Magnesium superoxide dismutase (MnSOD) plasmid/liposome pulmonary radioprotective gene therapy: Modulation of irradiation-induced mRNA for IL-I, TNF-α, and TGF-β correlates with delay of organizing alveolitis/fibrosis

Biology of Blood and Marrow Transplantation

Volumn 5, Issue 4, 1999, Pages 204-214

  Epperly, Michael W ^a   Travis, Elizabeth L ^b   Sikora, Christine ^a   Greenberger, Joel S ^a,c  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^c UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

Author keywords

Gene therapy; Lung radiation injury; Total body irradiation

Indexed keywords

CYTOKINE; INTERLEUKIN 1; LIPOSOME; MESSENGER RNA; RADIOPROTECTIVE AGENT; SUPEROXIDE DISMUTASE; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL; ARTICLE; C57BL MOUSE; CHEMICALLY INDUCED DISORDER; DRUG EFFECT; FEMALE; GENE THERAPY; GENETICS; INJURY; LUNG; LUNG ALVEOLUS; LUNG DISEASE; LUNG EMPHYSEMA; LUNG FIBROSIS; METABOLISM; MOUSE; PATHOLOGY; PLASMID; RADIATION EXPOSURE; TIME;

ANIMALS; CYTOKINES; FEMALE; GENE THERAPY; INTERLEUKIN-1; LIPOSOMES; LUNG; LUNG DISEASES; MICE; MICE, INBRED C57BL; PLASMIDS; PULMONARY ALVEOLI; PULMONARY EMPHYSEMA; PULMONARY FIBROSIS; RADIATION-PROTECTIVE AGENTS; RNA, MESSENGER; SUPEROXIDE DISMUTASE; TIME FACTORS; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0032605109     PISSN: 10838791     EISSN: None     Source Type: Journal    
DOI: 10.1053/bbmt.1999.v5.pm10465100     Document Type: Article

References (56)

1. Deeg HJ, Storb R, Longton G, Graham TC, Shulman HM, Appelbaum F, Thomas ED: Single dose or fractionated TBI and autologous marrow transplantation in dogs: effects of exposure rate, fraction size, and fractionation interval on acute and delayed toxicity. Int J Radiat Oncol Biol Phys 15:647, 1988.
2. Deeg HJ, Storb R, Weiden PL, Schumacher D, Shulman H, Graham T, Thomas ED: High-dose total-body irradiation and autologous marrow reconstitution in dogs: dose-rate-related acute toxicity and fractionation-dependent long-term survival. Radiat Res 88:385, 1981.
3. Storb R, Raff R, Deeg HJ, Graham T, Appelbaum FR, Schuening FG, Shulman H, Seidel K, Leisenring W: Dose rate-dependent sparing of the gastrointestinal tract by fractionated TBI in dogs given marrow autografts. Int J Radiat Oncol Biol Phys 40(4):961, 1988.
4. Mah K, Van Dyk J, Keane T, Poon P: Acute radiation-induced pulmonary damage: a clinical study on the response to fractionated radiation therapy. Int J. Radiat Oncol Biol Phys 13: 179, 1987.
5. Latini P, Aristei C, Aversa F, Checcaglini F, Maranzano E, Panizza M, Perrucci E, Carotti A, Martelli MF: Interstitial pneumonitis after hyperfractionated TBI in HLA-matched T-depleted bone marrow transplantation. Int J Radiat Oncol Biol Phys 23:401, 1992.
6. Bradley J, Reft C, Goldman S, Rubin C, Nachman J, Larson R, Hallahan D: High-energy TBI as preparation for bone marrow transplantation in leukemia patients: treatment technique and related complications. Int J Radiat Oncol Biol Phys 40(2):391, 1998.
7. Lockhart SP, Down JD, Steel GG: The effect of low-dose-rate and cyclophosphamide on the radiation tolerance of the mouse lung. Int J Radiat Oncol Biol Phys 12:1437, 1986.
8. Anderson JE, Appelbaum FR, Barnett T, Chauncey TR, Flowers M, Storb R: Relapse after allogeneic bone marrow transplantation (BMT) for myelodysplasia (MDS) subtype refractory anemia (RA) is increased by shielding lungs and liver during irradiation. Blood 92(10):Suppl #1.1:659A, 1998.
9. Murray JE, Merrill JP, Dammin GJ, Dealy JB, Walter CW, Brooke MS, Wilson, RE: Study on transplantation immunity after TBI: clinical and experimental investigation. J NIH Res 5: 65, 1993.
10. Shank B: Total body irradiation for marrow or stem-cell transplantation. Can Invest 16(6):397, 1998.
11. Vriesendorp HN, Herman MG, Saral R: Future analyses of TBI. Int J Radiat Oncol Biol Phys 20: 635, 1991.
12. Tarbell NJ, Amato DA, Down JD, Mauch P, Hellman S: Fractionation and dose rate effects in mice: A model for bone marrow transplantation in man. Int J Radiat Oncol Biol Phys 13:1065, 1987.
13. Waer W, Ang KK, Vandeputte M, van der Schueren E: Influence of overall treatment time in a fractionated total lymphoid irradiation as an immunosuppressive therapy in allogeneic bone marrow transplantation in mice. Int J Radiat Oncol Biol Phys 8:1915, 1982.
14. Thomas ED: Total body irradiation regimens for marrow grafting. Int J Radiat Oncol Biol Phys 19:1285, 1990.
15. Peters LJ, Withers HR, Cundiff JH, Dicke KA: Radiobiological considerations in the use of TBI for bone marrow transplantation. Radiology 131(1):243, 1979.
16. Goolden AWG, Goldman JM, Kam KC, Dunn PA, Baughan ASJ, McCarthy DM, Worsley AM, Gordon-Smith EC, Samson D, Catovsky D, Galton DAG: Fractionation of whole body irradiation before bone marrow transplantation for patients with leukaemia. Brit J Radiol 56:245, 1983.
17. Thomas ED, Clift RA, Hersman J, Sanders JE, Stewart P, Buckner CD, Fefer A, McGuffin R, Smith JW, Storb R: Marrow transplantation for acute nonlymphoblastic leukemia in first remission using fractionated or single-dose irradiation. Int J Radiat Oncol Biol Phys 8:817, 1982.
18. Socie G, Devergie A, Girinsky T, Reiffers J, Vernant JP, Le Bourgeois JP, Herve P, Guyotat D, Maraninchi D, Rio B, Michallet M, Jouet JP, Milpied N, Leblond V, Pico J, Attal M, Belanger C, Gluckman E, Cosset JM: Influence of the fractionation of TBI on complications and relapse rate for chronic myelogenous leukemia. Int J Radiat Oncol Biol Phys 20:397, 1991.
19. Shank B, Hopfan S, Kim JH, Chu FCH, Grossbard E, Kapoor N, Kirkpatrick D, Dinsmore R, Simpson L, Reid A, Chui C, Mohan R, Finegan D, O'Reilly R: Hyperfractionated TBI for bone marrow transplantation: I. early results in leukemia patients. Int J Radiat Oncol Biol Phys 7:1109, 1981.
20. Altschuer C, Resbeut M, Blaise D, Maraninchi D, Stoppa AM, Lagrange JL, Guillet JP, Carcassonne Y: Fractionated TBI and bone marrow transplantation in acute lymphoblastic leukemia. Int J Radiat Oncol Biol Phys 19:1151, 1990.
21. Copelan EA, Deeg HJ: Conditioning for allogeneic marrow transplantation in patients with lymphohematopoietic malignancies without the use of TBI. Blood 80(7):1648, 1992.
22. Ozkaynak MF, Matthay K, Cairo M, Harris RE, Feig S, Reynolds CP, Buckley J, Villablanca JG, Seeger RC: Double-alkylator non-TBI regimen with autologous hematopoietic stem-cell transplantation in pediatric solid tumors. J Clin Oncol 16(3):937, 1998.
23. Shank B: Can TBI be supplanted by busulfan in cytoreductive regimens for bone marrow transplantation. Int J Radiat Oncol Biol Phys 31(1):195, 1994.
24. Dusenbery KE, Daniels KA, McCLure JS, McGlave PB, Ramsay NK, Blazar BR, Neglia JP, Kersey JH, Woods WG: Randomized comparison of cyclophosphamide-TBI versus busulfan-cyclophosphamide conditioning in autologous bone marrow transplantation for acute myeloid leukemia. Int J Radiat Oncol Biol Phys 31(1):119, 1994.
25. Blume KG, Kopecky KJ, Henslee-Downey JP, Forman SJ, Stiff PJ, LeMaistre CF, Appelbaum FR: A prospective randomized comparison of TBI-etoposide versus busulfan-cyclophosphamide as preparatory regimens for bone marrow transplantation in patients with leukemia who were not in first remission: a Southwest Oncology Group study. Blood 81(8):2187, 1993.
26. Lawton C, Barber-Derus S, Murray KJ, Casper JT, Ash RC, Gillin MT, Wilson JF: Technical modifications in hyperfractionated TBI for T-lymphocyte deplete bone marrow transplant. Int J Radiat Oncol Biol Phys 17(2):319, 1989.
27. Long GD, Amylon MD, Stockerl-Goldstein KE, Negrin RS, Chao NJ, Hu WW, Nademanee AP, Snyder DS, Hoppe RT, Vora N, Wong R, Niland J, Reichardt VL, Forman SJ, Blume KG: Fractionated TBI, etoposide, and cyclophosphamide followed by allogeneic bone marrow transplantation for patients with high-risk or advanced-stage hematological malignancies. Biol Blood Marrow Transplantation 3:324, 1997.
28. Kallinger W, Alth G, Müller, Hinterberger W, Kolbabek H, Danzer M, Schmidmeier W, Klumaier J, Koren H: Attempt for a complete protocol of TBI. Exp Hematol 13:Suppl #17:35, 1985.
29. Johnston CJ, Piedbouef B, Baggs R, Rubin P, Finkelstein JN: Differences in correlation of mRNA gene expression in mice sensitive and resistant to radiation-induced pulmonary fibrosis. Radiat Res 142:197, 1995.
30. Rubin P, Casarett GW: Clinical Radiation Pathology. WB Saunders, Philadelphia, 1968.
31. Dileto C, Travis EL: Fibroblast radiosensitivity in vitro and lung fibrosis in vivo: comparison between a fibrosis-prone and fibrosis-resistant mouse strain. Radiat Res 146:61, 1996.
32. Kawana A, Shioya S, Katoh K, Tsuji C, Tsuda M, Ohta Y: Expression of intercellular adhesion molecule-1 and lymphocyte function-associated antigen-1 on alveolar macrophages in the acute stage of radiation-induced lung injury in rats. Radiat Res 147:431, 1997.
33. Franko AJ, Sharplin J, Ghahary Z, Barcellos-Hoff MH: Immunohistochemical localization of TGF-β and TNF-α in the lungs of fibrosis-prone and "nonfibrosing" mice during the latent period and early phase after irradiation. Radiat Res 148:245, 1997.
34. Franko AJ, Sharplin J: Development of fibrosis after lung irradiation in relation to inflammation and lung function in a mouse strain prone to fibrosis. Radiat Res 140:347, 1994.
35. Finkelstein JN, Johnston CJ, Baggs R, Rubin P: Early alterations in extracellular matrix and TGF-β gene expression in mouse lung indicative of late radiation fibrosis. Int J Radiat Oncol Biol Phys 28:621, 1994.
36. Parkins C, Fowler JF, Denekamp J: Low radioprotection by thiol in lung: The role of local tissue oxygenation. Eur J Can Clin Oncol 19:1169, 1983.
37. White CR, Brock TA, Chang L, Crapo J, Briscoe P, Ku D, Bradley WA, Gianturco SH, Gore J, Freeman BA, Tarpey MM: Superoxide and peroxynitrite in atherosclerosis. Proc Natl Acad Sci USA 91:1044, 1994.
38. Epperly MW, Bray JA, Kraeger S, Zwacka R, Engelhardt J, Travis E, Greenberger JS: Prevention of late effects of irradiation lung damage by MnSOD gene therapy. Gene Therapy 5:196, 1998.
39. Zwacka RM, Dudus L, Epperly MW, Greenberger JS, Engelhardt JF: Redox gene therapy protects against ionizing radiation-induced apoptosis. Human Gene Therapy 9:1381, 1998.
40. Epperly MW, Bray JA, Kraeger S, Beny LA, Gooding W, Engelhardt JF, Zwacka R, Travis EL, Greenberger JS: Intratracheal injection of adenovirus containing the human MnSOD transgene protects athymic nude mice from irradiation-induced organizing alveolitis. Int J Radiat Oncol Biol Phys 43(1):171, 1999.
41. Ward HE, Kemsley L, Davies L, Holecek M, Berend N: The pulmonary response to sublethal thoracic irradiation in the rat. Radiat Res 136:15, 1993.
42. Haimovitz-Friedman A, Balaban N, McLoughlin M, Ehleiter D, Michaeli J, Vlodavsky I, Fuks Z: Protein kinase C mediates basic fibroblast growth factor protection of endothelial cells against radiation-induced apoptosis. Cancer Res 54:2591, 1994.
43. Wispe JR, Warner BB, Clark JC, Dey CR, Neuman J, Glasser SW, Crapo JD, Chang LY, Whitsett JA: Human MnSOD in pulmonary epithelial cells of transgenic mice confers protection from oxygen injury. J Biol Chem 267:23937, 1992.
44. Engelhardt JF, Simon RH, Yang Y, Zepeda M, Weber-Pendleton S, Doranz B, Grossman M, Wilson JM: Adenovirus-mediated transfer of the CFTR gene to lung of non-human primates: biological efficacy study. Human Gene Therapy 4:759, 1993.
45. Watkins S: Cryosectioning. In: Ausubel FM, Brent R, Kingston RA, Moore DD, Seidman JG, Smith JA. Struhl K (eds). Current Protocols in Molecular Biology. Greene Publishing & Wiley-Interscience, NY, pp. 14.2.1., 1989.
46. Kaplan E, Meier P: Nonparametric estimation from incomplete observations. J Am Statistical Assoc 457, 1958.
47. Peto R, Pike M, Armitage P, Breslow NE, Cox DR, Howard SV, Mantel N, McPherson K, Peto J, Smith PG: Design and analysis of randomized clinical trials requiring prolonged observations of each patient: II. Analysis and examples. Brit J Cancer 35(1):1, 1977.
48. Cox DR: Regression models and life tables (with discussion). J Royal Statistical Soc, Series B, 74:187-220, 1972.
49. Holland M, Wolfe D: Nonparametric statistical methods. New York: John Wiley and Sons, 1973.
50. Mack G, Skillings H: A Friedman type rank test for main effects in a two-factor ANOVA. J Am Stat Assoc 17:947, 1980.
51. Anscher MS, Kong FM, Marks LB, Bentel GC, Jirtle RL: Changes in plasma TGF-β during radiotherapy and the risk of symptomatic radiation-induced pneumonitis. Int J Radiat Oncol Biol Phys 37:253, 1997.
52. Hallahan DE, Virudachalam S: Intercellular adhesion molecule 1 knockout abrogates radiation-induced pulmonary inflammation. Proc Natl Acad Sci USA 94:6432, 1997.
53. Coppes RP, Zeilstra LJW, Vissink A, Konings AWT: Sialogogue-related radioprotection of salivary gland function: the degranulation concept revisited. Radiat Res 148:240, 1997.
54. Nagler RM, Laufer D: Protection against irradiation-induced damage to salivary glands by adrenergic agonist administration. Int J Radiat Oncol Biol Phys 40(2):477, 1998.
55. Jahroudi N, Ardekani AM, Greenberger JS: Ionizing irradiation increases transcription of the von Willebrand factor gene in endothelial cells. Blood 88:3801, 1996.
56. Coker RK, Laurent GJ, Shahzeidi S, Lympany PA, du Bois RM, Jeffery PK, McAnulty RJ: TGF-β1, β2 and β3 stimulate fibroblast procollagen production in vitro but are differentially expressed during bleomycin-induced lung fibrosis. Am J Path 150:981, 1997.