An Alternative Splice Form of Mdm2 Induces p53-independent Cell Growth and Tumorigenesis

Journal of Biological Chemistry

Volumn 279, Issue 6, 2004, Pages 4877-4886

  Steinman, Heather A ^b   Burstein, Ezra ^a   Lengner, Christopher ^b   Gosselin, Joseph ^b   Pihan, German ^b   Duckett, Colin S ^a   Jones, Stephen N ^b  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; PROTEINS; TUMORS;

APOPTOSIS; CELL GROWTH;

GENES;

PROTEIN MDM2; PROTEIN P53; TRANSCRIPTION FACTOR RELA; TUMOR SUPPRESSOR PROTEIN;

ALTERNATIVE RNA SPLICING; ARTICLE; CARCINOGENESIS; CELL CYCLE S PHASE; CELL GROWTH; CELL IMMORTALIZATION; CELL PROLIFERATION; CELL TYPE; GENE; GENE AMPLIFICATION; GENE FUNCTION; GROWTH INHIBITION; HUMAN; HUMAN CELL; MDM2 GENE; PRIORITY JOURNAL; PROGNOSIS; SIGNAL TRANSDUCTION;

ALTERNATIVE SPLICING; AMINO ACID SEQUENCE; ANIMALS; APOPTOSIS; BASE SEQUENCE; CELL DIVISION; DNA, COMPLEMENTARY; HUMANS; MICE; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; NIH 3T3 CELLS; NUCLEAR PROTEINS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-MDM2; SARCOMA, EXPERIMENTAL; SEQUENCE HOMOLOGY, AMINO ACID; TRANSFECTION; TUMOR SUPPRESSOR PROTEIN P53;

MUS MUSCULUS;

EID: 1042266626     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M305966200     Document Type: Article

References (51)

1. Cahilly-Snyder, L., Yang-Feng, T., Francke, U., and George, D. L. (1987) Somat. Cell Mol. Genet. 13, 235-244
2. Finlay, C. A. (1993) Mol. Cell. Biol. 13, 301-306
3. Momand, J., Zambetti, G. P., Olson, D. C., George, D., and Levine, A. J. (1992) Cell 69, 1237-1245
4. Chen, J., Marechal, V., and Levine, A. J. (1993) Mol. Cell. Biol. 13, 4107-4114
5. Oliner, J. D., Pietenpol, J. A., Thiagalingam, S., Gyuris, J., Kinzler, K. W., and Vogelstein, B. (1993) Nature 362, 857-860
6. Haupt, Y., Maya, R., Kazaz, A., and Oren, M. (1997) Nature 387, 296-299
7. Kubbatat, M., Jones, S. N., and Vousden, K. H. (1997) Nature 387, 299-303
8. Barak, Y., Juven, T., Haffner, R., and Oren, M. (1993) EMBO J. 12, 461-468
9. Wu, X., Bayle, J. H., Olson, D., and Levine, A. J. (1993) Genes Dev. 7, 1126-1136
10. Pomerantz, J., Schreiber-Agus, N., Liegeois, N. J., Silverman, A., Alland, L., Chin, L., Potes, J., Orlow, I., Lee, H. W., Cordon-Cardo, C., and DePinho, R. A. (1998) Cell 92:713-723
11. Maya, R., Balass, M., Kim, S. T., Shkedy, D., Leal, J. F., Shifman, O., Moas, M., Buschmann, T., Ronai, Z., Shiloh, Y., Kastan, M. B., Katzir, E., and Oren, M. (2001) Genes Dev. 15, 1067-1077
12. Jones, S. N., Roe, A. E., Donehower, L. A., and Bradley, A. (1995) Nature 378, 206-208
13. Montes de Oca Luna, R., Wagner, D. S., and Lozano, G. (1995) Nature 378, 203-206
14. O'liner, J. D., Kinzler, K. W., Meltzer, P. S., George, D. L., and Vogelstein, B. (1992) Nature 358, 80-83
15. Reifenberger, G., Liu, L., Ichimura, K., Schmidt, E. E., and Collins, V. P. (1993) Cancer Res. 53, 2736-2739
16. Bueso-Ramos, C. E., Yang, Y., deLeon, E., McCown, P., Stass, S. A., and Albitar, M. (1993) Blood 82, 2617-2623
17. Cordon-Cardo, C., Latres, E., Drobnjak, M., Oliva, M. R., Pollack, D., Woodruff, J. M., Marechal, V., Chen, J., Brennan, M. F., and Levine. A. J. (1994) Cancer Res. 54:794-799
18. Xiao, Z. X., Chen, J., Levine, A. J., Modjtahedi, N., Xing, J., Sellers, W. R., and Livingston, D. M. (1995) Nature 375, 694-698
19. Martin, K., Trouche, D., Hagemeier, C., Sorensen, T. S., La Thangue, N. B., and Kouzarides, T. (1995) Nature 375, 691-694
20. Juven-Gershon, T., Shifman, O. Unger, T., Elkeles, A., Haupt, Y., and Oren, M. (1998) Mol. Cell. Biol. 18, 3974-3982
21. Boyd, M. T., Vlatkovic, N., and Haines, D. S. (2000) J. Biol. Chem. 275, 31883-31890
22. Yam, C. H., Siu, W. Y., Arooz, T., Chiu, C. H., Lau, A., Wang, X. Q., and Poon, R. Y. (1999) Cancer Res. 59, 5075-5078
23. Legube, G., Linares, L. K., Lemercier, C., Scheffner, M., Khochbin, S., and Trouche, D. (2002) EMBO J. 21, 1704-1712
24. Shenoy, S. K., McDonald, P. H., Kohout, T. A., and Lefkowitz, R. J. (2001) Science 294, 1307-1313
25. Lundgren, K., Montes de Oca Luna, R., McNeill, Y. B., Emerick, E. P., Spencer, B., Barfield, C. R., Lozano, G., Rosenberg, M. P., and Finlay, C. A. (1997) Genes Dev. 11, 714-725
26. Jones, S. N., Hancock, A. R., Vogel, H., Donehower, L. A., and Bradley, A. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 15608-15612
27. Bartel, F., Meye, A., Wurl, P., Kappler, M., Bache, M., Lautenschrunlager, C., Grunbaum, U., Schmidt, H., and Taubert, H. (2001) Int. J. Cancer (Pred. Oncol.) 95, 168-175
28. Matsumoto, R., Tada, M., Nozaki, M., Zhang, C. L., Sawamura, Y., and Abe, H. (1998) Cancer Res. 58, 609-613
29. Bartel, F., Pinkert, D., Fiedler, W., Kappler, M., Wurl, P., Schmidt, H., and Taubert, H. (2002) Cancer Cell 2, 9-15
30. Sigalas, I., Calvert, A. H., Anderson, J. J., Neal, D. E., and Lunec, J. (1996) Nat. Med. 2, 912-917
31. Dang, J., Kuo, M. L., Eischen, C. M., Stepanova, L., Sherr, C. J., and Roussel, M. F. (2002) Cancer Res. 62, 1222-1230
32. Evans, S. C., Viswanathan, M. Grier, J. D., Narayana, M., El-Naggar, A. K., and Lozano, G. (2001) Oncogene 20, 4041-4049
33. Duckett, C. S., Gedrich, R. W., Gilfillan, M. C., and Thompson, C. B. (1997) Mol. Cell. Biol. 17, 1535-1542
34. Jones, S. N., Ansari-Lari, M. A., Hancock, A. R., Jones, W. J., Gibbs, R. A., Donehower, L. A., and Bradley, A. (1996) Gene (Amst.) 175, 209-213
35. de Toledo, S. M., Azzam, E. I., Dahlberg, W. K., Gooding, T. B., and Little, J. B. (2000) Oncogene 19, 6185-6193
36. Sionov, R. V., Moallem, E., Berger, M., Kazaz, A., Gerlitz, O., Ben-Neriah, Y., Oren, M., and Haupt, Y. (1999) J. Biol. Chem. 274, 8371-8374
37. Gerwirtz, D. A. (1999) Biochem. Pharm. 57, 727-741
38. Schmitz, M. L., and Baeuerle, P. A. (1991) EMBO J. 10, 3805-3817
39. Malek, S., Huxford, T., and Ghosh, G. (1998) J. Biol. Chem. 273, 25427-25435
40. Glasgow, J. N., Wood, T., and Perez-Polo J. R. (2000) J. Neurochem. 75, 1377-1389
41. Wang, C. Y., Guttridge, D. C., Mayo, M. W., and Baldwin, A. S., Jr. (1999) Mol. Cell. Biol. 19, 5923-5929
42. Wang, C. Y., Mayo, M. W., Korneluk, R. G., Goeddel, D. V., and Baldwin, A. S., Jr. (1998) Science 281, 1680-1683
43. Karin, M., Cao, Y., Greten, F. R., and Li, Z. W. (2002) Nat. Rev. Cancer 2, 301-310
44. Gu, L., Findley, H. W., and Zhou, M. (2002) Blood 99, 3367-3375
45. Grand, R. J. A., Lecane, P. S., Owen, D., Grant, M. L., Roberts, S., Levine, A. J., and Gallimore, P. H. (1995) Virology 210, 323-334
46. Fang, S., Jensen, J. P., Ludwig, R. L., Vousden, K. H., and Weissman, A. M. (2000) J. Biol. Chem. 275, 8945-8951
47. Brenner, M., and Messing, A. (1996) Methods 10, 351-364
48. Weissenberger, J., Steinbach, J. P., Malin, G., Spada, S., Rulicke, T., and Aguzzi, A. (1997) Oncogene 14, 2005-2013
49. Ryan, K. M., Ernst, M. K., Rice, N. R., and Vousden, K. H. (2000) Nature 404, 892-897
50. Jones, S. N., Sands, A. T., Hancock, A. R., Volgel, H., Donehower, L. A., Linke, S. P., Wahl, G. M., and Bradley, A. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 14106-14111
51. Richmond, A. (2002) Nat. Rev. Immunol. 2, 664-674