AMP-activated protein kinase activators can inhibit the growth of prostate cancer cells by multiple mechanisms

Biochemical and Biophysical Research Communications

Volumn 321, Issue 1, 2004, Pages 161-167

  Xiang, Xiaoqin ^a   Saha, Asish K ^a   Wen, Rong ^b   Ruderman, Neil B ^a   Luo, Zhijun ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Acetyl CoA carboxylase; AMP activated protein kinase; Fatty acid synthase; Growth; mTOR; p21; p70S6K; Prostate cancer cell; Survival

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; 5 AMINO 4 IMIDAZOLECARBOXAMIDE RIBOSIDE; ANDROGEN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MALONYL COENZYME A; METRIBOLONE; PROTEIN P21; ROSIGLITAZONE; S6 KINASE; 5 AMINO 4 IMIDAZOLECARBOXAMIDE; 5' AMP ACTIVATED PROTEIN KINASE; 5'-AMP-ACTIVATED PROTEIN KINASE; AICA RIBONUCLEOTIDE; ANTIDIABETIC AGENT; DRUG DERIVATIVE; MULTIENZYME COMPLEX; PROTEIN SERINE THREONINE KINASE; RIBONUCLEOTIDE;

ARTICLE; CANCER CELL; CANCER GROWTH; CELL CYCLE; CELL GROWTH; EXPOSURE; FATTY ACID SYNTHESIS; HUMAN; HUMAN CELL; MALE; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; CELL DIVISION; CELL SURVIVAL; DRUG EFFECT; ENZYME ACTIVATION; METABOLISM; PATHOLOGY; PHYSIOLOGY; PROSTATE TUMOR; TUMOR CELL LINE;

AMINOIMIDAZOLE CARBOXAMIDE; CELL DIVISION; CELL LINE, TUMOR; CELL SURVIVAL; ENZYME ACTIVATION; HUMANS; HYPOGLYCEMIC AGENTS; MALE; MULTIENZYME COMPLEXES; PROSTATIC NEOPLASMS; PROTEIN-SERINE-THREONINE KINASES; RIBONUCLEOTIDES; THIAZOLIDINEDIONES;

EID: 3543025724     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbrc.2004.06.133     Document Type: Article

References (42)

1. F.P. Kuhajda Fatty-acid synthase and human cancer: new perspectives on its role in tumor biology Nutrition 16 2000 202 208
2. M.S. Shurbaji, J.H. Kalbfleisch and T.S. Thurmond Immunohistochemical detection of a fatty acid synthase (OA-519) as a predictor of progression of prostate cancer Hum. Pathol. 27 1996 917 921
3. J.V. Swinnen, F. Vanderhoydonc, A.A. Elgamal, M. Eelen, I. Vercaeren, S. Joniau, H. Van Poppel, L. Baert, K. Goossens, W. Heyns and G. Verhoeven Selective activation of the fatty acid synthesis pathway in human prostate cancer Int. J. Cancer 88 2000 176 179
4. J.V. Swinnen, T. Roskams, S. Joniau, H. Van Poppel, R. Oyen, L. Baert, W. Heyns and G. Verhoeven Overexpression of fatty acid synthase is an early and common event in the development of prostate cancer Int. J. Cancer 98 2002 19 22
5. S. Rossi, E. Graner, P. Febbo, L. Weinstein, N. Bhattacharya, T. Onody, G. Bubley, S. Balk and M. Loda Fatty acid synthase expression defines distinct molecular signatures in prostate cancer Mol. Cancer Res. 1 2003 707 715
6. J.H. Bull, G. Ellison, A. Patel, G. Muir, M. Walker, M. Underwood, F. Khan and L. Paskins Identification of potential diagnostic markers of prostate cancer and prostatic intraepithelial neoplasia using cDNA microarray Br. J. Cancer 84 2001 1512 1519
7. J.B. Welsh, L.M. Sapinoso, A.I. Su, S.G. Kern, J. Wang-Rodriguez, C.A. Moskaluk, H.F. Frierson Jr. and G.M. Hampton Analysis of gene expression identifies candidate markers and pharmacological targets in prostate cancer Cancer Res. 61 2001 5974 5978
8. A. Baron, T. Migita, D. Tang and M. Loda Fatty acid synthase: a metabolic oncogene in prostate cancer? J. Cell Biochem. 91 2004 47 53
9. J.V. Swinnen, W. Ulrix, W. Heyns and G. Verhoeven Coordinate regulation of lipogenic gene expression by androgens: evidence for a cascade mechanism involving sterol regulatory element binding proteins Proc. Natl. Acad. Sci. USA 94 1997 12975 12980
10. E. De Schrijver, K. Brusselmans, W. Heyns, G. Verhoeven and J.V. Swinnen RNA interference-mediated silencing of the fatty acid synthase gene attenuates growth and induces morphological changes and apoptosis of LNCaP prostate cancer cells Cancer Res. 63 2003 3799 3804
11. D.G. Hardie and D. Carling The AMP-activated protein kinase-fuel gauge of the mammalian cell? Eur. J. Biochem. 246 1997 259 273
12. N.B. Ruderman, A.K. Saha, D. Vavvas and L.A. Witters Malonyl-CoA, fuel sensing, and insulin resistance Am. J. Physiol. 276 1999 E1 E18
13. B.E. Kemp, D. Stapleton, D.J. Campbell, Z.P. Chen, S. Murthy, M. Walter, A. Gupta, J.J. Adams, F. Katsis, B. Van Denderen, I.G. Jennings, T. Iseli, B.J. Michell and L.A. Witters AMP-activated protein kinase, super metabolic regulator Biochem. Soc. Trans. 31 2003 162 168
14. D.G. Hardie, J.W. Scott, D.A. Pan and E.R. Hudson Management of cellular energy by the AMP-activated protein kinase system FEBS Lett. 546 2003 113 120
15. J.M. Corton, J.G. Gillespie, S.A. Hawley and D.G. Hardie 5-aminoimidazole-4-carboxamide ribonucleoside. A specific method for activating AMP-activated protein kinase in intact cells? Eur. J. Biochem. 229 1995 558 565
16. T. Kawaguchi, K. Osatomi, H. Yamashita, T. Kabashima and K. Uyeda Mechanism for fatty acid sparing effect on glucose-induced transcription: regulation of carbohydrate-responsive element-binding protein by AMP-activated protein kinase J. Biol. Chem. 277 2002 3829 3835
17. I. Leclerc, A. Kahn and B. Doiron The 5′-AMP-activated protein kinase inhibits the transcriptional stimulation by glucose in liver cells, acting through the glucose response complex FEBS Lett. 431 1998 180 184
18. A. Woods, D. Azzout-Marniche, M. Foretz, S.C. Stein, P. Lemarchand, P. Ferre, F. Foufelle and D. Carling Characterization of the role of AMP-activated protein kinase in the regulation of glucose-activated gene expression using constitutively active and dominant negative forms of the kinase Mol. Cell. Biol. 20 2000 6704 6711
19. K. Inoki, T. Zhu and K.L. Guan TSC2 mediates cellular energy response to control cell growth and survival Cell 115 2003 577 590
20. J.D. McGarry, M.J. Stark and D.W. Foster Hepatic malonyl-CoA levels of fed, fasted and diabetic rats as measured using a simple radioisotopic assay J. Biol. Chem. 253 1978 8291 8293
21. A.K. Saha, T.G. Kurowski and N.B. Ruderman A malonyl-CoA fuel-sensing mechanism in muscle: effects of insulin, glucose, and denervation Am. J. Physiol. 269 1995 E283 289
22. L.G. Fryer, A. Parbu-Patel and D. Carling The Anti-diabetic drugs rosiglitazone and metformin stimulate AMP-activated protein kinase through distinct signaling pathways J. Biol. Chem. 277 2002 25226 25232
23. G.N. Thalmann, R.A. Sikes, T.T. Wu, A. Degeorges, S.M. Chang, M. Ozen, S. Pathak and L.W. Chung LNCaP progression model of human prostate cancer: androgen-independence and osseous metastasis Prostate 44 2000 91 103 Jul 101; 144(102)
24. J.V. Swinnen, M. Esquenet, K. Goossens, W. Heyns and G. Verhoeven Androgens stimulate fatty acid synthase in the human prostate cancer cell line LNCaP Cancer Res. 57 1997 1086 1090
25. M.S. Neshat, I.K. Mellinghoff, C. Tran, B. Stiles, G. Thomas, R. Petersen, P. Frost, J.J. Gibbons, H. Wu and C.L. Sawyers Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR Proc. Natl. Acad. Sci. USA 98 2001 10314 10319
26. D.R. Bolster, S.J. Crozier, S.R. Kimball and L.S. Jefferson AMP-activated protein kinase suppresses protein synthesis in rat skeletal muscle through down-regulated mammalian target of rapamycin (mTOR) signaling J. Biol. Chem. 277 2002 23977 23980
27. K. Imamura, T. Ogura, A. Kishimoto, M. Kaminishi and H. Esumi Cell cycle regulation via p53 phosphorylation by a 5′-AMP activated protein kinase activator, 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranoside, in a human hepatocellular carcinoma cell line Biochem. Biophys. Res. Commun. 287 2001 562 567
28. X.B. Shi, N.J. Nesslinger, A.D. Deitch, P.H. Gumerlock and R.W. deVere White Complex functions of mutant p53 alleles from human prostate cancer Prostate 51 2002 59 72
29. A. Woods, S.R. Johnstone, K. Dickerson, F.C. Leiper, L.G. Fryer, D. Neumann, U. Schlattner, T. Wallimann, M. Carlson and D. Carling LKB1 is the upstream kinase in the AMP-activated protein kinase cascade Curr. Biol. 13 2003 2004 2008
30. S.A. Hawley, J. Boudeau, J.L. Reid, K.J. Mustard, L. Udd, T.P. Makela, D.R. Alessi and D.G. Hardie Complexes between the LKB1 tumor suppressor, STRADalpha/beta and MO25alpha/beta are upstream kinases in the AMP-activated protein kinase cascade J. Biol. 2 2003 28
31. J. Boudeau, G. Sapkota and D.R. Alessi LKB1, a protein kinase regulating cell proliferation and polarity FEBS Lett. 546 2003 159 165
32. J.M. Lizcano, O. Goransson, R. Toth, M. Deak, N.A. Morrice, J. Boudeau, S.A. Hawley, L. Udd, T.P. Makela, D.G. Hardie and D.R. Alessi LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1 EMBO J. 23 2004 833 843
33. Y. Li, M.N. Corradetti, K. Inoki and K.L. Guan TSC2: filling the GAP in the mTOR signaling pathway Trends Biochem. Sci. 29 2004 32 38
34. J. Young and S. Povey The genetic basis of tuberous sclerosis Mol. Med. Today 4 1998 313 319
35. D. Meisse, M. Vande Casteele, C. Beauloye, I. Hainault, B.A. Kefas, M.H. Rider, F. Foufelle and L. Hue Sustained activation of AMP-activated protein kinase induces c-Jun N-terminal kinase activation and apoptosis in liver cells FEBS Lett. 526 2002 38 42
36. B.A. Kefas, Y. Cai, Z. Ling, H. Heimberg, L. Hue, D. Pipeleers and M. Van de Casteele AMP-activated protein kinase can induce apoptosis of insulin-producing MIN6 cells through stimulation of c-Jun-N-terminal kinase J. Mol. Endocrinol. 30 2003 151 161
37. J. Li, P. Jiang, M. Robinson, T.S. Lawrence and Y. Sun AMPK-beta1 subunit is a p53-independent stress responsive protein that inhibits tumor cell growth upon forced expression Carcinogenesis 24 2003 827 834
38. C. Blazquez, M.J. Geelen, G. Velasco and M. Guzman The AMP-activated protein kinase prevents ceramide synthesis de novo and apoptosis in astrocytes FEBS Lett. 489 2001 149 153
39. Y. Ido, M. Zou, K. Chen, R. Cohen, J.F. Keaney and N.B. Ruderman The AMP-Kinase (AMPK) activator, AICAR, inhibits the increase in oxidative stress induced by hyperglycemia and palmitate Diabetes (abstract) 51 2002 1624-P
40. R.J. Shaw, M. Kosmatka, N. Bardeesy, R.L. Hurley, L.A. Witters, R.A. DePinho and L.C. Cantley The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress Proc. Natl. Acad. Sci. USA 101 2004 3329 3335
41. Y. Ido, D. Carling and N. Ruderman Hyperglycemia-induced apoptosis in human umbilical vein endothelial cells: inhibition by the AMP-activated protein kinase activation Diabetes 51 2002 159 167
42. N.B. Ruderman, J.M. Cacicedo, S. Itani, N. Yagihashi, A.K. Saha, J.M. Ye, K. Chen, M. Zou, D. Carling, G. Boden, R.A. Cohen, J. Keaney, E.W. Kraegen and Y. Ido Malonyl-CoA and AMP-activated protein kinase (AMPK): possible links between insulin resistance in muscle and early endothelial cell damage in diabetes Biochem. Soc. Trans. 31 2003 202 206