Prevention of pancreatic cancer induction in hamsters by metformin

Gastroenterology

Volumn 120, Issue 5, 2001, Pages 1263-1270

  Schneider, Matthias B ^a   Matsuzaki, Hosei ^b   Haorah, James ^a   Ulrich, Alexis ^a   Standop, Jens ^a   Ding, Xian Zhong ^c   Adrian, Thomas E ^c   Pour, Parviz M ^a,d  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^b KUMAMOTO UNIV SCHOOL OF MEDICINE   (Japan)

^c CREIGHTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIS(2 OXOPROPYL)NITROSAMINE; METFORMIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER DIAGNOSIS; CANCER PREVENTION; CARCINOGENESIS; CELL PROLIFERATION; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; LIPID DIET; MALIGNANT NEOPLASTIC DISEASE; NONHUMAN; OBESITY; PANCREAS CARCINOMA; PANCREAS ISLET CELL; PRIORITY JOURNAL;

EID: 0035082644     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/gast.2001.23258     Document Type: Article

References (56)

1. Experimental pancreas tumor
2. Focal acinar cell dysplasia in human pancreas
3. Experimental pancreatic cancer
4. Islet cells as a component of pancreatic ductal neoplasms. I. Experimental study: Ductular cells, including islet cell precursors, as primary progenitor cells of tumors
5. Histogenesis of exocrine pancreatic cancer in the hamster model
6. Comparative studies on expression of tumor-associated antigens in human and induced pancreatic cancer in Syrian hamsters
7. Patterns of growth and metastases of induced pancreatic cancer in relation to the prognosis and its clinical implications
8. Expression of human tumor-associated antigens in pancreatic cancer induced in Syrian hamsters
9. Pancreatic ductal adenocarcinomas induced in Syrian hamsters by N-nitrosobis(2-oxopropyl)amine contain a c-Ki-ras oncogene with a point-mutated codon 12
10. Comparison of p53 protein expression and cellular localization in human and hamster pancreatic cancer cell lines
11. Pancreatic neoplasms in an animal model: Morphological, biological, and comparative studies
12. Modification of pancreatic carcinogenesis in the hamster model. 3. Inhibitory effect of alloxan
13. Importance of diabetes in inhibition of pancreatic cancer by streptozotocin
14. Influence of diabetes on susceptibility to experimental pancreatic cancer
15. Inhibition of streptozotocin-induced islet cell tumors and N-nitrosobis(2-oxopropyl)amine-induced pancreatic exocrine tumors in Syrian hamsters by exogenous insulin
16. Stimulation of islet cell proliferation enhances pancreatic ductal carcinogenesis in the hamster model
17. Increased tumorigenesis induced by N-nitrosobis(2-oxopropyl)amine in Syrian golden hamsters fed high-fat diets
18. Enhancement of pancreatic carcinogenesis in hamsters fed a high-fat diet ad libitum and at a controlled calorie intake
19. Effects of voluntary physical exercise on high-fat diet-promoted pancreatic carcinogenesis in the hamster model
20. Metformin: An update
21. Biguanides and NIDDM
22. In vivo metformin treatment ameliorates insulin resistance: Evidence for potentiation of insulin-induced translocation and increased functional activity of glucose transporters in obese (fa/fa) Zucker rat adipocytes
23. Metformin and liver glycogen synthase activity in obese Zucker rats
24. Pathogenesis of type 2 diabetes: Implications for metformin
25. Metformin
26. The antihyperglycaemic effect of metformin: Therapeutic and cellular mechanisms
27. Metabolic effects of metformin in non-insulin-dependent diabetes mellitus
28. Metformin reverses fatty liver disease in obese, leptin-deficient mice
29. Thiazolidinediones and insulin resistance: Peroxisome proliferator activated receptor gamma activation stimulates expression of the CAP gene
30. Troglitazone: Antihyperglycemic activity and potential role in the treatment of type 2 diabetes
31. Metabolic effects of troglitazone monotherapy in type 2 diabetes mellitus. A randomized, double-blind, placebo-controlled trial
32. Troglitazone-associated hepatic failure
33. Hepatic dysfunction associated with troglitazone
34. Islet amyloid polypeptide in patients with pancreatic cancer and diabetes
35. A new multilabeling technique for simultaneous demonstration of different islet cells in permanent slides
36. Lymph node involvement in carcinoma of the head of the pancreas area
37. Summary of a Canadian study of smoking and health
38. The Dorn study of smoking and mortality among U.S. veterans: Report on eight and one-half years of observation
39. Smoking in relation to the death rates of one million men and women
40. Smoking in relation to death rates of 265, 118 men and women in Japan. A report on 5 years of follow-up
41. Collaborative studies in the diagnosis of pancreatic cancer
42. A prospective evaluation of glucose intolerance in patients suspected of having pancreatic cancer
43. Cancer mortality among diabetics
44. Nutritional cancer risks derived from energy and fat
45. Dietary and nutritional factors and pancreatic cancer: A case-control study based on direct interviews
46. Diabetes mellitus, other medical conditions and familial history of cancer as risk factors for pancreatic cancer
47. Insulin therapy prevents spontaneous recovery from streptozotocin-induced diabetes in Syrian hamsters. An autoradiographic and immunohistochemical study
48. Modification of pancreatic carcinogenesis in the hamster model. VIII. Inhibitory effect of exogenous insulin
49. Dietary energy restriction does not inhibit pancreatic carcinogenesis by N-nitrosobis-2-(oxopropyl)amine in the Syrian hamster
50. Spontaneous tumors and common diseases in two colonies of Syrian hamsters. III. Urogenital system and endocrine glands
51. Diagnosis of pancreatic cancer. Alteration of glucose metabolism
52. Insulin secretion and action in patients with pancreatic cancer
53. Morphologic characteristics of pancreatic carcinoma with diabetes mellitus
54. Diabetes and the risk of pancreatic cancer
55. Histologic and biologic patterns of microscopic pancreatic ductal adenocarcinomas detected incidentally at autopsy