Successful treatment of radiation-induced fibrosis using Cu/Zn-SOD and Mn-SOD: An experimental study

International Journal of Radiation Oncology Biology Physics

Volumn 35, Issue 2, 1996, Pages 305-312

  Lefaix, Jean Louis ^a   Delanian, Sylvie ^a,b   Leplat, Jean Jacques ^a   Tricaud, Yves ^a   Martin, Michèle ^a   Nimrod, Abraham ^c   Baillet, François ^d   Daburon, François ^a  

^a CEA SACLAY   (France)

^b Hôpital Neker Saint Louis   (France)

^c BioTechnology General Ltd   (Israel)

^d PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

Author keywords

Cu Zn superoxide dismutase; Fibrosis; Late radiation effects; Mn superoxide dismutase

Indexed keywords

COPPER ZINC SUPEROXIDE DISMUTASE; DIPALMITOYLPHOSPHATIDYLCHOLINE; LIPOSOME; MANGANESE; OCTADECYLAMINE; SUPEROXIDE DISMUTASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENCAPSULATION; FEMALE; GAMMA IRRADIATION; INTRAMUSCULAR DRUG ADMINISTRATION; MYOFIBROSIS; NONHUMAN; PRIORITY JOURNAL; RADIATION INJURY; SCAR; SKIN FIBROSIS; SUBCUTANEOUS TISSUE; SWINE; TISSUE REGENERATION;

ANIMALS; FEMALE; FIBROSIS; LIPOSOMES; RADIATION INJURIES, EXPERIMENTAL; SKIN; SKIN DISEASES; SUPEROXIDE DISMUTASE; SWINE;

EID: 0029996626     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/0360-3016(96)00061-2     Document Type: Article

References (37)

1. Baillet, F.; Housset, M.; Michelson, A. M.; Puget, K. Treatment of radiofibrosis with liposomial superoxide dismutase. Preliminary results of 50 cases. Free. Radic. Res. Commun. 1:387-394; 1986.
2. Canney, P. A.; Dean, S. Transforming growth factor: A promotor of late connective tissue injury following radiotherapy? Br. J. Radiol. 63:620-623; 1990.
3. Delanian, S.; Baillet, F.; Huart, J.; Lefaix, J.-L.; Maulard, C.; Housset, M. Successful treatment of radiation-induced fibrosis using liposomial Cu/Zn superoxide dismutase: Clinical trial. Radiother. Oncol. 32:12-20; 1994.
4. Delanian, S.; Bravard, A.; Luccioni, C.; Martin, M.; Lefaix, J.-L.; Daburon, F. Métabolisme antioxydant et fibrose cutanéo-musculaire radio-induite: Modulation du phénotype fibroblastique par la superoxyde dismutase Cu/Zn bovine sous forme liposomiale (Lipsod)? Bull. Cancer Radiother. 81:4, 475; 1994.
5. Delanian, S.; Lefaix, J. L.; Housset, M. Iatrogenic fibrosis in oncology (Part II): Etiologic conditions and possible therapeutic attitude (in French). Bull. Cancer 80:202-212; 1993.
6. Delanian, S.; Martin, M.; Housset, M. Iatrogenic fibrosis in oncology (Part I): Description and pathophysiological aspects (in French). Bull. Cancer 80:192-201; 1993.
7. Delanian, S.; Martin, M.; Lefaix, J. L. TGFb1, collagen I and III gene expression in human skin fibrosis induced by therapeutic irradiation. Br. J. Radiol. Suppl. 65:82; 1992.
8. Dion, M. W.; Hussey, D. H.; Doornbos, J. F.; Vigliotti, A. P.; Wen, B. C.; Anderson, B. Preliminary results of a pilot study of pentoxifylline in the treatment of late radiation soft tissue necrosis. Int. J. Radiat. Oncol. Biol. Phys. 19:401-407; 1990.
9. Edsmyr, F.; Menander-Huber, X. Orgotein efficacy in ameliorating side effects due to radiation therapy. Eur. J. Rheumatol. Inflamm. 4:228-236; 1981.
10. Emami, B.; Lyman, J.; Brown, A.; Coia, L.; Goitein, M.; Munzenrider, J.; Shank, B.; Solin, L.; Wesson, M. Tolerance of normal tissue to therapeutic irradiation. Int. J. Radiat. Oncol. Biol. Phys. 21:109-122; 1991.
11. Emerit, J.; Michelson, A. M.; Robert, H. G.; Chomette, G.; Guerin, R.; Blondon, J.; Bertrand, M. Treatment with superoxide dismutase of two cases of radiation-induced sclerosis (in French). Semin. Hop. Paris 59:277-281; 1983.
12. Golstein, P.; Ojcius, D.; Young, J. Cell death mechanisms and the immune system. Immunol. Rev. 121:29-65; 1991.
13. Gorecki, M.; Beck, Y.; Hartman, J. R.; Fischer, M.; Weiss, L.; Tochner, Z.; Slavin, S.; Nimrod, R. Recombinant human superoxide dismutases: Production and potential therapeutical uses. Free Radic. Res. Commun. 12-13:401-410; 1991.
14. Kovacs, E. Fibrogenic cytokines: The role of immune mediators in the development of scar tissue (review). Immunol. Today. 12:17-23; 1991.
15. Krane, S. The turnover and degradation of collagen. In: Evered, D.; Whelan, J., eds. Fibrosis. Ciba Foundation Symposium 114. London: Pittman; 1985:97-110.
16. 192Ir gamma rays. Health Phys. 63:692-694; 1992.
17. 192Ir gamma rays. Br. J. Radiol. 66:537-544; 1993.
18. Lortat-Jacob, H.; Kleiman, H.; Grimaud, J. High affinity binding of IFN-gamma to a basement membrane complex. J. Clin. Invest. 87:878-883; 1991.
19. Marklund, S.; Westman, N.; Lundergreen, E.; Ross, G. Copper and zinc containing superoxide dismutase, manganese containing SOD, catalase and glutathione peroxidase in normal and neoplasic human cell lines and normal human tissues. Cancer Res. 42:1955-1961; 1982.
20. Martin, M.; Rémy, J.; Daburon, F. Abnormal proliferation and aging of cultured fibroblasts from pig with subcutaneous fibrosis induced gamma irradiation. J. Invest. Dermatol. 93:497-500; 1989.
21. Martin, M.; Lefaix, J. L.; Pinton, P.; Crechet, F.; Daburon, F. Temporal modulation of TGFβ1 and β-actin gene expression in pig skin and muscular fibrosis after ionizing radiation. Radiat. Res. 134:63-70; 1993.
22. Michelson, A. M.; Puget, K. Cell penetration by exogenous superoxide dismutase. Acta. Physiol. Scand. Suppl. 492:67-80; 1980.
23. Michelson, A. M.; Puget, K.; Jadot, G. Anti-inflammatory activity of superoxide dismutases: Comparison of enzymes from different sources in different models in rats, mechanism of action. Free. Radic. Res. Commun. 2:43-56; 1986.
24. Michelson, A. M. Medical aspects of superoxide dismutase. Life Chem. Rep. 6:1-142; 1987.
25. Oyanagui, Y.; Sato, S.; Inoue, M. Inhibition of carrageenan-induced paw edema by superoxide dismutase that binds to heparan sulfates on vascular endothelial cells. Biochem. Pharmacol. 42:991-995; 1991.
26. Parizada, B.; Werber, M. M.; Nimrod, R. Protective effects of human recombinant Mn-SOD in adjuvant arthritis and bleomycin-induced lung fibrosis. Free Radic. Res. Commun. 15:297-301; 1991.
27. Perdereau, B.; Campana, F.; Vilcoq, J. R.; de la Rochefordière, A.; Barnaroux, C.; Fourquet, A.; Magdelenat, H. Superoxide dismutase (Cu/Zn) as an ointment for radiofibrosis therapy (in French). Bull. Cancer 81:659-669; 1994.
28. Petkau, A. Scientific basis for the clinical use of superoxide dismutase. Cancer Treat. Rev. 13:17-44; 1986.
29. Rémy, J.; Wegrowski, J.; Crechet, F.; Martin, M.; Daburon, F. Long term overproduction of collagen in radiation-induced fibrosis. Radiat. Res. 125:14-19; 1991.
30. Rubin, P. Late effects of chemotherapy and radiation therapy: A new hypothesis (The Frenz Buschke Lecture). Int. J. Radiat. Oncol. Biol. Phys. 10:5-34; 1986.
31. Rubin, P.; Finkelstein, J.; Shapiro, D. Molecular biology mechanisms in the radiation induction of pulmonary injury syndromes: Interrelationship between the alveolar macrophage and the septal fibroblast. Int. J. Radiat. Oncol. Biol. Phys. 24:93-101; 1992.
32. Sappino, A.; Schüren, W.; Gabbiabi, G. Differentiation repertoire of fibroblastic cells: Expression of cytoskeletal proteins as marker of phenotypic modulations. Lab. Invest. 63:144-160; 1990.
33. Turrens, J.; Crapo, J.; Freeman, B. Protection against toxicity by intravenous injection of liposome-entrapped catalase and superoxide dismutase. J. Clin. Invest. 73:87-95; 1984.
34. Vaille, A.; Jadot, G.; Elizagaray, A. Antiinflammatory activity of various SOD's on polyarthritis in the Lewis rat. Biochem. Pharmacol. 39:247-255; 1990.
35. Wegrowski, J.; Lefaix, J. L.; Lafuma, C. Accumulation of glycosaminoglycans in radiation-induced muscular fibrosis. Int. J. Radiat. Biol. 61:685-693; 1992.
36. Werner-Wasik, M.; Madoc-Jones, H. Trental (pentoxifylline) relieves pain from postradiation fibrosis. Int. J. Radiat. Oncol. Biol. Phys. 25:757-758; 1993.
37. Wong, G.; Elwell, J.; Oberley, L.; Goeddel, D. Manganous superoxide dismutase is essential for cellular resistance to cytotoxicity of tumor necrosis factor. Cell 58:923-931; 1989.