The cell cycle as a therapeutic target against Trypanosoma brucei: Hesperadin inhibits Aurora kinase-1 and blocks mitotic progression in bloodstream forms

Molecular Microbiology

Volumn 72, Issue 2, 2009, Pages 442-458

  Jetton, Neal ^a   Rothberg, Karen G ^a   Hubbard, James G ^a   Wise, John ^a   Li, Yan ^b   Ball, Haydn L ^b   Ruben, Larry ^a  

^a SOUTHERN METHODIST UNIVERSITY   (United States)

^b UNIVERSITY OF TEXAS AT DALLAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AURORA A KINASE; AURORA B KINASE; AURORA KINASE 1; HESPERADIN; HISTONE H3; UNCLASSIFIED DRUG;

ARTICLE; CELL CYCLE PROGRESSION; CYTOKINESIS; ENZYME PHOSPHORYLATION; IC 50; IN VITRO STUDY; KINETOPLAST; MASS SPECTROMETRY; MITOSIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; RNA INTERFERENCE; TRYPANOSOMA; TRYPANOSOMA BRUCEI;

AMINO ACID SEQUENCE; ANIMALS; ANTIPROTOZOAL AGENTS; BINDING SITES; CELL CYCLE; CELLS, CULTURED; HISTONES; INDOLES; MICE; MOLECULAR SEQUENCE DATA; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; PROTEIN-SERINE-THREONINE KINASES; RNA INTERFERENCE; RNA, PROTOZOAN; SEQUENCE ALIGNMENT; SULFONAMIDES; TRYPANOSOMA BRUCEI BRUCEI; TRYPANOSOMIASIS, AFRICAN;

MUS; TRYPANOSOMA BRUCEI;

EID: 64149090456     PISSN: 0950382X     EISSN: 13652958     Source Type: Journal    
DOI: 10.1111/j.1365-2958.2009.06657.x     Document Type: Article

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