Cellular basis for progesterone neuroprotection in the injured spinal cord

Journal of Neurotrauma

Volumn 19, Issue 3, 2002, Pages 343-355

  Labombarda, Florencia ^a   Gonzalez, Susana L ^a   Gonzalez Deniselle, Maria Claudia ^a   Guennoun, Rachida ^b   Schumacher, Michael ^b   De Nicola, Alejandro F ^a,c  

^a INST DE BIOL Y MED EXPERIMENTAL   (Argentina)

^b INSERM   (France)

^c Argentina   (Argentina)

Author keywords

Choline acetyltransferase; GAP 43; Na, k ATPase; Neuroprotection; Progesterone; Spinal cord injury

Indexed keywords

ACETYLCHOLINE; ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); CHOLINE ACETYLTRANSFERASE; GROWTH ASSOCIATED PROTEIN; MESSENGER RNA; PROGESTERONE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CATALYSIS; CELL FUNCTION; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; HISTOGRAM; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; ION TRANSPORT; MALE; MEMBRANE POTENTIAL; MOTONEURON; NERVE CELL; NEUROPROTECTION; NONHUMAN; NUTRIENT; PERIPHERAL NERVOUS SYSTEM; RAT; SPINAL CORD INJURY; SPINAL CORD TRANSSECTION; SPINAL CORD VENTRAL HORN;

ANIMALS; CHOLINE O-ACETYLTRANSFERASE; GAP-43 PROTEIN; IN SITU HYBRIDIZATION; MALE; MODELS, ANIMAL; NA(+)-K(+)-EXCHANGING ATPASE; NEUROPROTECTIVE AGENTS; PROGESTERONE; RATS; RATS, SPRAGUE-DAWLEY; RECOVERY OF FUNCTION; SPINAL CORD; SPINAL CORD INJURIES;

EID: 0036126449     PISSN: 08977151     EISSN: None     Source Type: Journal    
DOI: 10.1089/089771502753594918     Document Type: Article

References (61)

1. Methylprednisolone inhibits early inflammatory processes but not ischemic cell death after experimental spinal cord lesion in the rat
2. GAP-43: An intrinsic determinant of neuronal development and plasticity
3. Spinal neurons and synapses
4. The expression of growth-associated proein GAP-43 mRNA in the rat hippocampus in response to adrenalectomy and aging
5. Neuroprotective effects of progesterone after transient middle cerebral artery occlusion in rat
6. Methylprednidolone administration improves axonal regeneration into Schwann cell grafts in transected adult rat thoracic spinal cord
7. The distribution of GAP-43 in the normal spinal cord
8. Up-regulation of GAP-43 and growth of axons in rat spinal cord after compression
9. Steroid hormones and neuronal regeneration
10. Regulation of the human Na/K-ATPase β1 gene promoter by mineralocorticiod and glucocorticoid receptors
11. Progesterone stimulates the activity of the promoters of peripheral myelin protein-22 and protein zero genes in Schwann cells
12. Increased neurosteroid synthesis after brain and spinal cord injury in rats
13. 3H-corticosterone in the rat spinal cord
14. Transsynaptic degeneration of motoneurons caudal to spinal cord lesions
15. Involvement of insulin-like growth factors I and II and their receptors in medroxyprogesterone acetated-induced growth of mouse mammary adenocarcinomas
16. Effect of proximal axotomy on GAP-43 expression in cortical neurons in the mouse
17. Aldosterone selectively increases Na/K ATPase α3-subunit mRNA expression in rat hippocampus
18. Immunocytochemical localization of glucocorticoid receptors in the spinal cord: Effects of adrenalectomy, glucocorticoid treatment, and spinal cord transection
19. Estradiol abolishes autologous down-regulation of glucocorticoid receptors in brain
20. Ciliary neurotrophic factor receptor in spinal motoneurons is regulated by gonadal hormones
21. Dexamethasone up-regulates mRNA for Na, K-ATPase in some spinal cord neurons after cord transection
22. Glucocorticoid regulation of motoneuronal parameters in rats with spinal cord injury
23. Evidence for down-regulation of GAP-43 mRNA in Wobbler mouse spinal motoneurons by corticosterone and a 21-aminosteroid
24. Aldosterone up-regulates mRNA for the α3 and β1 isoforms of (Na, K)-ATPase in several brain regions from adrenalectomized rats
25. Key role for pregnenolone in combination therapy promotes recovery after spinal cord injury
26. The neuroprotective pharmacology of methylprednisolone
27. Neuroprotective actions of glucocorticoid and non-glucocorticoid steroids in acute neuronal injury
28. Increase in α-CGRP and GAP-43 in aged motoneurons: A study of peptides, growth factors, and ChAT mRNA in the lumbar spinal cord of senescent rats with symptoms of hindlimb incapacities
29. Gonadal steroids as promoting factors in axonal regeneration
30. Progesterone synthesis and myelin formation by Schwann cells
31. Differential regulation of motor neuron survival and choline acetyltransferase expression following axotomy
32. Modulation of NADPH-diaphorase and glial fibrillary acidic protein by progesterone in astrocytes from normal and injured rat spinal cord
33. Immunocytochemical evidence for a progesterone receptor in neurons and glial cells of the rat spinal cord
34. Convergence of progesterone and epidermal growth factor signaling in breast cancer. Potentation of mitogen-activated protein kinase pathways
35. Inhibition of sodium-potassium-ATPase: A potencial ubiquitous mechanism contributing to central nervous system neurophatology
36. Differential expression of GAP-43 mRNA in adult central cholinergic neuronal populations
37. Is synaptic transmission modulated by progesterone?
38. Transient decrease of acetylcholinesterase in ventral horn neurons caudal to a low thoracic spinal cord hemisection in the adult rat
39. B-50, the growth associated protein-43: Modulation of cell morphology and communication in the nervous system
40. Steroid hormones protect spinal cord neurons from glutamate toxicity
41. The adrenal cortex. Diseases of the adrenal cortex
42. Long-term effects of methylprednisolone following transection of adult rat spinal cord
43. Progesterone maintains large rat granulosa cell viability by stimulating small granulosa cells to synthesize basic fibroblast growth factor
44. Posttranscriptional regulation of GAP-43 gene expression in PC12 cells through protein kinase C-dependent stabilization of the mRNA
45. Axotomy induces a different modulation of both low-affinity nerve growth factor receptor and choline acetyltransferase between adult rat spinal brainsterm neurons
46. Progesterone facilitates cognitive recovery and reduces secondary neuronal loss caused by cortical contusion injury in male rats
47. Progesterone protects against lipid peroxidation following traumatic brain injury in rats
48. Gender differences in acute CNS trauma and stroke: Neuroprotective effects and progesterone
49. Expression of cytochrome PROG50 side-chain cleavage enzyme and 3β-hydroxysteroid dehydrogenase in the rat central nervous system: A study by polymerase chain reaction and in situ hybridization
50. GAP-43 (B-50) and c-Jun are up-regulated in axotomized neurons of Clarke's nucleus after spinal cord injury in the adult rat
51. The Na, K-ATPase of nervous tissue
52. Progesterone and recovery after traumatic brain injury: An overview
53. Cytoarchitecture of the rat spinal cord
54. Progesterone is neuroprotective after acute experimental spinal cord trauma in rats
55. Nuclear receptors, transcriptional regulation, and oncogenesis
56. +-ATPase α and β subunit isoform within the central nervous system
57. Nerve growth factor receptor is associated with colinergic neurons of the basal forebrain but not the pontomesencephalon
58. The biological responses of axotomized adult motoneurons to brain-derived neurotrophic factor
59. Survival of motoneurons following axotomy is enhanced by lactation or by progesterone treatment
60. Structural determinants of DNA-binding specificity by steroid receptor