Quercetin reverses d-galactose induced neurotoxicity in mouse brain

Behavioural Brain Research

Volumn 171, Issue 2, 2006, Pages 251-260

  Lu, Jun ^a,b   Zheng, Yuan lin ^a   Luo, Lan ^c   Wu, Dong mei ^a   Sun, Dong xu ^a   Feng, You jian ^a  

^a JIANGSU NORMAL UNIVERSITY   (China)

^b Institute of Molecular Medicine   (China)

^c NANJING UNIVERSITY   (China)

Author keywords

Behavior; Calcium; d Galactose; GAP43; Neurotoxicity; Quercetin

Indexed keywords

CALCIUM ION; GALACTOSE; MALONALDEHYDE; MESSENGER RNA; NEUROMODULIN; NEUROPROTECTIVE AGENT; QUERCETIN; SUPEROXIDE DISMUTASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANXIETY; ARTICLE; BEHAVIOR; BRAIN NERVE CELL; CALCIUM HOMEOSTASIS; CELL DAMAGE; CELL FUNCTION; CONTROLLED STUDY; ENZYME ACTIVITY; IN SITU HYBRIDIZATION; LEARNING; MALE; MAZE TEST; MEMORY; MOUSE; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; OPEN FIELD TEST; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; TASK PERFORMANCE;

AGING; ANALYSIS OF VARIANCE; ANIMALS; ANTIOXIDANTS; AVOIDANCE LEARNING; BRAIN; CALCIUM; DISCRIMINATION LEARNING; EXPLORATORY BEHAVIOR; GALACTOSE; GAP-43 PROTEIN; MALE; MALONDIALDEHYDE; MICE; MICE, INBRED STRAINS; NEUROPROTECTIVE AGENTS; NEUROTOXICITY SYNDROMES; QUERCETIN; RNA, MESSENGER; SUPEROXIDE DISMUTASE;

EID: 33745377482     PISSN: 01664328     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbr.2006.03.043     Document Type: Article

References (52)

1. Croft K.D. The chemistry and biological effects of flavonoids and phenolic acids. Ann NY Acad Sci 854 (1998) 435-442
2. Rice-Evans C.A., Miller N.J., and Paganga G. Structure-antioxidant activity relationships of flavonoids and phenolic acids. Free Rad Biol Med 20 (1996) 933-956
3. Molina M.F., Sanchez-Reus I., Iglesias I., and Benedi J. Quercetin, a flavonoid antioxidant, prevents and protects against ethanol-induced oxidative stress in mouse liver. Biol Pharm Bull 26 (2003) 1398-1402
4. Harman D. The aging process. Proc Natl Acad Sci USA 78 11 (1981) 7124-7128
5. Dufour E., and Larsson N.G. Understanding aging: revealing order out of chaos. Biochim Biophys Acta 1658 (2004) 122-132
6. Kirkinezosa I.G., and Moraes C.T. Reactive oxygen species and mitochondrial diseases. Semin Cell Dev Biol 12 6 (2001) 449-457
7. Lu C.Y., Lee H.C., Fahn H.J., and Wei Y.H. Oxidative damage elicited by imbalance of free radical scavenging enzymes is associated with large-scale mtDNA deletions in aging human skin. Mut Res 423 1-2 (1999) 11-21
8. Gallagher M., and Pelleymounter M.A. An age-related spatial learning deficit: choline uptake distinguishes 'impaered' and 'unimpaired' rats. Neurobiol Aging 9 (1988) 363-369
9. Johnson F.B., Sinclair D.A., and Guarente L. Molecular biology of aging. Cell 96 (1999) 291-302
10. Serranoa F., and Klann E. Reactive oxygen species and synaptic plasticity in the aging hippocampus. Ageing Res Rev 3 (2004) 431-443
11. Cui X., Li W., and Zhang B. Studies on cell senescence induced by d-galactose in cultured neurons and fibroblasts. Chin J Appl Physiol 13 (1997) 131-133
12. Wei H.F., Li L., Song Q.J., Ai H.X., Chu J., and Li W. Behavioural study of the d-galactose induced aging model in C57BL/6J mice. Behav Brain Res 157 (2005) 245-251
13. Zhang Q., Li Xk, Cui X., and Zuo P.P. d-Galactose injured neurogenesis in the hippocampus of adult mice. Neurol Res 27 (2005) 552-556
14. Orr W.C., and Sohal R.S. Extension of life-span by overexpression of superoxide dismutase and catalase in Drosophila melanogaster. Science 263 (1994) 1128-1130
15. Parkes T.L., Elia A.J., Dickinson D., Hilliker A.J., Phillips J.P., and Boulianne G.L. Extension of Drosophila lifespan by overexpression of human SOD1 in motorneurons. Nat Genet 19 (1998) 171-174
16. Berridge M.J., Lipp P., and Bootman M.D. The versatility and universality of calcium signalling. Nat Rev Mol Cell Biol 1 (2000) 11-21
17. Beal M.F. Energetics in the pathogenesis of neurodegenerative diseases. Trends Neurosci 23 (2000) 298-304
18. 2+ dysregulation with brain aging. J Neurosci 21 (2001) 4066-4073
19. 2+ channel Cav1.2 during aging. Proc Natl Acad Sci USA 100 (2003) 16018-16023
20. Schauwecker P.E., Cheng H.W., Serquinia R.M., Mori N., and McNeil T.H. Lesion-induced sprouting of commissural/vassociational axons and induction of GAP-43 mRNA in Hilar and CA3 pyramidal neurons in the hippocampus are Ddiminished in aged rats. J Neurosci 15 (1995) 2462-2470
21. Introini-Collison I.B., Castellani C., and McGaugh J.L. Interaction of GABAergic and β-noradrenergic drugs in regulation of memory storage. Behav Neural Biol 61 (1994) 150-155
22. Wang R., Zhang H.Y., Tang X.C., and Huperzine. A attenuates cognitive dysfunction and neuronal degeneration caused by betaamyloid protein-(1-40) in rat. Eur J Pharmacol 421 (2001) 149-156
23. McCord J.M., and Fridowich I. An enzymic function for erythrocuprein. J Biol Chem 244 (1969) 6049-6055
24. Uchiyama M., and Mihara M. Determination of malondialdehyde precursor in tissues by thiobarbituric acid test. Anal Biochem 86 (1978) 271-278
25. McGovern S., Maguire M.E., Gurd R.S., Mahler H.R., and Moore W.J. Separation of adrenergic and cholinergic synaptosomes from immature rat brain. FEBS Lett 31 (1973) 193-198
26. 2+ indicators with greatly improved fluorescence properties. J Biol Chem 260 (1985) 3440-3450
27. Sihra T.S., and Nichols R.A. Mechanisms in the regulation of neurotransmitter release from brain nerve terminals: current hypotheses. Neurochem Res 18 (1993) 47-58
28. Hadley E.C., Lakatta E.G., Morrison-Bogorad M., Warner H.R., and Hodes R.J. The future of aging therapies. Cell 120 (2005) 557-567
29. Imam S.Z., and Ali S.F. Aging increases the susceptiblity to methamphetamine-induced dopaminergic neurotoxicity in rats: correlation with peroxynitrite production and hyperthermia. J Neurochem 78 5 (2001) 952-959
30. Eric V.R., van Tol A.F., and van Noort J.M. Oral flavonoids delay recovery from experimental autoimmune encephalomyelitis in SJL mice. Biochem Pharmacol 70 2 (2005) 220-228
31. Jeong Y.J., Choi Y.J., Kwon H.M., Kang S.W., Park H.S., Lee M., et al. Differential inhibition of oxidized LDL-induced apoptosis in human endothelial cells treated with different flavonoids. Br J Nutr 93 5 (2005) 581-591
32. Mardla V., Kobzar G., and Samel N. Potentiation of antiaggregating effect of prostaglandins by alpha-tocopherol and quercetin. Platelets 15 5 (2004) 319-324
33. Shen S.C., Chen Y.C., Hsu F.L., and Lee W.R. Differential apoptosis-inducing effect of quercetin and its glycosides in human promyeloleukemic HL-60 cells by alternative activation of the caspase 3 cascade. J Cell Biochem 89 5 (2003) 1044-1055
34. Nguyen T.T., Tran E., Nguyen T.H., Do P.T., Huynh T.H., and Huynh H. The role of activated MEK-ERK pathway in quercetin-induced growth inhibition and apoptosis in A549 lung cancer cells. Carcinogenesis 25 5 (2004) 647-659
35. Li L., Ng T.B., Gao W., Li W., Fu M., Niu S.M., et al. Antioxidant activity of gallic acid from rose flowers in senescence accelerated mice. Life Sci 77 (2005) 230-240
36. Ingram D. Analysis of age-related impairments in learning and memory in rodents models. Ann NY Acad Sci. 44 (1986) 312-321
37. Lei H., Wang B., Li W.P., Yang Y., Zhou A.W., and Chen M.Z. Anti-aging effect of astragalosides and its mechanism of action. Acta Pharmacol Sin 24 3 (2003) 230-234
38. Koc A., Gasch A.P., Rutherford J.C., Kim H.Y., Vadim N., and Gladyshev V.N. Methionine sulfoxide reductase regulation of yeast lifespan reveals reactive oxygen species-dependent and -independent components of aging. Proc Natl Acad Sci USA 101 (2004) 7999-8004
39. 2+-loaded brain neurons. Brain Res 635 (1994) 125-129
40. Montine T.J., Neely M.D., Quinn J.F., Beal M.F., Markesbery W.R., Roberts L.J., et al. Lipid peroxidation in aging brain and Alzheimer's disease. Free Rad Biol Med 33 (2002) 620-626
41. Wang H., and Joseph J.A. Mechanisms of hydrogen peroxide-induced calcium dysregulation in PC12 cells. Free Rad Biol Med 28 (2000) 1222-1231
42. Khachaturian Z.S. Towards theories of brain aging. In: Kay D., and Burrows G.D. (Eds). Handbook of studies on psychiatry and old age (1984), Elsevier, Amsterdam 7-30
43. 2+ regulation. Mech Aging Dev 25 (1984) 215-225
44. Hall K.E., and Wiley J.W. Neural injury, repair, and adaptation in the GI Tract I. New insights into neuronal injury: a cautionary tale. Am J Physiol Gastrointest Liver Physiol 274 (1998) G978-G983
45. Brizze K.R., and Ordy J.M. Age pigments, cell loss and hippocampal function. Mech Ageing Dev 9 (1979) 143-162
46. Mattson M.P., Cheng B., and Smith-Swintosky V.L. Mechanisms of neurotrophic factor protection against calcium- and free radical-mediated excitotoxic injury: implications for treating neurodegenerative disorders. Exp Neurol 124 (1993) 89-95
47. Dani J.W., Armstrong D.M., and Benowitz L.I. Mapping the development of the rat brain by GAP-43. Neuroscience 40 (1990) 277-287
48. Zwiers H., Oestreicher A.B., Bisby M.A., De Graan P.N.E., and Gispen W.H. In: Bisby M.A., and Smith R.S. (Eds). PKC substrate B-50 in adult and developing rat brain is identical to axonally-transported GAP43 in regenerating peripheral rat nerve (1987), Wiley-Liss, Axonal Transport, New York 385-406
49. Verhaagen J., Van Hooff C.O.M., Edwards P.M., De Graan P.N.E., Oestreicher A.B., Schotman P., et al. The kinase C substrate protein B-50 and axonal regeneration. Brain Res Bull 17 (1986) 737-741
50. Skene J.H.P., and Willard M. Axonally transported proteins associated with axon growth in rabbit central and peripheral nervous systems. J Cell Biol 89 (1981) 96-103
51. Ida H., Ishibashi K., Reiser K., Hjelmeland L.M., and Handa J.T. Ultrastructural aging of the RPE-Bruch's membrane-choriocapillaris complex in the d-galactose-treated mouse. Invest Ophthalmol Vis Sci 45 (2004) 2348-2354
52. Tian J., Ishibashi K., Ishibashi K., Reiser K., Grebe R., Shyam Biswal S., et al. Advanced glycation endproduct-Induced aging of the retinal pigment epithelium and choroid: a comprehensive transcriptional response. Proc Natl Acad Sci USA 102 (2005) 11846-11851