메뉴 건너뛰기




Volumn , Issue , 2008, Pages 369-383

Allopregnanolone and pregnenolone alterations following pharmacological agents in rodents and clinic populations

Author keywords

allopregnanolone; antidepressant; antipsychotic; mood stabilizer; Neuroactive steroid; neurosteroid; pregnenolone

Indexed keywords


EID: 67849131091     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-1-4020-6854-6_18     Document Type: Chapter
Times cited : (2)

References (106)
  • 1
    • 0025987983 scopus 로고
    • Anxiolytic activity of the progesterone metabolite 5α-pregnan- 3α-ol-20-one
    • Wieland S, Lan NC, Mirasedeghi S, et al. Anxiolytic activity of the progesterone metabolite 5α-pregnan-3α-ol-20-one. Brain Res 1991;565:263-268.
    • (1991) Brain Res , vol.565 , pp. 263-268
    • Wieland, S.1    Lan, N.C.2    Mirasedeghi, S.3
  • 2
    • 0028932249 scopus 로고
    • The neurosteroid, 3α-hydroxy-5α-pregnan-20-one, protects against bicuculline-induced seizures during ethanol withdrawal in rats
    • Devaud LL, Purdy RH, Morrow AL. The neurosteroid, 3α-hydroxy- 5α-pregnan-20-one, protects against bicuculline-induced seizures during ethanol withdrawal in rats. Alcohol Clin Exp Res 1995;19:350-355.
    • (1995) Alcohol Clin Exp Res , vol.19 , pp. 350-355
    • Devaud, L.L.1    Purdy, R.H.2    Morrow, A.L.3
  • 3
    • 0030472538 scopus 로고    scopus 로고
    • Neuroactive steroids protect against pilocarpine- and kainic acid-induced limbic seizures and status epilepticus in mice
    • Kokate TG, Cohen AL, Karp E, et al. Neuroactive steroids protect against pilocarpine- and kainic acid-induced limbic seizures and status epilepticus in mice. Neuropharmacology 1996;35:1049-1056.
    • (1996) Neuropharmacology , vol.35 , pp. 1049-1056
    • Kokate, T.G.1    Cohen, A.L.2    Karp, E.3
  • 4
    • 0037452699 scopus 로고    scopus 로고
    • In socially isolated mice, the reversal of brain allopregnanolone down-regulation mediates the anti-aggressive action of fluoxetine
    • Pinna G, Dong E, Matsumoto K, et al. In socially isolated mice, the reversal of brain allopregnanolone down-regulation mediates the anti-aggressive action of fluoxetine. Proc Natl Acad Sci USA 2003;100:2035-2040.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 2035-2040
    • Pinna, G.1    Dong, E.2    Matsumoto, K.3
  • 5
    • 0029970863 scopus 로고    scopus 로고
    • Fluoxetine-elicited changes in brain neurosteroid content measured by negative ion mass fragmentography
    • Uzunov DP, Cooper TB, Costa E, et al. Fluoxetine-elicited changes in brain neurosteroid content measured by negative ion mass fragmentography. Proc Natl Acad Sci USA 1996;93:12599-12604.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 12599-12604
    • Uzunov, D.P.1    Cooper, T.B.2    Costa, E.3
  • 6
    • 0032539862 scopus 로고    scopus 로고
    • Increase in the cerebrospinal fluid content of neurosteroids in patients with unipolar major depression who are receiving fluoxetine or fluvoxamine
    • Uzunova V, Sheline Y, Davis JM, et al. Increase in the cerebrospinal fluid content of neurosteroids in patients with unipolar major depression who are receiving fluoxetine or fluvoxamine. Proc Natl Acad Sci USA 1998;95:3239-3244.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 3239-3244
    • Uzunova, V.1    Sheline, Y.2    Davis, J.M.3
  • 7
    • 0033672097 scopus 로고    scopus 로고
    • Antidepressant-like effect of the neurosteroid 3á-hydroxy- 5á-pregnan-20-one in mice forced swim test
    • Khisti RT, Chopde CT, Jain SP. Antidepressant-like effect of the neurosteroid 3á-hydroxy-5á-pregnan-20-one in mice forced swim test. Pharmacol Biochem Behav 2000;67:137-143.
    • (2000) Pharmacol Biochem Behav , vol.67 , pp. 137-143
    • Khisti, R.T.1    Chopde, C.T.2    Jain, S.P.3
  • 8
    • 0034844443 scopus 로고    scopus 로고
    • Clozapine, but not haloperidol, increases brain concentrations of neuroactive steroids in the rat
    • Barbaccia ML, Affricano D, Purdy RH, et al. Clozapine, but not haloperidol, increases brain concentrations of neuroactive steroids in the rat. Neuropsychopharmacology 2001;25:489-497.
    • (2001) Neuropsychopharmacology , vol.25 , pp. 489-497
    • Barbaccia, M.L.1    Affricano, D.2    Purdy, R.H.3
  • 9
    • 0034212307 scopus 로고    scopus 로고
    • Olanzapine increases allopregnanolone in the rat cerebral cortex
    • Marx CE, Duncan GE, Gilmore JH, et al. Olanzapine increases allopregnanolone in the rat cerebral cortex. Biol Psychiatry 2000;47:1000-1004.
    • (2000) Biol Psychiatry , vol.47 , pp. 1000-1004
    • Marx, C.E.1    Duncan, G.E.2    Gilmore, J.H.3
  • 10
    • 0037208990 scopus 로고    scopus 로고
    • Olanzapine and clozapine increase the GABAergic neuroactive steroid allopregnanolone in rodents
    • Marx CE, Van Doren MJ, Duncan GE, et al. Olanzapine and clozapine increase the GABAergic neuroactive steroid allopregnanolone in rodents. Neuropsychopharmacology 2003;28:1-13.
    • (2003) Neuropsychopharmacology , vol.28 , pp. 1-13
    • Marx, C.E.1    Van Doren, M.J.2    Duncan, G.E.3
  • 11
    • 34447639040 scopus 로고    scopus 로고
    • Olanzapine and fluoxetine administration and coadministration increase rat hippocampal pregnenolone, allopregnanolone and peripheral deoxycorticosterone: Implications for therapeutic actions
    • Marx CE, Shampine LJ, Khisti RT, et al. Olanzapine and fluoxetine administration and coadministration increase rat hippocampal pregnenolone, allopregnanolone and peripheral deoxycorticosterone: implications for therapeutic actions. Pharmacol Biochem Behav 2006;84:609-617.
    • (2006) Pharmacol Biochem Behav , vol.84 , pp. 609-617
    • Marx, C.E.1    Shampine, L.J.2    Khisti, R.T.3
  • 12
    • 0041405983 scopus 로고    scopus 로고
    • Progesterone and its derivatives dihydroprogesterone and tetrahydroprogesterone reduce myelin fiber morphological abnormalities and myelin fiber loss in the sciatic nerve of aged rats
    • Azcoitia I, Leonelli E, Magnaghi V, et al. Progesterone and its derivatives dihydroprogesterone and tetrahydroprogesterone reduce myelin fiber morphological abnormalities and myelin fiber loss in the sciatic nerve of aged rats. Neurobiol Aging 2003;24:853-860.
    • (2003) Neurobiol Aging , vol.24 , pp. 853-860
    • Azcoitia, I.1    Leonelli, E.2    Magnaghi, V.3
  • 13
    • 0041730324 scopus 로고    scopus 로고
    • Progesterone and its metabolites increase myelin basic protein expression in organotypic slice cultures of rat cerebellum
    • Ghoumari AM, Ibanez C, El-Etr M, et al. Progesterone and its metabolites increase myelin basic protein expression in organotypic slice cultures of rat cerebellum. J Neurochem 2003;86:848-859.
    • (2003) J Neurochem , vol.86 , pp. 848-859
    • Ghoumari, A.M.1    Ibanez, C.2    El-Etr, M.3
  • 14
    • 18644371723 scopus 로고    scopus 로고
    • The neurosteroid allopregnanolone promotes proliferation of rodent and human neural progenitor cells and regulates cell-cycle gene and protein expression
    • Wang JM, Johnston PB, Ball BG, et al. The neurosteroid allopregnanolone promotes proliferation of rodent and human neural progenitor cells and regulates cell-cycle gene and protein expression. J Neurosci 2005;25:4706-4718.
    • (2005) J Neurosci , vol.25 , pp. 4706-4718
    • Wang, J.M.1    Johnston, P.B.2    Ball, B.G.3
  • 15
    • 3142774112 scopus 로고    scopus 로고
    • Niemann-Pick type C disease involves disrupted neurosteroidogenesis and responds to allopregnanolone
    • Griffin LD, Gong W, Verot L, et al. Niemann-Pick type C disease involves disrupted neurosteroidogenesis and responds to allopregnanolone. Nat Med 2004;10:704-711.
    • (2004) Nat Med , vol.10 , pp. 704-711
    • Griffin, L.D.1    Gong, W.2    Verot, L.3
  • 16
    • 0026542895 scopus 로고
    • Memory-enhancing effects in male mice of pregnenolone and steroids metabolically derived from it
    • Flood JF, Morley JE, Roberts E. Memory-enhancing effects in male mice of pregnenolone and steroids metabolically derived from it. Proc Natl Acad Sci USA 1992;89:1567-1571.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 1567-1571
    • Flood, J.F.1    Morley, J.E.2    Roberts, E.3
  • 17
    • 0028853687 scopus 로고
    • Pregnenolone sulfate enhances post-training memory processes when injected in very low doses into limbic system structures: The amygdala is by far the most sensitive
    • Flood JF, Morley JE, Roberts E. Pregnenolone sulfate enhances post-training memory processes when injected in very low doses into limbic system structures: the amygdala is by far the most sensitive. Proc Natl Acad Sci USA 1995;92:10806-10810.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 10806-10810
    • Flood, J.F.1    Morley, J.E.2    Roberts, E.3
  • 18
    • 13144279291 scopus 로고    scopus 로고
    • Neurosteroids: Deficient cognitive performance in aged rats depends on low pregnenolone sulfate levels in the hippocampus
    • Vallee M, Mayo W, Darnaudery M, et al. Neurosteroids: deficient cognitive performance in aged rats depends on low pregnenolone sulfate levels in the hippocampus. Proc Natl Acad Sci USA 1997;94:14865-14870.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 14865-14870
    • Vallee, M.1    Mayo, W.2    Darnaudery, M.3
  • 19
    • 0035923595 scopus 로고    scopus 로고
    • The synthetic enantiomer of pregnenolone sulfate is very active on memory in rats and mice, even more so than its physiological neurosteroid counterpart: Distinct mechanisms?
    • Akwa Y, Ladurelle N, Covey DF, et al. The synthetic enantiomer of pregnenolone sulfate is very active on memory in rats and mice, even more so than its physiological neurosteroid counterpart: distinct mechanisms? Proc Natl Acad Sci USA 2001;98:14033-14037.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 14033-14037
    • Akwa, Y.1    Ladurelle, N.2    Covey, D.F.3
  • 20
    • 33645230194 scopus 로고    scopus 로고
    • Microtubule-associated protein 2 (MAP2) is a neurosteroid receptor
    • Fontaine-Lenoir V, Chambraud B, Fellous A, et al. Microtubule-associated protein 2 (MAP2) is a neurosteroid receptor. Proc Natl Acad Sci USA 2006;103:4711-4716.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 4711-4716
    • Fontaine-Lenoir, V.1    Chambraud, B.2    Fellous, A.3
  • 21
    • 31444453266 scopus 로고    scopus 로고
    • Pregnenolone stabilizes microtubules and promotes zebrafish embryonic cell movement
    • Hsu HJ, Liang MR, Chen CT, et al. Pregnenolone stabilizes microtubules and promotes zebrafish embryonic cell movement. Nature 2006;439:480-483.
    • (2006) Nature , vol.439 , pp. 480-483
    • Hsu, H.J.1    Liang, M.R.2    Chen, C.T.3
  • 22
    • 0034784651 scopus 로고    scopus 로고
    • Opposite effects of short-versus long-term administration of fluoxetine on the concentrations of neuroactive steroids in rat plasma and brain
    • Serra M, Pisu MG, Muggironi M, et al. Opposite effects of short-versus long-term administration of fluoxetine on the concentrations of neuroactive steroids in rat plasma and brain. Psychopharmacology 2001;158:48-54.
    • (2001) Psychopharmacology , vol.158 , pp. 48-54
    • Serra, M.1    Pisu, M.G.2    Muggironi, M.3
  • 23
    • 35848966767 scopus 로고    scopus 로고
    • Clozapine markedly elevates pregnenolone in rat hippocampus, cerebral cortex, and serum: Candidate mechanism for superior efficacy?
    • Marx CE, Shampine LJ, Duncan GE, et al. Clozapine markedly elevates pregnenolone in rat hippocampus, cerebral cortex, and serum: candidate mechanism for superior efficacy? Pharmacol Biochem Behav 2006;84:598-608.
    • (2006) Pharmacol Biochem Behav , vol.84 , pp. 598-608
    • Marx, C.E.1    Shampine, L.J.2    Duncan, G.E.3
  • 24
    • 0027971029 scopus 로고
    • Pregnenolone and pregnenolone sulfate, alone and with ethanol, in mice on the plus-maze
    • Melchior CL, Ritzmann RF. Pregnenolone and pregnenolone sulfate, alone and with ethanol, in mice on the plus-maze. Pharmacol Biochem Behav 1994;48:893-897.
    • (1994) Pharmacol Biochem Behav , vol.48 , pp. 893-897
    • Melchior, C.L.1    Ritzmann, R.F.2
  • 25
    • 0033860968 scopus 로고    scopus 로고
    • Dehydroepiandrosterone sulfate is neuroprotective in a reversible spinal cord ischemia model: Possible involvement of GABAA receptors
    • Lapchak PA, Chapman DF, Nunez SY, et al. Dehydroepiandrosterone sulfate is neuroprotective in a reversible spinal cord ischemia model: possible involvement of GABAA receptors. Stroke 2000;31:1953-1956.
    • (2000) Stroke , vol.31 , pp. 1953-1956
    • Lapchak, P.A.1    Chapman, D.F.2    Nunez, S.Y.3
  • 26
    • 0036126449 scopus 로고    scopus 로고
    • Cellular basis for progesterone neuroprotection in the injured spinal cord
    • Labombarda F, Gonzalez SL, Gonzalez DM, et al. Cellular basis for progesterone neuroprotection in the injured spinal cord. J Neurotrauma 2002;19:343-355.
    • (2002) J Neurotrauma , vol.19 , pp. 343-355
    • Labombarda, F.1    Gonzalez, S.L.2    Gonzalez, D.M.3
  • 27
    • 12544255204 scopus 로고    scopus 로고
    • The neurosteroids progesterone and allopregnanolone reduce cell death, gliosis, and functional deficits after traumatic brain injury in rats
    • Djebaili M, Guo Q, Pettus EH, et al. The neurosteroids progesterone and allopregnanolone reduce cell death, gliosis, and functional deficits after traumatic brain injury in rats. J Neurotrauma 2005;22:106-118.
    • (2005) J Neurotrauma , vol.22 , pp. 106-118
    • Djebaili, M.1    Guo, Q.2    Pettus, E.H.3
  • 28
    • 10044248596 scopus 로고    scopus 로고
    • Pregnenolone sulfate enhances neurogenesis and PSANCAM in young and aged hippocampus
    • Mayo W, Lemaire V, Malaterre J, et al. Pregnenolone sulfate enhances neurogenesis and PSANCAM in young and aged hippocampus. Neurobiol Aging 2005;26:103-114.
    • (2005) Neurobiol Aging , vol.26 , pp. 103-114
    • Mayo, W.1    Lemaire, V.2    Malaterre, J.3
  • 29
    • 33645857366 scopus 로고    scopus 로고
    • Preclinical analyses of the therapeutic potential of allopregnanolone to promote neurogenesis in vitro and in vivo in transgenic mouse model of Alzheimer's disease
    • Brinton RD, Wang JM. Preclinical analyses of the therapeutic potential of allopregnanolone to promote neurogenesis in vitro and in vivo in transgenic mouse model of Alzheimer's disease. Curr Alzheimer Res 2006;3:11-17.
    • (2006) Curr Alzheimer Res , vol.3 , pp. 11-17
    • Brinton, R.D.1    Wang, J.M.2
  • 30
    • 2642677680 scopus 로고    scopus 로고
    • Effects of antidepressant treatment on neuroactive steroids in major depression
    • Romeo E, Strohle A, Spalletta G, et al. Effects of antidepressant treatment on neuroactive steroids in major depression. Am J Psychiatry 1998;155:910-913.
    • (1998) Am J Psychiatry , vol.155 , pp. 910-913
    • Romeo, E.1    Strohle, A.2    Spalletta, G.3
  • 31
    • 33745650483 scopus 로고    scopus 로고
    • Neuroactive steroids are altered in schizophrenia and bipolar disorder: Relevance to pathophysiology and therapeutics
    • Marx CE, Stevens RD, Shampine LJ, et al. Neuroactive steroids are altered in schizophrenia and bipolar disorder: relevance to pathophysiology and therapeutics. Neuropsychopharmacology 2006;31:1249-1263.
    • (2006) Neuropsychopharmacology , vol.31 , pp. 1249-1263
    • Marx, C.E.1    Stevens, R.D.2    Shampine, L.J.3
  • 32
    • 33847216593 scopus 로고    scopus 로고
    • Differences in blood pregnenolone and dehydroepiandrosterone levels between schizophrenia patients and healthy subjects
    • Ritsner M, Maayan R, Gibel A, et al. Differences in blood pregnenolone and dehydroepiandrosterone levels between schizophrenia patients and healthy subjects. Eur Neuropsychopharmacol 2007;17:358-365.
    • (2007) Eur Neuropsychopharmacol , vol.17 , pp. 358-365
    • Ritsner, M.1    Maayan, R.2    Gibel, A.3
  • 33
    • 0034039055 scopus 로고    scopus 로고
    • Allopregnanolone and dehydroepiandrosterone response to corticotropin-releasing factor in patients suffering from Alzheimer's disease and vascular dementia
    • Bernardi F, Lanzone A, Cento RM, et al. Allopregnanolone and dehydroepiandrosterone response to corticotropin-releasing factor in patients suffering from Alzheimer's disease and vascular dementia. Eur J Endocrinol 2000;142:466-471.
    • (2000) Eur J Endocrinol , vol.142 , pp. 466-471
    • Bernardi, F.1    Lanzone, A.2    Cento, R.M.3
  • 34
    • 33744497811 scopus 로고    scopus 로고
    • 3α, 5α-THP: A potential plasma neurosteroid biomarker in Alzheimer's disease and perhaps non-Alzheimer's dementia
    • Smith CD, Wekstein DR, Markesbery WR, et al. 3α, 5α-THP: a potential plasma neurosteroid biomarker in Alzheimer's disease and perhaps non-Alzheimer's dementia. Psychopharmacology 2006;186:481-485.
    • (2006) Psychopharmacology , vol.186 , pp. 481-485
    • Smith, C.D.1    Wekstein, D.R.2    Markesbery, W.R.3
  • 35
    • 33751539032 scopus 로고    scopus 로고
    • The neurosteroid allopregnanolone is reduced in prefrontal cortex in Alzheimer's disease
    • Marx CE, Trost WT, Shampine LJ, et al. The neurosteroid allopregnanolone is reduced in prefrontal cortex in Alzheimer's disease. Biol Psychiatry 2006;60:1287-1294.
    • (2006) Biol Psychiatry , vol.60 , pp. 1287-1294
    • Marx, C.E.1    Trost, W.T.2    Shampine, L.J.3
  • 36
    • 0033626831 scopus 로고    scopus 로고
    • A - Antagonistic neurosteroids in patients with combat-related post-traumatic stress disorder
    • A - antagonistic neurosteroids in patients with combat-related post-traumatic stress disorder. Psychol Med 2000;30:1227-1231.
    • (2000) Psychol Med , vol.30 , pp. 1227-1231
    • Spivak, B.1    Maayan, R.2    Kotler, M.3
  • 37
    • 33748901641 scopus 로고    scopus 로고
    • Decreased cerebrospinal fluid allopregnanolone levels in women with posttraumatic stress disorder
    • Rasmusson AM, Pinna G, Paliwal P, et al. Decreased cerebrospinal fluid allopregnanolone levels in women with posttraumatic stress disorder. Biol Psychiatry 2006;60:704-713.
    • (2006) Biol Psychiatry , vol.60 , pp. 704-713
    • Rasmusson, A.M.1    Pinna, G.2    Paliwal, P.3
  • 38
    • 0035145064 scopus 로고    scopus 로고
    • Plasma levels of neuroactive steroids are increased in untreated women with anorexia nervosa or bulimia nervosa
    • Monteleone P, Luisi M, Colurcio B, et al. Plasma levels of neuroactive steroids are increased in untreated women with anorexia nervosa or bulimia nervosa. Psychosom Med 2001;63:62-68.
    • (2001) Psychosom Med , vol.63 , pp. 62-68
    • Monteleone, P.1    Luisi, M.2    Colurcio, B.3
  • 39
    • 0035701427 scopus 로고    scopus 로고
    • Analysis of neurosteroid levels in attention deficit hyperactivity disorder
    • Strous RD, Spivak B, Yoran-Hegesh R, et al. Analysis of neurosteroid levels in attention deficit hyperactivity disorder. Int J Neuropsychopharmacol 2001;4:259-264.
    • (2001) Int J Neuropsychopharmacol , vol.4 , pp. 259-264
    • Strous, R.D.1    Spivak, B.2    Yoran-Hegesh, R.3
  • 40
    • 0036357699 scopus 로고    scopus 로고
    • A receptor-modulating neuroactive steroid composition in patients with panic disorder before and during paroxetine treatment
    • A receptor-modulating neuroactive steroid composition in patients with panic disorder before and during paroxetine treatment. Am J Psychiatry 2002;159:145-147.
    • (2002) Am J Psychiatry , vol.159 , pp. 145-147
    • Strohle, A.1    Romeo, E.2    Di Michele, F.3
  • 41
    • 0022483382 scopus 로고
    • Steroid hormone metabolites are barbituratelike modulators of the GABA receptor
    • Majewska MD, Harrison NL, Schwartz RD, et al. Steroid hormone metabolites are barbituratelike modulators of the GABA receptor. Science 1986;232:1004-1007.
    • (1986) Science , vol.232 , pp. 1004-1007
    • Majewska, M.D.1    Harrison, N.L.2    Schwartz, R.D.3
  • 43
  • 44
  • 45
    • 0023548049 scopus 로고
    • Steroid hormone metabolites potentiate GABA receptormediated chloride ion flux with nanomolar potency
    • Morrow AL, Suzdak PD, Paul SM. Steroid hormone metabolites potentiate GABA receptormediated chloride ion flux with nanomolar potency. Eur J Pharmacol 1987;142:483-485.
    • (1987) Eur J Pharmacol , vol.142 , pp. 483-485
    • Morrow, A.L.1    Suzdak, P.D.2    Paul, S.M.3
  • 47
    • 0023940075 scopus 로고
    • Neurosteroid pregnenolone sulfate antagonizes electrophysiological responses to GABA in neurons
    • Majewska MD, Mienville JM, Vicini S. Neurosteroid pregnenolone sulfate antagonizes electrophysiological responses to GABA in neurons. Neurosci Lett 1988;90:279-284.
    • (1988) Neurosci Lett , vol.90 , pp. 279-284
    • Majewska, M.D.1    Mienville, J.M.2    Vicini, S.3
  • 49
    • 0032562092 scopus 로고    scopus 로고
    • Modulation of gaba-gated chloride ion influx in the brain by dehydroepiandrosterone and its metabolites
    • Imamura M, Prasad C. Modulation of gaba-gated chloride ion influx in the brain by dehydroepiandrosterone and its metabolites. Biochem Biophys Res Commun 1998;243:771-775.
    • (1998) Biochem Biophys Res Commun , vol.243 , pp. 771-775
    • Imamura, M.1    Prasad, C.2
  • 50
    • 0025995802 scopus 로고
    • Pregnenolone sulfate: A positive allosteric modulator at the N-methyl-D-aspartate receptor
    • Wu FS, Gibbs TT, Farb DH. Pregnenolone sulfate: a positive allosteric modulator at the N-methyl-D-aspartate receptor. Mol Pharmacol 1991;40:333-336.
    • (1991) Mol Pharmacol , vol.40 , pp. 333-336
    • Wu, F.S.1    Gibbs, T.T.2    Farb, D.H.3
  • 51
    • 0032516063 scopus 로고    scopus 로고
    • Dehydroepiandrosterone: A potential signalling molecule for neocortical organization during development
    • Compagnone NA, Mellon SH. Dehydroepiandrosterone: a potential signalling molecule for neocortical organization during development. Proc Natl Acad Sci USA 1998;95:4678-4683.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 4678-4683
    • Compagnone, N.A.1    Mellon, S.H.2
  • 52
    • 18144374519 scopus 로고    scopus 로고
    • 3H]ifenprodil to the N-methyl-d-aspartate receptor in rat frontal cortex membrane
    • 3H]ifenprodil to the N-methyl-d-aspartate receptor in rat frontal cortex membrane. J Steroid Biochem Mol Biol 2005;94:263-266.
    • (2005) J Steroid Biochem Mol Biol , vol.94 , pp. 263-266
    • Johansson, T.1    Le Greves, P.2
  • 54
    • 0029926722 scopus 로고    scopus 로고
    • Antidepressants and hypothalamic-pituitary-adrenocortical regulation
    • Holsboer F, Barden N. Antidepressants and hypothalamic-pituitary- adrenocortical regulation. Endocr Rev 1996;17:187-205.
    • (1996) Endocr Rev , vol.17 , pp. 187-205
    • Holsboer, F.1    Barden, N.2
  • 55
    • 0027990941 scopus 로고
    • The neurosteroid tetrahydroprogesterone counteracts corticotropin- releasing hormone-induced anxiety and alters the release and gene expression of corticotropin-releasing hormone in the rat hypothalamus
    • Patchev VK, Shoaib M, Holsboer F, et al. The neurosteroid tetrahydroprogesterone counteracts corticotropin-releasing hormone-induced anxiety and alters the release and gene expression of corticotropin-releasing hormone in the rat hypothalamus. Neuroscience 1994;62:265-271.
    • (1994) Neuroscience , vol.62 , pp. 265-271
    • Patchev, V.K.1    Shoaib, M.2    Holsboer, F.3
  • 56
    • 0028927039 scopus 로고
    • Evidence for a role of neurosteroids in modulation of diurnal changes and acute stress-induced corticosterone secretion in rats
    • Guo AL, Petraglia F, Criscuolo M, et al. Evidence for a role of neurosteroids in modulation of diurnal changes and acute stress-induced corticosterone secretion in rats. Gynecol Endocrinol 1995;9:1-7.
    • (1995) Gynecol Endocrinol , vol.9 , pp. 1-7
    • Guo, A.L.1    Petraglia, F.2    Criscuolo, M.3
  • 57
    • 0029552745 scopus 로고
    • Neuroactive steroid modulators of the stress response
    • Morrow AL, Devaud LL, Purdy RH, et al. Neuroactive steroid modulators of the stress response. Ann NY Acad Sci 1995;771:257-272.
    • (1995) Ann NY Acad Sci , vol.771 , pp. 257-272
    • Morrow, A.L.1    Devaud, L.L.2    Purdy, R.H.3
  • 58
    • 0030560881 scopus 로고    scopus 로고
    • The neurosteroid tetrahydroprogesterone attenuates the endocrine response to stress and exerts glucocorticoid-like effects on vasopressin gene transcription in the rat hypothalamus
    • Patchev VK, Hassan AH, Holsboer DF, et al. The neurosteroid tetrahydroprogesterone attenuates the endocrine response to stress and exerts glucocorticoid-like effects on vasopressin gene transcription in the rat hypothalamus. Neuropsychopharmacology 1996;15:533-540.
    • (1996) Neuropsychopharmacology , vol.15 , pp. 533-540
    • Patchev, V.K.1    Hassan, A.H.2    Holsboer, D.F.3
  • 59
    • 33744504184 scopus 로고    scopus 로고
    • Fluoxetine and norfluoxetine stereospecifically and selectively increase brain neurosteroid content at doses that are inactive on 5-HT reuptake
    • Pinna G, Costa E, Guidotti A. Fluoxetine and norfluoxetine stereospecifically and selectively increase brain neurosteroid content at doses that are inactive on 5-HT reuptake. Psychopharmacology 2006;186:362-372.
    • (2006) Psychopharmacology , vol.186 , pp. 362-372
    • Pinna, G.1    Costa, E.2    Guidotti, A.3
  • 60
    • 0035986376 scopus 로고    scopus 로고
    • Prevention of the stress-induced increase in the concentration of neuroactive steroids in rat brain by long-term administration of mirtazapine but not of fluoxetine
    • Serra M, Pisul MG, Dazzi L, et al. Prevention of the stress-induced increase in the concentration of neuroactive steroids in rat brain by long-term administration of mirtazapine but not of fluoxetine. J Psychopharmacol 2002;16:133-138.
    • (2002) J Psychopharmacol , vol.16 , pp. 133-138
    • Serra, M.1    Pisul, M.G.2    Dazzi, L.3
  • 61
    • 0042884347 scopus 로고    scopus 로고
    • Brain neurosteroid changes after paroxetine administration in mice
    • Nechmad A, Maayan R, Spivak B, et al. Brain neurosteroid changes after paroxetine administration in mice. Eur Neuropsychopharmacol 2003;13:327-332.
    • (2003) Eur Neuropsychopharmacol , vol.13 , pp. 327-332
    • Nechmad, A.1    Maayan, R.2    Spivak, B.3
  • 62
    • 17044444204 scopus 로고    scopus 로고
    • Concentrations of 3α-reduced neuroactive steroids and their precursors in plasma of patients with major depression and after clinical recovery
    • Strohle A, Romeo E, Hermann B, et al. Concentrations of 3α-reduced neuroactive steroids and their precursors in plasma of patients with major depression and after clinical recovery. Biol Psychiatry 1999;45:274-277.
    • (1999) Biol Psychiatry , vol.45 , pp. 274-277
    • Strohle, A.1    Romeo, E.2    Hermann, B.3
  • 63
    • 33644624254 scopus 로고    scopus 로고
    • Influence of mirtazapine on plasma concentrations of neuroactive steroids in major depression and on 3α-hydroxysteroid dehydrogenase activity
    • Schule C, Romeo E, Uzunov DP, et al. Influence of mirtazapine on plasma concentrations of neuroactive steroids in major depression and on 3α-hydroxysteroid dehydrogenase activity. Mol Psychiatry 2006;11:261-272.
    • (2006) Mol Psychiatry , vol.11 , pp. 261-272
    • Schule, C.1    Romeo, E.2    Uzunov, D.P.3
  • 64
    • 22144480217 scopus 로고    scopus 로고
    • Plasma concentrations of anxiolytic neuroactive steroids in men with panic disorder
    • Brambilla F, Mellado C, Alciati A, et al. Plasma concentrations of anxiolytic neuroactive steroids in men with panic disorder. Psychiatry Res 2005;135:185-190.
    • (2005) Psychiatry Res , vol.135 , pp. 185-190
    • Brambilla, F.1    Mellado, C.2    Alciati, A.3
  • 65
    • 0028234068 scopus 로고
    • CSF neuroactive steroids in affective disorders: Pregnenolone, progesterone, and DBI
    • George MS, Guidotti A, Rubinow D, et al. CSF neuroactive steroids in affective disorders: pregnenolone, progesterone, and DBI. Biol Psychiatry 1994;35:775-780.
    • (1994) Biol Psychiatry , vol.35 , pp. 775-780
    • George, M.S.1    Guidotti, A.2    Rubinow, D.3
  • 66
    • 1642430891 scopus 로고    scopus 로고
    • Chronic pregnenolone effects in normal humans: Attenuation of benzodiazepine-induced sedation
    • Meieran SE, Reus VI, Webster R, et al. Chronic pregnenolone effects in normal humans: attenuation of benzodiazepine-induced sedation. Psychoneuroendocrinology 2004;29:486-500.
    • (2004) Psychoneuroendocrinology , vol.29 , pp. 486-500
    • Meieran, S.E.1    Reus, V.I.2    Webster, R.3
  • 67
    • 0025882098 scopus 로고
    • Stress-induced elevations of γ-aminobutyric acid type A receptor-active steroids in the rat brain
    • Purdy RH, Morrow AL, Moore PH, Jr., et al. Stress-induced elevations of γ-aminobutyric acid type A receptor-active steroids in the rat brain. Proc Natl Acad Sci USA 1991;88:4553-4557.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 4553-4557
    • Purdy, R.H.1    Morrow, A.L.2    Moore Jr., P.H.3
  • 68
    • 0034884258 scopus 로고    scopus 로고
    • Effects of CRH and ACTH administration on plasma and brain neurosteroid levels
    • Torres JM, Ruiz E, Ortega E. Effects of CRH and ACTH administration on plasma and brain neurosteroid levels. Neurochem Res 2001;26:555-558.
    • (2001) Neurochem Res , vol.26 , pp. 555-558
    • Torres, J.M.1    Ruiz, E.2    Ortega, E.3
  • 69
    • 0038128413 scopus 로고    scopus 로고
    • DHEA, PREG and their sulphate derivatives on plasma and brain after CRH and ACTH administration
    • Torres JM, Ortega E. DHEA, PREG and their sulphate derivatives on plasma and brain after CRH and ACTH administration. Neurochem Res 2003;28:1187-1191.
    • (2003) Neurochem Res , vol.28 , pp. 1187-1191
    • Torres, J.M.1    Ortega, E.2
  • 70
    • 0034933967 scopus 로고    scopus 로고
    • Reduction in basal afternoon plasma ACTH during early treatment of depression with fluoxetine
    • Inder WJ, Prickett TC, Mulder RT, et al. Reduction in basal afternoon plasma ACTH during early treatment of depression with fluoxetine. Psychopharmacology 2001;156:73-78.
    • (2001) Psychopharmacology , vol.156 , pp. 73-78
    • Inder, W.J.1    Prickett, T.C.2    Mulder, R.T.3
  • 71
    • 33746390104 scopus 로고    scopus 로고
    • Alterations in stress reactivity after long-term treatment with paroxetine in women with posttraumatic stress disorder
    • Vermetten E, Vythilingam M, Schmahl C, et al. Alterations in stress reactivity after long-term treatment with paroxetine in women with posttraumatic stress disorder. Ann NY Acad Sci 2006;1071:184-202.
    • (2006) Ann NY Acad Sci , vol.1071 , pp. 184-202
    • Vermetten, E.1    Vythilingam, M.2    Schmahl, C.3
  • 72
    • 77956688556 scopus 로고    scopus 로고
    • Atypical antipsychotic drugs and stress
    • Steckler T, Kalin NH, Reul JMHM eds, Philadelphia, PA: Elsevier
    • Marx CE, Grobin AC, Deutch AY, et al. Atypical antipsychotic drugs and stress. In: Steckler T, Kalin NH, Reul JMHM (eds). Handbook of stress and the brain, Vol. 15. Philadelphia, PA: Elsevier, 2005, pp. 301-313.
    • (2005) Handbook of Stress and the Brain , vol.15 , pp. 301-313
    • Marx, C.E.1    Grobin, A.C.2    Deutch, A.Y.3
  • 73
    • 4344702377 scopus 로고    scopus 로고
    • Role of neuroactive steroid allopregnanolone in antipsychoticlike action of olanzapine in rodents
    • Ugale RR, Hirani K, Morelli M, et al. Role of neuroactive steroid allopregnanolone in antipsychoticlike action of olanzapine in rodents. Neuropsychopharmacology 2004;29:1597-1609.
    • (2004) Neuropsychopharmacology , vol.29 , pp. 1597-1609
    • Ugale, R.R.1    Hirani, K.2    Morelli, M.3
  • 74
    • 3242723179 scopus 로고    scopus 로고
    • Long-term treatment with clozapine does not affect morning circulating levels of allopregnanolone and THDOC in patients with schizophrenia: A preliminary study
    • Monteleone P, Fabrazzo M, Serra M, et al. Long-term treatment with clozapine does not affect morning circulating levels of allopregnanolone and THDOC in patients with schizophrenia: a preliminary study. J Clin Psychopharmacol 2004;24:437-440.
    • (2004) J Clin Psychopharmacol , vol.24 , pp. 437-440
    • Monteleone, P.1    Fabrazzo, M.2    Serra, M.3
  • 75
    • 0037212021 scopus 로고    scopus 로고
    • Clozapine decreases rat brain dehydroepiandrosterone and dehydroepiandrosterone sulfate levels
    • Nechmad A, Maayan R, Ramadan E, et al. Clozapine decreases rat brain dehydroepiandrosterone and dehydroepiandrosterone sulfate levels. Eur Neuropsychopharmacol 2003;13:29-31.
    • (2003) Eur Neuropsychopharmacol , vol.13 , pp. 29-31
    • Nechmad, A.1    Maayan, R.2    Ramadan, E.3
  • 76
    • 0020517481 scopus 로고
    • Specific and potent interactions of carbamazepine with brain adenosine receptors
    • Marangos PJ, Post RM, Patel J, et al. Specific and potent interactions of carbamazepine with brain adenosine receptors. Eur J Pharmacol 1983;93:175-182.
    • (1983) Eur J Pharmacol , vol.93 , pp. 175-182
    • Marangos, P.J.1    Post, R.M.2    Patel, J.3
  • 77
    • 0021807531 scopus 로고
    • Differential mediation of the anticonvulsant effects of carbamazepine and diazepam
    • Weiss SR, Post RM, Patel J, et al. Differential mediation of the anticonvulsant effects of carbamazepine and diazepam. Life Sci 1985;36:2413-2419.
    • (1985) Life Sci , vol.36 , pp. 2413-2419
    • Weiss, S.R.1    Post, R.M.2    Patel, J.3
  • 78
    • 0024853180 scopus 로고
    • Mitochondrial benzodiazepine receptors regulate steroid biosynthesis
    • Mukhin AG, Papadopoulos V, Costa E, et al. Mitochondrial benzodiazepine receptors regulate steroid biosynthesis. Proc Natl Acad Sci USA 1989;86:9813-9816.
    • (1989) Proc Natl Acad Sci USA , vol.86 , pp. 9813-9816
    • Mukhin, A.G.1    Papadopoulos, V.2    Costa, E.3
  • 79
    • 0025254066 scopus 로고
    • The peripheral-type benzodiazepine receptor is functionally linked to Leydig cell steroidogenesis
    • Papadopoulos V, Mukhin AG, Costa E, et al. The peripheral-type benzodiazepine receptor is functionally linked to Leydig cell steroidogenesis. J Biol Chem 1990;265:3772-3779.
    • (1990) J Biol Chem , vol.265 , pp. 3772-3779
    • Papadopoulos, V.1    Mukhin, A.G.2    Costa, E.3
  • 80
    • 0033884102 scopus 로고    scopus 로고
    • Steroidogenesis in rat brain induced by short- and longterm administration of carbamazepine
    • Serra M, Littera M, Pisu MG, et al. Steroidogenesis in rat brain induced by short- and longterm administration of carbamazepine. Neuropharmacology 2000;39:2448-2456.
    • (2000) Neuropharmacology , vol.39 , pp. 2448-2456
    • Serra, M.1    Littera, M.2    Pisu, M.G.3
  • 81
    • 0033665055 scopus 로고    scopus 로고
    • Effects of some centrally active drugs on the allopregnanolone synthesis in rat brain
    • Jaworska-Feil L, Budziszewska B, Leskiewicz M, et al. Effects of some centrally active drugs on the allopregnanolone synthesis in rat brain. Pol J Pharmacol 2000;52:359-365.
    • (2000) Pol J Pharmacol , vol.52 , pp. 359-365
    • Jaworska-Feil, L.1    Budziszewska, B.2    Leskiewicz, M.3
  • 82
    • 0033539661 scopus 로고    scopus 로고
    • Selective serotonin reuptake inhibitors directly alter activity of neurosteroidogenic enzymes
    • Griffin LD, Mellon SH. Selective serotonin reuptake inhibitors directly alter activity of neurosteroidogenic enzymes. Proc Natl Acad Sci USA 1999;96:13512-13517.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 13512-13517
    • Griffin, L.D.1    Mellon, S.H.2
  • 83
    • 0037069355 scopus 로고    scopus 로고
    • Kinetics of allopregnanolone formation catalyzed by human 3α-hydroxysteroid dehydrogenase type III (AKR1C2)
    • Trauger JW, Jiang A, Stearns BA, et al. Kinetics of allopregnanolone formation catalyzed by human 3α-hydroxysteroid dehydrogenase type III (AKR1C2). Biochemistry 2002;41:13451-13459.
    • (2002) Biochemistry , vol.41 , pp. 13451-13459
    • Trauger, J.W.1    Jiang, A.2    Stearns, B.A.3
  • 84
    • 1942443197 scopus 로고    scopus 로고
    • Chronic lithium treatment affects rat brain and serum dehydroepiandrosterone (DHEA) and DHEA-sulphate (DHEA-S) levels
    • Maayan R, Shaltiel G, Poyurovsky M, et al. Chronic lithium treatment affects rat brain and serum dehydroepiandrosterone (DHEA) and DHEA-sulphate (DHEA-S) levels. Int J Neuropsychopharmacol 2004;7:71-75.
    • (2004) Int J Neuropsychopharmacol , vol.7 , pp. 71-75
    • Maayan, R.1    Shaltiel, G.2    Poyurovsky, M.3
  • 85
    • 84891991972 scopus 로고    scopus 로고
    • Neuroactive steroids, mood stabilizers, and neuroplasticity: Alterations following lithium and changes in Bcl-2 knockout mice
    • Marx CE, Yuan P, Shampine LJ, et al. Neuroactive steroids, mood stabilizers, and neuroplasticity: alterations following lithium and changes in Bcl-2 knockout mice. Biol Psychiatry 2005;57:205S.
    • (2005) Biol Psychiatry , vol.57
    • Marx, C.E.1    Yuan, P.2    Shampine, L.J.3
  • 86
    • 33750915455 scopus 로고    scopus 로고
    • Differential effects of antiepileptic drugs on neuroactive steroids in men with epilepsy
    • Herzog AG, Drislane FW, Schomer DL, et al. Differential effects of antiepileptic drugs on neuroactive steroids in men with epilepsy. Epilepsia 2006;47:1945-1948.
    • (2006) Epilepsia , vol.47 , pp. 1945-1948
    • Herzog, A.G.1    Drislane, F.W.2    Schomer, D.L.3
  • 87
    • 0032856246 scopus 로고    scopus 로고
    • Clinical outcome in a randomized 1-year trial of clozapine versus treatment as usual for patients with treatment-resistant illness and a history of mania
    • Suppes T, Webb A, Paul B, et al. Clinical outcome in a randomized 1-year trial of clozapine versus treatment as usual for patients with treatment-resistant illness and a history of mania. Am J Psychiatry 1999;156:1164-1169.
    • (1999) Am J Psychiatry , vol.156 , pp. 1164-1169
    • Suppes, T.1    Webb, A.2    Paul, B.3
  • 88
    • 0033863937 scopus 로고    scopus 로고
    • Efficacy of olanzapine in acute bipolar mania: A double-blind, placebo-controlled study
    • Tohen M, Jacobs TG, Grundy SL, et al. Efficacy of olanzapine in acute bipolar mania: a double-blind, placebo-controlled study. Arch Gen Psychiatry 2000;57:841-849.
    • (2000) Arch Gen Psychiatry , vol.57 , pp. 841-849
    • Tohen, M.1    Jacobs, T.G.2    Grundy, S.L.3
  • 89
    • 33746891173 scopus 로고    scopus 로고
    • Increased neuroactive steroid concentrations in women with bipolar disorder or major depressive disorder
    • Hardoy MC, Serra M, Carta MG, et al. Increased neuroactive steroid concentrations in women with bipolar disorder or major depressive disorder. J Clin Psychopharmacol 2006;26:379-384.
    • (2006) J Clin Psychopharmacol , vol.26 , pp. 379-384
    • Hardoy, M.C.1    Serra, M.2    Carta, M.G.3
  • 90
    • 0346418309 scopus 로고
    • Effects of administered pregnenolone on fatiguing psychomotor performance
    • Pincus G, Hoagland H. Effects of administered pregnenolone on fatiguing psychomotor performance. J Aviation Med 1944;15:98-115.
    • (1944) J Aviation Med , vol.15 , pp. 98-115
    • Pincus, G.1    Hoagland, H.2
  • 91
    • 67449162526 scopus 로고
    • Effects of delta 5 pregnenolone in rheumatoid arthritis
    • Davison R, Koets P, Snow WG, et al. Effects of delta 5 pregnenolone in rheumatoid arthritis. Arch Intern Med 1950;85:365-389.
    • (1950) Arch Intern Med , vol.85 , pp. 365-389
    • Davison, R.1    Koets, P.2    Snow, W.G.3
  • 93
    • 33744456750 scopus 로고    scopus 로고
    • Pharmacokinetic and behavioral effects of allopregnanolone in healthy women
    • Timby E, Balgard M, Nyberg S, et al. Pharmacokinetic and behavioral effects of allopregnanolone in healthy women. Psychopharmacology 2006;186:414-424.
    • (2006) Psychopharmacology , vol.186 , pp. 414-424
    • Timby, E.1    Balgard, M.2    Nyberg, S.3
  • 94
    • 34249021356 scopus 로고    scopus 로고
    • Effects of allopregnanolone on sedation in men, and in women on oral contraceptives
    • Van Broekhoven F, Backstrom T, Van Luijtelaar G, et al. Effects of allopregnanolone on sedation in men, and in women on oral contraceptives. Psychoneuroendocrinology 2007;32:555-564.
    • (2007) Psychoneuroendocrinology , vol.32 , pp. 555-564
    • Van Broekhoven, F.1    Backstrom, T.2    Van Luijtelaar, G.3
  • 95
    • 0141957322 scopus 로고    scopus 로고
    • Vaginal administration of allopregnanolone to postmenopausal women undergoing estrogen replacement therapy: Preliminary results
    • Navarro PA, Kaddouz D, De Ziegler D, et al. Vaginal administration of allopregnanolone to postmenopausal women undergoing estrogen replacement therapy: preliminary results. Maturitas 2003;46:147-152.
    • (2003) Maturitas , vol.46 , pp. 147-152
    • Navarro, P.A.1    Kaddouz, D.2    De Ziegler, D.3
  • 96
    • 0018246104 scopus 로고
    • Alphaxolone-alphadolone anaesthesia in laboratory animals
    • Green CJ, Halsey MJ, Precious S, et al. Alphaxolone-alphadolone anaesthesia in laboratory animals. Lab Anim 1978;12:85-89.
    • (1978) Lab Anim , vol.12 , pp. 85-89
    • Green, C.J.1    Halsey, M.J.2    Precious, S.3
  • 97
    • 0035032016 scopus 로고    scopus 로고
    • Antinociceptive properties of neurosteroids III: Experiments with alphadolone given intravenously, intraperitoneally, and intragastrically
    • Nadeson R, Goodchild CS. Antinociceptive properties of neurosteroids III: experiments with alphadolone given intravenously, intraperitoneally, and intragastrically. Br J Anaesth 2001;86:704-708.
    • (2001) Br J Anaesth , vol.86 , pp. 704-708
    • Nadeson, R.1    Goodchild, C.S.2
  • 98
    • 0018115136 scopus 로고
    • Adverse response to alphadolone/alphaxalone: Possible role of IgD
    • Watkins J, Allen R, Ward AM. Adverse response to alphadolone/alphaxalone: possible role of IgD. Lancet 1978;2:736.
    • (1978) Lancet , vol.2 , pp. 736
    • Watkins, J.1    Allen, R.2    Ward, A.M.3
  • 100
    • 0034101871 scopus 로고    scopus 로고
    • Acute and chronic effects of the synthetic neuroactive steroid, ganaxolone, against the convulsive and lethal effects of pentylenetetrazol in seizure-kindled mice: Comparison with diazepam and valproate
    • Gasior M, Ungard JT, Beekman M, et al. Acute and chronic effects of the synthetic neuroactive steroid, ganaxolone, against the convulsive and lethal effects of pentylenetetrazol in seizure-kindled mice: comparison with diazepam and valproate. Neuropharmacology 2000;39:1184-1196.
    • (2000) Neuropharmacology , vol.39 , pp. 1184-1196
    • Gasior, M.1    Ungard, J.T.2    Beekman, M.3
  • 101
    • 3042816099 scopus 로고    scopus 로고
    • A receptors protect against partial seizures induced by 6-Hz electrical stimulation in mice
    • A receptors protect against partial seizures induced by 6-Hz electrical stimulation in mice. Epilepsia 2004;45:864-867.
    • (2004) Epilepsia , vol.45 , pp. 864-867
    • Kaminski, R.M.1    Livingood, M.R.2    Rogawski, M.A.3
  • 102
    • 33846194013 scopus 로고    scopus 로고
    • Progress report on new antiepileptic drugs: A summary of the Eigth Eilat Conference (EILAT VIII)
    • Bialer M, Johannessen SI, Kupferberg HJ, et al. Progress report on new antiepileptic drugs: a summary of the Eigth Eilat Conference (EILAT VIII). Epilepsy Res 2007;73:1-52.
    • (2007) Epilepsy Res , vol.73 , pp. 1-52
    • Bialer, M.1    Johannessen, S.I.2    Kupferberg, H.J.3
  • 103
    • 0033714804 scopus 로고    scopus 로고
    • Chronic treatment with the neuroactive steroid ganaxolone in the rat induces anticonvulsant tolerance to diazepam but not to itself
    • Reddy DS, Rogawski MA. Chronic treatment with the neuroactive steroid ganaxolone in the rat induces anticonvulsant tolerance to diazepam but not to itself. J Pharmacol Exp Ther 2000;295:1241-1248.
    • (2000) J Pharmacol Exp Ther , vol.295 , pp. 1241-1248
    • Reddy, D.S.1    Rogawski, M.A.2
  • 104
    • 0030869099 scopus 로고    scopus 로고
    • Initial human experience with ganaxolone, a neuroactive steroid with antiepileptic activity
    • Monaghan EP, Navalta LA, Shum L, et al. Initial human experience with ganaxolone, a neuroactive steroid with antiepileptic activity. Epilepsia 1997;38:1026-1031.
    • (1997) Epilepsia , vol.38 , pp. 1026-1031
    • Monaghan, E.P.1    Navalta, L.A.2    Shum, L.3
  • 106
    • 0033759542 scopus 로고    scopus 로고
    • Ganaxolone for treating intractable infantile spasms: A multicenter, open-label, add-on trial
    • Kerrigan JF, Shields WD, Nelson TY, et al. Ganaxolone for treating intractable infantile spasms: a multicenter, open-label, add-on trial. Epilepsy Res 2000;42:133-139.
    • (2000) Epilepsy Res , vol.42 , pp. 133-139
    • Kerrigan, J.F.1    Shields, W.D.2    Nelson, T.Y.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.