Leptin beyond body weight regulation-Current concepts concerning its role in immune function and inflammation

Cellular Immunology

Volumn 252, Issue 1-2, 2008, Pages 139-145

  Lago, Rocío ^a   Gómez, Rodolfo ^a   Lago, Francisca ^a   Gómez Reino, Juan ^a   Gualillo, Oreste ^a  

^a Instituto de Salud Carlos III   (Spain)

Author keywords

Articular degenerative diseases; Immune system; Inflammation; Leptin

Indexed keywords

ADIPONECTIN; LEPTIN; LEPTIN RECEPTOR; VISFATIN;

ALLERGIC ENCEPHALOMYELITIS; CARTILAGE CELL; CELLULAR IMMUNITY; CONGENITAL LEPTIN DEFICIENCY; FOOD INTAKE; HOMEOSTASIS; HUMAN; HUMORAL IMMUNITY; IMMUNE SYSTEM; IMMUNITY; IMMUNOPATHOLOGY; INFLAMMATION; INSULIN DEPENDENT DIABETES MELLITUS; JOINT DEGENERATION; MULTIPLE SCLEROSIS; NONHUMAN; OSTEOARTHRITIS; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SYNTHESIS; REVIEW; RHEUMATOID ARTHRITIS; T LYMPHOCYTE; WEIGHT CONTROL; WEIGHT REDUCTION;

ANIMALS; BODY WEIGHT; HUMANS; INFLAMMATION; LEPTIN; OBESITY;

EID: 48149112746     PISSN: 00088749     EISSN: 10902163     Source Type: Journal    
DOI: 10.1016/j.cellimm.2007.09.004     Document Type: Review

References (53)

1. Zhang Y., Proenca R., Maffei M., et al. Positional cloning of the mouse obese gene and its human homologue. Nature 372 (1994) 425-432
2. Otero M., Lago R., Lago F., et al. Leptin, from fat to inflammation: old questions and new insights. FEBS Lett. 579 (2005) 295-301
3. Ahima R.S., Prabakaran D., Mantzoros C., et al. Role of leptin in the neuroendocrine response to fasting. Nature 382 (1996) 250-252
4. Chan J.L., Heist K., DePaoli A.M., et al. The role of falling leptin levels in the neuroendocrine and metabolic adaptation to short-term starvation in healthy men. J. Clin. Invest. 111 (2003) 1409-1421
5. Boden G., Chen X., Kolaczynski J.W., and Polansky M. Effects of prolonged hyperinsulinemia on serum leptin in normal human subjects. J. Clin. Invest. 100 (1997) 1107-1113
6. Zakrzewska K.E., Cusin I., Sainsbury A., et al. Glucocorticoids as counterregulatory hormones of leptin: toward an understanding of leptin resistance. Diabetes 46 (1997) 717-719
7. Sarraf P., Frederich R.C., Turner E.M., et al. Multiple cytokines and acute inflammation raise mouse leptin levels: potential role in inflammatory anorexia. J. Exp. Med. 185 (1997) 171-175
8. Gualillo O., Eiras S., Lago F., et al. Elevated serum leptin concentrations induced by experimental acute inflammation. Life Sci. 67 (2000) 2433-2441
9. Blum W.F., Englaro P., Hanitsch S., et al. Plasma leptin levels in healthy children and adolescents: dependence on body mass index, body fat mass, gender, pubertal stage, and testosterone. Clin. Endocrinol. Metab. 82 (1997) 2904-2910
10. Otero M., Lago R., Gomez R., et al. Towards a pro-inflammatory and immunomodulatory emerging role of leptin. Rheumatology (Oxford) 45 (2006) 944-950
11. Fruhbeck G. Intracellular signalling pathways activated by leptin. Biochem. J. 393 (2006) 7-20
12. Gualillo O., Eiras S., White D.W., et al. Leptin promotes the tyrosine phosphorylation of SHC proteins and SHC association with GRB2. Mol. Cell. Endocrinol. 190 (2002) 83-89
13. Bates S.H., Stearns W.H., Dundon T.A., et al. STAT3 signalling is required for leptin regulation of energy balance but not reproduction. Nature 421 (2003) 856-859
14. Prodi F., and Obici S. The brain as a molecular target for diabetic therapy. Endocrinology 147 (2006) 2664-2669
15. Bjorbaek C., El-Haschimi K., Frantz J.D., and Flier J.S. The role of SOCS3 in leptin signalling and leptin resistance. J. Biol. Chem. 274 (1999) 30059-30065
16. Kimura M., Tanaka S., Isoda F., et al. T lymphopenia in obese diabetic (db/db) mice is non-selective and thymus independent. Life Sci. 62 (1998) 1243-1250
17. Tilg H., and Moschen A.R. Adipocytokines: mediators linking adipose tissue, inflammation and immunity. Nat. Rev. Immunol. 6 (2006) 772-783
18. Matarese G., Moschos S., and Mantzoros C.S. Leptin in immunology. J. Immunol. 174 (2005) 3137-3142
19. Zarkesh-Esfahani H., Pockley G., Metcalfe R.A., et al. High-dose leptin activates human leukocytes via receptor expression on monocytes. J. Immunol. 167 (2001) 4593-4599
20. Mancuso P., Canetti C., Gottschalk A., et al. Leptin augments alveolar macrophage leukotriene synthesis by increasing phospholipase activity and enhancing group IVC iPLA2 (cPLA2gamma) protein expression. Am. J. Physiol. Lung Cell. Mol. Physiol. 287 (2004) 497-502
21. Raso G.M., Pacilio M., Esposito E., et al. Leptin potentiates IFN-gamma-induced expression of nitric oxide synthase and cyclo-oxygenase-2 in murine macrophage J774A.1. Br. J. Pharmacol. 137 (2002) 799-804
22. Caldefie-Chezet F., Poulin A., Tridon A., et al. Leptin: a potential regulator of polymorphonuclear neutrophil bactericidal action?. J. Leukoc. Biol. 69 (2001) 414-418
23. Caldefie-Chezet F., Poulin A., and Vasson M.P. Leptin regulates functional capacities of polymorphonuclear neutrophils. Free Radic. Res. 37 (2003) 809-814
24. Tian Z., Sun R., Wei H., and Gao B. Impaired natural killer (NK) cell activity in leptin receptor deficient mice: leptin as a critical regulator in NK cell development and activation. Biochem. Biophys. Res. Commun. 298 (2002) 297-302
25. Lam Q.L., Liu S., Cao X., and Lu L. Involvement of leptin signaling in the survival and maturation of bone marrow-derived dendritic cells. Eur. J. Immunol. 36 (2006) 3118-3130
26. Howard J.K., Lord G.M., Matarese G., et al. Leptin protects mice from starvation-induced lymphoid atrophy and increases thymic cellularity in ob/ob mice. J. Clin. Invest. 104 (1999) 1051-1059
27. Ruter J., Hoffmann T., Demuth H.U., et al. Evidence for an interaction between leptin, T cell costimulatory antigens CD28, CTLA-4 and CD26 (dipeptidyl peptidase IV) in BCG-induced immune responses of leptin- and leptin receptor-deficient mice. Biol. Chem. 385 (2004) 537-541
28. Farooqi I.S., Matarese G., Lord G.M., et al. Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency. J. Clin. Invest. 110 (2002) 1093-1103
29. Lord G.M., Matarese G., Howard J.K., et al. Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression. Nature 394 (1998) 897-901
30. Faggioni R., Feingold K.R., and Grunfeld C. Leptin regulation of the immune response and the immunodeficiency of malnutrition. FASEB J. 15 (2001) 2565-2571
31. Sanna V., Di Giacomo A., La Cava A., et al. Leptin surge precedes onset of autoimmune encephalomyelitis and correlates with development of pathogenic T cell responses. J. Clin. Invest. 111 (2003) 241-250
32. Faggioni R., Fantuzzi G., Gabay C., et al. Leptin deficiency enhances sensitivity to endotoxin-induced lethality. Am. J. Physiol. 276 (1999) 136-142
33. Williams L., Bradley L., Smith A., and Foxwell B. Signal transducer and activator of transcription 3 is the dominant mediator of the anti-inflammatory effects of IL-10 in human macrophages. J. Immunol. 172 (2004) 567-576
34. Busso N., So A., Chobaz-Peclat V., et al. Leptin signaling deficiency impairs humoral and cellular immune responses and attenuates experimental arthritis. J. Immunol. 168 (2002) 875-882
35. Siegmund B., Sennello J.A., Jones-Carson J., et al. Leptin receptor expression on T lymphocytes modulates chronic intestinal inflammation in mice. Gut 53 (2004) 965-972
36. Barbier M., Cherbut C., Aube A.C., et al. Elevated plasma leptin concentrations in early stages of experimental intestinal inflammation in rats. Gut 43 (1998) 783-790
37. Tuzun A., Uygun A., Yesilova Z., et al. Leptin levels in the acute stage of ulcerative colitis. J. Gastroenterol. Hepatol. 19 (2004) 429-432
38. Matarese G., Di Giacomo A., Sanna V., et al. Requirement for leptin in the induction and progression of autoimmune encephalomyelitis. J. Immunol. 166 (2001) 5909-5916
39. Matarese G., Carrieri P.B., La Cava A., et al. Leptin increase in multiple sclerosis associates with reduced number of CD4(+)CD25+ regulatory T cells. Proc. Natl. Acad. Sci. 102 (2005) 5150-5155
40. Fantuzzi G., Sennello J.A., Batra A., et al. Defining the role of T cell-derived leptin in the modulation of hepatic or intestinal inflammation in mice. Clin. Exp. Immunol. 142 (2005) 31-38
41. Palmer G., Aurrand-Lions M., Contassot E., et al. Indirect effects of leptin receptor deficiency on lymphocyte populations and immune response in db/db mice. J. Immunol. 177 (2006) 2899-2907
42. Matarese G., Sanna V., Lechler R.I., et al. Leptin accelerates autoimmune diabetes in female NOD mice. Diabetes 51 (2002) 1356-1361
43. Canavan B., Salem R.O., Schurgin S., et al. Effects of physiological leptin administration on markers of inflammation, platelet activation, and platelet aggregation during caloric deprivation. J. Clin. Endocrinol. Metab. 90 (2005) 5779-5785
44. Sennello J.A., Fayad R., Morris A.M., et al. Regulation of T cell-mediated hepatic inflammation by adiponectin and leptin. Endocrinology 146 (2005) 2157-2164
45. Fraser D.A., Thoen J., Reseland J.E., et al. Decreased CD4+ lymphocyte activation and increased interleukin-4 production in peripheral blood of rheumatoid arthritis patients after acute starvation. Clin. Rheumatol. 18 (1999) 394-401
46. Otero M., Lago R., Gomez R., et al. Changes in plasma levels of fat-derived hormones adiponectin, leptin, resistin and visfatin in patients with rheumatois arthritis. Ann. Rheum. Dis. 65 (2006) 1198-1201
47. Bokarewa M., Bokarew D., Hultgren O., and Tarkowski A. Leptin consumption in the inflamed joints of patients with rheumatoid arthritis. Ann. Rheum. Dis. 62 (2003) 952-956
48. Goldring M.B. The role of the chondrocyte in osteoarthritis. Arthritis Rheum. 43 (2000) 1916-1926
49. Goldring M.B., and Berenbaum F. The regulation of chondrocyte function by proinflammatory mediators: prostaglandins and nitric oxide. Clin. Orthop. Relat. Res. 427 (2004) 27-46
50. Dumond H., Presle N., Terlain B., et al. Evidence for a key role of leptin in osteoarthritis. Arthritis Rheum. 48 (2003) 3118-3129
51. Teichtahl A.J., Wluka A.E., Proietto J., and Cicuttini F.M. Obesity and the female sex, risk factors for knee osteoarthritis that may be attributable to systemic or local leptin biosynthesis and its cellular effects. Med. Hypotheses 65 (2005) 312-315
52. Otero M., Gomez-Reino J.J., and Gualillo O. Synergistic induction of nitric oxide synthase type II: in vitro effect of leptin and interferon-gamma in human chondrocytes and ATDC5 chondrogenic cells. Arthritis Rheum. 48 (2003) 404-409
53. Otero M., Lago R., Lago F., et al. Signalling pathway involved in nitric oxide synthase type II activation in chondrocytes: synergistic effect of leptin with interleukin-1. Arthritis Res. Ther. 7 (2005) 581-591