Protein kinases as drug targets in trypanosomes and Leishmania

Biochimica et Biophysica Acta - Proteins and Proteomics

Volumn 1754, Issue 1-2, 2005, Pages 151-159

  Naula, Christina ^a,d   Parsons, Marilyn ^b,c   Mottram, Jeremy C ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b SEATTLE BIOMEDICAL RESEARCH INSTITUTE   (United States)

^c UNIVERSITY OF WASHINGTON   (United States)

^d UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

Cell cycle; Chemotherapy; Leishmania; Protein kinase; Trypanosoma

Indexed keywords

AMPHOTERICIN B; ANTIMONY DERIVATIVE; BENZNIDAZOLE; FLAVOPIRIDOL; GEFITINIB; IMATINIB; MILTEFOSINE; NIFURTIMOX; NITROFURAN; NITROIMIDAZOLE DERIVATIVE; PAROMOMYCIN; PENTAMIDINE; PROTEIN KINASE; PROTEIN TYROSINE KINASE; SITAMAQUINE;

ALZHEIMER DISEASE; CARDIOVASCULAR DISEASE; CELL CYCLE; CELL DIFFERENTIATION; CHRONIC MYELOID LEUKEMIA; CONFERENCE PAPER; CYTOSOL; DNA SYNTHESIS; DRUG TARGETING; EUKARYOTE; GASTROINTESTINAL STROMAL TUMOR; GENE SEQUENCE; HUMAN; LEISHMANIA MAJOR; LEISHMANIASIS; LIFE CYCLE; LUNG NON SMALL CELL CANCER; NONHUMAN; PARASITE; PRIORITY JOURNAL; PROTOZOON; RNA INTERFERENCE; SIDE EFFECT; TRYPANOSOMA; TRYPANOSOMA BRUCEI; TRYPANOSOMA CRUZI; TSETSE FLY;

ANIMALS; CYCLIN-DEPENDENT KINASES; GENOME, PROTOZOAN; HUMANS; LEISHMANIA MAJOR; LIFE CYCLE STAGES; MITOGEN-ACTIVATED PROTEIN KINASES; MODELS, BIOLOGICAL; PROTEIN KINASE INHIBITORS; PROTEIN KINASES; TRYPANOSOMA CRUZI; TRYPANOSOMATINA;

ANIMALIA; EUKARYOTA; LEISHMANIA MAJOR; MAMMALIA; PROTOZOA; TRYPANOSOMA; TRYPANOSOMA BRUCEI; TRYPANOSOMA CRUZI; TRYPANOSOMATIDAE;

EID: 29144480979     PISSN: 15709639     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbapap.2005.08.018     Document Type: Conference Paper

References (52)

1. C. Naula, and R. Burchmore A plethora of targets, a paucity of drugs: progress towards the development of novel chemotherapies for human African trypanosomiasis Expert. Rev. Anti. Infect. Ther. 1 2003 157 165
2. F.J. Perez-Victoria, S. Castanys, and F. Gamarro Leishmania donovani resistance to miltefosine involves a defective inward translocation of the drug Antimicrob. Agents Chemother. 47 2003 2397 2403
3. S.L. Croft, and G.H. Coombs Leishmaniasis-current chemotherapy and recent advances in the search for novel drugs Trends Parasitol. 19 2003 502 508
4. M. Ouellette, J. Drummelsmith, and B. Papadopoulou Leishmaniasis: drugs in the clinic, resistance and new developments Drug Resist. Updat. 7 2004 257 266
5. J.A. Urbina, and R. Docampo Specific chemotherapy of Chagas disease: controversies and advances Trends Parasitol. 19 2003 495 501
6. R. Buijsman Structural aspects of kinases and their inhibitors H. Kubinyi G. Müller Chemogenomics in Drug Discovery: A Medicinal Chemistry Perspective 2004 Wiley Publishers 191 219
7. A.C. Ivens, C.S. Peacock, E.A. Worthey, L. Murphy, G. Aggarwal, M. Berriman, E. Sisk, M.A. Rajandream, E. Adlem, R. Aert, A. Anupama, Z. Apostolou, P. Attipoe, N. Bason, C. Bauser, A. Beck, S.M. Beverley, G. Bianchettin, K. Borzym, G. Bothe, C.V. Bruschi, M. Collins, E. Cadag, L. Ciarloni, C. Clayton, R.M.R. Coulson, A. Cronin, A.K. Cruz, R.M. Davies, J. De Gaudenzi, D.E. Dobson, A. Duesterhoeft, G. Fazelina, N. Fosker, A.C. Frasch, A. Fraser, M. Fuchs, C. Gabel, A. Goble, A. Goffeau, D. Harris, C. Hertz-Fowler, H. Hilbert, D. Horn, Y. Huang, S. Klages, A. Knights, M. Kube, N. Larke, L. Litvin, A. Lord, T. Louie, M. Marra, D. Masuy, K. Matthews, S. Michaeli, J.C. Mottram, S. Muller-Auer, H. Munden, S. Nelson, H. Norbertczak, K. Oliver, S. O'Neil, M. Pentony, T.M. Pohl, C. Price, B. Purnelle, M.A. Quail, E. Rabbinowitsch, R. Reinhardt, M. Rieger, J. Rinta, J. Robben, L. Robertson, J.C. Ruiz, S. Rutter, D. Saunders, M. Schafer, J. Schein, D.C. Schwartz, K. Seeger, A. Seyler, S. Sharp, H. Shin, D. Sivam, R. Squares, S. Squares, V. Tosato, C. Vogt, G. Volckaert, R. Wambutt, T. Warren, H. Wedler, J. Woodward, S. Zhou, W. Zimmermann, D.F. Smith, J.M. Blackwell, K.D. Stuart, B. Barrell, and P.J. Myler The genome of the kinetoplastid parasite, Leishmania major Science 309 2005 436 442
8. M. Berriman, E. Ghedin, C. Hertz-Fowler, G. Blandin, H. Renauld, D.C. Bartholomeu, N.J. Lennard, E. Caler, N.E. Hamlin, B. Haas, U. Bohme, L. Hannick, M.A. Aslett, J. Shallom, L. Marcello, L. Hou, B. Wickstead, U.C. Alsmark, C. Arrowsmith, R.J. Atkin, A.J. Barron, F. Bringaud, K. Brooks, M. Carrington, I. Cherevach, T.J. Chillingworth, C. Churcher, L.N. Clark, C.H. Corton, A. Cronin, R.M. Davies, J. Doggett, A. Djikeng, T. Feldblyum, M.C. Field, A. Fraser, I. Goodhead, Z. Hance, D. Harper, B.R. Harris, H. Hauser, J. Hostetler, A. Ivens, K. Jagels, D. Johnson, J. Johnson, K. Jones, A.X. Kerhornou, H. Koo, N. Larke, S. Landfear, C. Larkin, V. Leech, A. Line, A. Lord, A. MacLeod, P.J. Mooney, S. Moule, D.M.A. Martin, G.W. Morgan, K. Mungall, H. Norbertczak, D. Ormond, G. Pai, C.S. Peacock, J. Peterson, M.A. Quail, E. Rabbinowitsch, M.A. Rajandream, C. Reitter, S.L. Salzberg, M. Sanders, S. Schobel, S. Sharp, M. Simmonds, A.J. Simpson, L. Tallon, C.M. Turner, A. Tait, A.R. Tivey, S. Van Aken, D. Walker, D. Wanless, S. Wang, B. White, O. White, S. Whitehead, J. Woodward, J. Wortman, M.D. Adams, T.M. Embley, K. Gull, E. Ullu, J.D. Barry, A.H. Fairlamb, F. Opperdoes, B.G. Barrell, J.E. Donelson, N. Hall, C.M. Fraser, S.E. Melville, and N.M. El Sayed The genome of the African trypanosome Trypanosoma brucei Science 309 2005 416 422
9. N.M. El Sayed, P.J. Myler, D.C. Bartholomeu, D. Nilsson, G. Aggarwal, A.N. Tran, E. Ghedin, E.A. Worthey, A.L. Delcher, G. Blandin, S.J. Westenberger, E. Caler, G.C. Cerqueira, C. Branche, B. Haas, A. Anupama, E. Arner, L. Aslund, P. Attipoe, E. Bontempi, F. Bringaud, P. Burton, E. Cadag, D.A. Campbell, M. Carrington, J. Crabtree, H. Darban, J.F. da Silveira, P. de Jong, K. Edwards, P.T. Englund, G. Fazelina, T. Feldblyum, M. Ferella, A.C. Frasch, K. Gull, D. Horn, L. Hou, Y. Huang, E. Kindlund, M. Klingbeil, S. Kluge, H. Koo, D. Lacerda, M.J. Levin, H. Lorenzi, T. Louie, C.R. Machado, R. McCulloch, A. McKenna, Y. Mizuno, J.C. Mottram, S. Nelson, S. Ochaya, K. Osoegawa, G. Pai, M. Parsons, M. Pentony, U. Pettersson, M. Pop, J.L. Ramirez, J. Rinta, L. Robertson, S.L. Salzberg, D.O. Sanchez, A. Seyler, R. Sharma, J. Shetty, A.J. Simpson, E. Sisk, M.T. Tammi, R. Tarleton, S. Teixeira, S. Van Aken, C. Vogt, P.N. Ward, B. Wickstead, J. Wortman, O. White, C.M. Fraser, K.D. Stuart, and B. Andersson The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas disease Science 309 2005 409 415
10. P. Ward, L. Equinet, J. Packer, and C. Doerig Protein kinases of the human malaria parasite Plasmodium falciparum: the kinome of a divergent eukaryote BMC Genomics 5 2004 79
11. G. Manning, D.B. Whyte, R. Martinez, T. Hunter, and S. Sudarsanam The protein kinase complement of the human genome Science 298 2002 1912 1934
12. B. Pils, and J. Schultz Inactive enzyme-homologues find new function in regulatory processes J. Mol. Biol. 340 2004 399 404
13. T.C. Hammarton, J. Clark, F. Douglas, M. Boshart, and J.C. Mottram Stage-specific differences in cell cycle control in Trypansoma brucei revealed by RNA interference of a mitotic cyclin J. Biol. Chem. 278 2003 22877 22886
14. T.C. Hammarton, J.C. Mottram, and C. Doerig The cell cycle of parasitic protozoa: potential for chemotherapeutic exploitation Prog. Cell Cycle Res. 5 2003 91 101
15. G.I. Shapiro Preclinical and clinical development of the cyclin-dependent kinase inhibitor flavopiridol Clin. Cancer Res. 10 2004 4270s 4275s
16. J.L. Affranchino, S.A. Gonzalez, and E. Pays Isolation of a mitotic-like cyclin homologue from the protozoan Trypanosoma brucei Gene 132 1993 75 82
17. T.C. Hammarton, J.R. Ford, and J.C. Mottram Trypanosoma brucei CYC1 does not have characteristics of a mitotic cyclin Mol. Biochem. Parasitol. 111 2000 229 233
18. M. Parsons, E.A. Worthey, P.N. Ward, and J.C. Mottram Comparative analysis of the kinomes of three pathogenic trypanosomatids; Leishmania major, Trypanosoma brucei and Trypanosoma cruzi, BMC Genomics 6 1 2005 (Sept 15) 127
19. K.M. Grant, P. Hassan, J.S. Anderson, and J.C. Mottram The CRK3 gene of Leishmania mexicana encodes a stage-regulated cdc2-related histone H1 kinase that associates with p12 J Biol. Chem. 273 1998 10153 10159
20. P. Hassan, D. Fergusson, K.M. Grant, and J.C. Mottram The CRK3 protein kinase is essential for cell cycle progression of Leishmania mexicana Mol. Biochem. Parasitol. 113 2001 189 198
21. J.C. Mottram, B.P. McCready, K.G. Brown, and K.M. Grant Gene disruptions indicate an essential function for the LmmCRK1 cdc2-related kinase of Leishmania mexicana Mol. Microbiol. 22 1996 573 583
22. suc1, associates with a stage-regulated histone H1 kinase Biochem. J. 316 Pt. 3 1996 833 839
23. Y. Wang, K. Dimitrov, L.K. Garrity, S. Sazer, and S.M. Beverley Stage-specific activity of the Leishmania major CRK3 kinase and functional rescue of a Schizosaccharomyces pombe cdc2 mutant Mol. Biochem. Parasitol. 96 1998 139 150
24. J.C. Mottram, J.H. Kinnaird, B.R. Shiels, A. Tait, and J.D. Barry A novel CDC2-related protein kinase from Leishmania mexicana, LmmCRK1, is post-translationally regulated during the life cycle J. Biol. Chem. 268 1993 21044 21052
25. K.M. Grant, M.H. Dunion, V. Yardley, A.L. Skaltsounis, D. Marko, G. Eisenbrand, S.L. Croft, L. Meijer, and J.C. Mottram Inhibitors of Leishmania mexicana CRK3 cyclin-dependent kinase: chemical library screen and antileishmanial activity Antimicrob. Agents Chemother. 48 2004 3033 3042
26. T.C. Hammarton, M. Engstler, and J.C. Mottram The Trypanosoma brucei cyclin, CYC2, is required for cell cycle progression through G1 phase and for maintenance of procyclic form cell morphology J. Biol. Chem. 279 2004 24757 24764
27. X. Tu, and C.C. Wang Pairwise knockdowns of cdc2-related kinases (CRKs) in Trypanosoma brucei Identified the CRKs for G1/S and G2/M transitions and demonstrated distinctive cytokinetic regulations between two developmental stages of the organism Eukaryot. Cell 4 2005 755 764
28. X. Tu, and C.C. Wang The involvement of two cdc2-related kinases (CRKs) in Trypanosoma brucei cell cycle regulation and the distinctive stage-specific phenotypes caused by CRK3 depletion J. Biol. Chem. 279 2004 20519 20528
29. Z. Li, and C.C. Wang A PHO80-like cyclin and a B-type cyclin control the cell cycle of the procyclic form of Trypanosoma brucei J Biol. Chem. 278 2003 20652 20658
30. J.J. Van Hellemond, P. Neuville, R.T. Schwarz, K.R. Matthews, and J.C. Mottram Isolation of Trypanosoma brucei CYC2 and CYC3 cyclin genes by rescue of a yeast G(1) cyclin mutant. Functional characterization of CYC2 J Biol. Chem. 275 2000 8315 8323
31. J.P. da Cunha, E.S. Nakayasu, M.C. Elias, D.C. Pimenta, M.T. Tellez-Inon, F. Rojas, M. Manuel, I.C. Almeida, and S. Schenkman Trypanosoma cruzi histone H1 is phosphorylated in a typical cyclin dependent kinase site accordingly to the cell cycle Mol. Biochem. Parasitol. 140 2005 75 86
32. E.B. Gomez, A.R. Kornblihtt, and M.T. Tellez-Inon Cloning of a cdc2-related protein kinase from Trypanosoma cruzi that interacts with mammalian cyclins Mol. Biochem. Parasitol. 91 1998 337 351
33. E.B. Gomez, M.I. Santori, S. Laria, J.C. Engel, J. Swindle, H. Eisen, P. Szankasi, and M.T. Tellez-Inon Characterization of the Trypanosoma cruzi Cdc2p-related protein kinase 1 and identification of three novel associating cyclins Mol. Biochem. Parasitol. 113 2001 97 108
34. M.I. Santori, S. Laria, E.B. Gomez, I. Espinosa, N. Galanti, and M.T. Tellez-Inon Evidence for CRK3 participation in the cell division cycle of Trypanosoma cruzi Mol. Biochem. Parasitol. 121 2002 225 232
35. J.S. Sebolt-Leopold, and R. Herrera Targeting the mitogen-activated protein kinase cascade to treat cancer Nat. Rev., Cancer 4 2004 937 947
36. D. Strumberg, and S. Seeber Raf kinase inhibitors in oncology Onkologie 28 2005 101 107
37. F. Bengs, A. Scholz, D. Kuhn, and M. Wiese LmxMPK9, a mitogen-activated protein kinase homologue affects flagellar length in Leishmania mexicana Mol. Microbiol. 55 2005 1606 1615
38. M. Wiese, Q. Wang, and I. Gorcke Identification of mitogen-activated protein kinase homologues from Leishmania mexicana Int. J Parasitol. 33 2003 1577 1587
39. M. Wiese, D. Kuhn, and C.G. Grunfelder Protein kinase involved in flagellar-length control Eukaryot. Cell 2 2003 769 777
40. M. Wiese, and I. Gorcke Homologues of LMPK, a mitogen-activated protein kinase from Leishmania mexicana, in different Leishmania species Med. Microbiol. Immunol. (Berl) 190 2001 19 22
41. M. Wiese A mitogen-activated protein (MAP) kinase homologue of Leishmania mexicana is essential for parasite survival in the infected host EMBO J. 17 1998 2619 2628
42. I.B. Muller, D. Domenicali-Pfister, I. Roditi, and E. Vassella Stage-specific requirement of a mitogen-activated protein kinase by Trypanosoma brucei Mol. Biol. Cell 13 2002 3787 3799
43. S.B. Hua, and C.C. Wang Interferon-gamma activation of a mitogen-activated protein kinase, KFR1, in the bloodstream form of Trypanosoma brucei J. Biol. Chem. 272 1997 10797 10803
44. S.B. Hua, and C.C. Wang Differential accumulation of a protein kinase homolog in Trypanosoma brucei J. Cell. Biochem. 54 1994 20 31
45. J. Ellis, M. Sarkar, E. Hendriks, and K. Matthews A novel ERK-like, CRK-like protein kinase that modulates growth in Trypanosoma brucei via an autoregulatory C-terminal extension Mol. Microbiol. 53 2004 1487 1499
46. M. Gale Jr., V. Carter, and M. Parsons Translational control mediates the developmental regulation of the Trypanosoma brucei Nrk protein kinase J. Biol. Chem. 269 1994 31659 31665
47. M. Gale Jr., V. Carter, and M. Parsons Cell cycle-specific induction of an 89 kDa serine/threonine protein kinase activity in Trypanosoma brucei J. Cell Sci. 107 Pt. 7 1994 1825 1832
48. M. Gale Jr., and M. Parsons A Trypanosoma brucei gene family encoding protein kinases with catalytic domains structurally related to Nek1 and NIMA Mol. Biochem. Parasitol. 59 1993 111 121
49. M. Knockaert, N. Gray, E. Damiens, Y.T. Chang, P. Grellier, K. Grant, D. Fergusson, J. Mottram, M. Soete, J.F. Dubremetz, K. Le Roch, C. Doerig, P. Schultz, and L. Meijer Intracellular targets of cyclin-dependent kinase inhibitors: identification by affinity chromatography using immobilised inhibitors Chem. Biol. 7 2000 411 422
50. T.C. Hammarton, S.G. Lillico, S.C. Welburn, and J.C. Mottram Trypanosoma brucei MOB1 is required for accurate and efficient cytokinesis but not for exit from mitosis Mol. Microbiol. 56 2005 104 116
51. M. Vieth, R.E. Higgs, D.H. Robertson, M. Shapiro, E.A. Gragg, and H. Hemmerle Kinomics-structural biology and chemogenomics of kinase inhibitors and targets Biochim. Biophys. Acta 1697 2004 243 257
52. N.P. Shah, C. Tran, F.Y. Lee, P. Chen, D. Norris, and C.L. Sawyers Overriding imatinib resistance with a novel ABL kinase inhibitor Science 305 2004 399 401