Autoregulation of hepatic glucose production

European Journal of Endocrinology

Volumn 138, Issue 3, 1998, Pages 240-248

  Moore, Mary Courtney ^a   Connolly, Cynthia C ^a   Cherrington, Alan D ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; GLYCOGEN; INSULIN;

AUTOREGULATION; CENTRAL NERVOUS SYSTEM; DOG; GLUCONEOGENESIS; GLUCOSE BLOOD LEVEL; GLYCOGENOLYSIS; HUMAN; HYPERGLYCEMIA; HYPOGLYCEMIA; LIVER METABOLISM; NERVE TRACT; NONHUMAN; PRIORITY JOURNAL; REVIEW;

EID: 0031957026     PISSN: 08044643     EISSN: None     Source Type: Journal    
DOI: 10.1530/eje.0.1380240     Document Type: Review

References (48)

1. Soskin S, Essex HE, Herrick JF & Mann FC. The mechanism of the regulation of blood sugar by the liver. American Journal of Physiology 1938 124 558-567.
2. Exton JH & Park CR. Control of gluconeogenesis in liver. I. General features of gluconeogenesis in the perfused liver of rats. Journal of Biological Chemistry 1967 242 2622-2636.
3. Glinsmann WH, Hern EP & Lynch A. Intrinsic regulation of glucose output by rat liver. American Journal of Physiology 1969 216 698-703.
4. McCraw EF, Peterson MJ & Ashmore J. Autoregulation of glucose metabolism in the isolated perfused rat liver. Proceedings of the Society for Experimental Biology and Medicine 1967 126 232-236.
5. Ruderman NB & Herrera MG. Glucose regulation of hepatic gluconeogenesis. American Journal of Physiology 1968 214 1346-1351.
6. Shulman GI, Liljenquist JE, Williams PE, Lacy WW & Cherrington AD. Glucose disposal during insulinopenia in somatostatin-treated dogs: the roles of glucose and glucagon. Journal of Clinical Investigation 1978 62 487-491.
7. Shulman GI, Lacy WW, Liljenquist JE, Keller U, Williams PE & Cherrington AD. Effect of glucose, independent of changes in insulin and glucagon secretion, on alanine metabolism in the conscious dog. Journal of Clinical Investigation 1980 65 496-505.
8. Müller MI, Möring J & Seitz HJ. Regulation of hepatic glucose output by glucose in vivo. Metabolism 1988 37 55-60.
9. Saccá L, Hendler R & Sherwin RS. Hyperglycemia inhibits glucose production in man independent of changes in glucoregulatory hormones. Journal of Clinical Endocrinology and Metabolism 1978 47 1160-1163.
10. Chu CA, Sindelar DK, Neal DW, Allen EJ, Donahue EP & Cherrington AD. Comparison of the direct and indirect effects of epinephrine on hepatic glucose production. Journal of Clinical Investigation 1997 99 1044-1056.
11. Chu CA, Sindelar DK, Neal DW, Allen EJ, Donahue EP & Cherrington AD. The effects of a selective rise in hepatic sinusoidal norepinephrine on hepatic glucose production are solely attributable to an increase in glycogenolysis. American Journal of Physiology 1998 37 E162-E171.
12. Davidson MB. Autoregulation by glucose of hepatic glucose balance: permissive effect of insulin. Metabolism 1981 30 279-284.
13. Wahren J, Felig P, Cerasi E & Luft R. Splanchnic and peripheral glucose and amino acid metabolism in diabetes mellitus. Journal of Clinical Investigation 1972 51 1870-1878.
14. Del Prato S, Matsuda M, Simonson DC, Groop LC, Sheehan P, Leonetti F, et al. Studies on the mass action effect of glucose in NIDDM and IDDM: evidence for glucose resistance. Diabetologia 1997 40 687-697.
15. Shimazu T & Fujimoto T. Regulation of glycogen metabolism in liver by the autonomic nervous system. IV. Neural control of glycogen biosynthesis. Biochimica et Biophysica Acta 1971 252 18-27.
16. Niijima A. Blood glucose levels modulate efferent activity in the vagal supply to the rat liver. Journal of Physiology 1985 364 105-112.
17. Shimazu T & Amakawa A. Regulation of glycogen metabolism in liver by the autonomic nervous system. II. Neural control of glycogenolytic enzymes. Biochimica et Biophysica Acta 1968 165 335-348.
18. Edwards AV & Silver M. The glycogenolytic response to stimulation of the splanchnic nerves in adrenalectomized calves. Journal of Physiology 1970 211 109-124.
19. Ikeda T, Scott M, Emshwiller MG, Monohan MT, Allen E, Sindelar DK et al. Hyperglycemia reduces sympathetic nervous signaling to the liver and gut in the dog. Diabetes 1997 46 (Suppl 1) 232A.
20. Rossetti L, Giaccari A, Barzilai N, Howard K, Sebel G & Hu M. Mechanism by which hyperglycemia inhibits hepatic glucose production in conscious rats: implications for the pathophysiology of fasting hyperglycemia in diabetes. Journal of Clinical Investigation 1993 92 1126-1134.
21. Shiota M, Green R, Colburn CA, Mitchell G & Cherrington AD. Inability of hyperglycemia to counter the ability of glucagon to increase net glucose output and activate glycogen phosphorylase in the perfused rat liver. Metabolism 1996 45 481-485.
22. Petersen KF, Laurent D, Rothman DL, Cline GW & Shulman GI. Mechanism by which insulin inhibits net hepatic glycogenolysis in man. Diabetologia 1997 40 (Suppl 1) A25.
23. Clore JN, Helm ST & Blackard WH. Loss of hepatic autoregulation after carbohydrate overfeeding in normal man. Journal of Clinical Investigation 1995 96 1967-1972.
24. Hellerstein MK, Neese RA, Schwarz JM, Turner S, Faix D & Wu K. Altered fluxes responsible for reduced hepatic glucose production and gluconeogenesis by exogenous glucose in rats. American Journal of Physiology 1997 272 E163-E172.
25. Sànchez-Gutiérrez JC, Lechuga CG, Sànchez-Arias JA, Samper B & Felíu JE. Impairment of the modulation by glucose of hepatic gluconeogenesis in the genetically obese (fa/fa) Zucker rat. Endocrinology 1995 136 1877-1884.
26. Argaud D, Kirby TL, Newgard CB & Lange AJ. Stimulation of glucose-6-phosphatase gene expression by glucose and fructose-2,6-bisphosphate. Journal of Biological Chemistry 1997 272 12854-12861.
27. Vaulont S & Kahn A. Transcriptional control of metabolic regulation genes by carbohydrates. FASEB Journal 1994 8 28-35.
28. Pessin JE & Bell GI. Mammalian facilitative glucose transporter family: structure and molecular regulation. Annual Review of Physiology 1992 54 911-930.
29. Lefrancois-Martinez AM, Diaz-Guerra MJM, Vallet V, Kahn A & Antoine B. Glucose-dependent regulation of the L-pyruvate kinase gene in a hepatoma cell line is independent of insulin and cyclic AMP. FASEB Journal 1994 8 89-96.
30. Villar-Palasi C & Guinovart JJ. The role of glucose 6-phosphate in the control of glycogen synthase. FASEB Journal 1997 11 544-558.
31. Brichard SM, Henquin JC & Girard J. Phlorizin treatment of diabetic rats partially reverses the abnormal expression of genes involved in hepatic glucose metabolism. Diabetologia 1993 36 292-298.
32. Saccá L, Cryer PE & Sherwin RS. Blood glucose regulates the effects of insulin and counterregulatory hormones on glucose production in vivo. Diabetes 1979 28 533-536.
33. Frizzell RT, Hendrick GL, Brown LL, Lacy DB, Donahue EP, Carr RK et al. Stimulation of glucose production through hormone secretion and other mechanisms during insulin-induced hypoglycemia. Diabetes 1988 37 1531-1541.
34. Bolli G, De Feo P, Perriello G, De Cosmo S, Ventura M, Campbell P et al. Role of hepatic autoregulation in defense against hypoglycemia in humans. Journal of Clinical Investigation 1985 75 1623-1631.
35. Cryer PE. Glucose counterregulation: prevention and correction of hypoglycemia in humans. American Journal of Physiology 1993 264 E149-E155.
36. Hansen I, Firth R, Haymond M, Cryer P & Rizza R. The role of autoregulation of the hepatic glucose production in man: response to a physiologic decrement in plasma glucose. Diabetes 1986 35 186-191.
37. Tse T, Clutter W, Shah S & Cryer P. Mechanisms of postprandial glucose counterregulation in man: physiologic roles of glucagon and epinephrine vis-a-vis insulin in the prevention of hypoglycemia later after glucose ingestion. Journal of Clinical Investigation 1983 72 278-286.
38. Connolly CC, Adkins-Marshall BA, Neal DW, Pugh W, Jaspan JB & Cherrington AD. Relationship between decrements in glucose level and metabolic response to hypoglycemia in absence of counterregulatory hormones in the conscious dog. Diabetes 1992 41 1308-1319.
39. Connolly CC, Steiner KE, Stevenson RW, Neal DW, Williams PE, Alberti KGMM et al. Regulation of glucose metabolism by norepinephrine in the conscious dog. American Journal of Physiology 1991 261 E764-E772.
40. Biggers DW, Myers SR, Neal D, Stinson R, Cooper NB, Jaspan JB et al. Role of brain in counterregulation of insulin-induced hypoglycemia in dogs. Diabetes 1989 37 7-16.
41. Edwards AV. The hyperglycaemic response to stimulation of the hepatic sympathetic innervation in adrenalectomised cats and dogs. Journal of Physiology 1972 220 697-710.
42. Edwards AV & Silver M. Comparison of the hyperglycaemic and glycogenolytic responses to catecholamines with those to stimulation of the hepatic sympathetic innervation in the dog. Journal of Physiology 1972 223 571-593.
43. Shimazu T, Fukuda A & Ban T. Reciprocal influences of the ventromedial and lateral hypothalamic nuclei on blood glucose level and liver glycogen content. Nature 1966 210 1178-1179.
44. Shimazu T & Matsushita H. Role of the norepinephrine-and acetylcholine-sensitive neurons of the hypothalamus in the regulation of hepatic metabolism. In Catecholamines: Basic and Clinical Frontiers, vol 1, pp 980-982. Eds E Usdin, IJ Kopin & J Barchas. New York: Pergamon Press, 1978.
45. Connolly CC, Myers SR, Neal DW, Hastings JR & Cherrington AD. In the absence of counterregulatory hormones, the increase in hepatic glucose production during insulin-induced hypoglycemia in the dog is initiated in the liver rather than the brain. Diabetes 1996 45 1805-1813.
46. Tappy L. Regulation of hepatic glucose production in healthy subjects and patients with non-insulin-dependent diabetes mellitus Diabete et Metabolisme 1995 21 233-240.
47. Sindelar DK, Chu CA, Venson P, Donahue EP, Neal DW & Cherrington AD. Basal hepatic glucose production is regulated by the portal vein insulin concentration. Diabetes 1998 (In Press).
48. Sindelar DK, Chu CA, Neal DW & Cherrington AD. The interaction between equal increments in peripheral and portal vein insulin in regulating hepatic glucose production in the conscious dog. American Journal of Physiology 273 E972-E980.