy of cancer gene therapy in aging: adenocarcinoma cells engineered to release IL-2 are rejected but do not induce tumor specific immune memory in old mice. Gene Ther 2000;7:624-632.
38. Alberti S, Cevenini E, Ostan R, Capri M, Salvioli S, Bucci L, Ginaldi L, De Martinis M, Franceschi C, Monti D. Age-dependent modifications of Type 1 and Type 2 cytokines within virgin and memory CD4+ T cells in humans. Mech Ageing Dev 2006;27:560-566.
39. Wakikawa A, Utsuyama M, Wakabayashi A, Kitagawa M, Hirokawa K. Age-related alteration of cytokine production profile by T cell subsets in mice: a flow cytometric study. Exp Gerontol 1999;34:231-242.
40. Plackett TP, Schilling EM, Faunce DE, Choudhry MA, Witte PL, Kovacs EJ. Aging enhances lymphocyte cytokine defects after injury. FASEB J 2003;17:688-689.
41. Donnini A, Re F, Bollettini M, Moresi F, Tesei S, Bernardini G, Provinciali M. Age-related susceptibility of naive and memory CD4 T cells to apoptosis induced by IL-2 deprivation or PHA addition. Biogerontol 2005;6:193-204.
42. Argentati K, Re F, Donnini A, Tucci MG, Franceschi C, Bartozzi B, Bernardini G, Provinciali M. Numerical and functional alterations of circulating gammadelta T lymphocytes in aged people and centenarians. J Leukoc Biol 2002;72:65-71.
43. Donnini A, Argentati K, Mancini R, Smorlesi A, Bartozzi B, Bernardini G, Provinciali M. Phenotype, antigen-presenting capacity, and migration of antigen-presenting cells in young and old age. Exp Gerontol 2002;37:1097-1112.