Olanzapine and fluoxetine administration and coadministration increase rat hippocampal pregnenolone, allopregnanolone and peripheral deoxycorticosterone: Implications for therapeutic actions

Pharmacology Biochemistry and Behavior

Volumn 84, Issue 4, 2006, Pages 609-617

  Marx, Christine E ^a,b   Shampine, Lawrence J ^a,b   Khisti, Rahul T ^c   Trost, William T ^a,b   Bradford, Daniel W ^a,b   Grobin, A Chistina ^c   Massing, Mark W ^b   Madison, Roger D ^a,b   Butterfield, Marian I ^a,b   Lieberman, Jeffrey A ^d   Morrow, A Leslie ^c  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b DURHAM VA MEDICAL CENTER   (United States)

^c UNIVERSITY OF NORTH CAROLINA   (United States)

^d Columbia University College of Physicians and Surgeons ^*  (United States)

Author keywords

Allopregnanolone; Antipsychotic; Deoxycorticosterone; Fluoxetine; Neuroactive steroid; Neurosteroid; Olanzapine; Pregnenolone

Indexed keywords

3ALPHA HYDROXY 5ALPHA PREGNAN 20 ONE; DEOXYCORTICOSTERONE; FLUOXETINE; NEUROLEPTIC AGENT; OLANZAPINE; PREGNENOLONE; BENZODIAZEPINE DERIVATIVE; CORTICOSTERONE; DRUG DERIVATIVE; ELTANOLONE; SEROTONIN UPTAKE INHIBITOR; TETRAHYDRODEOXYCORTICOSTERONE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; GAS CHROMATOGRAPHY; HIPPOCAMPUS; MALE; MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; RADIOIMMUNOASSAY; RAT; RAT STRAIN; RODENT; ANIMAL; DRUG EFFECT; DRUG POTENTIATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS FRAGMENTOGRAPHY; METABOLISM; SPRAGUE DAWLEY RAT;

RATTUS; RODENTIA;

ANIMALS; ANTIPSYCHOTIC AGENTS; BENZODIAZEPINES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CORTICOSTERONE; DESOXYCORTICOSTERONE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; FLUOXETINE; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HIPPOCAMPUS; MALE; PREGNANOLONE; PREGNENOLONE; RADIOIMMUNOASSAY; RATS; RATS, SPRAGUE-DAWLEY; SEROTONIN UPTAKE INHIBITORS;

EID: 34447639040     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pbb.2006.07.032     Document Type: Article

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