Increased serum leptin protects from adiposity despite the increased glucose uptake in white adipose tissue in mice lacking p85α phosphoinositide 3-kinase

Diabetes

Volumn 53, Issue 9, 2004, Pages 2261-2270

  Terauchi, Yasuo ^a,b   Matsui, Junji ^a   Kamon, Junyi ^a   Yamauchi, Toshimasa ^a,b   Kubota, Naoto ^a,b,c   Komeda, Kajuro ^d   Aizawa, Shinichi ^e   Akanuma, Yasuo ^b,f   Tomita, Motowo ^g   Kadowaki, Takashi ^a,b,c  

^a UNIVERSITY OF TOKYO   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c NATIONAL INSTITUTE OF HEALTH AND NUTRITION   (Japan)

^d TOKYO MEDICAL UNIVERSITY   (Japan)

^e RIKEN   (Japan)

^f INSTITUTE FOR ADULT DISEASES   (Japan)

^g SHOWA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; INSULIN; LEPTIN; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE;

ADIPOCYTE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DIET; FOOD INTAKE; GENE; GENOTYPE; GLUCOSE TOLERANCE; GLUCOSE TRANSPORT; INSULIN SENSITIVITY; LEPTIN BLOOD LEVEL; LEPTIN RESISTANCE; LIPID DIET; MOUSE; MOUSE STRAIN; NONHUMAN; NUCLEOTIDE SEQUENCE; OBESITY; P85ALPHA PHOSPHOINOSITIDE 3 KINASE GENE; PRIORITY JOURNAL; SKELETAL MUSCLE; STRAIN DIFFERENCE; WEIGHT GAIN; WEIGHT REDUCTION; WHITE ADIPOSE TISSUE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ADIPOCYTES; ADIPONECTIN; ADIPOSE TISSUE; ANIMALS; BODY WEIGHT; DIETARY FATS; FEMALE; GLUCOSE; INSULIN RESISTANCE; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LEPTIN; MICE; MICE, INBRED C57BL; MICE, INBRED CBA; MICE, MUTANT STRAINS; OBESITY; PROTEINS; URIDINE DIPHOSPHATE N-ACETYLGALACTOSAMINE;

EID: 4344566155     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.53.9.2261     Document Type: Article

References (48)

1. Spiegelman BM, Flier JS: Adipogenesis and obesity: Founding out the big picture. Cell 87:377-389, 1996
2. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM: Positional cloning of the mouse obese gene and its human homologue. Nature 372:425-432, 1994
3. Schwartz MW, Woods SC, Porte D, Seeley RJ, Baskin DG: Central nervous system control of food intake. Nature 404:661-671, 2000
4. Saladin R, De Vos P, Guerre-Millo M, Leturque A, Girard J, Staels B, Auwerx J: Transient increase in obese gene expression after food intake or insulin administration. Nature 377:527-529, 1995
5. Barr VA, Malide D, Zarnowski MJ, Taylor SI, Cushman SW: Insulin stimulates both leptin secretion and production by rat white adipose tissue. Endocrinol 138:4463-4472, 1997
6. Bradley RL, Cheatham B: Regulation of ob gene expression and leptin secretion by insulin and dexamethasone in rat adipocytes. Diabetes 48:272-278, 1999
7. Mueller WM, Gregoire FM, Stanhope KL, Mobbs CV, Mizuno TM, Warden CH, Stern JS, Havel PJ: Evidence that glucose metabolism regulates leptin secretion from cultured rat adipocytes. Endocrinol 139:551-558, 1998
8. Rossetti L: Perspective: Hexosamines and nutrient sensing. Endocrinol 141:1922-1925, 2000
9. Wang J, Liu R, Hawkins M, Barzilai N, Rossetti L: A nutrient-sensing pathway regulates leptin gene expression in muscle and fat. Nature 393:684-688, 1998
10. Hebert LF, Daniels MC, Zhou J, Crook ED, Turner RL, Simmons ST, Neidigh JL, Zhu JS, Baron AD, McClain AD: Overexpression of glutamine: fructose-6-phosphate amidotransferase in transgenic mice leads to insulin resistance. J Clin Invest 98:930-936, 1996
11. McClain DA, Alexander T, Cooksey RC, Considine RV: Hexosamines stimulate leptin production in transgenic mice. Endocrinol 141:1999-2002, 2000
12. Maeda K, Okubo K, Shimomura I, Funahashi T, Matsuzawa Y, Matsubara K: cDNA cloning and expression of a novel adipose specific collagen-like factor, apM1 (adipose most abundant gene transcript 1). Biochem Biophys Res Commun 221:286-289, 1996
13. Scherer PE, Williams S, Fogliano M, Baldini G, Lodish HF: A novel serum protein similar to C1q, produced exclusively in adipocytes. J Biol Chem 270:26746-26749, 1995
14. Hu E, Liang P, Spiegelman BM: AdipoQ is a novel adipose-specific gene dysregulated in obesity. J Biol Chem 271:10697-10703, 1996
15. Nakano Y, Tobe T, Choi-Miura NH, Mazda T, Tomita M: Isolation and characterization of GBP28, a novel gelatin-binding protein purified from human plasma. J Biochem (Tokyo) 120:802-812, 1996
16. Arita Y, Kihara S, Ouchi N, Takahashi M, Maeda K, Miyagawa J, Hotta K, Shimomura I, Nakamura T, Miyaoka K, Kuriyama H, Nishida M, Yamashita S, Okubo K, Matsubara K, Muraguchi M, Ohmoto Y, Funahashi T, Matsuzawa Y: Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochem Biophys Res Commun 257:79-83, 1999
17. Hotta K, Funahashi T, Arita Y, Takahashi M, Matsuda M, Okamoto Y, Iwahashi H, Kuriyama H, Ouchi N, Maeda K, Nishida M, Kihara S, Sakai N, Nakajima T, Hasegawa K, Muraguchi M, Ohmoto Y, Nakamura T, Yamashita S, Hanafusa T, Matsuzawa Y: Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients. Arterioscler Thromb Vasc Biol 20:1595-1599, 2000
18. Fruebis J, Tsao TS, Javorschi S, Ebbets-Reed D, Mary RS: Erickson MRS, Yen FT, Bihain BE, Lodish HF: Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice. Proc Natl Acad Sci USA 98:2005-2010, 2001
19. Yamauchi T, Kamon J, Waki H, Terauchi Y, Kubota N, Kara K, Mori Y, Abe M, Tanaka J, Ohsumi J, Ide T, Murakami K, Kagechika H, Shudo K, Akanuma Y, Nagai R, Gavrilova O, Vinson C, Reitman ML, Yoda M, Nakano Y, Tobe K, Kimura S, Tomita M, Froguel P, Kadowaki T: Replenishment of the fat-derived hormone adiponectin reverses insulin resistance in lipoatrophic diabetes and type 2 diabetes. Nat Med 7:941-946, 2001
20. Berg AH, Combs TP, Du X, Brownlee M, Scherer PE: The adipocyte-secreted protein Acrp30 enhances hepatic insulin action. Nat Med 7:947-953, 2001
21. Bogan JS, Lodish HF: Two compartments for insulin-stimulated exocytosis in 3T3-L1 adipocytes defined by endogenous ACRP30 and GLUT4. J Cell Biol 146:609-620, 1999
22. Carpenter CL, Cantley LC: Phosphoinositide kinases. Curr Opin Cell Biol 8:153-158, 1996
23. Kadowaki T, Tobe K, Honda-Yamamoto R, Tamemoto H, Kaburagi Y, Momomura K, Ueki K, Takahashi Y, Yamauchi T, Akanuma Y, Yazaki Y: Signal transduction mechanism of insulin and insulin-like growth factor-1. Endocrine J 43:S33-S41, 1996
24. Escobedo JA, Navankasattusas S, Kavanaugh WM, Milfay D, Fried VA, Williams LT: cDNA cloning of a novel 85 kd protein that has SH2 domains and regulates binding of PI3-kinase to the PDGF β-receptor. Cell 65:75-82, 1991
25. Otsu M, Hiles I, Gout I, Fry MJ, Ruiz-Larrea F, Panayotou G, Thompson A, Dhand R, Hsuan J, Totty N, Smith AD, Morgan SJ, Courtneige SA, Parker PJ, Waterfield MD: Characterization of two 85 kd proteins that associate with receptor tyrosine kinases, middle-T/pp60c-src complexe, and PI3-kinase. Cell 65:91-104, 1991
26. Skolnik EY, Margolis B, Mohammadi M, Lowenstein E, Fisher R, Drepps A, Ullrich A, Schlessinger J: Cloning of PI3 kinase-associated p85 utilizing a novel method for expression/cloning of target proteins for receptor tyrosine kinases. Cell 65:83-90, 1991
27. Terauchi Y, Tsuji Y, Satoh S, Minoura H, Murakami K, Okuno A, Inukai K, Asaho T, Kaburagi Y, Ueki K, Nakajima H, Hanafusa T, Matsuzawa Y, Sekihara H, Yin Y, Barrett JC, Oda H, Ishikawa T, Akanuma Y, Komuro I, Suzuki M, Yamamura K, Kodama T, Suzuki H, Koyasu S, Aizawa S, Tobe K, Fukui Y, Yazaki Y, Kadowaki T: Increased insulin sensitivity and hypoglycaemia in mice lacking the p85a subunit of phosphoinositide 3-kinase. Nat Genet 21:230-235, 1999
28. Fruman DA, Mauvais-Jarvis F, Pollard DA, Yballe CM, Brazil D, Bronson RT, Kahn CR, Cantley LC: Hypoglycaemia, liver necrosis and perinatal death in mice lacking all isoforms of phosphoinositide 3-kinase p85alpha. Nat Genet 26:379-382, 2000
29. Ueki K, Fruman DA, Brachmann SM, Tseng YH, Cantley LC, Kahn CR: Molecular balance between the regulatory and catalytic subunits of phosphoinositide 3-kinase regulates cell signaling and survival. Mol Cell Biol 22:965-977, 2002
30. Shepherd PR, Gnudi L, Tozzo E, Yang H, Leach F, Kahn BB: Adipose cell hyperplasia and enhanced glucose disposal in transgenic mice overexpressing GLUT4 selectively in adipose tissue. J Biol Chem 268:22243-22246, 1993
31. Terauchi Y, Iwamoto K, Tamemoto H, Komeda K, Ishii C, Kanazawa Y, Asanuma N, Aizawa T, Akanuma Y, Yasuda K, Kodama T, Tobe Y, Yazaki Y, Kadowaki T: Development of non-insulin-dependent diabetes mellitus in the double knockout mice with disruption of insulin receptor substrate-1 and β-cell glucokinase genes. J Clin Invest 99:861-866, 1997
32. Kubota N, Terauchi Y, Mild H, Tamemoto H, Yamauchi T, Komeda K, Nakano R, Ishii C, Sugiyama T, Eto K, Tsubamoto T, Okuno A, Murakami K, Ezaki O, Hasegawa G, Naito M, Toyoshima Y, Tanaka S, Shiota K, Aizawa S, Nagai R, Tobe K, Kimura S, Kadowaki T: PPARγ mediates high-fat diet-induced adipocyte hypertrophy and insulin resistance. Mol Cell 4:597-609, 1999
33. Giaccari A, Rossetti L: Isocratic high-performance liquid Chromatographic determination of the concentration and specific radioactivity of phosphoenolpyruvate and uridine diphosphate glucose in tissue extracts. J Chromatogr 497:69-78, 1989
34. Giaccari A, Rossetti L: Predominant role of gluconeogenesis in the hepatic glycogen repletion of diabetic rats. J Clin Invest 89:36-45, 1992
35. Lagunas R, Diez-Masa JC: Separation and analysis of 4′-epimeric UDP-sugars by ion-pair reversed-phase HPLC. Anal Biochem 216:188-194, 1994
36. Ikemoto S, Thompson KS, Takahashi M, Itakura H, Lane MD, Ezaki O: High fat diet-induced hyperglycemia: prevention by low level expression of a glucose transporter (GLUT4) minigene in transgenic mice. Proc Natl Acad Sci U S A 92:3096-3099, 1995
37. Yamauchi T, Tobe K, Tamemoto H, Ueki K, Kaburagi Y, Yamamoto-Honda R, Takahashi Y, Yoshizawa F, Aizawa S, Akanuma Y, Sonenberg N, Yazaki Y, Kadowaki T: Insulin signalling and insulin actions in the muscle and liver of insulin resistant, IRS-1 deficient mice. Mol Cell Biol 16:3074-3084, 1996
38. Ogawa Y, Masuzaki H, Hosoda K, Aizawa-Abe M, Suga J, Suda M, Ebihara K, Iwai H, Matsuoka N, Satoh N, Odaka H, Kasuga H, Fujisawa Y, Inoue G, Nishimura H, Yoshimasa Y, Nakao K: Increased glucose metabolism and insulin sensitivity in transgenic skinny mice overexpressing leptin. Diabetes 48:1822-1829, 1999
39. Burks DJ, Font de Mora J, Schubert M, Withers DJ, Myers MG, Towery HH, Altamuro SL, Flint CL, White MF: IRS-2 pathways integrate female reproduction and energy homeostasis. Nature 407:377-382, 2000
40. Tobe K, Suzuki R, Aoyama M, Yamauchi T, Kamon J, Kubota N, Terauchi Y, Matsui J, Akanuma Y, Kimura S, Tanaka J, Abe M, Ohsumi J, Nagai R, Kadowaki T: Increased expression of the sterol regulatory element-binding protein-1 gene in insulin receptor substrate-2(-/-) mouse liver. J Biol Chem 276:38337-38340, 2001
41. Brüning JC, Gautam D, Burks DJ, Gillette J, Schubert M, Orban PC, Klein R, Krone W, Muller-Wieland D, Kahn CR: Role of brain insulin receptor in control of body weight and reproduction. Science 289:2122-2125, 2000
42. + channels in hypothalamic neurons of lean, but not obese rats. Nat Neurosci 3:757-758, 2000
43. Spanswick D, Smith MA, Groppi VE, Logan SD, Ashford ML: Leptin inhibits hypothalamic neurons by activation of ATP-sensitive potassium channels. Nature 390:521-525, 1997
44. Niswender KD, Morton GJ, Stearns WH, Rhodes CJ, Myers MG, Schwartz MW: Key enzyme in leptin-induced anorexia. Nature 413:794-795, 2001
45. Suzuki H, Terauchi Y, Fujiwara M, Aizawa S, Yazaki Y, Kadowaki T, Koyasu S: Xid-like immunodeficiency in mice with disruption of the p85a subunit of phosphoinositide 3-kinase. Science 283:390-392, 1999
46. Kolaczynski JW, Nyce MR, Considine RV, Boden G, Nolan JJ, Henry R, Mudaliar SR, Olefsky J, Caro JF: Acute and chronic effects of insulin on leptin productionin humans: studies in vivo and and in vitro. Diabetes 45:699-701, 1996
47. Gettys TW, Harkness PJ, Watson PM: The beta 3-adrenergic receptor inhibits insulin-stimulated leptin secretion from isolated rat adipocytes. Endocrinol 137:4054-4057, 1996
48. Yamauchi T, Waki H, Kamon J, Murakami K, Motojima K, Komeda K, Miki H, Kubota N, Terauchi Y, Tsuchida A, Tsuboyama-Kasaoka N, Yamauchi N, Ide T, Hori W, Kato S, Fukayama M, Akanuma Y, Ezaki O, Itai A, Nagai R, Kimura S, Tobe K, Kagechika H, Shudo K, Kadowaki T: Inhibition of RXR and PPARγ ameliorates diet-induced obesity and type 2 diabetes. J Clin Invest 108:1001-1013, 2001