Acute and chronic effects of the synthetic neuroactive steroid, ganaxolone, against the convulsive and lethal effects of pentylenetetrazol in seizure-kindled mice: Comparison with diazepam and valproate

Neuropharmacology

Volumn 39, Issue 7, 2000, Pages 1184-1196

  Gasior, MacIej ^a   Ungard, Jesse T ^a   Beekman, Marjolein ^a,b   Carter, Richard B ^c   Witkin, Jeffrey M ^a  

^a Drug Development Group   (United States)

^b UNIVERSITY OF GRONINGEN   (Netherlands)

^c Department of Pharmacokinetics and Drug Metabolism   (United States)

Author keywords

Antiepileptic drugs; Behavioral effects; Convulsions; Epilepsy; Lethality; Locomotor activity

Indexed keywords

DIAZEPAM; GANAXOLONE; PENTETRAZOLE; STEROID; VALPROIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ARTICLE; CLONIC SEIZURE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; KINDLING; LETHALITY; LOCOMOTION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SEIZURE; STEREOTYPY; TONIC SEIZURE;

ANIMALS; ANTICONVULSANTS; CONVULSANTS; DIAZEPAM; DOSE-RESPONSE RELATIONSHIP, DRUG; KINDLING, NEUROLOGIC; MALE; MICE; MOTOR ACTIVITY; PENTYLENETETRAZOLE; PREGNANOLONE; SEIZURES; STEREOTYPIC MOVEMENT DISORDER; VALPROIC ACID;

EID: 0034101871     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(99)00190-2     Document Type: Article

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