5-Aminoimidazole-4-carboxamide-1-β-D-ribofuranoside inhibits cancer cell proliferation in vitro and in vivo via AMP-activated protein kinase

Journal of Biological Chemistry

Volumn 280, Issue 47, 2005, Pages 39582-39593

  Rattan, Ramandeep ^a   Giri, Shailendra ^a   Singh, Avtar K ^b   Singh, Inderjit ^a,c  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b RALPH H JOHNSON VA MEDICAL CENTER   (United States)

^c MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME INHIBITION; GENES; METABOLISM; PROTEINS; TUMORS; VIRUSES;

AKT PHOSPHORYLATION; AMP-ACTIVATED PROTEIN KINASE; METABOLIC STRESS; RIBOFURANOSIDE INHIBITS; THERAPEUTIC DRUG TO INHIBIT CANCER;

CELLS;

5 AMINO 4 IMIDAZOLECARBOXAMIDE RIBOSIDE; ADENOSINE KINASE INHIBITOR; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; IODOTUBERICIDIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN P21; PROTEIN P27; PROTEIN P53; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CELL CYCLE S PHASE; CELL PROLIFERATION; CONTROLLED STUDY; ENERGY METABOLISM; ENZYME PHOSPHORYLATION; FIBROBLAST; GENETIC TRANSFECTION; HOMEOSTASIS; HUMAN; HUMAN CELL; LKB GENE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR SUPPRESSOR GENE;

AMINOIMIDAZOLE CARBOXAMIDE; ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BASE SEQUENCE; CELL LINE, TUMOR; CELL PROLIFERATION; ENZYME ACTIVATION; HUMANS; MALE; MICE; MICE, KNOCKOUT; MODELS, BIOLOGICAL; MULTIENZYME COMPLEXES; NEOPLASMS, EXPERIMENTAL; OLIGODEOXYRIBONUCLEOTIDES, ANTISENSE; PROTEIN-SERINE-THREONINE KINASES; RATS; RATS, WISTAR; RIBONUCLEOTIDES; S PHASE; TRANSFECTION;

ANIMALIA;

EID: 28244466264     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M507443200     Document Type: Article

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