Effects of antidepressant treatment on neuroactive steroids in major depression

American Journal of Psychiatry

Volumn 155, Issue 7, 1998, Pages 910-913

  Romeo, Elena ^b   Ströhle, Andreas ^b   Spalletta, Gianfranco ^b   Di Michele, Flavia ^b   Hermann, Bettina ^b   Holsboer, Florian ^b   Pasini, Augusto ^b   Rupprecht, Rainer ^a  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

3ALPHA HYDROXY 5ALPHA PREGNAN 20 ONE; 4 AMINOBUTYRIC ACID RECEPTOR; ANTIDEPRESSANT AGENT; FLUOXETINE;

ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEPRESSION; DRUG EFFECT; DRUG EFFICACY; GABAERGIC TRANSMISSION; HUMAN; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; NEUROTRANSMISSION; PRIORITY JOURNAL; PROGESTERONE SYNTHESIS;

EID: 2642677680     PISSN: 0002953X     EISSN: None     Source Type: Journal    
DOI: 10.1176/ajp.155.7.910     Document Type: Article

References (18)

1. Burke MJ, Preskorn SH: Short-term treatment of mood disorders with standard antidepressants, in Psychopharmacology: The Fourth Generation of Progress. Edited by Bloom F, Kupfer D. New York, Raven Press, 1995, pp 1053-1065
2. Holsboer F, Barden N: Antidepressams and hypothalamic-pituitary-adrenocortical regulation. Endocr Rev 1996; 17:187-205
3. Uzunov DP, Cooper TB, Costa E, Guidotti A: Fluoxetine-elicited changes in brain neurosreroid content measured by negative ion mass fragmentography. Proc Natl Acad Sci USA 1996; 93: 12599-12604
4. Majewska MD, Harrison ML, Schwanz RD, Barker JL, Paul SM: Steroid hormone metabolites are barbiturate-like modulators of the GABA receptor. Science 1986; 232:1004-1007
5. Paul SM, Purdy RH: Neuroactive steroids. FASEB J 1992; 6: 2311-2322
6. Rupprecht R: The neuropsychopharmacological potential of neuroactive steroids. J Psychiatr Res 1997; 31:297-314
7. Rupprecht R, Reul JMHM, Trapp T, van Steensel B, Wetzel C, Damm K, Zieglgänsberger W, Holsboer F: Progesterone receptor mediated effects of neuroactive steroids. Neuron 1993; 11: 523-530
8. Patchev VK, Shoaib M, Holsboer F, Almeida OFX: The neurosteroid tetrahydroprogesterone counteracts corticotropin-releasing hormone-induced anxiety and alters the release and gene expression of corticotropin-releasing hormone in the rat hypothalamus. Neuroscience 1994; 62:265-271
9. Romeo E, Cheney DL, Zivkovic I, Costa E, Guidotti A: Mitochondrial diazepam-binding inhibitor receptor complex agonists antagonize dizocilpine amnesia: putative role for allopregnanoione. J Pharmacol Exp Ther 1994; 270:89-96
10. Prince RJ, Simmonds MA: 5β-Pregnan-3β-ol-20-one, a specific antagonist at the neurosteroid site of the GABAA receptor complex. Neurosci Lett 1992; 135:273-275
11. Krause JE, Karavolas HJ: Pituitary 5α-dihydroprogesterone 3cthydroxysteroid oxidoreductases. J Biol Chem 1980; 255:11807-11814
12. Holsboer F, Spengler D, Heuser IJ: The role of corticotropm-releasing hormone in the pathogenesis of Cushing's disease, anorexia nervosa, alcoholism, affective disorders and dementia. Prog Brain Res 1992; 93:385-417
13. Nemeroff CB, Widerlöv E, Bisette G, Walleus H, Karlsson I, Eklund K, Kilts CD, Loosen PT, Vale W: Elevated concentrations of CSF corticotropin-releasing factor-like immunoreactivity in depressed patients. Science 1984; 226:1342-1343
14. A receptor modulators. Am J Physiol 1996; 271:E763-E772
15. Friess E, Tagaya H, Trachsel L, Holsboer F, Rupprecht R: Progesterone-induced changes in sleep in male subjects. Am J Physiol 1997; 272:E885-E891
16. George MS, Guidotri A, Rubinow D, Pan B, Mikalauskas K, Post RM: CSF neuroactive steroids in affective disorders: pregnenolone, progesterone, and DBL Biol Psychiatry 1994; 35: 775-730
17. Wang M, Seippel L, Purdy RH, Bäckström T: Relationship between symptom severity and steroid variation in women with premenstrual syndrome: study on serum pregnenolone, pregnenolone sulfate, 5a-pregnane-3, 20-dione and 3ot-hydroxy-5α-pregnan-20-one. J Clin Endocrinol Metab 1996; 81: 1076-1082
18. McCauley LD, Gee KW: Influence of the estrus cycle on the discrimination of apparent neuroactive steroid site subtypes on the y-aminobutyric acidA receptor complex in the rat, J Pharmacol Exp Ther 1995; 275:1412-1417