Tissue renin-angiotensin systems: New insights from experimental animal models in hypertension research

Journal of Molecular Medicine

Volumn 79, Issue 2, 2001, Pages 76-102

  Bader, Michael ^a   Peters, Jörg ^b   Baltatu, Ovidiu ^a   Müller, Dominik N ^a   Luft, Friedrich C ^a   Ganten, Detlev ^a,c  

^a MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Angiotensin; Gene targeting; Renin; Transgenic rats

Indexed keywords

ANGIOTENSIN; ANGIOTENSIN I; ANGIOTENSIN RECEPTOR; ANGIOTENSINOGEN; RENIN; STAT PROTEIN;

ADRENAL GLAND; ANIMAL MODEL; BLOOD PRESSURE; BLOOD VESSEL INJURY; DISEASE ASSOCIATION; GENE TARGETING; HEART HYPERTROPHY; HEART VENTRICLE REMODELING; HYPERTENSION; MEDICAL RESEARCH; NONHUMAN; PROTEIN EXPRESSION; RAT; REGULATORY MECHANISM; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; REVIEW; TRANSGENIC ANIMAL;

EID: 0035074165     PISSN: 09462716     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001090100210     Document Type: Review

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293. Angiotensin II type 2 receptor-modulated changes in potassium currents in cultured neurons
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296. Signal Transduction from the Angiotensin II AT2 Receptor
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299. Angiotensin peptides and inducible transcription factors
300. The mas oncogene encodes an angiotensin receptor
301. The mas oncogene enhances angiotensin-induced [Ca2+]i responses in cells with pre-existing angiotensin II receptors
302. Expression of the mouse and rat mas proto-oncogene in the brain and peripheral tissues
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314. The renin angiotensin system and the stress response
315. Brain angiotensin receptor subtypes in the control of physiological and behavioral responses
316. Neural signalling. Neuromodulatory astro-cytes
317. Autoradiographic localization of binding sites for vasoactive intestinal peptide and angiotensin II on neurons and astrocytes of cultured rat central nervous system
318. Electrophysiologi-cal evidence for receptors for vasoactive intestinal peptide and angiotensin II on astrocytes of cultured rat central nervous system
319. Peptide receptors in astroglia: Focus on angiotensin II and atrial natri-uretic peptide
320. Angiotensin II induces secretion of plasminogen activator inhibitor 1 and a tissue metalloprotease inhibitor-related protein from rat brain astrocytes
321. Angiotensin II receptor subtypes are coupled with distinct signal-trans-duction mechanisms in neurons and astrocytes from rat brain
322. Physiological and pharmacological comparisons of angiotensin II receptors in neuronal and astrocyte glial cultures
323. Angiotensin II modulates the activity of Na+,K+-ATPase in cultured rat astrocytes via the AT1 receptor and protein kinase C-delta activation
324. Angiotensin II-induced calcium signalling in neurons and astro-cytes of rat circumventricular organs
325. Angiotensin II regulation of intracellular calcium in astroglia cultured from rat hypothalamus and brainstem
326. Angiotensin II-induced decrease in expression of inducible nitric oxide synthase in rat astroglial cultures: Role of protein kinase C
327. Cytokine- and endotoxin-induced nitric oxide synthase in rat astroglial cultures: Differential modulation by angiotensin II
328. Angiotensin II decreases inducible nitric oxide synthase expression in rat astroglial cultures
329. Hypothalamic angiotensin receptor subtypes in normotensive and hypertensive rats
330. Both brain angiotensin II and "ouabain" contribute to sympathoexcitation and hypertension in Dahl S rats on high salt intake
331. Increased brain transcription factor expression by angiotensin in genetic hypertension
332. The effects of central administration of angiotensin II type-1 receptor antagonist, CV-11974, in nephrectomized spontaneously hypertensive rats
333. Measurement of immunoreactive angiotensin II levels in microdissected brain nuclei from developing spontaneously hypertensive and Wistar Kyoto rats
334. Quantitative autoradiography of angiotensin II receptors in the SHR brain
335. Angiotensinogen levels in the brain and cerebrospinal fluid of the genetically hypertensive rat
336. Increased expression of angiotensin peptides in the brain of transgenic hypertensive rats
337. Blood pressure reduction and diabetes insipidus in transgenic rats deficient in brain angiotensinogen
338. Alterations of central vasopressinergic system in transgenic rats with low brain angiotensinogen
339. The brain renin-angiotensin system modulates angiotensin II-induced hypertension and cardiac hypertrophy
340. Alterations in blood pressure and heart rate variability in transgenic rats with low brain angiotensinogen
341. Altered cardiovascular functionality of the renin-angiotensin system at the rostral ventrolateral medulla of transgenic rats with low brain angiotensinogen
342. Glial angiotensinogen regulates brain angiotensin II receptors in transgenic rats TGR (ASrAOGEN)
343. Angiotensin peptides acting at the rostral ventrolateral medulla contribute to the hypertension of TGR (mREN2)27 transgenic rats
344. Basic principles of using anti-sense oligonucleotides in vivo
345. Antisense inhibition of hypertension in the spontaneously hypertensive rat
346. Antisense oligonucleotide to AT1 receptor mRNA inhibits central angiotensin induced thirst and vasopressin
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348. Delivery of antisense DNA by vectors for prolonged effects in vitro and in vivo
349. Is gene therapy for hypertension possible?
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373. Effect of vitamin D2 calciferol in dog
374. Effect of changes in sodium or potassium balance, and nephrectomy, on adrenal renin and aldosterone concentrations
375. Analysis by immunocytochemistry and in situ hybridization of renin and its mRNA in kidney, testis, adrenal, and pituitary of the rat
376. Losartan and angiotensin II inhibit aldosterone production in anephric rats via different actions on the intraadrenal renin-angiotensin system
377. Expression of murine renin genes during fetal development
378. Coexpression of renin, angiotensinogen, and their messenger ribonucleic acids in adrenal tissues
379. Regulation of adrenal renin messenger ribonucleic acid by dietary sodium chloride
380. Role of the adrenal renin-angiotensin system on adrenocorticotropic hormone-and potassium-stimulated aldosterone production by rat adrenal glomerulosa cells in monolayer culture
381. Increased adrenal renin in transgenic hypertensive rats, TGR (mREN2)27, and its regulation by cAMP, angiotensin II, and calcium
382. The role of the adrenal gland in the hypertensive transgenic rats TGR (mREN2)27
383. Mechanisms by which nephrectomy stimulates adrenal renin
384. Changes of AT2 receptor levels in the rat adrenal cortex and medulla induced by bilateral nephrectomy and its modulation by circulating ANGII
385. Reciprocal influence of salt intake on adrenal glomerulosa and renal vascular responses to angiotensin II in normal man
386. The effect of sodium intake on angiotensin content of the rat adrenal gland
387. Functional derangements in the regulation of aldosterone secretion in hypertension
388. Converting-enzyme inhibition corrects the altered adrenal response to angiotensin II in essential hypertension
389. Production of renin, angiotensin II, and aldosterone by adrenal explant cultures: Response to potassium and converting enzyme inhibition
390. Exogenous and locally synthesized angiotensin II and glomerulosa cell functions
391. In vitro evidence for local generation of renin and angiotensin II/III immunoreactivity by the human adrenal gland
392. Locally generated angiotensin II in the adrenal gland regulates basal, cortico-tropin-, and potassium-stimulated aldosterone secretion
393. The effect of losartan on potassium-stimulated aldosterone secretion in vitro
394. Local renin-angiotensin system is involved in K+-induced aldosterone secretion from human adrenocortical NCI-H295 cells
395. Immunological evidence that kidney is primary source of circulating inactive prorenin in rats
396. Adrenal renin expression and its role in ren-2 transgenic rats TGR (mREN2)27
397. Chronic dexametha-sone treatment suppresses hypertension development in the transgenic rat TGR (mREN2)27
398. Adrenal renin: A possible regulator of aldosterone production
399. Zonal distribution and regulation of adrenal renin in a transgenic model of hypertension in the rat
400. Enhanced adrenal renin and aldosterone biosynthesis during sodium restriction in TGR (mREN2)27
401. Abnormally increased adrenal sensitivity to angiotensin II in hypertensive transgenic rats (mRen2-27) with high salt diets and a paradoxical effect of low salt
402. Morphology, physiology, and molecular biology of renin secretion
403. Structure and function of the mannose 6-phosphate/insulinlike growth factor II receptors
404. The cytoplasmic tail of the mannose 6-phosphate/insulin-like growth factor-II receptor has two signals for lysosomal enzyme sorting in the Golgi
405. Renin-1 is essential for normal renal juxtaglomerular cell granulation and macula densa morphology
406. Adrenaline cells of the rat adrenal cortex and medulla contain renin and prorenin
407. Different secretory pathways of renin from mouse cells transfected with the human renin gene
408. Cell-dependent posttranslational processing and secretion of recombinant mouse renin-2
409. The effects of calcium and calcium-ionophores (X 537 A and A 23187) on renin release in the isolated perfused rat kidney
410. Hypothetical interpretation of the calcium paradox in renin secretion
411. Effect of angiotensin II on renin production by rat adrenal glomerulosa cells in culture
412. Presence of renin secretory granules in rat adrenal gland and stimulation of renin secretion by angiotensin II but not by adrenocorticotropin
413. Kidney function and renin processing in transgenic rats, TGR (mREN2)27
414. Intracellular production of adrenal renin in the fetal mouse. An immuno-electron microscopical study
415. Morphological and biochemical analysis of angiotensin II internalization in cultured rat aortic smooth muscle cells
416. Correlation of receptor sequestration with sustained diacylglycerol accumulation in angiotensin II-stimulated cultured vascular smooth muscle cells
417. Purification and properties of a soluble angiotensin II-binding protein from rabbit liver
418. Effect of angiotensin II on RNA synthesis by isolated nuclei
419. Angiotensin II receptors in chromatin fragments generated by micrococcal nuclease
420. Effects of intracellular angiotensin II in vascular smooth muscle cells
421. Angiotensin II: Rapid localization in nuclei of smooth and cardiac muscle
422. Angiotensin II signal transduction in vascular smooth muscle: Role of tyrosine kinases