Increased mitochondrial mass in cells with functionally compromised mitochondria after exposure to both direct γ radiation and bystander factors

Radiation Research

Volumn 168, Issue 1, 2007, Pages 134-142

  Nugent, Sharon M E ^a   Mothersill, Carmel E ^b   Seymour, Colin ^b   McClean, Brendan ^c   Lyng, Fiona M ^a   Murphy, James E J ^a  

^a DUBLIN INSTITUTE OF TECHNOLOGY   (Ireland)

^b MCMASTER UNIVERSITY   (Canada)

^c ST LUKE S HOSPITAL   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL TISSUE; ARTICLE; CELL CULTURE; GAMMA RADIATION; HAMSTER; HUMAN; HUMAN CELL; KERATINOCYTE; MITOCHONDRIAL MEMBRANE; NONHUMAN; OVARY CELL CULTURE; OXYGEN CONSUMPTION; PRIORITY JOURNAL; RADIATION EXPOSURE; STRESS; ANIMAL; BYSTANDER EFFECT; CELL LINE; METABOLISM; MITOCHONDRIAL SIZE; MITOCHONDRION; PATHOLOGY;

CRICETULUS GRISEUS; HUMAN PAPILLOMAVIRUS;

OXYGEN;

ANIMALS; BYSTANDER EFFECT; CELL LINE; CRICETINAE; GAMMA RAYS; HUMANS; MITOCHONDRIA; MITOCHONDRIAL SIZE; OXYGEN;

EID: 34548564427     PISSN: 00337587     EISSN: None     Source Type: Journal    
DOI: 10.1667/RR0769.1     Document Type: Article

References (43)

1. C. Mothersill and C. B. Seymour, Radiation-induced bystander effects - implications for cancer. Nat. Rev. Cancer 4, 158-164 (2004).
2. P. J. Coates, S. A. Lorimore and E. G. Wright, Damaging and protective cell signalling in the untargeted effects of ionizing radiation. Mutat. Res. 568, 5-20 (2004).
3. E. I. Azzam and J. B. Little, The radiation-induced bystander effect: Evidence and significance. Hum. Exp. Toxicol. 23, 61-65 (2004).
4. W. F. Morgan, Non-targeted and delayed effects of exposure to ionizing radiation: I. Radiation-induced genomic instability and bystander effects in vitro. Radiat. Res. 159, 567-580 (2003).
5. S. A. Lorimore, M. A. Kadhim, D. A. Pocock, D. Papworth, D. L. Stevens, D. T. Goodhead and E. G. Wright, Chromosomal instability in the descendents of unirradiated surviving cells after α-particle irradiation. Proc. Natl. Acad. Sci. USA 95, 5730-5733 (1998).
6. K. M. Prise, O. V. Belyakov, M. Folkard and B. D. Michael, Studies of the bystander effect in human fibroblasts using a charged particle microbeam. Int. J. Radiat. Biol. 74, 793-798 (1998).
7. E. I. Azzam, S. M. de Toledo, T. Gooding and J. B. Little, Intercellular communications is involved in the bystander regulation of gene expression in human cells exposed to very low fluences of α particles. Radiat. Res. 150, 497-504 (1998).
8. H. Nagasawa and J. B. Little, Induction of sister chromatid exchanges by extremely low doses of alpha particles. Cancer Res. 52, 6394-6396 (1992).
9. F. M. Lyng, C. B. Seymour and C. Mothersill, Production of a signal by irradiated cells which leads to a response in unirradiated cells characteristic of initiation of apoptosis. Br. J. Cancer 83, 1223-1230 (2000).
10. P. K. Narayanan, E. H. Goodwin and B. E. Lehnert, Alpha particles initiate biological production of superoxide anions and hydrogen peroxide in human cells. Cancer Res. 57, 3963-3971 (1997).
11. C. B. Seymour and C. Mothersill, Delayed expression of lethal mutations and genomic instability in the progeny of human epithelial cells that survived in a bystander-killing environment. Radiat. Oncol. Investig. 5, 106-110 (1997).
12. C. Mothersill and C. Seymour, Medium from irradiated human epithelial cells but not human fibroblasts reduces the clonogenic survival of unirradiated cells. Int. J. Radiat. Biol. 71, 421-427 (1997).
13. C. B. Seymour and C. Mothersill, Relative contribution of bystander and targeted cell killing to the low-dose region of the radiation dose-response curve. Radiat. Res. 153, 508-511 (2000).
14. R. C. Miller, G. Randers-Pehrson, C. R. Geard, E. J. Hall and D. J. Brenner, The oncogenic transforming potential of the passage of single alpha particles through mammalian cell nuclei. Proc. Natl. Acad. Sci. USA 96, 19-22 (1999).
15. C. Mothersill and C. Seymour, Medium from irradiated human epithelial cells but not human fibroblasts reduces the clonogenic survival of unirradiated cells. Int. J. Radiat. Biol. 71, 421-427 (1997).
16. J. L. Boore, Animal mitochondrial genomes. Nucleic Acids Res. 27, 1767-1780 (1999).
17. F. Morel, R. Debise, M. Renoux, S. Touraille, M. Ragno and S. Alziari, Biochemical and molecular consequences of ethidium bromide treatment on Drosophila cells. Insect Biol. Mol. Biol. 29, 835-843 (1999).
18. C. L. Limoli, E. Giedzinski, W. F. Morgan, S. G. Swarts, G. D. D. Jones and W. Hyun, Persistent oxidative stress in chromosomally unstable cells. Cancer Res. 63, 3107-3111 (2003).
19. C. F. Lee, C. Y. Liu, R. H. Hsieh and Y. H. Wei, Oxidative stress-induced depolymerization of microtubules and alteration of mitochondrial mass in human cells. Ann. NY Acad. Sci. 1042, 246-254 (2005).
20. J. H. Spodnik, M. Wozniak, D. Budzko, M. A. Teranishi, M. Karbowski, Y. Nishizawa, J. Usukura and T. Wakabayashi, Mechanism of leflunomide-induced proliferation of mitochondria in mammalian cells. Mitochondrion 2, 163-179 (2002).
21. F. M. Lyng, C. B. Seymour and C. Mothersill, Initiation of apoptosis in cells exposed to medium from the progeny of irradiated cells: A possible mechanism for bystander-induced genomic instability? Radiat. Res. 157, 365-370 (2002).
22. R. Iyer, B. E. Lehnert and R. Svensson, Factors underlying the cell growth-related bystander responses to alpha particles. Cancer Res. 60, 1290-1298 (2000).
23. M. Mancini, B. O. Anderson, E. Caldwell, M. Sedghinasab, P. B. Paty and D. M. Hockenbery, Mitochondrial proliferation and paradoxical membrane depolarization during terminal differentiation and apoptosis in a human colon carcinoma cell line. J. Cell Biol. 138, 449-469 (2005).
24. M. C. Pagliacci, F. Spinozzi and G. Migliorati, Genistein inhibits tumour growth in vitro but enhances mitochondrial reduction of tetrazolium salts: A further pitfall in the use of the MTT assay for evaluating cell growth and survival. Eur. J. Cancer 29, 1573-1577 (1993).
25. M. Karbowski, J. H. Spodnik, M. Teranishi, M. Wozniak, Y. Nishizawa, J. Usukura and T. Wakabayashi, Opposite effects of microtubule-stabilizing and microtubule-destabilizing drugs on biogenesis of mitochondria in mammalian cells. J. Cell Sci. 114, 281-291 (2001).
26. X. Xu, J. W. Williams, E. G. Bremer, A. Finnegan and A. S. Chong, Inhibition of protein tyrosine phosphorylation in T cells by a novel immunosuppressive agent, leflunomide. J. Biol. Chem. 270, 12398-12403 (1995).
27. E. J. Cupler, M. J. Danon, C. Jay, K. Hench, M. Rapka and M. C. Dalakos, Early features of zidobudine-associated myopathy: Histopathological findings and clinical correlations. Acta Neuropathol. 90, 1-6 (1995).
28. H. C. Lee, P. H. Yin, C. Y. Lu, C. W. Chi and Y. H. Wei, Increase of mitochondrial DNA in response to oxidative stress in human cells. Biochem. J. 348, 425-432 (2000).
29. J. E. J. Murphy, S. Nugent, C. Seymour and C. Mothersill, Mitochondrial DNA point mutations and a novel deletion induced by direct low-LET radiation and by medium from irradiated cells. Mutat. Res. 585, 127-136 (2005).
30. R. Rossignol, B. Faustin, C. Rocher, M. Malgat, J. P. Mazat and T. Letellier, Mitochondrial threshold effects. Biochem. J. 370, 751-762 (2003).
31. C. Mothersill, C. B. Seymour and M. C. Joiner, Relationship between radiation-induced low-dose hypersensitivity and the bystander effect. Radiat. Res. 157, 526-532 (2002).
32. L. Pirisi, K. E. Creek, J. Doniger and J. A. DiPaolo, Continuous cell lines with altered growth and differentiation properties originate after transfection of human keratinocytes with human papillomavirus type 16 DNA. Carcinogenesis 9, 1573-1579 (1988).
33. F. T. Kao and T. T. Puck, Genetics of somatic mammalian cells, VII. Induction and isolation of nutritional mutants in Chinese hamster cells. Proc. Natl. Acad. Sci. USA 60, 1275-1281 (1968).
34. 2 solubility in aqueous media determined by a kinetic method. Anal. Biochem. 145, 406-418 (1985).
35. 2) oxygen uptake rates in animal cell cultures. J. Biotechnol. 63, 85-95 (1998).
36. M. Vrbacky, J. Krijt, Z. Drahota and Z. Melkova, Inhibitory effects of Bcl-2 on mitochondrial respiration. Physiol. Res. 52, 545-554 (2003).
37. J. Minners, L. Lacerda, J. McCarthy, J. J. Meiring, D. M. Yellon and M. N. Sack, Ischemic and pharmacological preconditioning in Girardi cells and C2C12 myotubes induce mitochondrial uncoupling. Circ. Res. 89, 787-792 (2001).
38. M. Battino, E. Ferri, E. Gattavecchia, A. Breccia, M. L. Genova, G. P. Littarru and G. Lenaz, Mitochondrial respiratory chain features after γ irradiation. Radiat. Res. 26, 431-438 (1996).
39. N. A. Pham and D. W. Hedley, Respiratory chain-generated oxidative stress following treatment of leukemic blasts with DNA-damaging agents. Exp. Cell Res. 264, 345-352 (2001).
40. G. P. Davey and J. B. Clarke, Threshold effects and control of oxidative phosphorylation in nonsynaptic rat brain mitochondria. Mitochondria, cell death and DNA damage. J. Neurochem. 66, 1617-1624 (1996).
41. R. Rossignol, T. Letellier, M. Malgat, C. Rocher and J. P. Mazat, Tissue variation in the control of oxidative phosphorylation: Implication for mitochondrial diseases. Biochem. J. 347, 45-53 (2000).
42. P. Maguire, C. Mothersill, C. Seymour and F. M. Lyng, Medium from irradiated cells induces dose-dependent mitochondrial changes and BCL2 responses in unirradiated human keratinocytes. Radiat. Res. 163, 384-390 (2005).
43. C. Mothersill, C. B. Seymour and M. C. Joiner, Relationship between radiation-induced low-dose hypersensitivity and the bystander effect. Radiat. Res. 157, 526-532 (2002).