Interleukin-1β enhances nucleotide-induced and α-secretase- dependent amyloid precursor protein processing in rat primary cortical neurons via up-regulation of the P2Y2 receptor

Journal of Neurochemistry

Volumn 109, Issue 5, 2009, Pages 1300-1310

  Kong, Qiongman ^b   Peterson, Troy S ^b   Baker, Olga ^a   Stanley, Emily ^b   Camden, Jean ^a   Seye, Cheikh I ^a   Erb, Laurie ^a   Simonyi, Agnes ^a   Wood, W Gibson ^c   Sun, Grace Y ^a,b   Weisman, Gary A ^a,b  

^a University of Missouri   (United States)

^b UNIVERSITY OF MISSOURI   (United States)

^c UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

Author keywords

Alzheimer's disease; Amyloid precursor protein; P2Y2; Primary neuron

Indexed keywords

2 [1 (3 DIMETHYLAMINOPROPYL) 3 INDOLYL] 3 (3 INDOLYL)MALEIMIDE; 2 MORPHOLINO 8 PHENYLCHROMONE; ALPHA SECRETASE; AMYLOID PRECURSOR PROTEIN; DISINTEGRIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; MESSENGER RNA; METALLOPROTEINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PURINERGIC P2Y2 RECEPTOR; URIDINE TRIPHOSPHATE; 4 O METHYLPHORBOL 13 ACETATE 12 MYRISTATE; 4-O-METHYL-12-O-TETRADECANOYLPHORBOL 13-ACETATE; DRUG DERIVATIVE; ENZYME INHIBITOR; NUCLEOTIDE; PHORBOL 13 ACETATE 12 MYRISTATE; PURINERGIC P2 RECEPTOR; SECRETASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BRAIN NERVE CELL; CONTROLLED STUDY; INCUBATION TIME; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; UPREGULATION; ANALYSIS OF VARIANCE; ANIMAL; ANIMAL EMBRYO; BRAIN CORTEX; CYTOLOGY; DOSE RESPONSE; DRUG EFFECT; DRUG INTERACTION; GENETIC TRANSFECTION; GENETICS; HUMAN; METABOLISM; METHODOLOGY; NERVE CELL; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT;

RATTUS;

AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANALYSIS OF VARIANCE; ANIMALS; CEREBRAL CORTEX; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; EMBRYO, MAMMALIAN; ENZYME INHIBITORS; HUMANS; INTERLEUKIN-1BETA; NEURONS; NUCLEOTIDES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, PURINERGIC P2; RNA, MESSENGER; SIGNAL TRANSDUCTION; TETRADECANOYLPHORBOL ACETATE; TRANSFECTION; UP-REGULATION; URIDINE TRIPHOSPHATE;

EID: 65549114123     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2009.06048.x     Document Type: Article

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