Phosphorylation of MDMX mediated by Akt leads to stabilization and induces 14-3-3 binding

Journal of Biological Chemistry

Volumn 283, Issue 20, 2008, Pages 13707-13713

  Lopez Pajares, Vanessa ^a   Kim, Mihee M ^a   Yuan, Zhi Min ^a,b  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^b Bldg 1 507 ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMICAL REACTIONS; STABILIZATION; TUMORS;

ALTERNATIVE MECHANISMS; BINDING PARTNERS; C TERMINUSES; COMPLEX FUNCTIONS; KINASE AKT; PROTEIN LEVELS; TUMOR CELLS; TUMOR SUPPRESSORS;

PHOSPHORYLATION;

PROTEIN 14 3 3; PROTEIN KINASE B; PROTEIN MDM2; PROTEIN MDMX; PROTEIN P53; SERINE; MDM4 PROTEIN, HUMAN; NUCLEAR PROTEIN; ONCOPROTEIN;

ARTICLE; CARCINOGENESIS; CONTROLLED STUDY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION; PROTEIN STABILITY; TUMOR SUPPRESSOR GENE; AMINO ACID SEQUENCE; BIOLOGICAL MODEL; CELL LINE; CHEMISTRY; GENE EXPRESSION REGULATION; METABOLISM; MOLECULAR GENETICS; PHOSPHORYLATION; PHYSIOLOGY; PROTEIN MOTIF; PROTEIN TERTIARY STRUCTURE; SEQUENCE HOMOLOGY;

14-3-3 PROTEINS; AMINO ACID MOTIFS; AMINO ACID SEQUENCE; CELL LINE; GENE EXPRESSION REGULATION; HUMANS; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; NUCLEAR PROTEINS; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; SEQUENCE HOMOLOGY, AMINO ACID; TUMOR SUPPRESSOR PROTEIN P53;

EID: 46649088994     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M710030200     Document Type: Article

References (48)

1. Vogelstein, B., Lane, D., and Levine, A. J. (2000) Nature 408, 307-310
2. Michael, D., and Oren, M. (2003) Semin. Cancer Biol. 13, 49-58
3. Finch, R. A., Donoviel, D. B., Potter, D., Shi, M., Fan, A., Freed, D. D., Wang, C. Y., Zambrowicz, B. P., Ramirez-Solis, R., Sands, A. T., and Zhang, N. (2002) Cancer Res. 62, 3221-3225
4. Parant, J., Chavez-Reyes, A., Little, N. A., Yan, W., Reinke, V., Jochemsen, A. G., and Lozano, G. (2001) Nat. Genet. 29, 92-95
5. Jackson, M. W., and Berberich, S. J. (2000) Mol. Cell. Biol. 20, 1001-1007
6. Shvarts, A., Steegenga, W. T., Riteco, N., van Laar, T., Dekker, P., Bazuine, M., van Ham, R. C., van der Houven van Oordt, W., Hateboer, G., van der Eb, A. J., and Jochemsen, A. G. (1996) EMBO J. 15, 5349-5357
7. Gu, J., Kawai, H., Nie, L., Kitao, H., Wiederschain, D., Jochemsen, A. G., Parant, J., Lozano, G., and Yuan, Z.-M. (2002) J. Biol. Chem. 277, 19251-19254
8. Badciong, J. C., and Haas, A. L. (2002) J. Biol. Chem. 277, 49668-49675
9. de Graaf, P., Little, N. A., Ramos, Y. F., Meulmeester, E., Letteboer, S. J., and Jochemsen, A. G. (2003) J. Biol. Chem. 278, 38315-38324
10. Kawai, H., Lopez-Pajares, V., Kim, M. M., Wiederschain, D., and Yuan, Z.-M. (2007) Cancer Res. 67, 6026-6030
11. Linares, L. K., Hengstermann, A., Ciechanover, A., Muller, S., and Scheffner, M. (2003) Proc. Natl. Acad. Sci. U. S. A. 100, 12009-12014
12. Danovi, D., Meulmeester, E., Pasini, D., Migliorini, D., Capra, M., Frenk, R., de Graaf, P., Francoz, S., Gasparini, P., Gobbi, A., Helin, K., Pelicci, P. G., Jochemsen, A. G., and Marine, J. C. (2004) Mol. Cell. Biol. 24, 5835-5843
13. Riemenschneider, M. J., Buschges, R., Wolter, M., Reifenberger, J., Bostrom, J., Kraus, J. A., Schlegel, U., and Reifenberger, G. (1999) Cancer Res. 59, 6091-6096
14. Ramos, Y. F., Stad, R., Attema, J., Peltenburg, L. T., van der Eb, A. J., and Jochemsen, A. G. (2001) Cancer Res. 61, 1839-1842
15. Downward, J. (2004) Semin. Cell Dev. Biol. 15, 177-182
16. Brazil, D. P., Park, J., and Hemmings, B. A. (2002) Cell 111, 293-303
17. Wendel, H. G., De Stanchina, E., Fridman, J. S., Malina, A., Ray, S., Kogan, S., Cordon-Cardo, C., Pelletier, J., and Lowe, S. W. (2004) Nature 428, 332-337
18. Obsil, T., Ghirlando, R., Anderson, D. E., Hickman, A. B., and Dyda, F. (2003) Biochemistry 42, 15264-15272
19. You, H., Jang, Y., You-Ten, A. I., Okada, H., Liepa, J., Wakeham, A., Zaugg, K., and Mak, T. W. (2004) Proc. Natl. Acad. Sci. U. S. A. 101, 14057-14062
20. Basu, S. (2003) Cell Cycle 2, 69-70
21. Hermeking, H. (2003) Nat. Rev. Cancer 3, 931-943
22. Dougherty, M. K., and Morrison, D. K. (2004) J. Cell Sci. 117, 1875-1884
23. Yaffe, M. B. (2002) FEBS Lett. 513, 53-57
24. Ashcroft, M., Ludwig, R. L., Woods, D. B., Copeland, T. D., Weber, H. O., MacRae, E. J., and Vousden, K. H. (2002) Oncogene 21, 1955-1962
25. Feng, J., Tamaskovic, R., Yang, Z., Brazil, D. P., Merlo, A., Hess, D., and Hemmings, B. A. (2004) J. Biol. Chem. 279, 35510-35517
26. Gottlieb, T. M., Leal, J. F., Seger, R., Taya, Y., and Oren, M. (2002) Oncogene 21, 1299-1303
27. Milne, D., Kampanis, P., Nicol, S., Dias, S., Campbell, D. G., Fuller-Pace, F., and Meek, D. (2004) FEBS Lett. 577, 270-276
28. Mayo, L. D., and Donner, D. B. (2001) Proc. Natl. Acad. Sci. U. S. A. 98, 11598-11603
29. Ogawara, Y., Kishishita, S., Obata, T., Isazawa, Y., Suzuki, T., Tanaka, K., Masuyama, N., and Gotoh, Y. (2002) J. Biol. Chem. 277, 21843-21850
30. Zhou, B. P., Liao, Y., Xia, W., Zou, Y., Spohn, B., and Hung, M. C. (2001) Nat. Cell Biol. 3, 973-982
31. Sharp, D. A., Kratowicz, S. A., Sank, M. J., and George, D. L. (1999) J. Biol. Chem. 274, 38189-38196
32. Kawai, H., Wiederschain, D., Kitao, H., Stuart, J., Tsai, K. K., and Yuan, Z.-M. (2003) J. Biol. Chem. 278, 45946-45953
33. Gentiletti, F., Mancini, F., D'Angelo, M., Sacchi, A., Pontecorvi, A., Jochemsen, A. G., and Moretti, F. (2002) Oncogene 21, 867-877
34. Pereg, Y., Lam, S., Teunisse, A., Biton, S., Meulmeester, E., Mittelman, L., Buscemi, G., Okamoto, K., Taya, Y., Shiloh, Y., and Jochemsen, A. G. (2006) Mol. Cell. Biol. 26, 6819-6831
35. Lebron, C., Chen, L., Gilkes, D. M., and Chen, J. (2006) EMBO J. 25, 1196-1206
36. Jin, Y., Dai, M. S., Lu, S. Z., Xu, Y., Luo, Z., Zhao, Y., and Lu, H. (2006) EMBO J. 25, 1207-1218
37. Pereg, Y., Shkedy, D., de Graaf, P., Meulmeester, E., Edelson-Averbukh, M., Salek, M., Biton, S., Teunisse, A. F., Lehmann, W. D., Jochemsen, A. G., and Shiloh, Y. (2005) Proc. Natl. Acad. Sci. U. S. A. 102, 5056-5061
38. Okamoto, K., Kashima, K., Pereg, Y., Ishida, M., Yamazaki, S., Nota, A., Teunisse, A., Migliorini, D., Kitabayashi, I., Marine, J. C., Prives, C., Shiloh, Y., Jochemsen, A. G., and Taya, Y. (2005) Mol. Cell. Biol. 25, 9608-9620
39. Gu, J., Chen, D., Rosenblum, J., Rubin, R. M., and Yuan, Z.-M. (2000) Mol. Cell. Biol. 20, 1243-1253
40. Kawai, H., Wiederschain, D., and Yuan, Z.-M. (2003) Mol. Cell. Biol. 23, 4939-4947
41. Obenauer, J. C., Cantley, L. C., and Yaffe, M. B. (2003) Nucleic Acids Res. 31, 3635-3641
42. Migliorini, D., Denchi, E. L., Danovi, D., Jochemsen, A., Capillo, M., Gobbi, A., Helin, K., Pelicci, P. G., and Marine, J. C. (2002) Mol. Cell. Biol. 22, 5527-5538
43. Meulmeester, E., Maurice, M. M., Boutell, C., Teunisse, A. F., Ovaa, H., Abraham, T. E., Dirks, R. W., and Jochemsen, A. G. (2005) Mol. Cell 18, 565-576
44. Chen, L., Gilkes, D. M., Pan, Y., Lane, W. S., and Chen, J. (2005) EMBO J. 24, 3411-3422
45. Stad, R., Ramos, Y. F., Little, N., Grivell, S., Attema, J., van der Eb, A. J., and Jochemsen, A. G. (2000) J. Biol. Chem. 275, 28039-28044
46. Singh, R. K., Iyappan, S., and Scheffner, M. (2007) J. Biol. Chem. 282, 10901-10907
47. Chene, P. (2003) Nat. Rev. Cancer 3, 102-109
48. Momand, J., Jung, D., Wilczynski, S., and Niland, J. (1998) Nucleic Acids Res. 26, 3453-3459