Neuronal pathway from the liver modulates energy expenditure and systemic insulin sensitivity

Science

Volumn 312, Issue 5780, 2006, Pages 1656-1659

  Uno, Kenji ^a   Katagiri, Hideki ^a   Yamada, Tetsuya ^a   Ishigaki, Yasushi ^a   Ogihara, Takehide ^a   Imai, Junta ^a   Hasegawa, Yutaka ^a   Gao, Junhong ^a   Kaneko, Keizo ^a   Iwasaki, Hiroko ^a   Ishihara, Hisamitsu ^a   Sasano, Hironobu ^a   Inukai, Kouichi ^b   Mizuguchi, Hiroyuki ^c   Asano, Tomoichiro ^d   Shiota, Masakazu ^e   Nakazato, Masamitsu ^f   Oka, Yoshitomo ^a  

^a TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b SAITAMA MEDICAL UNIVERSITY   (Japan)

^c NATIONAL INSTITUTE OF BIOMEDICAL INNOVATION   (Japan)

^d UNIVERSITY OF TOKYO   (Japan)

^e VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f UNIVERSITY OF MIYAZAKI   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL ORGANS; ENERGY STORAGE; GLUCOSE; INSULIN; METABOLISM; PERTURBATION TECHNIQUES; PROTECTION; TISSUE;

ADIPOSE TISSUE; PERIPHERAL ADIPOSITY; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR (PPAR); STEATOSIS;

NEUROLOGY;

2,4 THIAZOLIDINEDIONE DERIVATIVE; ADENOVIRUS VECTOR; ANTIDIABETIC AGENT; BETA GALACTOSIDASE; FATTY ACID; GLUCOSE; HORMONE SENSITIVE LIPASE; INSULIN; LEPTIN; OXYGEN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA AGONIST; TUMOR NECROSIS FACTOR ALPHA; UNCOUPLING PROTEIN 1;

GLUCOSE; HOMEOSTASIS; METABOLISM; NEUROLOGY; SENSITIVITY ANALYSIS;

ADIPOSE TISSUE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BROWN ADIPOSE TISSUE; CONTROLLED STUDY; ENERGY EXPENDITURE; EPIDIDYMIS FAT; FATTY LIVER; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; GLUCOSE TOLERANCE; HYPERGLYCEMIA; HYPERLEPTINEMIA; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIPID STORAGE; LIVER; LIVER WEIGHT; METABOLIC SYNDROME X; MOUSE; NERVE TRACT; NONHUMAN; OBESITY; PRIORITY JOURNAL; VAGOTOMY; VAGUS NERVE; WHITE ADIPOSE TISSUE;

ADIPOSE TISSUE; AFFERENT PATHWAYS; ANIMALS; BLOOD GLUCOSE; DIETARY FATS; EFFERENT PATHWAYS; ENERGY METABOLISM; FATTY LIVER; GLUCOSE; GLUCOSE TOLERANCE TEST; HYPOGLYCEMIC AGENTS; INSULIN; INSULIN RESISTANCE; LIPOLYSIS; LIVER; MALE; MICE; MICE, INBRED C57BL; MUSCLE, SKELETAL; OXYGEN CONSUMPTION; PPAR GAMMA; RATS; RATS, SPRAGUE-DAWLEY; SYMPATHETIC NERVOUS SYSTEM; VAGOTOMY; VAGUS NERVE; WEIGHT GAIN;

ADENOVIRIDAE;

EID: 33745151403     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1126010     Document Type: Article

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26. We thank M. Kaji, T. Takai, Y. Sato, H. Yawo, T. Hashikawa, M. Kanzaki, Y. Minokoshi, and M. Tominaga for advice and discussions. Supported by grants-in-aid from the Ministry of Education, Science, Sports, and Culture of Japan (H.K.), a grant-in-aid from the Ministry of Health, Labor, and Welfare of Japan (Y.O.), and the 21st Century Center of Excellence Programs (H.K. and Y.O.).