DNA-dependent protein kinase

International Journal of Biochemistry and Cell Biology

Volumn 29, Issue 7, 1997, Pages 935-938

  Jackson, Stephen P ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

DNA repair; DNA PK; Radiosensitivity; V(D)J recombination

Indexed keywords

DOUBLE STRANDED DNA; PROTEIN KINASE;

DNA DAMAGE; DNA REPAIR; DNA STRAND BREAKAGE; ENZYME ACTIVITY; ENZYME STRUCTURE; HUMAN; RADIOSENSITIVITY; SHORT SURVEY;

ATAXIA; ATAXIA TELANGIECTASIA;

EID: 0030682172     PISSN: 13572725     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1357-2725(97)00006-X     Document Type: Article

References (15)

1. Blunt T., Gell D., Fox M., Taccioli G. E., Lehmarm A. R., Jackson S. P. and Jeggo P. A. (1996) Identification of a nonsense mutation in the carboxyl-terminal region of DNA-dependent protein kinase catalytic subunit in the scid mouse. Proc. Natl Acad. Sci. U.S.A. 93, 10285-10290.
2. Boulton S. J. and Jackson S. P. (1996a) Saccharomyces cerevisiae Ku 70 potentiates illegitimate DNA double-strand break repair and serves as a barrier to error-prone DNA repair pathways. EMBO J. 15, 5093-5103.
3. Boulton, S. J. and Jackson, S. P. (1996b) Identification of a Saccharomyces cerevisiae Ku80 homologue: roles in DNA double-strand break rejoining and telomeric maintenance. Nucl. Acids Res. 24, 4639-4648.
4. Danska J. S., Holland D. P., Mariathasan S., Williams K. M. and Guidos C. J. (1996) Biochemical and genetic defects in the DNA-dependent protein kinase in murine scid lymphocytes. Mol. Cell Biol. 16, 5507-5517.
5. Gottlieb T. M. and Jackson S. P. (1993) The DNA-dependent protein kinase: requirement for DNA ends and association with Ku antigen. Cell 72, 131-142.
6. Hartley K. O., Gell D., Smith G. C. M., Zhang H., Divecha N., Connelly M. A., Admon A., Lees-Miller S. P., Anderson C. W. and Jackson S. P. (1995) DNA-dependent protein kinase catalytic subunit: a relative of phosphatidylinositol 3-kinase and the ataxia-telangiectasia gene product. Cell 82, 849-856.
7. Jackson S. P. (1995) Ataxia-telangiectasia at the cross-roads. Current Biology 5, 1210-1212.
8. Jackson S. P. and Jeggo P. A. (1995) DNA double-strand break repair and V(D)J recombination: involvement of DNA-PK. TIBS 20, 412-415.
9. Keith C. T. and Schreiber S. L. (1995) PIK-related kinases: DNA repair, recombination, and cell cycle checkpoints. Science 270, 50-51.
10. Kuhn A., Gottlieb T. M., Jackson S. P. and Grummt I. (1995) DNA-dependent protein kinase: a potent inhibitor of transcription by RNA polymerase I. Genes Dev. 9, 193-203.
11. Metcalfe J. A., Parkhill J., Campbell L., Stacey M., Biggs P., Byrd P. J. and Taylor A. M. R. (1996) Accelerated telomere shortening in ataxia - telangiectasia. Nature Genetics 13, 350-353.
12. Milne G. T., Jin S., Shannon K. B. and Weaver D. T. (1996) Mutations in two Ku homologs define a DNA end-joining repair pathway in Saccharomyces cerevisiae. Mol. Cell Biol. 16, 4189-4198.
13. Song Q., Lees-Miller S. P., Kumar S., Zhang N., Chan D. W., Smith G. C. M., Jackson S. P., Alnemri E. S., Litwack G., Khanna K. K. and Lavin M. F. (1996) DNA-dependent protein kinase catalytic subunit: a target for an ICE-like protease in apoptosis. EMBO J. 15, 3238-3246.
14. Walker A. I., Hunt T., Jackson R. L. and Anderson C. W. (1985) Double-stranded DNA induces the phosphorylation of several proteins including the 90 000 mol wt heat-shock protein in animal cell extracts. EMBO J. 4, 139-145.
15. Wu X. and Lieber M. R. (1996) Protein - protein and protein - DNA interaction regions within the DNA end-binding protein Ku70-Ku86. Mol. Cell Biol. 16, 5186-5193.