The influence of brain inflammation upon neuronal adenosine A2B receptors

Journal of Neurochemistry

Volumn 86, Issue 1, 2003, Pages 220-227

  Rosi, Susanna ^a   McGann, Kristin ^a   Hauss Wegrzyniak, Beatrice ^a   Wenk, Gary L ^a,b  

^a UNIVERSITY OF ARIZONA   (United States)

^b UNIVERSITY OF ARIZONA   (United States)

Author keywords

Alzheimer's disease; Anti inflammatory; Lipopolysaccharide; Microglia; Rats

Indexed keywords

ADENOSINE A2B RECEPTOR; CYCLIC AMP; FLURBIPROFEN 4 NITROXYBUTYL ESTER; LIPOPOLYSACCHARIDE; N SEC BUTYL 1 (2 CHLOROPHENYL) N METHYL 3 ISOQUINOLINECARBOXAMIDE; NITRIC OXIDE; NONSTEROID ANTIINFLAMMATORY AGENT;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BRAIN FOURTH VENTRICLE; CONTROLLED STUDY; CYTOKINE RELEASE; DRUG TOLERABILITY; ENCEPHALITIS; IMMUNOREACTIVITY; MALE; MICROGLIA; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RECEPTOR DOWN REGULATION; SECOND MESSENGER;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CHRONIC DISEASE; DISEASE MODELS, ANIMAL; ENCEPHALITIS; FLURBIPROFEN; IMMUNOHISTOCHEMISTRY; LIPOPOLYSACCHARIDES; MALE; MICROGLIA; NEURONS; NITRIC OXIDE DONORS; RATS; RATS, INBRED F344; RECEPTOR, ADENOSINE A2B; RECEPTORS, PURINERGIC P1; SECOND MESSENGER SYSTEMS;

ANIMALIA;

EID: 0038308448     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2003.01825.x     Document Type: Article

References (43)

1. Adanin S., Yalovetskiy I. V., Nardulli B. A., Sam A. D., Jonjev Z. S. and Law W. R. (2002) Inhibiting adenosine deaminase modulates the systemic inflammatory response syndrome in endotoxemia and sepsis. Am. J. Physiol. 282, R1324-R1332.
2. Akiyama H., Barger S., Bamum S., Bradt B., Bauer J., Cooper N. R., Eikelenboom P., Emmerling M., Fiebich B., Finch C. E., Frautschy S., Griffin W. S. T., Hampel H., Landreth G., McGeer P. L., Mrak R., MacKenzie I., O'Banion K., Pachter J., Pasinetti G., Plata-Salaman C., Rogers J., Rydel R., Shen Y., Streit W., Strohmeyer R., Tooyoma I., Van Muiswinkel F. L., Veerhuis R., Walker D., Webster S., Wegrzyniak B., Wenk G. and Wyss-Coray A. (2000) Inflammation in Alzheimer's disease. Neurobiol. Aging 21, 383-421.
3. Aldini G., Carini M., Orioli M., Facino R. M. and Wenk G. L. (2002) Metabolic profile of NO-flurbiprofen (HCT1026) in rat brain and plasma: a LC-MS study. Life Sci. 71, 1487-1500.
4. Benton H. P., MacDonald M. H. and Tesch A. M. (2002) Effects of adenosine on bacterial lipopolysaccharide- and interleukin 1-induced nitric oxide release from equine articular chondrocytes. Am. J. Vet. Res. 63, 204-210.
5. Benveniste E. N., Tang L. P. and Law R. M. (1995) Differential regulation of astrocyte TNF-α expression by the cytokines TGF-β, IL-6 and IL-10. Int. J. Dev Neuroscience 13, 341-349.
6. Bouma M. G., Stad R. K., van den Wildenberg F. A. and Buurman W. A. (1994) Differential regulatory effects of adenosine on cytokine release by activated human monocytes. J. Immunol. 153, 4159-4168.
7. Cagnin A., Brooks D. J., Kennedy A. M., Gunn R. N., Myers R. and Turkheimer F. E. (2001) In vivo measurement of activated microglia in dementia. Lancet 358, 461-467.
8. 2B adenosine receptor in Chinese hamster ovary cells. J. Pharm. Pharmacol. 53, 1153-1156.
9. Cronstein B. N. (1994) Adenosine, an endogenous anti-inflammatory agent. J. Appl. Physiol. 76, 5-13.
10. Cronstein B. N., Bouma M. G. and Becker B. F. (1996) Purinergic mechanisms in inflammation. Drug Devel. Res. 39, 426-435.
11. Dixon A. K., Gubitz A. K., Sirinathsinghji D. J., Richardson P. J. and Freeman T. C. (1996) Tissue distribution of adenosine receptor mRNAs in the rat. Br. J. Pharmacol. 118, 1461-1468.
12. Eigler A., Greten T. F., Sinha B., Haslberger C., Sullivan G. W. and Endres S. (1997) Endogenous adenosine curtails lipopolysaccharide-stimulated tumour necrosis factor synthesis. Scan. J. Immunol. 45, 132-139.
13. 2B receptors. Pharmacol. Rev. 49, 381-402.
14. 2b receptors mediate an increase in interleukin (IL)-6 mRNA and IL-6 protein synthesis in human astroglioma cells. J. Neurochem. 66, 1426-1431.
15. Fiebich B. L., Biber K., Lieb K., van Calker D., Berger M., Bauer J. and Gebicke-Haerter P. J. (1996b) Cyclooxygenase-2 expression in rat microglia is induced by adenosine A2a-receptors. Glia 18, 152-160.
16. Fredholm B. B., Arslan G., Halldner L., Kull B., Schulte G. and Wasserman W. (2000) Structure and function of adenosine receptors and their genes. Naunyn-Schmied. Arch. Pharmacol. 362, 364-374.
17. Hauss-Wegrzyniak B., Dobrzanski P., Stoehr J. D. and Wenk G. L. (1998a) Chronic neuroinflammation in rats reproduces components of the neurobiology of Alzheimer's disease. Brain Res. 780, 294-303.
18. Hauss-Wegrzyniak B., Baker L. B., Del Soldato P., Pepeu G. and Wenk G. L. (1998b) Peripheral administration of novel anti-inflammatories can attenuate the effect of chronic inflammation within the CNS. Brain Res. 815, 36-43.
19. Hauss-Wegrzyniak B., Vraniak P. and Wenk G. L. (1999) The effects of a novel NSAID upon chronic neuroinflammation are age dependent. Neurobiol. Aging 20, 305-313.
20. Hauss-Wegrzyniak B., Lynch M. A., Vraniak P. D. and Wenk G. L. (2002) Chronic brain inflammation results in cell loss in the entorhinal cortex and impaired LTP in perforant path-granule cell synapses. Exp. Neurol. 176, 336-341.
21. 2 receptors in the induction of long-term potentiation in the CA1 region of rat hippocampus. Brain Res. 756, 184-190.
22. Latini S. and Pedata F. (2001) Adenosine in the central nervous system, release mechanisms and extracellular concentrations. J. Neurochem. 79, 463-484.
23. Lowry O. H., Rosenbrough N. J., Farr A. L. and Randall R. J. (1951) Protein measurement with folin phenol reagent. J. Biol. Chem. 193, 265-275.
24. Lupica C. R., Cass W. A., Zahniser N. R. and Dunwiddie T. V. (1990) Effects of the selective adenosine A2 receptor agonist CGS 21680 on in vitro electrophysiology, cAMP formation and dopamine release in rat hippocampus and striatum. J. Pharmacol. Exp. Ther. 252, 1134-1141.
25. 2B adenosine receptor is mediated by a serine residue close to the COOH terminus. J. Biol. Chem. 276, 30199-30207.
26. - receptor activation reduces proinflammatory events and decreases cell death following intracerebral hemorrhage. Ann. Neurol. 49, 727-735.
27. McGeer E. G. and McGeer P. L. (1999) Inflammation of the brain in Alzheimer's disease: implications for therapy. J. Leuko. Biol. 65, 409-415.
28. Minghetti L. and Levi G. (1995) Induction of prostanoid biosynthesis by bacterial lipopolysaccharide and isoproterenol in rat microglial cultures. J. Neurochem. 65, 2690-2698.
29. Ohta A. and Sitkovsky M. (2001) Role of G-protein-coupled adenosine receptors in downregulation of inflammation and protection from tissue damage. Nature 414, 916-920.
30. 2 receptors modualte extracellular dopamine levels in rat striatum. Neurosci. Lett. 212, 53-56.
31. 2B-receptor-mediated cyclic AMP accumulation in primary rat astrocytes. Br. J. Pharmacol 111, 191-198.
32. Pilitsis J. G. and Kimelberg H. K. (1998) Adenosine receptor mediated stimulation of intracellular calcium in acutely isolated astrocytes. Brain Res. 798, 294-303.
33. i in hippocampal astrocytes in situ. J. Neurochem. 62, 1515-1523.
34. 3H]PK11195 binding in gerbil hippocampus after transient forebrain ischemia. J. Neurosci. Res. 64, 493-500.
35. Reinstein L. J., Lichtman S. N., Currin R. T., Wang J., Thurman R. G. and Lemasters J. J. (1994) Suppression of lipopolysaccharide-stimulated release of tumor necrosis factor by adenosine, evidence for A2 receptors on rat Kupffer cells. Hepatology 19, 1445-1452.
36. Santini G., Sciulli M. G., Padovano R., di Giamberardino M., Rotondo M. T., Del Soldato P. and Patrignani P. (1996) Effects of flurbiprofen and flurbinitroxybutylester on prostaglandin endoperoxidase synthases. Eur. J. Pharmacol. 316, 65-72.
37. Schubert P., Morino T., Miyazaki H., Ogata T., Nakamura Y., Marchini C. and Ferroni S. (2000) Cascading glia reactions: a common pathomechanism and its differentiated control by cyclic nucleotide signaling. Ann. NY Acad. Sci. 903, 224-233.
38. Stephenson D. T., Schober D. A., Smalstig E. B., Mincy R. E., Gehlert D. R. and Clemens J. A. (1995) Peripheral benzodiazepine receptors are colocalized with activated microglia following transient global forebrain ischemia in the rat. J. Neurosci. 15, 5263-5274.
39. 'T Veld B. A., Ruitenberg A., Hofman A., Launer L. J., van Duijin C. M., Stijnen T., Breteler M. M. B. and Stricker B. H. C. (2001) Nonsteroidal anti-inflammatory drugs and the risk of Alzheimer's disease. New Engl. J. Med. 346, 1515-1521.
40. Wenk G. L. and Hauss-Wegrzyniak B. (2001) Animal models of chronic neuroinflammation as a model of Alzheimer's Disease, in Inflammatory Events in Neurodegeneration (Bondy S. and Campbell A., eds), pp. 83-87. Prominent Press, Scottsdale, AZ.
41. Wenk G. L., McGann K., Fiorucci S., Mencarelli A., Hauss-Wegrzyniak B. and Del Soldato P. (2000) Mechanisms to prevent the toxicity of chronic neuroinflammation on forebrain cholinergic neurons. Eur. J. Pharmacol. 402, 77-85.
42. Willis S. A. and Nisen P. D. (1995) Inhibition of lipopolysaccharide-induced IL-1 beta transcription by cyclic monophosphate in human astrocytic cells. J. Immunol. 14, 1399-1406.
43. 2B adenosine receptor expression in macrophages: a mechanism of macrophage deactivation. J. Immunol. 162, 3607-3614.