Significance of HDMX-S (or MDM4) mRNA splice variant overexpression and HDMX gene amplification on primary soft tissue sarcoma prognosis

International Journal of Cancer

Volumn 117, Issue 3, 2005, Pages 469-475

  Bartel, Frank ^a   Schulz, Jördis ^a   Böhnke, Anja ^a   Blümke, Karen ^a   Kappler, Matthias ^a   Bache, Matthias ^a   Schmidt, Hannelore ^a   Würl, Peter ^b   Taubert, Helge ^a   Hauptmann, Steffen ^a  

^a MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

^b UNIVERSITY OF ULM   (Germany)

Author keywords

Alternative splicing; Amplification; Cancer; HDMX; Oncogene; Overexpression; Prognosis

Indexed keywords

GENOMIC DNA; MESSENGER RNA; ONCOPROTEIN; PROTEIN HDMX S; PROTEIN MDMX; PROTEIN P53; UNCLASSIFIED DRUG;

ADULT; ALTERNATIVE RNA SPLICING; ARTICLE; CANCER STAGING; CONTROLLED STUDY; FEMALE; FIBROSARCOMA; FOLLOW UP; GENE; GENE AMPLIFICATION; GENE OVEREXPRESSION; HDMX4 GENE; HEMANGIOPERICYTOMA; HUMAN; HUMAN CELL; HUMAN TISSUE; LEIOMYOSARCOMA; LIPOSARCOMA; MAJOR CLINICAL STUDY; MALE; MALIGNANT FIBROUS HISTIOCYTOMA; MALIGNANT MESOTHELIOMA; MALIGNANT TRANSFORMATION; MULTIVARIATE LOGISTIC REGRESSION ANALYSIS; NEUROFIBROSARCOMA; PRIORITY JOURNAL; PROGNOSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RHABDOMYOSARCOMA; RNA SEQUENCE; RNA TRANSLATION; SOFT TISSUE SARCOMA; SURVIVAL TIME; SYNOVIAL SARCOMA; TREATMENT OUTCOME; WESTERN BLOTTING;

ADULT; ALTERNATIVE SPLICING; CARRIER PROTEINS; DNA PRIMERS; DNA, NEOPLASM; FEMALE; FIBROSARCOMA; GENE AMPLIFICATION; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LIPOSARCOMA; MALE; NEOPLASM STAGING; NUCLEAR PROTEINS; PROGNOSIS; PROTO-ONCOGENE PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA, NEOPLASM; SARCOMA; SURVIVAL ANALYSIS;

EID: 26444599546     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/ijc.21206     Document Type: Article

References (22)

1. Shvarts A, Steegenga WT, Riteco N, van Laar T, Dekker P, Bazuine M, van Ham RC, van der Houven van Oordt , Hateboer G, van der Eb AJ, Jochemsen AG. MDMX: a novel p53-binding protein with some functional properties of MDM2. EMBO J 1996;15:5349-57.
2. Shvarts A, Bazuine M, Dekker P, Ramos YF, Steegenga WT, Merckx G, van Ham RC, van der Houven van Oordt, van der Eb AJ, Jochemsen AG. Isolation and identification of the human homolog of a new p53-binding protein, Mdmx. Genomics 1997;43:34-42.
3. Jackson MW, Berberich SJ. MdmX protects p53 from Mdm2-mediated degradation. Mol Cell Biol 2000;20:1001-7.
4. Jones SN, Roe AE, Donehower LA, Bradley A. Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53. Nature 1995;378:206-8.
5. Parant J, Chavez-Reyes A, Little NA, Yan W, Reinke V, Jochemsen AG, Lozano G. Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53. Nat Genet 2001;29:92-5.
6. Linares LK, Hengstermann A, Ciechanover A, Muller S, Scheffner M. HdmX stimulates Hdm2-mediated ubiquitination and degradation of p53. Proc Natl Acad Sci USA 2003;100:12009-14.
7. Michael D, Oren M. The p53 and Mdm2 families in cancer. Curr Opin Genet Dev 2002;12:53-9.
8. Riemenschneider MJ, Buschges R, Wolter M, Reifenberger J, Bostrom J, Kraus JA, Schlegel U, Reifenberger G. Amplification and overexpression of the MDM4 (MDMX) gene from 1q32 in a subset of malignant gliomas without TP53 mutation or MDM2 amplification. Cancer Res 1999;59:6091-6.
9. Riemenschneider MJ, Knobbe CB, Reifenberger G. Refined mapping of 1q32 amplicons in malignant gliomas confirms MDM4 as the main amplification target. Int J Cancer 2003;104:752-7.
10. Danovi D, Meulmeester E, Pasini D, Migliorini D, Capra M, Frenk R, de Graaf P, Francoz S, Gasparini P, Gobbi A, Helin K, Pelicci PG, et al. Amplification of Mdmx (or Mdm4) directly contributes to tumor formation by inhibiting p53 tumor suppressor activity. Mol Cell Biol 2004;24:5835-43.
11. Ramos YF, Stad R, Attema J, Peltenburg LT, van der Eb AJ, Jochemsen AG. Aberrant expression of HDMX proteins in tumor cells correlates with wild-type p53. Cancer Res 2001;61:1839-42.
12. Rallapalli R, Strachan G, Cho B, Mercer WE, Hall DJ. A novel MDMX transcript expressed in a variety of transformed cell lines encodes a truncated protein with potent p53 repressive activity. J Biol Chem 1999;274:8299-308.
13. de Graaf P, Little NA, Ramos YF, Meulmeester E, Letteboer SJF, Jochemsen AG. Hdmx protein stability is regulated by the ubiquitin ligase activity of Mdm2. J Biol Chem 2003;278:38315-24.
14. Kappler M, Kohler T, Kampf C, Diestelkotter P, Wurl P, Schmitz M, Bartel F, Lautenschlager C, Rieber EP, Schmidt H, Bache M, Taubert H, et al. Increased survivin transcript levels: an independent negative predictor of survival in soft tissue sarcoma patients. Int J Cancer 2001;95:360-3.
15. Wurl P, Kappler M, Meye A, Bartel F, Kohler T, Lautenschlager C, Bache M, Schmidt H, Taubert H. Co-expression of survivin and TERT and risk of tumour-related death in patients with soft-tissue sarcoma. Lancet 2002;359:943-5.
16. van Unnik JAM, Coindre JM, Contesso C, Albus-Lutter CE, Schiodt T, Sylvester R, Thomas D, Bramwell V, Mouridsen HAT. Grading of soft tissue sarcomas: experience of the EORTC Soft and Bone Sarcoma Group. Eur J Cancer 1993;29A:2089-93.
17. Wittekind C, Wagner G. UICC-TNM-Klassifikation maligner, 5th. Tumoren 1997.
18. Bartel F, Meye A, Wurl P, Kappler M, Bache M, Lautenschlager C, Grunbaum U, Schmidt H, Taubert H. Amplification of the MDM2 gene, but not expression of splice variants of MDM2 MRNA, is associated with prognosis in soft tissue sarcoma. Int J Cancer 2001;95:168-75.
19. Wurl P, Taubert H, Meye A, Berger D, Lautenschlager C, Holzhausen HJ, Schmidt H, Kalthoff H, Rath FW, Dralle H. Prognostic value of immunohistochemistry for p53 in primary soft-tissue sarcomas: a multivariate analysis of five antibodies. J Cancer Res Clin Oncol 1997;123:502-8.
20. Taubert H, Meye A, Würl P. Prognosis is correlated with p53 mutation type for soft tissue sarcoma patients. Cancer Res 1996;56:4134-6.
21. Orlow I, Drobnjak M, Zhang ZF, Lewis J, Woodruff JM, Brennan MF, Cordon-Cardo C. Alterations of INK4A and INK4B genes in adult soft tissue sarcomas: effect on survival. J Natl Cancer Inst 1999;91:73-9.
22. Anderson L, Seilhamer J. A comparison of selected mRNA and protein abundances in human liver. Electrophoresis 1997;18:533-7.