Initial human experience with ganaxolone, a neuroactive steroid with antiepileptic activity

Epilepsia

Volumn 38, Issue 9, 1997, Pages 1026-1031

  Monaghan, Edward P ^a   Navalta, Laura A ^b   Shum, Linyee ^c   Ashbrook, Donald W ^d   Lee, David A ^a  

^a Department of Pharmacokinetics and Drug Metabolism   (United States)

^b BAXTER HEALTHCARE CORPORATION   (United States)

^c Quest Pharmaceutical Services   (United States)

^d Global Pharmaceutical Services   (United States)

Author keywords

Antiepileptic; Epalon; GABA agonist; Ganaxolone; Neurosteroid

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID RECEPTOR STIMULATING AGENT; GANAXOLONE; NEUROSTEROID; PROGESTERONE DERIVATIVE;

ADULT; AREA UNDER THE CURVE; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DIGESTIVE SYSTEM FUNCTION DISORDER; DOUBLE BLIND PROCEDURE; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG METABOLISM; DRUG SAFETY; DRUG TOLERABILITY; DRUG TOLERANCE; FEMALE; HEADACHE; HUMAN; HUMAN EXPERIMENT; MALAISE; MALE; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; SEIZURE; SOMNOLENCE; TRANQUILIZING ACTIVITY; VERTIGO;

ADMINISTRATION, ORAL; ADULT; ANTICONVULSANTS; AREA UNDER CURVE; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; DRUG ADMINISTRATION SCHEDULE; EXCIPIENTS; FEMALE; HUMANS; INTESTINAL ABSORPTION; MALE; PLACEBOS; PREGNANOLONE; RECEPTORS, GABA;

EID: 0030869099     PISSN: 00139580     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1528-1157.1997.tb01486.x     Document Type: Article

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