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Volumn 10, Issue 1, 2009, Pages 42-50

MDM4 (MDMX) and its transcript variants

Author keywords

MDM2; MDM4; MDM4 211; MDM4 S; p53; Transcript variants

Indexed keywords

CASEIN KINASE IALPHA; CELL PROTEIN; CYCLIN DEPENDENT KINASE 1; CYCLIN DEPENDENT KINASE INHIBITOR 2A; KARYOPHERIN ALPHA; MESSENGER RNA; PEPTIDASE; PROTEIN 14 3 3; PROTEIN MDM2; PROTEIN MDM4 211; PROTEIN MDM4 A; PROTEIN MDM4 G; PROTEIN MDM4 S; PROTEIN MDM4 XALT1; PROTEIN MDM4 XALT2; PROTEIN MDMX; PROTEIN P21; PROTEIN P300; PROTEIN P53; PROTEIN S II; RETINOBLASTOMA PROTEIN; SMAD3 PROTEIN; SMAD4 PROTEIN; TRANSCRIPTION FACTOR E2F1; UBIQUITIN SPECIFIC PEPTIDASE 7; UNCLASSIFIED DRUG;

EID: 65949093491     PISSN: 13892029     EISSN: None     Source Type: Journal    
DOI: 10.2174/138920209787581280     Document Type: Review
Times cited : (35)

References (73)
  • 3
    • 0037452725 scopus 로고    scopus 로고
    • Flexible lid to the p53-binding domain of human Mdm2: Implications for p53 regulation
    • McCoy, M.A., Gesell, J.J., Senior, M.M., Wyss, D.F. Flexible lid to the p53-binding domain of human Mdm2: Implications for p53 regulation. Proc. Natl. Acad. Sci. USA 2003, 100: 1645-1648.
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 1645-1648
    • McCoy, M.A.1    Gesell, J.J.2    Senior, M.M.3    Wyss, D.F.4
  • 4
    • 0030981049 scopus 로고    scopus 로고
    • A genetic approach to mapping the p53 binding site in the MDM2 protein
    • Freedman, D.A., Epstein, C.B., Roth, J.C., Levine, A.J. A genetic approach to mapping the p53 binding site in the MDM2 protein. Mol. Med. 1997, 3: 248-59.
    • (1997) Mol. Med , vol.3 , pp. 248-259
    • Freedman, D.A.1    Epstein, C.B.2    Roth, J.C.3    Levine, A.J.4
  • 7
    • 48849117864 scopus 로고    scopus 로고
    • Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain
    • Popowicz, G., Czarna, A., Holak, T. Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain. Cell Cycle 2008, 7: 2441-3.
    • (2008) Cell Cycle , vol.7 , pp. 2441-2443
    • Popowicz, G.1    Czarna, A.2    Holak, T.3
  • 9
    • 56449125249 scopus 로고    scopus 로고
    • Targeting the Conformational Transitions of MDM2 and MDMX: Insights into Dissimilarities and Similarities of p53 Recognition
    • Macchiarulo, A., Giacchè, N., Carotti, A., Baroni, M., Cruciani, G., Pellicciari, R. Targeting the Conformational Transitions of MDM2 and MDMX: Insights into Dissimilarities and Similarities of p53 Recognition. J. Chem. Inf. Model 2008, 48: 1999-2009.
    • (2008) J. Chem. Inf. Model , vol.48 , pp. 1999-2009
    • Macchiarulo, A.1    Giacchè, N.2    Carotti, A.3    Baroni, M.4    Cruciani, G.5    Pellicciari, R.6
  • 11
    • 33845256980 scopus 로고    scopus 로고
    • MDMX overexpression prevents p53 activation by the MDM2 inhibitor Nutlin
    • Hu, B., Gilkes, D.M., Farooqi, B., Sebti, S.M., Chen, J. MDMX overexpression prevents p53 activation by the MDM2 inhibitor Nutlin. J. Biol. Chem. 2006, 281: 33030-5.
    • (2006) J. Biol. Chem , vol.281 , pp. 33030-33035
    • Hu, B.1    Gilkes, D.M.2    Farooqi, B.3    Sebti, S.M.4    Chen, J.5
  • 12
    • 33645511223 scopus 로고    scopus 로고
    • Levels of HdmX expression dictate the sensitivity of normal and transformed cells to Nutlin-3
    • Patton, J.T., Mayo, L.D., Singhi, A.D., Gudkov, A.V., Stark, G.R., Jackson, M.W. Levels of HdmX expression dictate the sensitivity of normal and transformed cells to Nutlin-3. Cancer Res. 2006, 66: 3169-76.
    • (2006) Cancer Res , vol.66 , pp. 3169-3176
    • Patton, J.T.1    Mayo, L.D.2    Singhi, A.D.3    Gudkov, A.V.4    Stark, G.R.5    Jackson, M.W.6
  • 13
    • 33845251005 scopus 로고    scopus 로고
    • Hdmx modulates the outcome of p53 activation in human tumor cells
    • Wade, M., Wong, E.T., Tang, M., Stommel, J.M., Wahl, G.M. Hdmx modulates the outcome of p53 activation in human tumor cells. J. Biol. Chem. 2006, 281: 33036-44.
    • (2006) J. Biol. Chem , vol.281 , pp. 33036-33044
    • Wade, M.1    Wong, E.T.2    Tang, M.3    Stommel, J.M.4    Wahl, G.M.5
  • 14
    • 0034708458 scopus 로고    scopus 로고
    • Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53
    • Fang, S., Jensen, J.P., Ludwig, R.L., Vousden, K.H., Weissman, A.M. Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53. J. Biol. Chem. 2000, 275: 8945-51.
    • (2000) J. Biol. Chem , vol.275 , pp. 8945-8951
    • Fang, S.1    Jensen, J.P.2    Ludwig, R.L.3    Vousden, K.H.4    Weissman, A.M.5
  • 15
    • 0034624678 scopus 로고    scopus 로고
    • Activity of MDM2, a ubiquitin ligase, toward p53 or itself is dependent on the RING finger domain of the ligase
    • Honda, R., Yasuda, H. Activity of MDM2, a ubiquitin ligase, toward p53 or itself is dependent on the RING finger domain of the ligase. Oncogene 2000, 19: 1473-6.
    • (2000) Oncogene , vol.19 , pp. 1473-1476
    • Honda, R.1    Yasuda, H.2
  • 18
    • 33748920505 scopus 로고    scopus 로고
    • Solution structure of the Hdm2 C2H2C4 RING, a domain critical for ubiquitination of p53
    • Kostic, M., Matt, T., Martinez-Yamout, M.A., Dyson, H.J., Wright, P.E. Solution structure of the Hdm2 C2H2C4 RING, a domain critical for ubiquitination of p53. J. Mol. Biol. 2006, 363: 433-50.
    • (2006) J. Mol. Biol , vol.363 , pp. 433-450
    • Kostic, M.1    Matt, T.2    Martinez-Yamout, M.A.3    Dyson, H.J.4    Wright, P.E.5
  • 19
    • 33846239416 scopus 로고    scopus 로고
    • The Mdm2 RING domain C-terminus is required for supramolecular assembly and ubiquitin ligase activity
    • Poyurovsky, M.V., Priest, C., Kentsis, A., Borden, K.L., Pan, Z.Q., Pavletich, N., Prives, C. The Mdm2 RING domain C-terminus is required for supramolecular assembly and ubiquitin ligase activity. EMBO J. 2007, 26: 90-101.
    • (2007) EMBO J , vol.26 , pp. 90-101
    • Poyurovsky, M.V.1    Priest, C.2    Kentsis, A.3    Borden, K.L.4    Pan, Z.Q.5    Pavletich, N.6    Prives, C.7
  • 20
    • 33846193699 scopus 로고    scopus 로고
    • An essential function of the extreme C-terminus of MDM2 can be provided by MDMX
    • Uldrijan, S., Pannekoek, W.J., Vousden, K.H. An essential function of the extreme C-terminus of MDM2 can be provided by MDMX. EMBO J. 2007, 26: 102-12.
    • (2007) EMBO J , vol.26 , pp. 102-112
    • Uldrijan, S.1    Pannekoek, W.J.2    Vousden, K.H.3
  • 21
    • 34249711818 scopus 로고    scopus 로고
    • Hetero-oligomerization with MdmX rescues the ubiquitin/Nedd8 ligase activity of RING finger mutants of Mdm2
    • Singh, R.K., Iyappan, S., Scheffner, M. Hetero-oligomerization with MdmX rescues the ubiquitin/Nedd8 ligase activity of RING finger mutants of Mdm2. J. Biol. Chem. 2007, 282: 10901-7.
    • (2007) J. Biol. Chem , vol.282 , pp. 10901-10907
    • Singh, R.K.1    Iyappan, S.2    Scheffner, M.3
  • 22
    • 0033621415 scopus 로고    scopus 로고
    • Stabilization of the MDM2 oncoprotein by interaction with the structurally related MDMX protein
    • Sharp, D.A., Kratowicz, S.A., Sank, M.J., George, D.L. Stabilization of the MDM2 oncoprotein by interaction with the structurally related MDMX protein. J. Biol. Chem. 1999, 274: 38189-96.
    • (1999) J. Biol. Chem , vol.274 , pp. 38189-38196
    • Sharp, D.A.1    Kratowicz, S.A.2    Sank, M.J.3    George, D.L.4
  • 24
    • 34447123808 scopus 로고    scopus 로고
    • RING domain-mediated interaction is a requirement for MDM2's E3 ligase activity
    • Kawai, H., Lopez-Pajares, V., Kim, M.M., Wiederschain, D., Yuan, Z.M. RING domain-mediated interaction is a requirement for MDM2's E3 ligase activity. Cancer Res. 2007, 67: 6026-30.
    • (2007) Cancer Res , vol.67 , pp. 6026-6030
    • Kawai, H.1    Lopez-Pajares, V.2    Kim, M.M.3    Wiederschain, D.4    Yuan, Z.M.5
  • 25
    • 42149105590 scopus 로고    scopus 로고
    • Structure of the MDM2/MDMX RING domain heterodimer reveals dimerization is required for their ubiquitylation in trans
    • Linke, K., Mace, P.D., Smith, C.A., Vaux, D.L., Silke, J., Day, C.L. Structure of the MDM2/MDMX RING domain heterodimer reveals dimerization is required for their ubiquitylation in trans. Cell Death Differ. 2008, 15: 841-8.
    • (2008) Cell Death Differ , vol.15 , pp. 841-848
    • Linke, K.1    Mace, P.D.2    Smith, C.A.3    Vaux, D.L.4    Silke, J.5    Day, C.L.6
  • 26
    • 33645290219 scopus 로고    scopus 로고
    • Regulation of MDMX nuclear import and degradation by Chk2 and 14-3-3
    • LeBron, C., Chen, L., Gilkes, D.M., Chen, J. Regulation of MDMX nuclear import and degradation by Chk2 and 14-3-3. EMBO J. 2006, 25: 1196-206.
    • (2006) EMBO J , vol.25 , pp. 1196-1206
    • LeBron, C.1    Chen, L.2    Gilkes, D.M.3    Chen, J.4
  • 30
    • 19744363342 scopus 로고    scopus 로고
    • Modification of MDMX by sumoylation
    • Pan, Y., Chen, J. Modification of MDMX by sumoylation. Biochem. Biophys. Res. Commun. 2005, 332: 702-9.
    • (2005) Biochem. Biophys. Res. Commun , vol.332 , pp. 702-709
    • Pan, Y.1    Chen, J.2
  • 31
    • 17844385110 scopus 로고    scopus 로고
    • Phosphorylation of MdmX by CDK2/ Cdc2(p34) is required for nuclear export of Mdm2
    • Elias, B., Laine, A., Ronai, Z. Phosphorylation of MdmX by CDK2/ Cdc2(p34) is required for nuclear export of Mdm2. Oncogene 2005, 24: 2574-9.
    • (2005) Oncogene , vol.24 , pp. 2574-2579
    • Elias, B.1    Laine, A.2    Ronai, Z.3
  • 32
    • 22544438112 scopus 로고    scopus 로고
    • Regulation of p53-MDMX interaction by casein kinase 1 alpha
    • Chen, L., Li, C., Pan, Y., Chen, J. Regulation of p53-MDMX interaction by casein kinase 1 alpha. Mol. Cell. Biol. 2005, 25: 6509-20.
    • (2005) Mol. Cell. Biol , vol.25 , pp. 6509-6520
    • Chen, L.1    Li, C.2    Pan, Y.3    Chen, J.4
  • 33
    • 27144444111 scopus 로고    scopus 로고
    • Chen, L., Gilkes, D.M., Pan, Y., Lane, W.S., Chen, J. ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage. EMBO J. 2005, 4: 3411-22.
    • Chen, L., Gilkes, D.M., Pan, Y., Lane, W.S., Chen, J. ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage. EMBO J. 2005, 4: 3411-22.
  • 36
    • 33645293151 scopus 로고    scopus 로고
    • 14-3-3gamma binds to MDMX that is phosphorylated by UV-activated Chk1, resulting in p53 activation
    • Jin, Y., Dai, M.S., Lu, S.Z., Xu, Y., Luo, Z., Zhao, Y., Lu, H. 14-3-3gamma binds to MDMX that is phosphorylated by UV-activated Chk1, resulting in p53 activation. EMBO J. 2006, 25: 1207-18.
    • (2006) EMBO J , vol.25 , pp. 1207-1218
    • Jin, Y.1    Dai, M.S.2    Lu, S.Z.3    Xu, Y.4    Luo, Z.5    Zhao, Y.6    Lu, H.7
  • 37
    • 46649088994 scopus 로고    scopus 로고
    • Phosphorylation of MDMX mediated by Akt leads to stabilization and induces 14-3-3 binding
    • Lopez-Pajares, V., Kim, M.M., Yuan, Z.M. Phosphorylation of MDMX mediated by Akt leads to stabilization and induces 14-3-3 binding. J. Biol. Chem. 2008, 283: 13707-13.
    • (2008) J. Biol. Chem , vol.283 , pp. 13707-13713
    • Lopez-Pajares, V.1    Kim, M.M.2    Yuan, Z.M.3
  • 39
    • 0034863683 scopus 로고    scopus 로고
    • Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53
    • Parant, J., Chavez-Reyes, A., Little, N.A., Yan, W., Reinke, V., Jochemsen, A.G., Lozano, G. Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53. Nat. Genet. 2001, 29: 92-5.
    • (2001) Nat. Genet , vol.29 , pp. 92-95
    • Parant, J.1    Chavez-Reyes, A.2    Little, N.A.3    Yan, W.4    Reinke, V.5    Jochemsen, A.G.6    Lozano, G.7
  • 40
    • 0036311067 scopus 로고    scopus 로고
    • Migliorini, D., Lazzerini, Denchi, E., Danovi, D., Jochemsen, A., Capillo, M., Gobbi, A., Helin, K., Pelicci, P.G., Marine, J.C. Mdm4 (Mdmx) regulates p53-induced growth arrest and neuronal cell death during early embryonic mouse development. Mol. Cell. Biol. 2002, 22: 5527-38.
    • Migliorini, D., Lazzerini, Denchi, E., Danovi, D., Jochemsen, A., Capillo, M., Gobbi, A., Helin, K., Pelicci, P.G., Marine, J.C. Mdm4 (Mdmx) regulates p53-induced growth arrest and neuronal cell death during early embryonic mouse development. Mol. Cell. Biol. 2002, 22: 5527-38.
  • 41
    • 0036606416 scopus 로고    scopus 로고
    • Finch, R.A., Donoviel, D.B., Potter, D., Shi, M., Fan, A., Freed, D.D., Wang, C.Y., Zambrowicz, B.P., Ramirez-Solis, R., Sands, A.T., Zhang, N. mdmx is a negative regulator of p53 activity in vivo. Cancer Res. 2002, 62: 3221-5.
    • Finch, R.A., Donoviel, D.B., Potter, D., Shi, M., Fan, A., Freed, D.D., Wang, C.Y., Zambrowicz, B.P., Ramirez-Solis, R., Sands, A.T., Zhang, N. mdmx is a negative regulator of p53 activity in vivo. Cancer Res. 2002, 62: 3221-5.
  • 42
    • 33845270990 scopus 로고    scopus 로고
    • Regulating the p53 pathway: In vitro hypotheses, in vivo veritas
    • Toledo, F., Wahl, G.M. Regulating the p53 pathway: in vitro hypotheses, in vivo veritas. Nat. Rev. Cancer 2006, 6: 909-23.
    • (2006) Nat. Rev. Cancer , vol.6 , pp. 909-923
    • Toledo, F.1    Wahl, G.M.2
  • 44
    • 0035895602 scopus 로고    scopus 로고
    • MDM2 and MDMX can interact differently with ARF and members of the p53 family
    • Wang, X., Arooz, T., Siu, W.Y., Chiu, C.H., Lau, A., Yamashita, K., Poon, R.Y. MDM2 and MDMX can interact differently with ARF and members of the p53 family. FEBS Lett. 2001, 490: 202-8.
    • (2001) FEBS Lett , vol.490 , pp. 202-208
    • Wang, X.1    Arooz, T.2    Siu, W.Y.3    Chiu, C.H.4    Lau, A.5    Yamashita, K.6    Poon, R.Y.7
  • 45
    • 0035958574 scopus 로고    scopus 로고
    • Little, N.A., Jochemsen, A.G. Hdmx and Mdm2 can repress transcription activation by p53 but not by p63. Oncogene 2001, 20: 4576-80.
    • Little, N.A., Jochemsen, A.G. Hdmx and Mdm2 can repress transcription activation by p53 but not by p63. Oncogene 2001, 20: 4576-80.
  • 47
    • 0037441475 scopus 로고    scopus 로고
    • The E2F-1 transcription factor is negatively regulated by its interaction with the MDMX protein
    • Strachan, G.D., Jordan-Sciutto, K.L., Rallapalli, R., Tuan, R.S., Hall, D.J. The E2F-1 transcription factor is negatively regulated by its interaction with the MDMX protein. J. Cell. Biochem. 2003, 88: 557-68.
    • (2003) J. Cell. Biochem , vol.88 , pp. 557-568
    • Strachan, G.D.1    Jordan-Sciutto, K.L.2    Rallapalli, R.3    Tuan, R.S.4    Hall, D.J.5
  • 49
    • 0035824686 scopus 로고    scopus 로고
    • A transcriptionally inactive E2F-1 targets the MDM family of proteins for proteolytic degradation
    • Strachan, G.D., Rallapalli, R., Pucci, B., Lafond, T.P., Hall, D.J. A transcriptionally inactive E2F-1 targets the MDM family of proteins for proteolytic degradation. J. Biol. Chem. 2001, 276: 45677-85.
    • (2001) J. Biol. Chem , vol.276 , pp. 45677-45685
    • Strachan, G.D.1    Rallapalli, R.2    Pucci, B.3    Lafond, T.P.4    Hall, D.J.5
  • 51
    • 25444478027 scopus 로고    scopus 로고
    • ATM-mediated phosphorylations inhibit Mdmx/Mdm2 stabilization by HAUSP in favor of p53 activation
    • Meulmeester, E., Pereg, Y., Shiloh, Y., Jochemsen, A.G. ATM-mediated phosphorylations inhibit Mdmx/Mdm2 stabilization by HAUSP in favor of p53 activation. Cell Cycle 2005, 4: 1166-70.
    • (2005) Cell Cycle , vol.4 , pp. 1166-1170
    • Meulmeester, E.1    Pereg, Y.2    Shiloh, Y.3    Jochemsen, A.G.4
  • 52
    • 0036837868 scopus 로고    scopus 로고
    • DNA damage induces MDMX nuclear translocation by p53-dependent and -independent mechanisms
    • Li, C., Chen, L., Chen, J. DNA damage induces MDMX nuclear translocation by p53-dependent and -independent mechanisms. Mol. Cell. Biol. 2002, 22: 7562-71.
    • (2002) Mol. Cell. Biol , vol.22 , pp. 7562-7571
    • Li, C.1    Chen, L.2    Chen, J.3
  • 53
    • 0035895602 scopus 로고    scopus 로고
    • MDM2 and MDMX can interact differently with ARF and members of the p53 family
    • Wang, X., Arooz, T., Siu,W.Y., Chiu, C.H., Lau, A., Yamashita, K., Poon, R.Y. MDM2 and MDMX can interact differently with ARF and members of the p53 family. FEBS Lett. 2001, 490: 202-8.
    • (2001) FEBS Lett , vol.490 , pp. 202-208
    • Wang, X.1    Arooz, T.2    Siu, W.Y.3    Chiu, C.H.4    Lau, A.5    Yamashita, K.6    Poon, R.Y.7
  • 54
    • 0035816560 scopus 로고    scopus 로고
    • MdmX binding to ARF affects Mdm2 protein stability and p53 transactivation
    • Jackson, M.W., Lindstrom, M.S., Berberich, S.J. MdmX binding to ARF affects Mdm2 protein stability and p53 transactivation. J. Biol. Chem. 2001, 276: 25336-41.
    • (2001) J. Biol. Chem , vol.276 , pp. 25336-25341
    • Jackson, M.W.1    Lindstrom, M.S.2    Berberich, S.J.3
  • 55
    • 25444526668 scopus 로고    scopus 로고
    • MdmX inhibits ARF mediated Mdm2 sumoylation
    • Ghosh, M., Weghorst, K., Berberich, S.J. MdmX inhibits ARF mediated Mdm2 sumoylation. Cell Cycle 2005, 4: 604-8.
    • (2005) Cell Cycle , vol.4 , pp. 604-608
    • Ghosh, M.1    Weghorst, K.2    Berberich, S.J.3
  • 56
    • 38949093780 scopus 로고    scopus 로고
    • MDMX promotes proteasomal turnover of p21 at G1 and early S phases independently of, but in cooperation with, MDM2
    • Jin, Y., Zeng, S.X., Sun, X.X., Lee, H., Blattner, C., Xiao, Z., Lu, H. MDMX promotes proteasomal turnover of p21 at G1 and early S phases independently of, but in cooperation with, MDM2. Mol. Cell. Biol. 2008, 28: 1218-29.
    • (2008) Mol. Cell. Biol , vol.28 , pp. 1218-1229
    • Jin, Y.1    Zeng, S.X.2    Sun, X.X.3    Lee, H.4    Blattner, C.5    Xiao, Z.6    Lu, H.7
  • 58
    • 0036059108 scopus 로고    scopus 로고
    • MDMX inhibits the p300/CBP-mediated acetylation of p53
    • Sabbatini, P., McCormick, F. MDMX inhibits the p300/CBP-mediated acetylation of p53. DNA Cell Biol. 2002, 21: 519-25.
    • (2002) DNA Cell Biol , vol.21 , pp. 519-525
    • Sabbatini, P.1    McCormick, F.2
  • 60
    • 0344995254 scopus 로고    scopus 로고
    • MDM2 and MDMX inhibit the transcriptional activity of ectopically expressed SMAD proteins
    • Yam, C.H., Siu, W.Y., Arooz, T., Chiu, C.H., Lau, A., Wang, X.Q., Poon, R.Y. MDM2 and MDMX inhibit the transcriptional activity of ectopically expressed SMAD proteins. Cancer Res. 1999, 59: 5075-8.
    • (1999) Cancer Res , vol.59 , pp. 5075-5078
    • Yam, C.H.1    Siu, W.Y.2    Arooz, T.3    Chiu, C.H.4    Lau, A.5    Wang, X.Q.6    Poon, R.Y.7
  • 62
    • 0033583205 scopus 로고    scopus 로고
    • A novel MDMX transcript expressed in a variety of transformed cell lines encodes a truncated protein with potent p53 repressive activity
    • Rallapalli, R., Strachan, G., Cho, B., Mercer, W.E., Hall, D.J. A novel MDMX transcript expressed in a variety of transformed cell lines encodes a truncated protein with potent p53 repressive activity. J. Biol. Chem. 1999, 274: 8299-308.
    • (1999) J. Biol. Chem , vol.274 , pp. 8299-8308
    • Rallapalli, R.1    Strachan, G.2    Cho, B.3    Mercer, W.E.4    Hall, D.J.5
  • 63
    • 0038022602 scopus 로고    scopus 로고
    • Identification of a domain within MDMX-S that is responsible for its high affinity interaction with p53 and high-level expression in mammalian cells
    • Rallapalli, R., Strachan, G., Tuan, R.S., Hall, D.J. Identification of a domain within MDMX-S that is responsible for its high affinity interaction with p53 and high-level expression in mammalian cells. J. Cell. Biochem. 2003, 1: 563-75.
    • (2003) J. Cell. Biochem , vol.1 , pp. 563-575
    • Rallapalli, R.1    Strachan, G.2    Tuan, R.S.3    Hall, D.J.4
  • 64
    • 26444599546 scopus 로고    scopus 로고
    • Significance of HDMX-S (or MDM4) mRNA splice variant overexpression and HDMX gene amplification on primary soft tissue sarcoma prognosis
    • Bartel, F., Schulz, J., Böhnke, A., Blümke, K., Kappler, M., Bache, M., Schmidt, H., Würl, P., Taubert, H., Hauptmann, S. Significance of HDMX-S (or MDM4) mRNA splice variant overexpression and HDMX gene amplification on primary soft tissue sarcoma prognosis. Int. J. Cancer 2005, 10: 469-75.
    • (2005) Int. J. Cancer , vol.10 , pp. 469-475
    • Bartel, F.1    Schulz, J.2    Böhnke, A.3    Blümke, K.4    Kappler, M.5    Bache, M.6    Schmidt, H.7    Würl, P.8    Taubert, H.9    Hauptmann, S.10
  • 66
    • 0343819885 scopus 로고    scopus 로고
    • Amplification and overexpression of the MDM4 (MDMX) gene from 1q32 in a subset of malignant gliomas without TP53 mutation or MDM2 amplification
    • Riemenschneider, M.J., Büschges, R., Wolter, M., Reifenberger, J., Boström, J., Kraus, J.A., Schlegel,U., Reifenberger, G. Amplification and overexpression of the MDM4 (MDMX) gene from 1q32 in a subset of malignant gliomas without TP53 mutation or MDM2 amplification. Cancer Res. 1999, 59: 6091-6.
    • (1999) Cancer Res , vol.59 , pp. 6091-6096
    • Riemenschneider, M.J.1    Büschges, R.2    Wolter, M.3    Reifenberger, J.4    Boström, J.5    Kraus, J.A.6    Schlegel, U.7    Reifenberger, G.8
  • 69
    • 33750378188 scopus 로고    scopus 로고
    • Genotoxic stress induces coordinately regulated alternative splicing of the p53 modulators MDM2 and MDM4
    • Chandler, D.S., Singh, R.K., Caldwell, L.C., Bitler, J.L., Lozano, G. Genotoxic stress induces coordinately regulated alternative splicing of the p53 modulators MDM2 and MDM4. Cancer Res. 2006, 66: 9502-8.
    • (2006) Cancer Res , vol.66 , pp. 9502-9508
    • Chandler, D.S.1    Singh, R.K.2    Caldwell, L.C.3    Bitler, J.L.4    Lozano, G.5
  • 70
    • 33947277697 scopus 로고    scopus 로고
    • Mdm2: P53's lifesaver?
    • Shmueli, A., Oren, M. Mdm2: p53's lifesaver? Mol. Cell 2007, 25: 794-6.
    • (2007) Mol. Cell , vol.25 , pp. 794-796
    • Shmueli, A.1    Oren, M.2
  • 71
    • 0036655060 scopus 로고    scopus 로고
    • Alternative and aberrant splicing of MDM2 mRNA in human cancer
    • Bartel, F., Taubert, H., Harris, L. Alternative and aberrant splicing of MDM2 mRNA in human cancer. Cancer Cell 2002, 2: 9-15.
    • (2002) Cancer Cell , vol.2 , pp. 9-15
    • Bartel, F.1    Taubert, H.2    Harris, L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.