Prevention of the stress-induced increase in the concentration of neuroactive steroids in rat brain by long-term administration of mirtazapine but not of fluoxetine

Journal of Psychopharmacology

Volumn 16, Issue 2, 2002, Pages 133-138

  Serra, Mariangela ^a,b   Pisu, M Giuseppina ^a   Dazzi, Laura ^a,b   Purdy, Robert H ^c   Biggio, Giovanni ^a,b  

^a UNIVERSITY OF CAGLIARI   (Italy)

^b CNR   (Italy)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Fluoxetine; Mirtazapine; Neuroactive steroids; Rat; Stress

Indexed keywords

3ALPHA HYDROXY 5ALPHA PREGNAN 20 ONE; ANTIDEPRESSANT AGENT; FLUOXETINE; MIRTAZAPINE; SEROTONIN UPTAKE INHIBITOR; STEROID; TETRAHYDROCORTISONE; 4 AMINOBUTYRIC ACID A RECEPTOR; ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; DEOXYCORTICOSTERONE; DRUG DERIVATIVE; ELTANOLONE; MIANSERIN; TETRAHYDRODEOXYCORTICOSTERONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN CORTEX; CONTROLLED STUDY; LONG TERM EXPOSURE; MALE; NONHUMAN; PLASMA; PRIORITY JOURNAL; RAT; STRESS; ANIMAL; BLOOD; BRAIN LEVEL; DRUG EFFECT; ELECTRIC SHOCK; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MENTAL STRESS; METABOLISM; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

ADRENERGIC ALPHA-ANTAGONISTS; ANIMALS; ANTIDEPRESSIVE AGENTS, SECOND-GENERATION; BRAIN CHEMISTRY; CEREBRAL CORTEX; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DESOXYCORTICOSTERONE; ELECTROSHOCK; FLUOXETINE; MALE; MIANSERIN; PREGNANOLONE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GABA-A; STEROIDS; STRESS, PSYCHOLOGICAL;

EID: 0035986376     PISSN: 02698811     EISSN: None     Source Type: Journal    
DOI: 10.1177/026988110201600203     Document Type: Article

References (43)

1. 2 inhalation
2. A receptor function after acute stress
3. The effects of inhihitors of GABAergic transmission and stress on brain and plasma allopregnanolone concentrations
4. GABAergic and dopaminergic transmission in the rat cerebral cortex: Effect of stress, and anxiolytic and anxiogenic drugs
5. Depressed in-patients respond differently to imipramine and mirtazapine
6. Role for serotonin3 receptors in the control of adrenocorticotropic hormone release from rat pituitary cell cultures
7. Anatomical specificity of noradrenergic inputs to the paraventricular and supraoptic nuclei of the rat hypothalamus
8. Inhibition by the neurosteroid allopregnanolone of basal and stress-induced acetylcholine release in the brain of freely moving rats
9. Inhibition of stress- or anxiogenic-druginduced increases in dopamine release in the rat prefrontal cortex by long-term treatment with antidepressant drugs
10. Longterm treatment with antidepressant drugs reduces the sensitivity of cortical cholinergic neurons to the activating actions of stress and the anxiogenic drug FG 7142
11. Chronic treatment with imipramine or mirtazapine antagonizes stress- and FG 7142-induced increase in cortical norepinephrine output in freely moving rats
12. Differential effects of chronic antidepressant treatment on swim stress- and fluoxetine-induced secretion of corticosterone and progesterone
13. Mirtazapine: Other indications
14. A meta-analysis of eight randomized double-blind controlled clinical trials of mirtazapine for the treatment of patients with major depression and symptoms of anxiety
15. Effect of serotonin reuptake inhibitor fluoxetine on corticotropin-releasing factor and vasopressin secretion into hypophysial portal blood
16. Mirtazapine in major depression with comorbid generalized anxiety disorder
17. Selective serotonin reuptake inhibitors directly alter activity of neurosteroidogenic enzymes
18. The corticosteroid receptor hypothesis of depression
19. Microinjection of norepinephrine into the paraventricular nucleus of the hypothalamus stimulates corticotropin-releasing factor gene expression in conscious rats
20. 2A induces fos-ir in hypothalamic neurons and stimulates ACTH, corticosterone, oxytocin and renin release
21. Adrenocorticotropic hormone secretion in rats induced by stimulation with serotoninergic compounds
22. A receptor function
23. 2-adrenoceptors
24. 1A agonist, 8-OH-DPAT, in male rats
25. Protein measurement with the Folin phenol reagent
26. A receptor: Mechanism of action and physiological significance
27. Inhibition of basal and stress-induced dopamine release in the cerebral cortex and nucleus accumbens of freely moving rats by the neurosteroid allopregnanolone
28. Recurrent depression and stressful life events
29. Facilitation of immunoreactive corticotropinreleasing factor secretion into the hypophysial-portal circulation after activation of catecholaminergic pathways or central norepinephrine injection
30. Synthesis, metabolism and pharmacological activity of 3α-hydroxysteroids which potentiate GABA-receptor-mediated chloride ion uptake in rat cerebral cortical synaptoneurosomes
31. Stress induced elevation of γ-aminobutyric acid type A receptor-active steroids in the rat brain
32. i/o/z proteins
33. Effect of antidepressant treatment on neuroactive steroids in major depression
34. 2-Phenyl-imidazo[1,2-a]pyridine derivatives as ligands for peripheral benzodiazepine receptors: Stimulation of neurosteroid synthesis and anticonflict action in rats
35. Current concepts in the treatment of panic disorder
36. Fluoxetine in the treatment of premenstrual dysphoria
37. Mirtazapine: An antidepressant with noradrenergic and specific serotoninergic effects
38. Concentrations of 3α-reduced neuroactive steroids and their precursor in plasma of patients with major depression and after clinical recovery
39. Mirtazapine versus selective serotonin reuptake inhibitors
40. Increase in the cerebrospinal fluid content of neurosteroids in patients with unipolar major depression who are receiving fluoxetine or fluvoxamine
41. Fluoxetineelicited changes in brain neurosteroid content measured by negative ion mass fragmentography
42. Serotonin-influencing drugs in the treatment of panic disorder
43. Long-term fluoxetine produces behavioural anxiolytic effects without inhibiting neuroendocrine responses to conditioned stress in rats