Activation of natural killer T cells by α-galactosylceramide rapidly induces the full maturation of dendritic cells in vivo and thereby acts as an adjuvant for combined CD4 and CD8 T cell immunity to a coadministered protein

Journal of Experimental Medicine

Volumn 198, Issue 2, 2003, Pages 267-279

  Fujii, Shin Ichiro ^a   Shimizu, Kanako ^a   Smith, Caroline ^a   Bonifaz, Laura ^a   Steinman, Ralph M ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

Author keywords

galactosylceramide; Dendritic cell maturation; Dendritic cells; Exogenous pathway; T cell mediated immunity

Indexed keywords

1 O (ALPHA GALACTOPYRANOSYL) 2 (N HEXACOSANOYLAMINO) 1,3,4 OCTADECANETRIOL; ADAPTOR PROTEIN; ALPHA GALACTOSYLCERAMIDE; CARBOHYDRATE DERIVATIVE; CD4 ANTIGEN; CD8 ANTIGEN; GAMMA INTERFERON; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; OVALBUMIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGEN EXPRESSION; ARTICLE; CELL MATURATION; CELL STIMULATION; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; DRUG EFFECT; DRUG MECHANISM; EXPOSURE; FEMALE; IN VIVO STUDY; INJECTION; MOUSE; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; SPLEEN CELL; T LYMPHOCYTE; TH1 CELL;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; ANTIGENS, DIFFERENTIATION; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; DENDRITIC CELLS; GALACTOSYLCERAMIDES; INTERFERON TYPE II; KILLER CELLS, NATURAL; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; MYELOID DIFFERENTIATION FACTOR 88; RECEPTORS, ANTIGEN, T-CELL; RECEPTORS, IMMUNOLOGIC;

EID: 0037787982     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.20030324     Document Type: Article

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