Small molecule receptor tyrosine kinase inhibitor of platelet-derived growth factor signaling (SU9518) modifies radiation response in fibroblasts and endothelial cells

BMC Cancer

Volumn 6, Issue , 2006, Pages

  Li, Minglun ^a,b,e   Ping, Gong ^a,b   Plathow, Christian ^b,e   Trinh, Thuy ^a,b   Lipson, Kenneth E ^d   Hauser, Kai ^a,b,f,g   Krempien, Robert ^c   Debus, Juergen ^c   Abdollahi, Amir ^a,b   Huber, Peter E ^a,b  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^d SUGEN INC   (United States)

^e UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

^f INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS ICREA   (Spain)

^g UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMATINIB; PLATELET DERIVED GROWTH FACTOR; PLATELET DERIVED GROWTH FACTOR RECEPTOR; PROTEIN TYROSINE KINASE INHIBITOR; SU 9518; SUNITINIB; UNCLASSIFIED DRUG; VASCULOTROPIN;

ARTICLE; CELL CULTURE; CELL PROLIFERATION; CELL SURVIVAL; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG POTENCY; ENDOTHELIUM CELL; FIBROBLAST; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; PARACRINE SIGNALING; PROTEIN PHOSPHORYLATION; RADIATION RESPONSE; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE; SURVIVAL RATE; WESTERN BLOTTING;

CELL PROLIFERATION; CELL SURVIVAL; CELLS, CULTURED; ENDOTHELIAL CELLS; FIBROBLASTS; HUMANS; IMMUNOHISTOCHEMISTRY; INDOLES; PHOSPHORYLATION; RECEPTORS, PLATELET-DERIVED GROWTH FACTOR; SIGNAL TRANSDUCTION;

EID: 33646575930     PISSN: 14712407     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-6-79     Document Type: Article

References (40)

1. Lasky JA, Coin PG, Lindroos PM, Ostrowski LE, Brody AR, Bonner JC: Chrysotile asbestos stimulates platelet-derived growth factor-AA production by rat lung fibroblasts in vitro: evidence for an autocrine loop. Am J Respir Cell Mol Biol 1995, 12:162-170.
2. Trott KR, Herrmann T, Kasper M: Target cells in radiation pneumopathy. International Journal of Radiation Oncology*Biology*Physics 2004, 58:463-469.
3. Plathow C, Li M, Gong P, Zieher H, Kiessling F, Peschke P, Kauczor HU, Abdollahi A, Huber PE: Computed tomography monitoring of radiation-induced lung fibrosis in mice. Invest Radiol 2004, 39:600-609.
4. Davis AM, Gerrand C, Griffin A, O'Sullivan B, Hill RP, Wunder JS, Abudu A, Bell RS: Evaluation of clinical utility of BTC-2000 for measuring soft tissue fibrosis. International Journal of Radiation Oncology*Biology*Physics 2004, 60:286-294.
5. Gridley DS, Bonnet RB, Bush DA, Franke C, Cheek GA, Slater JD, Slater JM: Time course of serum cytokines in patients receiving proton or combined photon/proton beam radiation for resectable but medically inoperable non-small-cell lung cancer. Int J Radiat Oncol Biol Phys 2004, 60:759-766.
6. Zerwes HG, Risau W: Polarized secretion of a platelet-derived growth factor-like chemotactic factor by endothelial cells in vitro. J Cell Biol 1987, 105:2037-2041.
7. Lindroos PM, Coin PG, Badgett A, Morgan DL, Bonner JC: Alveolar macrophages stimulated with titanium dioxide, chrysotile asbestos, and residual oil fly ash upregulate the PDGF receptor-alpha on lung fibroblasts through an IL-1beta-dependent mechanism. Am J Respir Cell Mol Biol 1997, 16:283-292.
8. Iida H, Seifert R, Alpers CE, Gronwald RG, Phillips PE, Pritzl P, Gordon K, Gown AM, Ross R, Bowen-Pope DF, Johson R: Platelet-derived growth factor (PDGF) and PDGF receptor are induced in mesangial proliferative nephritis in the rat. Proc Natl Acad Sci USA 1991, 88:6560-6564.
9. Wilcox JN, Smith KM, Williams LT, Schwartz SM, Gordon D: Platelet-derived growth factor mRNA detection in human atherosclerotic plaques by in situ hybridization. J Clin Invest 1988, 82:1134-1143.
10. Rice AB, Moomaw CR, Morgan DL, Bonner JC: Specific inhibitors of platelet-derived growth factor or epidermal growth factor receptor tyrosine kinase reduce pulmonary fibrosis in rats. Am J Pathol 1999, 155:213-221.
11. Zhuo Y, Zhang J, Laboy M, Lasky JA: Modulation of PDGF-C and PDGF-D expression during bleomycin-induced lung fibrosis. Am J Physiol Lung Cell Mol Physiol 2004, 286:L182-L188.
12. Heldin CH, Westermark B: Mechanism of action and in vivo role of platelet-derived growth factor. Physiol Rev 1999, 79:1283-1316.
13. Abdollahi A, Li M, Ping G, Plathow C, Domhan S, Kiessling F, Lee LB, McMahon G, Grone HJ, Lipson KE, Huber PE: Inhibition of platelet-derived growth factor signaling attenuates pulmonary fibrosis. J Exp Med 2005, 201:925-935.
14. Abdollahi A, Lipson KE, Han X, Krempien R, Trinh T, Weber KJ, Hahnfeldt P, Hlatky L, Debus J, Howlett AR, Huber PE: SU5416 and SU6668 attenuate the angiogenic effects of radiation-induced tumor cell growth factor production and amplify the direct anti-endothelial action of radiation in vitro. Cancer Res 2003, 63:3755-3763.
15. Luo J, Miller MW: Platelet-derived growth factor-mediated signal transduction underlying astrocyte proliferation: site of ethanol action. J Neurosci 1999, 19:10014-10025.
16. Pierce GF, Vande BJ, Rudolph R, Tarpley J, Mustoe TA: Platelet-derived growth factor-BB and transforming growth factor beta 1 selectively modulate glycosaminoglycans, collagen, and myofibroblasts in excisional wounds. Am J Pathol 1991, 138:629-646.
17. Shure D, Senior RM, Griffin GL, Deuel TF: PDGF AA homodimers are potent chemoattractants for fibroblasts and neutrophils, and for monocytes activated by lymphocytes or cytokines. Biochem Biophys Res Commun 1992, 186:1510-1514.
18. Siegbahn A, Hammacher A, Westermark B, Heldin CH: Differential effects of the various isoforms of platelet-derived growth factor on chemotaxis of fibroblasts, monocytes, and granulocytes. J Clin Invest 1990, 85:916-920.
19. Thornton SC, Walsh BJ, Bennett S, Robbins JM, Foulcher E, Morgan GW, Penny R, Breit SN: Both in vitro and in vivo irradiation are associated with induction of macrophage-derived fibroblast growth factors. Clin Exp Immunol 1996, 103:67-73.
20. Tada H, Ogushi F, Tani K, Nishioka Y, Miyata Jy, Sato K, Asano T, Sone S: Increased Binding and Chemotactic Capacities of PDGF-BB on Fibroblasts in Radiation Pneumonitis. Radiation Research 2003, 159:805-811.
21. Antoniades HN, Bravo MA, Avila RE, Galanopoulos T, Neville-Golden J, Maxwell M, Selman M: Platelet-derived growth factor in idiopathic pulmonary fibrosis. J Clin Invest 1990, 86:1055-1064.
22. Franke TF, Yang SI, Chan TO, Datta K, Kazlauskas A, Morrison DK, Kaplan DR, Tsichlis PN: The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase. Cell 1995, 81:727-736.
23. Canalis E: Effect of platelet-derived growth factor on DNA and protein synthesis in cultured rat calvaria. Metabolism 1981, 30:970-975.
24. Heldin P, Laurent TC, Heldin CH: Effect of growth factors on hyaluronan synthesis in cultured human fibroblasts. Biochem J 1989, 258:919-922.
25. Blatti SP, Foster DN, Ranganathan G, Moses HL, Getz MJ: Induction of fibronectin gene transcription and mRNA is a primary response to growth-factor stimulation of AKR-2B cells. Proc Natl Acad Sci USA 1988, 85:1119-1123.
26. Fambrough D, McClure K, Kazlauskas A, Lander ES: Diverse signaling pathways activated by growth factor receptors induce broadly overlapping, rather than independent, sets of genes. Cell 1999, 97:727-741.
27. Richeldi L, Davies HR, Ferrara G, Franco F: Corticosteroids for idiopathic pulmonary fibrosis. Cochrane Database Syst Rev 2003:CD002880.
28. Savikko J, Taskinen E, Von Willebrand E: Chronic allograft nephropathy is prevented by inhibition of platelet-derived growth factor receptor: tyrosine kinase inhibitors as a potential therapy. Transplantation 2003, 75:1147-1153.
29. Lang DS, Jorres RA, Mucke M, Siegfried W, Magnussen H: Interactions between human bronchoepithelial cells and lung fibroblasts after ozone exposure in vitro. Toxicol Lett 1998, 96-97:13-24.
30. Demayo F, Minoo P, Plopper CG, Schuger L, Shannon J, Torday JS: Mesenchymal-epithelial interactions in lung development and repair: are modeling and remodeling the same process? Am J Physiol Lung Cell Mol Physiol 2002, 283:L510-L517.
31. Ward WF, Molteni A, Solliday NH, Jones GE: The relationship between endothelial dysfunction and collagen accumulation in irradiated rat lung. Int J Radiat Oncol Biol Phys 1985, 11:1985-1990.
32. Yamasaki Y, Miyoshi K, Oda N, Watanabe M, Miyake H, Chan J, Wang X, Sun L, Tang C, McMahon G, Lipson KE: Weekly dosing with the platelet-derived growth factor receptor tyrosine kinase inhibitor SU9518 significantly inhibits arterial stenosis. Circ Res 2001, 88:630-636.
33. Allen JT, Spiteri MA: Growth factors in idiopathic pulmonary fibrosis: relative roles. Respir Res 2002, 3:13.
34. Battegay EJ, Raines EW, Seifert RA, Bowen-Pope DF, Ross R: TGF-beta induces bimodal proliferation of connective tissue cells via complex control of an autocrine PDGF loop. Cell 1990, 63:515-524.
35. Battegay EJ, Raines EW, Colbert T, Ross R: TNF-alpha stimulation of fibroblast proliferation. Dependence on platelet-derived growth factor (PDGF) secretion and alteration of PDGF receptor expression. J Immunol 1995, 154:6040-6047.
36. Raines EW, Dower SK, Ross R: Interleukin-1 mitogenic activity for fibroblasts and smooth muscle cells is due to PDGF-AA. Science 1989, 20(243):393-396.
37. Abdollahi A, Hahnfeldt P, Maercker C, Grone HJ, Debus J, Ansorge W, Folkman J, Hlatky L, Huber PE: Endostatin's antiangiogenic signaling network. Mol Cell 2004, 13:649-663.
38. Abdollahi A, Griggs DW, Zieher H, Roth A, Lipson KE, Saffrich R, Grone HJ, Hallahan DE, Reisfeld RA, Debus J, Niethammer AG, Huber PE: Inhibition of alpha(v)beta3 integrin survival signaling enhances antiangiogenic and antitumor effects of radiotherapy. Clin Cancer Res 2005, 11:6270-6279.
39. Huber PE, Hauser K, Abdollahi A: Genome wide expression profiling of angiogenic signaling and the Heisenberg uncertainty principle. Cell Cycle 2004, 3:1348-1351.
40. Huber PE, Bischof M, Jenne J, Heiland S, Peschke P, Saffrich R, Grone HJ, Debus J, Lipson KE, Abdollahi A: Trimodal cancer treatment: beneficial effects of combined antiangiogenesis, radiation, and chemotherapy. Cancer Res 2005, 65:3643-3655.