Kinetics of allopregnanolone formation catalyzed by human 3α-hydroxysteroid dehydrogenase type III (AKR1C2)

Biochemistry

Volumn 41, Issue 45, 2002, Pages 13451-13459

  Trauger, John W ^a   Jiang, Alice ^a   Stearns, Brian A ^a   LoGrasso, Philip V ^a,b  

^a MERCK RESEARCH LABORATORIES   (United States)

^b Avera Pharmaceuticals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PHARMACOLOGY;

BIOSYNTHESIS; CATALYSIS; ENZYMES; PHYSIOLOGY; SUBSTRATES; THIN LAYER CHROMATOGRAPHY;

BIOCHEMISTRY;

3ALPHA HYDROXY 5ALPHA PREGNAN 20 ONE; 3ALPHA HYDROXYSTEROID DEHYDROGENASE; 4 AMINOBUTYRIC ACID A RECEPTOR; 5ALPHA PREGNANE 3,20 DIONE; BROMSULFOPHTHALEIN; CARBAMAZEPINE; CLOZAPINE; FLUOXETINE; FLURBIPROFEN; NEUROSTEROID; NICOTINAMIDE ADENINE DINUCLEOTIDE; NORFLUOXETINE; PAROXETINE; SERTRALINE; TETRAHYDROPROGESTERONE;

ANTICONVULSANT ACTIVITY; ARTICLE; CATALYSIS; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DISSOCIATION; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME SUBSTRATE COMPLEX; HUMAN; KINETICS; OXIDATION; PRIORITY JOURNAL; RADIOMETRY; REDUCTION; STEADY STATE; STEROIDOGENESIS; THIN LAYER CHROMATOGRAPHY; TRANQUILIZING ACTIVITY;

3-ALPHA-HYDROXYSTEROID DEHYDROGENASE (B-SPECIFIC); 3-HYDROXYSTEROID DEHYDROGENASES; 5-ALPHA-DIHYDROPROGESTERONE; CARBAMAZEPINE; CATALYSIS; CLOZAPINE; ENZYME ACTIVATION; ENZYME INHIBITORS; FLUOXETINE; FLURBIPROFEN; HUMANS; HYDROXYSTEROID DEHYDROGENASES; KINETICS; OXIDATION-REDUCTION; PREGNANEDIONES; PREGNANOLONE; RECOMBINANT FUSION PROTEINS; SEROTONIN UPTAKE INHIBITORS; SUBSTRATE SPECIFICITY; URSODEOXYCHOLIC ACID;

EID: 0037069355     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi026109w     Document Type: Article

References (49)

1. Paul, S. M., and Purdy, R. H. (1992) FASEB J. 6, 2311-2322.
2. Robel, P., and Baulieu, E. E. (1994) Trends Endocrin. Metab. 5, 1-8.
3. Majewska, M. D. (1992) Prog. Neurobiol. 38, 379-395.
4. Rupprecht, R., and Holsboer, F. (1999) Trends Neurosci. 22, 410-416.
5. Wang, M., Seippel, L., Purdy, R. H., and Backstrom, T. (1996) J. Clin. Endocrinol. Metab. 81, 1076-1082.
6. Bicikova, M., Dibbelt, L., Hill, M., Hampl, R., and Starka, L. (1998) Hormone Metab. Res. 30, 227-230.
7. Rapkin, A. J., Morgan, M., Goldman, L., Brann, D. W., Simone, D., and Mahesh, V. B. (1997) Obstet. Gynecol. 90, 709-714.
8. Monteleone, P., Luisi, S., Tonetti, A., Bernardi, F., Genazzani, A. D., Luisi, M., Petraglia, F., and Genzzani, A. R. (2000) Eur. J. Endocrinol. 142, 269-273.
9. Uzunova, V., Sheline, Y., Davis, J. M., Rasmusson, A., Uzunov, D. P., Costa, E., and Guidotti, A. (1998) Proc. Natl. Acad. Sci. U.S.A. 95, 3239-3244.
10. Ströhle, A., Romeo, E., Hermann, B., Pasini, A., Spalletta, G., di Michele, F., Holsboer, F., and Rupprecht, R. (1999) Biol. Psych. 45, 274-277.
11. Ströhle, A., Pasini, A., Romeo, E., Hermann, B., Spalletta, G., di Michele, F., Holsboer, F., and Rupprecht, R. (2000) J. Psychiatr. Res. 34, 183-186.
12. Steiner, M., Steinberg, S., Stewart, D., Carter, D., Berger, C., Reid, R., Grover, D., and Streiner, D. (1995) N. Engl. J. Med. 332, 1529-1534.
13. Su, T.-P., Schmidt, P. J., Danaceau, M. A., Tobin, M. B., Rosenstein, D. L., Murphy, D. L., and Rubinow, D. R. (1997) Neuropsychopharmacology 16, 346-356.
14. Uzunov, D. P., Cooper, T. B., Costa, E., and Guidotti, A. (1996) Proc. Natl. Acad. Sci. U.S.A. 93, 12599-12604.
15. Corpechot, C., Young, J., Calvel, M., Wehrey, C., Veltz, J. N., Touyer, G., Mouren, M., Prasad, V. V., Banner, C., Sjovall, J., et al. (1993) Endocrinology 133, 1003-1009.
16. Penning, T. M., Pawlowski, J. E., Schlegel, B. P., Jez, J. M., Lin, H.-K., Hoog, S. S., Bennet, M. J., and Lewis, M. (1996) Steroids 61, 508-523.
17. Burczynski, M. E., Harvey, R. G., and Penning, T. M. (1998) Biochemistry 37, 6781-6790.
18. Penning, T. M., Burczynski, M. E., Jez, J. M., Hung, C.-F., Lin, H.-K., Ma, H., Moore, M., Palackal, N., and Ratnam, K. (2000) Biochem. J. 351, 67-77.
19. Griffin, L. D., and Mellon, S. H. (1999) Proc. Natl. Acad. Sci. U.S.A. 96, 13512-13517.
20. Askonas, L. J., Ricigliano, J. W., and Penning, T. M. (1991) Biochem. J. 278, 835-841.
21. Deyashiki, Y., Tamada, Y., Miyabe, Y., Nakanishi, M., Matsuura, K., and Hara, A. (1995) J. Biochem. 118, 285-290.
22. Pongsawasdi, P., and Anderson, B. M. (1984) Biochim. Biophys. Acta 799, 51-58.
23. Hara, A., Inoue, Y., Nakagawa, M., Naganeo, F., and Sawada, H. (1988) J. Biochem. (Tokyo) 103, 1027-1034.
24. Matsuura, K., Tamada, Y., Deyashiki, Y., Miyabe, Y., Nakanishi, Y., Ohya, I., and Hara, A. (1996) Biochem. J. 313, 179-184.
25. Matsuura, K., Tamada, Y., Sato, K., Iwasa, H., Miwa, G., Deyashiki, Y., and Hara, A. (1997) Biochem. J. 322, 89-93.
26. Akamanchi, K. G., Patel, H. C., and Meenakshi, R. (1992) Synth. Commun. 22, 1655-1660.
27. Segal, I. H. (1975) Enzyme Kinetics, John Wiley & Sons, Inc., New York.
28. Cleland, W. W. (1979) Methods Enzymol. 63, 103-138.
29. Cleland, W. W. (1982) Methods Enzymol. 87, 159-179.
30. Fromm, H. J. (1979) Methods Enzymol. 63, 467-486.
31. Lin, H. K., Jez, J. M., Schlegel, B. P., Peehl, D. M., Pachter, J. A., and Penning, T. M. (1997) Mol. Endocrinol. 11, 1971-1984.
32. Deyashiki, Y., Ogasawara, A., Nakayama, T., Nakanishi, M., Miiyabe, Y., Sato, K., and Hara, A. (1994) Biochem. J. 299, 545- 552.
33. Ma, H., and Penning, T. M. (1999) Proc. Natl. Acad. Sci. U.S.A. 96, 11161-11166.
34. Jin, Y., Stayrook, S. E., Albert, R. H., Palackal, N. T., Penning, T. M., and Lewis, M. (2001) Biochemistry 40, 10161-10168.
35. Hoog, S. S., Pawlowski, J. E., Alzari, P. M., Penning, T. M., and Lewis, M. (1994) Proc. Natl. Acad. Sci. U.S.A. 91, 2517-2521.
36. Bennet, M. J., Schlegel, B. P., Jez, J. M., Penning, T. M., and Lewis, M. (1996) Biochemistry 35, 10702-10711.
37. Bennet, M. J., Albert, R. H., Jez, J. M., Ma, H., Penning, T. M., and Lewis, M. (1997) Structure 5, 799-812.
38. Nahoum, V., Gangloff, A., Legrand, P., Zhu, D.-W., Cantin, L., Zhorov, B. S., Luu-The, V., Labrie, F., Breton, R., and Lin, S.- X. (2001) J. Biol. Chem. 276, 42091-42098.
39. Cleland, W. W. (1982) Methods Enzymol. 87, 366-369.
40. Alberty, R. A. (2001) Arch. Biochem. Biophys. 389, 94-109.
41. Fersht, A. (1985) Enzyme Structure and Mechanism, W. H. Freeman and Co., New York.
42. Jez, J. M., and Penning, T. M. (1998) Biochemistry 37, 9695-9703.
43. Serra, M., Littera, M., Pisu, M. G., Muggironi, M., Purdy, R. H., and Biggio, G. (2000) Neuropharmacology 39, 2448-2456.
44. Barbaccia, M. L., Affricano, D., Purdy, R. H., Maciocco, E., Spiga, F., and Biggio, G. (2001) Neuropsychopharmacology 25, 489-497.
45. Penning, T. M., Mukharji, I., Barrows, S., and Talalay, P. (1984) Biochem. J. 222, 601-611.
46. Yamamoto, T., Matsuura, K., Shintani, S., Hara, A., Miyabe, Y., Sugiyama, T., Katagiri, Y. (1998) Biol. Pharm. Bull. 21, 1148- 1153.
47. Guidotti, A., Dong, E., Matsumoto, K., Pinna, G., Rasmusson, A. M., and Costa, E. (2001) Brain Res. Rev. 37, 110-115.
48. Monaghan, E. P., McAuley, J. W., and Data, J. L. (1999) Expert Opin. Invest. Drugs 8, 1663-1671.
49. Vanover, K. E. et al. (2000) J. Pharmacol. Exp. Ther. 295, 337-345.