Palmitate increases L-type Ca2+ currents and the size of the readily releasable granule pool in mouse pancreatic β-cells

Journal of Physiology

Volumn 557, Issue 3, 2004, Pages 935-948

  Olofsson, Charlotta S ^a   Salehi, Albert ^a   Holm, Cecilia ^a   Rorsman, Patrik ^a,b  

^a LUND UNIVERSITY   (Sweden)

^b CHURCHILL HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM); CALCIUM CHANNEL L TYPE; DIAZOXIDE; FATTY ACID; GLUCOSE; INSULIN; ISRADIPINE; PALMITIC ACID; PALMITOYL COENZYME A; POTASSIUM CHANNEL; POTASSIUM ION; SATURATED FATTY ACID; TOLBUTAMIDE; ADENOSINE TRIPHOSPHATE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CALCIUM CELL LEVEL; CALCIUM CURRENT; CELL GRANULE; CELL MEMBRANE DEPOLARIZATION; CELL SIZE; CELL STIMULATION; CONTROLLED STUDY; EXOCYTOSIS; FEMALE; IN VITRO STUDY; INSULIN RELEASE; MEMBRANE ELECTROPHYSIOLOGY; MICROFLUOROMETRY; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; ELECTROPHYSIOLOGY; FATTY ACID ANALYSIS; GLUCOSE STIMULATED INSULIN SECRETION; MEMBRANE DEPOLARIZATION; PROTEIN LIPID INTERACTION; UPREGULATION; WHOLE CELL;

ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; CALCIUM; CALCIUM CHANNELS, L-TYPE; CELL POLARITY; CELL SEPARATION; CELL SIZE; CYCLIC AMP; CYTOPLASMIC GRANULES; ELECTROPHYSIOLOGY; EXOCYTOSIS; FEMALE; GLUCOSE; INSULIN; ISLETS OF LANGERHANS; MEMBRANE POTENTIALS; MICE; PALMITATES; PALMITOYL COENZYME A; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNELS; POTASSIUM CHANNELS, INWARDLY RECTIFYING; SERUM ALBUMIN, BOVINE;

EID: 3242670708     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1113/jphysiol.2004.066258     Document Type: Article

References (46)

1. Alcazar O, Qiu-yue Z, Gine E & Tamarit-Rodriguez J (1997). Stimulation of islet protein kinase C translocation by palmitate requires metabolism of the fatty acid. Diabetes 46, 1153-1158.
2. Ashcroft FM, Proks P, Smith PA, Ammala C, Bokvist K & Rorsman P (1994). Stimulus-secretion coupling in pancreatic beta cells. J Cell Biochem 55, 54-65.
3. Atwater I, Ribalet B & Rojas E (1979). Mouse pancreatic beta-cells: tetraethylammonium blockage of the potassium permeability increase induced by depolarization. J Physiol 288, 561-574.
4. 2+ channels in insulin-secreting mouse pancreatic B cells. Biophys J 81, 3308-3323.
5. Baukrowitz T & Fakler B (2000). KATP channels gated by intracellular nucleotides and phospholipids. Eur J Biochem 267, 5842-5848.
6. Berne C (1975). The metabolism of lipids in mouse pancreatic islets. The biosynthesis of triacylglycerols and phospholipids. Biochem J 152, 667-673.
7. Boden G & Shulman GI (2002). Free fatty acids in obesity and type 2 diabetes: defining their role in the development of insulin resistance and beta-cell dysfunction. Eur J Clin Invest 32 (Suppl. 3), 14-23.
8. Branstrom R, Aspinwall CA, Valimaki S, Ostensson CG, Tibell A, Eckhard M, Brandhorst H, Corkey BE, Berggren PO & Larsson O (2004 . Long-chain CoA esters activate human pancreatic beta-cell KATP channels: potential role in Type 2 diabetes. Diabetologia 47, 277-283.
9. Branstrom R, Leibiger IB, Leibiger B, Corkey BE, Berggren PO & Larsson O (1998). Long chain coenzyme A esters activate the pore-forming subunit (Kir6.2) of the ATP-regulated potassium channel. J Biol Chem 273, 31395-31400.
10. Campillo JE, Luyckx AS, Torres MD & Lefebvre PJ (1979). Effect of oleic acid on insulin secretion by the isolated perfused rat pancreas. Diabetologia 16, 267-273.
11. Corkey BE, Glennon MC, Chen KS, Deeney JT, Matschinsky FM & Prentki M (1989). A role for malonyl-CoA in glucose-stimulated insulin secretion from clonal pancreatic beta-cells. J Biol Chem 264, 21608-21612.
12. Deeney JT, Gromada J, Hoy M, Olsen HL, Rhodes CJ, Prentki M, Berggren PO & Corkey BE (2000). Acute stimulation with long chain acyl-CoA enhances exocytosis in insulin-secreting cells (HIT T-15 and NMRI beta-cells). J Biol Chem 275, 9363-9368.
13. Eddlestone GT, Oldham SB, Lipson LG, Premdas FH & Beigelman PM (1985). Electrical activity, cAMP concentration, and insulin release in mouse islets of Langerhans. Am J Physiol 248, C145-C153.
14. 2+-induced exocytosis in mouse pancreatic B-cells. J Physiol 503, 399-412.
15. Gillis KD, Mossner R & Neher E (1996). Protein kinase C enhances exocytosis from chromaffin cells by increasing the size of the readily releasable pool of secretory granules. Neuron 16, 1209-1220.
16. Goberna R, Tamarit J Jr, Osorio J, Fussganger R, Tamarit J & Pfeiffer EF (1974). Action of B-hydroxy butyrate, acetoacetate and palmitate on the insulin release in the perfused isolated rat pancreas. Horm Metab Res 6, 256-260.
17. Gopel S, Kanno T, Barg S, Galvanovskis J & Rorsman P (1999). Voltage-gated and resting membrane currents recorded from B-cells in intact mouse pancreatic islets. J Physiol 521, 717-728.
18. Gribble FM, Proks P, Corkey BE & Ashcroft FM (1998). Mechanism of cloned ATP-sensitive potassium channel activation by oleoyl-CoA. J Biol Chem 273, 26383-26387.
19. Gromada J, Ding WG, Barg S, Renstrom E & Rorsman P (1997). Multisite regulation of insulin secretion by cAMP-increasing agonists: evidence that glucagon-like peptide 1 and glucagon act via distinct receptors. Pflugers Arch 434, 515-524.
20. 2+ indicators with greatly improved fluorescence properties. J Biol Chem 260, 3440-3450.
21. Heding LG (1966). A simplified insulin radioimmunoassay method. In Labelled Proteins in Tracer Studies, ed. Donato L, Milhaud G & Sirchis J, pp. 345-350. Proceedings Conference on Problems Connected with the Preparation and Use of Labelled Proteins in Tracer Studies, Sponsored by the Medical Clinic, Nuclear Medicine Center of the University of Pisa and Euratom, Pisa, 17-19 January 1966.
22. Henquin JC & Meissner HP (1984). Significance of ionic fluxes and changes in membrane potential for stimulus-secretion coupling in pancreatic B-cells. Experientia 40, 1043-1052.
23. 2+-dependent electrical activity induced by glucose in mouse pancreatic B cells. Endocrinology 112, 2218-2220.
24. Ikeuchi M & Cook DL (1984). Glucagon and forskolin have dual effects upon islet cell electrical activity. Life Sci 35, 685-691.
25. 2+ oscillations in clusters of mouse pancreatic islet cells. J Physiol 520, 839-849.
26. Koyama K, Chen G, Wang MY, Lee Y, Shimabukuro M, Newgard CB & Unger RH (1997). beta-cell function in normal rats made chronically hyperleptinemic by adenovirus-leptin gene therapy. Diabetes 46, 1276-1280.
27. Lewis GF, Carpentier A, Adeli K & Giacca A (2002). Disordered fat storage and mobilization in the pathogenesis of insulin resistance and type 2 diabetes. Endocr Rev 23, 201-229.
28. Liu QY & Rosenberg RL (1996). Activation and inhibition of reconstituted cardiac L-type calcium channels by palmitoyl-L-carnitine. Biochem Biophys Res Commun 228, 252-258.
29. Malaisse WJ & Malaisse-Lagae F (1968). Stimulation of insulin secretion by noncarbohydrate metabolites. J Laboratory Clin Med 72, 438-448.
30. Nadal A, Quesada I & Soria B (1999). Homologous and heterologous asynchronicity between identified α-, β- and δ-cells within intact islets of Langerhans in the mouse. J Physiol 517, 85-93.
31. Olofsson CS, Gopel SO, Barg S, Galvanovskis J, Ma X, Salehi A, Rorsman P & Eliasson L (2002). Fast insulin secretion reflects exocytosis of docked granules in mouse pancreatic B-cells. Pflugers Arch 444, 43-51.
32. Prentki M & Corkey BE (1996). Are the beta-cell signaling molecules malonyl-CoA and cystolic long-chain acyl-CoA implicated in multiple tissue defects of obesity and NIDDM? Diabetes 45, 273-283.
33. Prentki M, Vischer S, Glennon MC, Regazzi R, Deeney JT & Corkey BE (1992). Malonyl-CoA and long chain acyl-CoA esters as metabolic coupling factors in nutrient-induced insulin secretion. J Biol Chem 267, 5802-5810.
34. 2+ signaling in pancreatic beta-cells. Mol Cell Endocrinol 212, 1-9.
35. Renstrom E, Ding WG, Bokvist K & Rorsman P (1996). Neurotransmitter-induced inhibition of exocytosis in insulin-secreting beta cells by activation of calcineurin. Neuron 17, 513-522.
36. Renstrom E, Eliasson L & Rorsman P (1997). Protein kinase A-dependent and -independent stimulation of exocytosis by cAMP in mouse pancreatic B-cells. J Physiol 502, 105-118.
37. Richieri GV, Anel A & Kleinfeld AM (1993). Interactions of long-chain fatty acids and albumin: determination of free fatty acid levels using the fluorescent probe ADIFAB. Biochemistry 32, 7574-7580.
38. 2+ channel null mice. EMBO J 22, 3844-3854.
39. Spector AA, Fletcher JE & Ashbrook JD (1971). Analysis of long-chain free fatty acid binding to bovine serum albumin by determination of stepwise equilibrium constants. Biochemistry 10, 3229-3232.
40. Stein DT, Esser V, Stevenson BE, Lane KE, Whiteside JH, Daniels MB, Chen S & McGarry JD (1996). Essentiality of circulating fatty acids for glucose-stimulated insulin secretion in the fasted rat. J Clin Invest 97, 2728-2735.
41. Tamarit-Rodriguez J, Vara E & Tamarit J (1984). Starvation-induced changes of palmitate metabolism and insulin secretion in isolated rat islets stimulated by glucose. Biochem J 221, 317-324.
42. Thams P & Capito K (2001). Differential mechanisms of glucose and palmitate in augmentation of insulin secretion in mouse pancreatic islets. Diabetologia 44, 738-746.
43. 2+ concentration resembling bursting electrical activity in single mouse islets of Langerhans. FEBS Lett 259, 19-23.
44. Vara E & Tamarit-Rodriguez J (1986). Glucose stimulation of insulin secretion in islets of fed and starved rats and its dependence on lipid metabolism. Metabolism 35, 266-271.
45. Warnotte C, Gilon P, Nenquin M & Henquin JC (1994). Mechanisms of the stimulation of insulin release by saturated fatty acids. A study of palmitate effects in mouse beta-cells. Diabetes 43, 703-711.
46. Yaney GC, Korchak HM & Corkey BE (2000). Long-chain acyl CoA regulation of protein kinase C and fatty acid potentiation of glucose-stimulated insulin secretion in clonal beta-cells. Endocrinology 141, 1989-1998.