Protein kinase C activation increases release of secreted amyloid precursor protein without decreasing Aβ production in human primary neuron cultures

Journal of Neuroscience

Volumn 18, Issue 8, 1998, Pages 2907-2913

  LeBlanc, Andréa C ^a,b   Koutroumanis, Maria ^b   Goodyer, Cynthia G ^a  

^a MCGILL UNIVERSITY   (Canada)

^b MCGILL UNIVERSITY   (Canada)

Author keywords

Alzheimer's disease; Amyloid precursor protein metabolism; Amyloid peptide; Phorbol esters; Protein kinase C; Secreted amyloid precursor protein

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; PHORBOL ESTER; PROTEIN KINASE C; PROTEIN KINASE C ACTIVATOR;

ALZHEIMER DISEASE; ARTICLE; CELL SPECIFICITY; CONTROLLED STUDY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; HUMAN TISSUE; NERVE CELL CULTURE; PRIORITY JOURNAL; PROTEIN METABOLISM; PROTEIN SECRETION; SPECIES DIFFERENCE;

EID: 0032523039     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.18-08-02907.1998     Document Type: Article

References (49)

1. Busciglio J, Gabuzda D, Matsudaira P, Yankner B (1993) Generation of β-amyloid in the secretory pathway in neuronal and nonneuronal cells. Proc Natl Acad Sci USA 90:2092-2096.
2. Buxbaum J, Ruefli A, Parker C, Cypress A, Greengard P (1993) Calcium regulates processing of the Alzheimer amyloid protein precursor in a protein kinase C-independent manner. Proc Natl Acad Sci USA 91:4489-4493.
3. Buxbaum JD, Oishi M, Chen HI, Pinkas-Kramarski R, Jaffe EA, Gandy S, Greengard P (1992) Cholinergic agonists and interleukin 1 regulate processing and secretion of the Alzheimer β/A4 amyloid protein precursor. Proc Natl Acad Sci USA 89:10075-10078.
4. Caporaso G, Gandy S, Buxbaum J, Ramabhadran T, Greengard P (1992) Protein phosphorylation regulates secretion of Alzheimer β3/A4 amyloid precursor protein. Proc Natl Acad Sci USA 89:3055-3059.
5. Dyrks T, Monning U, Beyreuther K, Turner J (1994) Amyloid precursor protein secretion and β/A4 amyloid generation are not mutually exclusive. FEBS Lett 349:210-214.
6. Estus S, Golde T, Kunishita T, Blades D, Lowery D, Eisen M, Usiak M, Qu X, Tabira T, Greenberg B, Younkin S (1992) Potentially amyloidogenic, carboxy-terminal derivatives of the amyloid protein precursor. Science 255:726-728.
7. Farber SA, Nitsch RM, Schulz JG, Wurtman RJ (1995) Regulated secretion of β-amyloid precursor protein in rat brain. J Neurosci 15:7442-7451.
8. Forloni G, Chiesa R, Smiroldo S, Verga L, Salmona M, Tagliavini F, Angeretti N (1993) Apoptosis mediated neurotoxicity induced by chronic application of β-amyloid fragment 25-35. NeuroReport 4:523-526.
9. Gadzuba D, Busciglio J, Yankner BA (1993) Inhibition of β-amyloid production by activation of protein kinase C. J Neurochem 61:2326-2329.
10. Giacobini E, Mori F, Lai CC (1996) The effect of cholinesterase inhibitors on the secretion of APPs from rat brain cortex. Ann NY Acad Sci 777:393-398.
11. Gillespie SL, Golde TE, Younkin SG (1992) Secretory processing of the Alzheimer amyloid β/A4 protein precursor is increased by protein phosphorylation. Biochem Biophys Res Commun 187:1285-1290.
12. Golde T, Estus S, Younkin L, Selkoe D, Younkin S (1992) Processing of the amyloid protein precursor to potentially amyloidogenic derivatives. Science 255:728-730.
13. Goldgaber D, Harris H, HLA T, Magiag T, Donnelly R, Jacobsen J, Vitek M, Gadjusek C (1989) Interleukin 1 regulates synthesis of amyloid β-protein precursor mRNA in human endothelial cells. Proc Natl Acad Sci USA 86:7606-7610.
14. Haass C, Koo E, Mellon A, Hung A, Selkoe D (1992a) Targeting of cell-surface β-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments. Nature 357:500-503.
15. Haass C, Schlossmacher M, Hung A, Vigo-Pelfrey C, Mellon A, Ostaszewski B, Lieberburg I, Koo E, Schenk D, Teplow D, Selkoe D (1992b) Amyloid β-peptide is produced by cultured cells during normal metabolism. Nature 359:322-325.
16. Haass C, Hung A, Schlossmacher M, Teplow D, Selkoe D (1993) β-amyloid peptide and a 3 kDa fragment are derived by distinct cellular mechanisms. J Biol Chem 268:3021-3024.
17. Haass C, Lemerc C, Capell A, Citron M, Seubert P, Schenk D, Lannfelt D, Selkoe D (1995) The Swedish mutation causes early-onset Alzheimer's disease by β-secretase cleavage within the secretory pathway. Nat Med 1:1291-1296.
18. Harlow E, Lane D (1988) Immunoprecipitations. In: Antibodies, a laboratory manual (Harlow L, ed), pp 421-466, Cold Spring Harbor, NY: Cold Spring Harbor Laboratory.
19. Hung AY, Haass C, Nitsch RM, Qiu WQ, Citron M, Wurtman RJ, Growdon JH, Selkoe DJ (1993) Activation of protein kinase C inhibits cellular production of the amyloid β-protein. J Biol Chem 268:22959-22962.
20. Jacobsen JS, Spruyt MA, Brown AM, Sahasrabhude S, Blume A, Vitek M, Muenkell H, Sonnenberg-Reines J (1994) The release of Alzheimer's disease β-amyloid peptide is reduced by phorbol treatment. J Biol Chem 269:8376-8382.
21. Jaken S (1990) Protein kinase C and tumor promoters. Curr Opin Cell Biol 2:192-197.
22. Kim K, Miller D, Sapienza V, Chen C, Bai C, Grundke-Iqbal I, Currie J, Wisniewski H (1990) Production and characterization of monoclonal antibodies reactive to synthetic cerebrovascular amyloid peptide. Neurosci Res Commun 2:121-130.
23. Koo EH, Squazzo SL (1994) Evidence that production of amyloid β-protein involves the endocytotic pathway. J Biol Chem 269:17386-17389.
24. LeBlanc AC (1995) Increased production of 4 kDa amyloid β peptide in serum deprived human primary neuron cultures: possible involvement of apoptosis. J Neurosci 15:7837-7846.
25. LeBlanc AC, Gambetti P (1994) Production of Alzheimer 4 kDa β-amyloid peptide requires the C-terminal cytosolic domain of the amyloid precursor protein. Biochem Biophys Res Commun 204:1371-1380.
26. LeBlanc AC, Xue R, Gambetti P (1996) APP metabolism in primary cell cultures of neurons, astrocytes and microglia. J Neurochem 66:2300-2310.
27. LeBlanc AC, Papadopoulos M, Bélair C, Chu W, Crosato M, Powell J, Goodyer C, (1997) Amyloid precursor protein metabolism in human neurons, astrocytes and microglia. J Neurochem 68:1183-1190.
28. Lee R, Wurtman R, Cox A, Nitsch R (1995) Amyloid precursor protein processing is stimulated by metabotropic glutamate receptors. Proc Natl Acad Sci USA 92:8083-8087.
29. Masliah E, Cole GM, Hansen L, Mallory M, Albright T, Terry R, Saitoh T (1991) Protein kinase C alteration is an early biochemical marker in Alzheimer's disease. J Neurosci 11:2759-2767.
30. Mattson M, Cheng B, Culwell A, Esch F, Lieberburg I, Rydel R (1993) Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the β-amyloid precursor protein. Neuron 10:243-254.
31. Munsick RA (1984) Human fetal extremity lengths in the interval from 9 to 21 menstrual weeks of pregnancy. Am J Obstet Gynecol 149:883-887.
32. Nitsch R, Slack B, Wurtman R, Growdon J (1992) Release of Alzheimer amyloid precursor derivatives stimulated by activation of muscarinic acetylcholine receptors. Science 258:304-307.
33. Nitsch R, Deng M, Growdon J, Wurtman R (1996) Serotonin 5-HT2a and 5-HT2c receptors stimulate amyloid precursor protein extodomain secretion. J Biol Chem 271:4188-4194.
34. Palmert M, Siedlak S, Podlinsny M, Greenberg B, Shelton E, Chan H, Usiak M, Selkoe D, Perry G, Younkin S (1989) Soluble derivatives of the β-amyloid protein precursor of Alzheimer's disease are labeled by antisera to the β-amyloid protein. Biochem Biophys Res Commun 165:182-188.
35. Paradis E, Douillard H, Koutroumanis M, Goodyer C, LeBlanc A (1996) Amyloid peptide of Alzheimer's disease downregulates Bcl-2 and upregulates Bax Expression in human neurons. J Neurosci 16:7533-7539.
36. Perez RG, Squazzo SL, Koo EH (1996) Enhanced release of amyloid-β-protein from codon 670-671 "Swedish" mutant β-amyloid precursor protein occurs in both secretory and endocytic pathway. J Biol Chem 271:9100-9107.
37. Pike CJ, Cummings BJ, Cotman CW (1992) β-amyloid induces neuritic dystrophy in vitro: similarities with Alzheimer pathology. NeuroReport 3:769-772.
38. Schagger H, Von Jagow G (1987) Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 KDa. Anal Biochem 166:368-379.
39. Selkoe D (1997) Alzheimer's Disease: genotypes, phenotype and treatments. Science 275:630.
40. Shoji M, Golde T, Ghiso J, Cheung T, Estus S, Shaffer L, Cai X, McKay D, Tintner R, Frangione B, Younkin S (1992) Production of the Alzheimer amyloid β protein by normal proteolytic processing. Science 258:126-129.
41. Simons M, DeStrooper B, Multhaup G, Tienari PJ, Dotti CG, Beyreuther K (1996) Amyloidogenic processing of the human amyloid precursor protein in primary cultures of rat hippocampal neurons. J Neurosci 16:899-908.
42. Slack BE, Breu J, Petryniak M, Srivastava K, Wurtman R (1995) Tyrosine phosphorylation-dependent stimulation of amyloid precursor protein secretion by the m3 muscarinic acetylcholine receptor. J Biol Chem 270:8337-8344.
43. Slack BE, Nitsch R, Livneh E, Kunz G, Breu J, Eldar H, Wurtman R (1943) Regulation by phorbol esters of amyloid precursor protein release from Swiss 3T3 fibroblasts overexpressing protein kinase C-alpha. J Biol Chem 268:21097-21101.
44. Thinakaran G, Teplow D, Siman R, Greenberg H, Sisodia S (1996) Metabolism of the "Swedish" amyloid precursor protein variant in Neuro2A (N2a) cells. J Biol Chem 16:9390-9397.
45. Wertkin AM, Turner RS, Pleasure SJ, Golde TE, Younkin SG, Trojanowski JQ, Lee V (1993) Human neurons derived from a terato-carcinoma cell line express solely the 695-amino acid amyloid precursor protein and produce intracellular β-amyloid or A4 peptides. Proc Natl Acad Sci USA 90:9513-9517.
46. Wolf B, Wertkin A, Jolly Y, Yasuda R, Wolfe B, Konrad R, Manning D, Ravi S, Williamson J, Lee V (1995) Muscarinic regulation of Alzheimer's disease amyloid precursor protein secretion and amyloid β-protein in human neuronal NT2N cells. J Biol Chem 270:4916-1922.
47. Xu H, Greengard P, Gandy S (1995) Regulated formation of Golgi secretory vesicles containing Alzheimer β-myloid precursor protein. J Biol Chem 270:21243-23245.
48. Yankner BA, Dawes LR, Fisher S, Villa-Komaroff L, Oster-Granite M, Neve RL (1989) Neurotoxicity of a fragment of the amyloid precursor protein associated with Alzheimer's disease. Science 245:417-420.
49. Yankner BA, Duffy LK, Kirschner DA (1990) Neurotrophic and neurotoxic effects of amyloid β protein: reversal by tachykinin neuropeptides. Science 250:279-286.