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Volumn 2, Issue 4, 2009, Pages 301-309

Energy homeostasis and cancer prevention: The AMP-activated protein kinase

Author keywords

[No Author keywords available]

Indexed keywords

A 769662; ANTIDIABETIC AGENT; DEGUELIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; LEVACECARNINE; METFORMIN; PHENFORMIN; ROSIGLITAZONE; TROGLITAZONE; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG; ADENYLATE KINASE;

EID: 67549131188     PISSN: 19406207     EISSN: None     Source Type: Journal    
DOI: 10.1158/1940-6207.CAPR-08-0166     Document Type: Review
Times cited : (75)

References (84)
  • 1
    • 34548079500 scopus 로고    scopus 로고
    • Targeting the AKT protein kinase for cancer chemoprevention
    • DOI 10.1158/1535-7163.MCT-07-0120
    • Crowell JA, Steele VE, Fay JR. Targeting the AKT protein kinase for cancer chemoprevention. Mol Cancer Ther 2007;6:2139-2148 (Pubitemid 47294742)
    • (2007) Molecular Cancer Therapeutics , vol.6 , Issue.8 , pp. 2139-2148
    • Crowell, J.A.1    Steele, V.E.2    Fay, J.R.3
  • 2
    • 34447530619 scopus 로고    scopus 로고
    • The mammalian target of rapamycin pathway as a potential target for cancer chemoprevention
    • DOI 10.1158/1055-9965.EPI-07-0045
    • Kopelovich L, Fay JR, Sigman CC, Crowell JA. The mammalian target of rapamycin pathway as a potential target for cancer chemoprevention. Cancer Epidemiol Biomarkers Prev 2007;16:1330-1340 (Pubitemid 47076862)
    • (2007) Cancer Epidemiology Biomarkers and Prevention , vol.16 , Issue.7 , pp. 1330-1340
    • Kopelovich, L.1    Fay, J.R.2    Sigman, C.C.3    Crowell, J.A.4
  • 3
    • 18144384816 scopus 로고    scopus 로고
    • Targeting epigenetic regulatory mechanisms in cancer chemoprevention
    • DOI 10.1517/14728222.9.2.315
    • Fay JR, Crowell JA, Kopelovich L. Targeting epigenetic regulatory mechanisms in cancer chemoprevention. Expert Opin Ther Targets 2005;9:315-328 (Pubitemid 40613871)
    • (2005) Expert Opinion on Therapeutic Targets , vol.9 , Issue.2 , pp. 315-328
    • Fay, J.R.1    Crowell, J.A.2    Kopelovich, L.3
  • 4
    • 34648828532 scopus 로고    scopus 로고
    • AMP-activated/SNF1 protein kinases: Conserved guardians of cellular energy
    • Hardie DG. AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy. Nat Rev Mol Cell Biol 2007;8:774-785
    • (2007) Nat Rev Mol Cell Biol , vol.8 , pp. 774-785
    • Hardie, D.G.1
  • 5
    • 33847072201 scopus 로고    scopus 로고
    • AMP-activated protein kinase as a drug target
    • DOI 10.1146/annurev.pharmtox.47.120505.105304
    • Hardie DG. AMP-activated protein kinase as a drug target. Annu Rev Pharmacol Toxicol 2007;47:185-210. (Pubitemid 46272128)
    • (2007) Annual Review of Pharmacology and Toxicology , vol.47 , pp. 185-210
    • Hardie, D.G.1
  • 6
    • 39049105534 scopus 로고    scopus 로고
    • AMP activated protein kinase: A next generation target for total metabolic control
    • DOI 10.1517/14728222.12.1.91
    • Misra P. AMP activated protein kinase: a next generation target for total metabolic control. Expert Opin Ther Targets 2008;12:91-100. (Pubitemid 351247165)
    • (2008) Expert Opinion on Therapeutic Targets , vol.12 , Issue.1 , pp. 91-100
    • Misra, P.1
  • 7
    • 33745225026 scopus 로고    scopus 로고
    • AMP-activated protein kinase - Development of the energy sensor concept
    • DOI 10.1113/jphysiol.2006.108944
    • Hardie DG, Hawley SA, Scott JW. AMP-activated protein kinase - development of the energy sensor concept. J Physiol 2006;574:7-15. (Pubitemid 43905792)
    • (2006) Journal of Physiology , vol.574 , Issue.1 , pp. 7-15
    • Hardie, D.G.1    Hawley, S.A.2    Scott, J.W.3
  • 8
    • 33847080728 scopus 로고    scopus 로고
    • AMP-activated protein kinase in metabolic control and insulin signaling
    • Towler MC, Hardie DG. AMP-activated protein kinase in metabolic control and insulin signaling. Circ Res 2007;100:328-341
    • (2007) Circ Res , vol.100 , pp. 328-341
    • Towler, M.C.1    Hardie, D.G.2
  • 9
    • 37349041710 scopus 로고    scopus 로고
    • Role of AMP-activated protein kinase in the metabolic syndrome and in heart disease
    • DOI 10.1016/j.febslet.2007.11.018, PII S0014579307011623
    • Hardie DG. Role of AMP-activated protein kinase in the metabolic syndrome and in heart disease. FEBS Lett 2008;582:81-89 (Pubitemid 350297243)
    • (2008) FEBS Letters , vol.582 , Issue.1 , pp. 81-89
    • Hardie, D.G.1
  • 11
    • 48449094498 scopus 로고    scopus 로고
    • AMPK and PPARδ agonists are exercise mimetics
    • Narkar VA, Downes M, Yu RT, et al. AMPK and PPARδ agonists are exercise mimetics. Cell 2008;134:405-415
    • (2008) Cell , vol.134 , pp. 405-415
    • Narkar, V.A.1    Downes, M.2    Yu, R.T.3
  • 12
    • 48549091164 scopus 로고    scopus 로고
    • Dietary energy restriction modulates the activity of AMP-activated protein kinase, Akt, and mammalian target of rapamycin in mammary carcinomas, mammary gland, and liver
    • Jiang W, Zhu Z, Thompson HJ. Dietary energy restriction modulates the activity of AMP-activated protein kinase, Akt, and mammalian target of rapamycin in mammary carcinomas, mammary gland, and liver. Cancer Res 2008;68:5492-5499
    • (2008) Cancer Res , vol.68 , pp. 5492-5499
    • Jiang, W.1    Zhu, Z.2    Thompson, H.J.3
  • 13
    • 37149042642 scopus 로고    scopus 로고
    • A role for LKB1 gene in human cancer beyond the Peutz-Jeghers syndrome
    • DOI 10.1038/sj.onc.1210594, PII 1210594
    • Sanchez-Cespedes M. A role for LKB1 gene in human cancer beyond the Peutz-Jeghers syndrome. Oncogene 2007;26:7825-7832 (Pubitemid 350261789)
    • (2007) Oncogene , vol.26 , Issue.57 , pp. 7825-7832
    • Sanchez-Cespedes, M.1
  • 17
    • 28244466264 scopus 로고    scopus 로고
    • 5-Aminoimidazole-4-carboxamide-1-β-D-ribofuranoside inhibits cancer cell proliferation in vitro and in vivo via AMP-activated protein kinase
    • DOI 10.1074/jbc.M507443200
    • Rattan R, Giri S, Singh AK, Singh I. 5-Aminoimidazole-4-carboxamide-1- β-D-ribofuranoside inhibits cancer cell proliferation in vitro and in vivo via AMP-activated protein kinase. J Biol Chem 2005;280:39582-39593 (Pubitemid 41713917)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.47 , pp. 39582-39593
    • Rattan, R.1    Giri, S.2    Singh, A.K.3    Singh, I.4
  • 19
    • 34248185949 scopus 로고    scopus 로고
    • LKB1 and AMPK maintain epithelial cell polarity under energetic stress
    • DOI 10.1083/jcb.200702053
    • Mirouse V, Swick LL, Kazgan N, St. Johnston D, Brenman JE. LKB1 and AMPK maintain epithelial cell polarity under energetic stress. J Cell Biol 2007;177:387-392 (Pubitemid 46718268)
    • (2007) Journal of Cell Biology , vol.177 , Issue.3 , pp. 387-392
    • Mirouse, V.1    Swick, L.L.2    Kazgan, N.3    St Johnston, D.4    Brenman, J.E.5
  • 20
  • 21
    • 37549005069 scopus 로고    scopus 로고
    • Implication of AMP-activated protein kinase and Akt-regulated survivin in lung cancer chemopreventive activities of deguelin
    • Jin Q, Feng L, Behrens C, et al. Implication of AMP-activated protein kinase and Akt-regulated survivin in lung cancer chemopreventive activities of deguelin. Cancer Res 2007;67:11630-11639
    • (2007) Cancer Res , vol.67 , pp. 11630-11639
    • Jin, Q.1    Feng, L.2    Behrens, C.3
  • 22
    • 34347220473 scopus 로고    scopus 로고
    • Defining the role of mTOR in cancer
    • Guertin DA, Sabatini DM. Defining the role of mTOR in cancer. Cancer Cell 2007;12:9-22.
    • (2007) Cancer Cell , vol.12 , pp. 9-22
    • Guertin, D.A.1    Sabatini, D.M.2
  • 24
    • 33847397874 scopus 로고    scopus 로고
    • Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40
    • DOI 10.1038/ncb1547, PII NCB1547
    • Vander Haar E, Lee S-I, Bandhakavi S, Griffin TJ, Kim D-H. Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40. Nat Cell Biol 2007;9:316-323 (Pubitemid 46344611)
    • (2007) Nature Cell Biology , vol.9 , Issue.3 , pp. 316-323
    • Haar, E.V.1    Lee, S.2    Bandhakavi, S.3    Griffin, T.J.4    Kim, D.-H.5
  • 25
    • 42949130656 scopus 로고    scopus 로고
    • AMPK and Raptor: Matching cell growth to energy supply
    • Hardie DG. AMPK and Raptor: matching cell growth to energy supply. Mol Cell 2008;30:263-265
    • (2008) Mol Cell , vol.30 , pp. 263-265
    • Hardie, D.G.1
  • 26
    • 42949139481 scopus 로고    scopus 로고
    • AMPK phosphorylation of raptor mediates a metabolic checkpoint
    • Gwinn DM, Shackelford DB, Egan DF, et al. AMPK phosphorylation of raptor mediates a metabolic checkpoint. Mol Cell 2008;30:214-226
    • (2008) Mol Cell , vol.30 , pp. 214-226
    • Gwinn, D.M.1    Shackelford, D.B.2    Egan, D.F.3
  • 27
    • 33750619348 scopus 로고    scopus 로고
    • Glucose metabolism and cancer
    • Shaw RJ. Glucose metabolism and cancer. Curr Opin Cell Biol 2006;18:598-608.
    • (2006) Curr Opin Cell Biol , vol.18 , pp. 598-608
    • Shaw, R.J.1
  • 30
    • 0035929359 scopus 로고    scopus 로고
    • Cell cycle regulation via p53 phosphorylation by a 5′-AMP activated protein kinase activator, 5-aminoimidazole-4-carboxamide-1-β-D- ribofuranoside, in a human hepatocellular carcinoma cell line
    • DOI 10.1006/bbrc.2001.5627
    • Imamura K, Ogura T, Kishimoto A, Kaminishi M, Esumi H. Cell cycle regulation via p53 phosphorylation by a 5′-AMP activated protein kinase activator, 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside, in a human hepatocellular carcinoma cell line. Biochem Biophys Res Commun 2001;287:562-567 (Pubitemid 32917636)
    • (2001) Biochemical and Biophysical Research Communications , vol.287 , Issue.2 , pp. 562-567
    • Imamura, K.1    Ogura, T.2    Kishimoto, A.3    Kaminishi, M.4    Esumi, H.5
  • 31
    • 3543025724 scopus 로고    scopus 로고
    • AMP-activated protein kinase activators can inhibit the growth of prostate cancer cells by multiple mechanisms
    • DOI 10.1016/j.bbrc.2004.06.133, PII S0006291X04014317
    • Xiang X, Saha AK, Wen R, Ruderman NB, Luo Z. AMP-activated protein kinase activators can inhibit the growth of prostate cancer cells by multiple mechanisms. Biochem Biophys Res Commun 2004;321:161-167 (Pubitemid 39055618)
    • (2004) Biochemical and Biophysical Research Communications , vol.321 , Issue.1 , pp. 161-167
    • Xiang, X.1    Saha, A.K.2    Wen, R.3    Ruderman, N.B.4    Luo, Z.5
  • 32
    • 0038035142 scopus 로고    scopus 로고
    • Increased AMP:ATP ratio and AMP-activated protein kinase activity during cellular senescence linked to reduced HuR function
    • DOI 10.1074/jbc.M300318200
    • Wang W, Yang X, Lopez de Silanes I, Carling D, Gorospe M. Increased AMP: ATP ratio and AMP-activated protein kinase activity during cellular senescence linked to reduced HuR function. J Biol Chem 2003;278:27016-27023 (Pubitemid 36876855)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.29 , pp. 27016-27023
    • Wang, W.1    Yang, X.2    De Silanes, I.L.3    Carling, D.4    Gorospe, M.5
  • 33
    • 34848861463 scopus 로고    scopus 로고
    • The energy sensor AMP-activated protein kinase directly regulates the mammalian FOXO3 transcription factor
    • Greer EL, Oskoui PR, Banko MR, et al. The energy sensor AMP-activated protein kinase directly regulates the mammalian FOXO3 transcription factor. J Biol Chem 2007;282:30107-30119
    • (2007) J Biol Chem , vol.282 , pp. 30107-30119
    • Greer, E.L.1    Oskoui, P.R.2    Banko, M.R.3
  • 34
  • 35
    • 20344365809 scopus 로고    scopus 로고
    • Therapy insight: Potential of statins for cancer chemoprevention and therapy
    • DOI 10.1038/ncponc0097
    • Katz MS. Therapy insight: Potential of statins for cancer chemoprevention and therapy. Nat Clin Pract Oncol 2005;2:82-89 (Pubitemid 40790141)
    • (2005) Nature Clinical Practice Oncology , vol.2 , Issue.2 , pp. 82-89
    • Katz, M.S.1
  • 36
    • 38449120272 scopus 로고    scopus 로고
    • The association between statins and cancer incidence in a veterans population
    • Farwell WR, Scranton RE, Lawler EV, et al. The association between statins and cancer incidence in a veterans population. J Natl Cancer Inst 2008;100:134-139
    • (2008) J Natl Cancer Inst , vol.100 , pp. 134-139
    • Farwell, W.R.1    Scranton, R.E.2    Lawler, E.V.3
  • 37
    • 34548019063 scopus 로고    scopus 로고
    • Statins and the risk of colorectal cancer: A meta-analysis of 18 studies involving more than 1.5 million patients
    • DOI 10.1200/JCO.2007.10.8936
    • Bonovas S, Filioussi K, Flordellis CS, Sitaras NM. Statins and the risk of colorectal cancer: a meta-analysis of 18 studies involving more than 1.5 million patients. J Clin Oncol 2007;25:3462-3468 (Pubitemid 47310884)
    • (2007) Journal of Clinical Oncology , vol.25 , Issue.23 , pp. 3462-3468
    • Bonovas, S.1    Filioussi, K.2    Flordellis, C.S.3    Sitaras, N.M.4
  • 38
    • 33751072349 scopus 로고    scopus 로고
    • Resveratrol improves health and survival of mice on a high-calorie diet
    • Baur JA, Pearson KJ, Price NL, et al. Resveratrol improves health and survival of mice on a high-calorie diet. Nature 2006;444:337-342
    • (2006) Nature , vol.444 , pp. 337-342
    • Baur, J.A.1    Pearson, K.J.2    Price, N.L.3
  • 39
    • 33751284806 scopus 로고    scopus 로고
    • Metformin is an AMP kinase-dependent growth inhibitor for breast cancer cells
    • DOI 10.1158/0008-5472.CAN-06-1500
    • Zakikhani M, Dowling R, Fantus IG, Sonenberg N, Pollak M. Metformin is an AMP kinase-dependent growth inhibitor for breast cancer cells. Cancer Res 2006;66:10269-10273 (Pubitemid 44799743)
    • (2006) Cancer Research , vol.66 , Issue.21 , pp. 10269-10273
    • Zakikhani, M.1    Dowling, R.2    Fantus, I.G.3    Sonenberg, N.4    Pollak, M.5
  • 40
    • 23044482013 scopus 로고    scopus 로고
    • RNA interference-mediated silencing of the acetyl-Coa-carboxylase-α gene induces growth inhibition and apoptosis of prostate cancer cells
    • DOI 10.1158/0008-5472.CAN-05-0571
    • Brusselmans K, De Schrijver E, Verhoeven G, Swinnen JV. RNA interference-mediated silencing of the acetyl-CoA-carboxylase-α gene induces growth inhibition and apoptosis of prostate cancer cells. Cancer Res 2005;65:6719-6725 (Pubitemid 41060709)
    • (2005) Cancer Research , vol.65 , Issue.15 , pp. 6719-6725
    • Brusselmans, K.1    De Schrijver, E.2    Verhoeven, G.3    Swinnen, J.V.4
  • 41
    • 12444252156 scopus 로고    scopus 로고
    • Fatty acid synthase inhibitors are chemopreventive for mammary cancer in neu-N transgenic mice
    • Alli PM, Pinn ML, Jaffee EM, McFadden JM, Kuhajda FP. Fatty acid synthase inhibitors are chemopreventive for mammary cancer in neu-N transgenic mice. Oncogene 2005;24:39-46.
    • (2005) Oncogene , vol.24 , pp. 39-46
    • Alli, P.M.1    Pinn, M.L.2    Jaffee, E.M.3    McFadden, J.M.4    Kuhajda, F.P.5
  • 42
    • 34848880141 scopus 로고    scopus 로고
    • Nicotine-induced activation of AMP-activated protein kinase inhibits fatty acid synthase in 3T3L1 adipocytes: A role for oxidant stress
    • An Z, Wang H, Song P, Zhang M, Geng X, Zou M-H. Nicotine-induced activation of AMP-activated protein kinase inhibits fatty acid synthase in 3T3L1 adipocytes: a role for oxidant stress. J Biol Chem 2007;282:26793-26801
    • (2007) J Biol Chem , vol.282 , pp. 26793-26801
    • An, Z.1    Wang, H.2    Song, P.3    Zhang, M.4    Geng, X.5    Zou, M.-H.6
  • 43
    • 0030706079 scopus 로고    scopus 로고
    • Enzymes of the fatty acid synthesis pathway are highly expressed in in situ breast carcinoma
    • Milgraum LZ, Witters LA, Pasternack GR, Kuhajda FP. Enzymes of the fatty acid synthesis pathway are highly expressed in in situ breast carcinoma. Clin Cancer Res 1997;3:2115-2120
    • (1997) Clin Cancer Res , vol.3 , pp. 2115-2120
    • Milgraum, L.Z.1    Witters, L.A.2    Pasternack, G.R.3    Kuhajda, F.P.4
  • 44
    • 0033808261 scopus 로고    scopus 로고
    • The expression of fatty acid synthase (FASE) is an early event in the development and progression of squamous cell carcinoma of the lung
    • Piyathilake CJ, Frost AR, Manne U, et al. The expression of fatty acid synthase (FASE) is an early event in the development and progression of squamous cell carcinoma of the lung. Hum Pathol 2000;31:1068-1073
    • (2000) Hum Pathol , vol.31 , pp. 1068-1073
    • Piyathilake, C.J.1    Frost, A.R.2    Manne, U.3
  • 47
    • 34547114031 scopus 로고    scopus 로고
    • Systemic treatment with the antidiabetic drug metformin selectively impairs p53-deficient tumor cell growth
    • Buzzai M, Jones RG, Amaravadi RK, et al. Systemic treatment with the antidiabetic drug metformin selectively impairs p53-deficient tumor cell growth. Cancer Res 2007;67:6745-6752
    • (2007) Cancer Res , vol.67 , pp. 6745-6752
    • Buzzai, M.1    Jones, R.G.2    Amaravadi, R.K.3
  • 48
    • 6344292389 scopus 로고    scopus 로고
    • Activation of the AMP-activated protein kinase by the anti-diabetic drug metformin in vivo. Role of mitochondrial reactive nitrogen species
    • Zou M-H, Kirkpatrick SS, Davis BJ, et al. Activation of the AMP-activated protein kinase by the anti-diabetic drug metformin in vivo. Role of mitochondrial reactive nitrogen species. J Biol Chem 2004;279:43940-43951
    • (2004) J Biol Chem , vol.279 , pp. 43940-43951
    • Zou, M.-H.1    Kirkpatrick, S.S.2    Davis, B.J.3
  • 50
    • 58149156184 scopus 로고    scopus 로고
    • Therapeutic metformin/AMPK activation promotes the angiogenic phenotype in the ERα negative MDA-MB-435 breast cancer model
    • Phoenix KN, Vumbaca F, Claffey KP. Therapeutic metformin/AMPK activation promotes the angiogenic phenotype in the ERα negative MDA-MB-435 breast cancer model. Breast Cancer Res Treat 2009;113:101-111
    • (2009) Breast Cancer Res Treat , vol.113 , pp. 101-111
    • Phoenix, K.N.1    Vumbaca, F.2    Kp, C.3
  • 51
    • 68349105831 scopus 로고    scopus 로고
    • Personal communication via email to author. 24 Mar
    • Claffey KP. "Re: Metformin." Personal communication via email to author. 24 Mar 2008.
    • (2008) Re: Metformin
    • Kp, C.1
  • 53
    • 32944461233 scopus 로고    scopus 로고
    • Thiazolidinediones inhibit insulin-like growth factor-I-induced activation of p70S6 kinase and suppress insulin-like growth factor-I tumor-promoting activity
    • DOI 10.1158/0008-5472.CAN-05-3111
    • He G, Sung YM, Digiovanni J, Fischer SM. Thiazolidinediones inhibit insulin-like growth factor-I-induced activation of p70S6 kinase and suppress insulin-like growth factor-I tumor-promoting activity. Cancer Res 2006;66:1873-1878 (Pubitemid 43259975)
    • (2006) Cancer Research , vol.66 , Issue.3 , pp. 1873-1879
    • He, G.1    Sung, Y.M.2    Digiovanni, J.3    Fischer, S.M.4
  • 54
    • 33644978143 scopus 로고    scopus 로고
    • Rosiglitazone suppresses human lung carcinoma cell growth through PPARγ-dependent and PPARγ-independent signal pathways
    • Han S, Roman J. Rosiglitazone suppresses human lung carcinoma cell growth through PPARγ-dependent and PPARγ-independent signal pathways. Mol Cancer Ther 2006;5:430-437
    • (2006) Mol Cancer Ther , vol.5 , pp. 430-437
    • Han, S.1    Roman, J.2
  • 55
    • 39049157916 scopus 로고    scopus 로고
    • Phosphatidylinositol ether lipid analogues induce AMP-activated protein kinase-dependent death in LKB1-mutant non small cell lung cancer cells
    • Memmott RM, Gills JJ, Hollingshead M, et al. Phosphatidylinositol ether lipid analogues induce AMP-activated protein kinase-dependent death in LKB1-mutant non small cell lung cancer cells. Cancer Res 2008;68:580-588
    • (2008) Cancer Res , vol.68 , pp. 580-588
    • Memmott, R.M.1    Gills, J.J.2    Hollingshead, M.3
  • 59
    • 33645766204 scopus 로고    scopus 로고
    • Increased cancer-related mortality for patients with type 2 diabetes who use sulfonylureas or insulin
    • Bowker SL, Majumdar SR, Veugelers P, Johnson JA. Increased cancer-related mortality for patients with type 2 diabetes who use sulfonylureas or insulin. Diabetes Care 2006;29:254-258 (Pubitemid 44106500)
    • (2006) Diabetes Care , vol.29 , Issue.2 , pp. 254-258
    • Bowker, S.L.1    Majumdar, S.R.2    Veugelers, P.3    Johnson, J.A.4
  • 60
    • 36348978499 scopus 로고    scopus 로고
    • Defining the mechanism of activation of AMP-activated protein kinase by the small molecule A-769662, a member of the thienopyridone family
    • DOI 10.1074/jbc.M706543200
    • Sanders MJ, Ali ZS, Hegarty BD, Heath R, Snowden MA, Carling D. Defining the mechanism of activation of AMP-activated protein kinase by the small molecule A-769662, a member of the thienopyridone family. J Biol Chem 2007;282:32539-32548 (Pubitemid 350159309)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.45 , pp. 32539-32548
    • Sanders, M.J.1    Ali, Z.S.2    Hegarty, B.D.3    Heath, R.4    Snowden, M.A.5    Carling, D.6
  • 63
    • 27944452718 scopus 로고    scopus 로고
    • Chemopreventive effects of deguelin, a novel Akt inhibitor, on tobacco-induced lung tumorigenesis
    • Lee H-Y, Oh S-H, Woo JK, et al. Chemopreventive effects of deguelin, a novel Akt inhibitor, on tobacco-induced lung tumorigenesis. J Natl Cancer Inst 2005;97:1695-1699
    • (2005) J Natl Cancer Inst , vol.97 , pp. 1695-1699
    • Lee, H.-Y.1    Oh, S.-H.2    Woo, J.K.3
  • 64
    • 33845789994 scopus 로고    scopus 로고
    • Apoptotic effect of EGCG in HT-29 colon cancer cells via AMPK signal pathway
    • DOI 10.1016/j.canlet.2006.03.030, PII S0304383506001960
    • Hwang J-T, Ha J, Park I-J, et al. Apoptotic effect of EGCG in HT-29 colon cancer cells via AMPK signal pathway. Cancer Lett 2007;247:115-121 (Pubitemid 46001507)
    • (2007) Cancer Letters , vol.247 , Issue.1-2 , pp. 115-121
    • Hwang, J.-T.1    Ha, J.2    Park, I.-J.3    Lee, S.-K.4    Baik, H.W.5    Kim, Y.M.6    Park, O.J.7
  • 65
    • 27744455616 scopus 로고    scopus 로고
    • Genistein, EGCG, and capsaicin inhibit adipocyte differentiation process via activating AMP-activated protein kinase
    • Hwang J-T, Park I-J, Shin J-I, et al. Genistein, EGCG, and capsaicin inhibit adipocyte differentiation process via activating AMP-activated protein kinase. Biochem Biophys Res Commun 2005;338:694-699
    • (2005) Biochem Biophys Res Commun , vol.338 , pp. 694-699
    • Hwang, J.-T.1    Park, I.-J.2    Shin, J.-I.3
  • 66
    • 33750535008 scopus 로고    scopus 로고
    • Selenium regulates cyclooxygenase-2 and extracellular signal-regulated kinase signaling pathways by activating AMP-activated protein kinase in colon cancer cells
    • Hwang J-T, Kim YM, Surh Y-J, et al. Selenium regulates cyclooxygenase-2 and extracellular signal-regulated kinase signaling pathways by activating AMP-activated protein kinase in colon cancer cells. Cancer Res 2006;66:10057-10063
    • (2006) Cancer Res , vol.66 , pp. 10057-10063
    • Hwang, J.-T.1    Kim, Y.M.2    Surh, Y.-J.3
  • 67
    • 33646028804 scopus 로고    scopus 로고
    • Molecular targets of dietary agents for prevention and therapy of cancer
    • Aggarwal BB, Shishodia S. Molecular targets of dietary agents for prevention and therapy of cancer. Biochem Pharmacol 2006;71:1397-1421
    • (2006) Biochem Pharmacol , vol.71 , pp. 1397-1421
    • Aggarwal, B.B.1    Shishodia, S.2
  • 68
    • 0013072999 scopus 로고    scopus 로고
    • Calorie Restriction, Aging, and Cancer Prevention: Mechanisms of Action and Applicability to Humans
    • DOI 10.1146/annurev.med.54.101601.152156
    • Hursting SD, Lavigne JA, Berrigan D, Perkins SN, Barrett JC. Calorie restriction, aging, and cancer prevention: mechanisms of action and applicability to humans. Annu Rev Med 2003;54:131-152 (Pubitemid 37386388)
    • (2003) Annual Review of Medicine , vol.54 , pp. 131-152
    • Hursting, S.D.1    Lavigne, J.A.2    Berrigan, D.3    Perkins, S.N.4    Barrett, J.C.5
  • 69
    • 0141720388 scopus 로고    scopus 로고
    • Calorie restriction and aging: Review of the literature and implications for studies in humans
    • Heilbronn LK, Ravussin E. Calorie restriction and aging: Review of the literature and implications for studies in humans. Am J Clin Nutr 2003;78:361-369 (Pubitemid 39663500)
    • (2003) American Journal of Clinical Nutrition , vol.78 , Issue.3 , pp. 361-369
    • Heilbronn, L.K.1    Ravussin, E.2
  • 70
    • 40349091247 scopus 로고    scopus 로고
    • Insulin, insulin-like growth factors, insulin resistance, and neoplasia
    • Pollack MN. Insulin, insulin-like growth factors, insulin resistance, and neoplasia. Am J Clin Nutr 2007;86:s820-2.
    • (2007) Am J Clin Nutr , vol.86
    • Pollack, M.N.1
  • 71
    • 33644787577 scopus 로고    scopus 로고
    • Identification of potential caloric restriction mimetics by microarray profiling
    • Dhahbi JM, Mote PL, Fahy GM, Spindler SR. Identification of potential caloric restriction mimetics by microarray profiling. Physiol Genomics 2005;23:343-350
    • (2005) Physiol Genomics , vol.23 , pp. 343-350
    • Dhahbi, J.M.1    Mote, P.L.2    Fahy, G.M.3    Spindler, S.R.4
  • 72
    • 46249121405 scopus 로고    scopus 로고
    • Cancer therapy: Staying current with AMPK
    • Fruman DA, Edinger AL. Cancer therapy: Staying current with AMPK. Biochem J 2008;412:e3-5.
    • (2008) Biochem J , vol.412
    • Fruman, D.A.1    Edinger, A.L.2
  • 73
    • 0034616634 scopus 로고    scopus 로고
    • Altered PTEN expression as a diagnostic marker for the earliest endometrial precancers
    • Mutter GL, Lin M-C, Fitzgerald JT, et al. Altered PTEN expression as a diagnostic marker for the earliest endometrial precancers. J Natl Cancer Inst 2000;92:924-931
    • (2000) J Natl Cancer Inst , vol.92 , pp. 924-931
    • Mutter, G.L.1    Lin, M.-C.2    Fitzgerald, J.T.3
  • 75
    • 26944444679 scopus 로고    scopus 로고
    • BRCA1 in hormonal carcinogenesis: Basic and clinical research
    • DOI 10.1677/erc.1.00972
    • Rosen EM, Fan S, Isaacs C. BRCA1 in hormonal carcinogenesis: Basic and clinical research. Endocr Relat Cancer 2005;12:533-548 (Pubitemid 41482992)
    • (2005) Endocrine-Related Cancer , vol.12 , Issue.3 , pp. 533-548
    • Rosen, E.M.1    Fan, S.2    Isaacs, C.3
  • 76
    • 50949114804 scopus 로고    scopus 로고
    • Acadesine, an adenosine-regulating agent with the potential for widespread indications
    • Drew BG, Kingwell BA. Acadesine, an adenosine-regulating agent with the potential for widespread indications. Expert Opin Pharmacother 2008;9:2137-2144
    • (2008) Expert Opin Pharmacother , vol.9 , pp. 2137-2144
    • Drew, B.G.1    Kingwell, B.A.2
  • 78
    • 34848843526 scopus 로고    scopus 로고
    • Crystal structure of the heterotrimer core of Saccharomyces cerevisiae AMPK homologue SNF1
    • DOI 10.1038/nature06127, PII NATURE06127
    • Amodeo GA, Rudolph MJ, Tong L. Crystal structure of the heterotrimer core of Saccharomyces cerevisiae AMPK homologue SNF1. Nature 2007;449:492-495 (Pubitemid 47509541)
    • (2007) Nature , vol.449 , Issue.7161 , pp. 492-495
    • Amodeo, G.A.1    Rudolph, M.J.2    Tong, L.3
  • 79
    • 0037026608 scopus 로고    scopus 로고
    • Critical roles of AMP-activated protein kinase in constitutive tolerance of cancer cells to nutrient deprivation and tumor formation
    • Kato K, Ogura T, Kishimoto A, et al. Critical roles of AMP-activated protein kinase in constitutive tolerance of cancer cells to nutrient deprivation and tumor formation. Oncogene 2002;21:6082-6090
    • (2002) Oncogene , vol.21 , pp. 6082-6090
    • Kato, K.1    Ogura, T.2    Kishimoto, A.3
  • 80
    • 33745840203 scopus 로고    scopus 로고
    • 5′-AMP-activated protein kinase (AMPK) is induced by low-oxygen and glucose deprivation conditions found in solid-tumor microenvironments
    • DOI 10.1128/MCB.00166-06
    • Laderoute KR, Amin K, Calaoagan JM, et al. 5′-AMP-activated protein kinase (AMPK) is induced by low-oxygen and glucose deprivation conditions found in solid-tumor microenvironments. Mol Cell Biol 2006:336-347 (Pubitemid 44036203)
    • (2006) Molecular and Cellular Biology , vol.26 , Issue.14 , pp. 5336-5347
    • Laderoute, K.R.1    Amin, K.2    Calaoagan, J.M.3    Knapp, M.4    Le, T.5    Orduna, J.6    Foretz, M.7    Viollet, B.8
  • 82
    • 33750684953 scopus 로고    scopus 로고
    • Role of insulin, adipocyte hormones, and nutrient-sensing pathways in regulating fuel metabolism and energy homeostasis: A nutritional perspective of diabetes, obesity, and cancer
    • Marshall S. Role of insulin, adipocyte hormones, and nutrient-sensing pathways in regulating fuel metabolism and energy homeostasis: a nutritional perspective of diabetes, obesity, and cancer. Si STKE 2006;re7.
    • (2006) Si STKE
    • Marshall, S.1
  • 83
    • 27844483012 scopus 로고    scopus 로고
    • Childhood obesity and type 2 diabetes mellitus
    • Hannon TS, Rao G, Arslanian SA. Childhood obesity and type 2 diabetes mellitus. Pediatrics 2005;116:473-480
    • (2005) Pediatrics , vol.116 , pp. 473-480
    • Hannon, T.S.1    Rao, G.2    Arslanian, S.A.3
  • 84
    • 33745683516 scopus 로고    scopus 로고
    • Progress in chemoprevention drug development: The promise of molecular biomarkers for prevention of Intraepithelial neoplasia and cancer - A plan to move forward
    • Kelloff GJ, Lippman SM, Dannenberg AJ, Sigman CC, et al. Progress in chemoprevention drug development: the promise of molecular biomarkers for prevention of Intraepithelial neoplasia and cancer - a plan to move forward. Clin Cancer Res 2006;12:3661-3697
    • (2006) Clin Cancer Res , vol.12 , pp. 3661-3697
    • Kelloff, G.J.1    Lippman, S.M.2    Dannenberg, A.J.3    Sigman, C.C.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.