메뉴 건너뛰기




Volumn , Issue , 2006, Pages 391-413

Pharmacokinetic, pharmacodynamic, and pharmacogenetic considerations

Author keywords

[No Author keywords available]

Indexed keywords


EID: 61449087672     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1017/CBO9780511471001.015     Document Type: Chapter
Times cited : (1)

References (273)
  • 1
    • 0032572912 scopus 로고    scopus 로고
    • Acute lymphoblastic leukemia
    • Pui, C. H.&Evans, W. E. Acute lymphoblastic leukemia. NEngl J Med, 1998; 339: 605-15.
    • (1998) NEngl J Med , vol.339 , pp. 605-615
    • Pui, C.H.1    Evans, W.E.2
  • 2
    • 0026729372 scopus 로고
    • Disposition of antineoplastic agents in the very young child
    • McLeod, H. L., Relling, M. V., Crom, W. R., et al. Disposition of antineoplastic agents in the very young child. Br J Cancer, 1992; 66: S23-29.
    • (1992) Br J Cancer , vol.66 , pp. S23-S29
    • McLeod, H.L.1    Relling, M.V.2    Crom, W.R.3
  • 3
    • 0024360395 scopus 로고
    • Clinical pharmacodynamics of antineoplastic agents in humans
    • Evans, W. E. & Relling, M. V. Clinical pharmacodynamics of antineoplastic agents in humans. Clin Pharmacokinet, 1989; 16: 327-36.
    • (1989) Clin Pharmacokinet , vol.16 , pp. 327-336
    • Evans, W.E.1    Relling, M.V.2
  • 5
    • 0019951735 scopus 로고
    • Synthesis, retention, and biological activity of methotrexate polyglutamates in cultured human breast cancer cells
    • Jolivet, J., Schilsky, R. L., Bailey, B. D., et al. Synthesis, retention, and biological activity of methotrexate polyglutamates in cultured human breast cancer cells. J Clin Invest, 1982; 70: 351-60.
    • (1982) J Clin Invest , vol.70 , pp. 351-360
    • Jolivet, J.1    Schilsky, R.L.2    Bailey, B.D.3
  • 6
    • 0021167732 scopus 로고
    • Polyglutamylation, an importantelementinmethotrexate cytotoxicityandselectivity in tumor versus murine granulocytic progenitor cells in vitro
    • Fabre, I., Fabre, G., & Goldman, I. D. Polyglutamylation, an importantelementinmethotrexate cytotoxicityandselectivity in tumor versus murine granulocytic progenitor cells in vitro. Cancer Res, 1984; 44: 3190-5.
    • (1984) Cancer Res , vol.44 , pp. 3190-3195
    • Fabre, I.1    Fabre, G.2    Goldman, I.D.3
  • 7
    • 0022410582 scopus 로고
    • Polyglutamation of methotrexate. Is methotrexate a prodrug?
    • Chabner, B. A., Allegra, C. J., Curt, G. A., et al. Polyglutamation of methotrexate. Is methotrexate a prodrug? J Clin Invest, 1985; 76: 907-12.
    • (1985) J Clin Invest , vol.76 , pp. 907-912
    • Chabner, B.A.1    Allegra, C.J.2    Curt, G.A.3
  • 8
    • 0029846176 scopus 로고    scopus 로고
    • Intrinsic and acquired resistance to methotrexate in acute leukemia
    • Gorlick, R., Goker, E., Trippett, T., et al. Intrinsic and acquired resistance to methotrexate in acute leukemia. N Engl J Med, 1996; 335: 1041-8.
    • (1996) N Engl J Med , vol.335 , pp. 1041-1048
    • Gorlick, R.1    Goker, E.2    Trippett, T.3
  • 9
    • 0025302665 scopus 로고
    • Accumulation of methotrexate and methotrexate polyglutamates in lymphoblasts at diagnosis of childhood acute lymphoblastic leukemia: A pilot prognostic factor analysis
    • Whitehead, V. M., Rosenblatt, D. S., Vuchich, M. J., et al. Accumulation of methotrexate and methotrexate polyglutamates in lymphoblasts at diagnosis of childhood acute lymphoblastic leukemia: a pilot prognostic factor analysis. Blood, 1990; 76: 44-9.
    • (1990) Blood , vol.76 , pp. 44-49
    • Whitehead, V.M.1    Rosenblatt, D.S.2    Vuchich, M.J.3
  • 10
    • 0028063423 scopus 로고
    • Blast cell methotrexate-polyglutamate accumulation in vivo differs by lineage, ploidy, and methotrexate dose in acute lymphoblastic leukemia
    • Synold, T. W., Relling, M. V., Boyett, J. M., et al. Blast cell methotrexate-polyglutamate accumulation in vivo differs by lineage, ploidy, and methotrexate dose in acute lymphoblastic leukemia. J Clin Invest, 1994; 94: 1996-2001.
    • (1994) J Clin Invest , vol.94 , pp. 1996-2001
    • Synold, T.W.1    Relling, M.V.2    Boyett, J.M.3
  • 11
    • 0023280787 scopus 로고
    • Evidencefor direct inhibition ofdenovopurine synthesis inhumanMCF-7breast cells as a principal mode of metabolic inhibition by methotrexate
    • Allegra, C. J., Hoang, K., Yeh, G. C., et al.Evidencefor direct inhibition ofdenovopurine synthesis inhumanMCF-7breast cells as a principal mode of metabolic inhibition by methotrexate. J Biol Chem, 1987; 262: 13 520-6.
    • (1987) J Biol Chem , vol.262 , Issue.13 , pp. 520-526
    • Allegra, C.J.1    Hoang, K.2    Yeh, G.C.3
  • 12
    • 0020081481 scopus 로고
    • Rapid formation of poly-gamma-glutamyl derivatives of methotrexate and their association with dihydrofolate reductase as assessed by high pressure liquid chromatography in the Ehrlich ascites tumor cell in vitro
    • Fry, D.W., Yalowich, J. C., & Goldman, I. D. Rapid formation of poly-gamma-glutamyl derivatives of methotrexate and their association with dihydrofolate reductase as assessed by high pressure liquid chromatography in the Ehrlich ascites tumor cell in vitro. J Biol Chem, 1982; 257: 1890-6.
    • (1982) J Biol Chem , vol.257 , pp. 1890-1896
    • Fry, D.W.1    Yalowich, J.C.2    Goldman, I.D.3
  • 13
    • 0028887425 scopus 로고
    • Isolation of a human cDNA that complements a mutant hamster cell defective in methotrexate uptake
    • Williams, F. M. & Flintoff, W. F. Isolation of a human cDNA that complements a mutant hamster cell defective in methotrexate uptake. J Biol Chem, 1995; 270: 2987-92.
    • (1995) J Biol Chem , vol.270 , pp. 2987-2992
    • Williams, F.M.1    Flintoff, W.F.2
  • 14
    • 0029147794 scopus 로고
    • Isolation of a gene encoding a human reduced folate carrier (RFC1) and analysis of its expression in transport-deficient, methotrexate-resistant human breast cancer cells
    • Moscow, J. A., Gong, M., He, R., et al. Isolation of a gene encoding a human reduced folate carrier (RFC1) and analysis of its expression in transport-deficient, methotrexate-resistant human breast cancer cells. Cancer Res, 1995; 55: 3790-4.
    • (1995) Cancer Res , vol.55 , pp. 3790-3794
    • Moscow, J.A.1    Gong, M.2    He, R.3
  • 15
    • 0029084385 scopus 로고
    • Isolation ofhuman cDNAsthat restoremethotrexate sensitivityandreducedfolate carrier activity in methotrexate transport-defective Chinese hamster ovary cells
    • Wong, S. C., Proefke, S. A., Bhushan, A., et al. Isolation ofhuman cDNAsthat restoremethotrexate sensitivityandreducedfolate carrier activity in methotrexate transport-defective Chinese hamster ovary cells. J Biol Chem, 1995; 270: 17 468-75.
    • (1995) J Biol Chem , vol.270 , Issue.17 , pp. 468-475
    • Wong, S.C.1    Proefke, S.A.2    Bhushan, A.3
  • 16
    • 0023935785 scopus 로고
    • Impaired polyglutamylation of methotrexate as a cause of resistance in CCRFCEMcells aftershort-term, high-dosetreatmentwiththisdrug
    • Pizzorno, G., Mini, E., Coronnello, M., et al. Impaired polyglutamylation of methotrexate as a cause of resistance in CCRFCEMcells aftershort-term, high-dosetreatmentwiththisdrug. Cancer Res, 1988; 48: 2149-55.
    • (1988) Cancer Res , vol.48 , pp. 2149-2155
    • Pizzorno, G.1    Mini, E.2    Coronnello, M.3
  • 17
    • 0025817134 scopus 로고
    • Decreased folylpolyglutamate synthetase activity as a mechanism of methotrexate resistance in CCRF-CEM human leukemia sublines
    • McCloskey, D. E., McGuire, J. J., Russell, C. A., et al. Decreased folylpolyglutamate synthetase activity as a mechanism of methotrexate resistance in CCRF-CEM human leukemia sublines. J Biol Chem, 1991; 266: 6181-7.
    • (1991) J Biol Chem , vol.266 , pp. 6181-6187
    • McCloskey, D.E.1    McGuire, J.J.2    Russell, C.A.3
  • 18
    • 0027378870 scopus 로고
    • Increased activity of gamma-glutamyl hydrolase in human sarcoma cell lines: A novel mechanism of intrinsic resistance to methotrexate (MTX)
    • Li, W. W., Waltham, M., Tong, W., et al. Increased activity of gamma-glutamyl hydrolase in human sarcoma cell lines: a novel mechanism of intrinsic resistance to methotrexate (MTX). Adv Exp Med Biol, 1993; 338: 635-8.
    • (1993) Adv Exp Med Biol , vol.338 , pp. 635-638
    • Li, W.W.1    Waltham, M.2    Tong, W.3
  • 19
    • 0027222801 scopus 로고
    • Acquisition of resistance to antifolates caused by enhanced gamma-glutamyl hydrolase activity
    • Rhee, M.S., Wang, Y., Nair, M.G., et al.Acquisition of resistance to antifolates caused by enhanced gamma-glutamyl hydrolase activity. Cancer Res, 1993; 53: 2227-30.
    • (1993) Cancer Res , vol.53 , pp. 2227-2230
    • Rhee, M.S.1    Wang, Y.2    Nair, M.G.3
  • 20
    • 0028291535 scopus 로고
    • Differences in constitutive and post-methotrexate folylpolyglutamate synthetase activity in B-lineage and T-lineage leukemia
    • Barredo, J. C., Synold, T.W., Laver, J., et al.Differences in constitutive and post-methotrexate folylpolyglutamate synthetase activity in B-lineage and T-lineage leukemia. Blood, 1994; 84: 564-9.
    • (1994) Blood , vol.84 , pp. 564-569
    • Barredo, J.C.1    Synold, T.W.2    Laver, J.3
  • 21
    • 0030756226 scopus 로고    scopus 로고
    • Differences in folylpolyglutamate synthetase and dihydrofolate reductase expression in human B-lineage versus T-lineage leukemic lymphoblasts: Mechanisms for lineage differences in methotrexate polyglutamylationandcytotoxicity
    • Galpin, A. J., Schuetz, J. D., Masson, E., et al. Differences in folylpolyglutamate synthetase and dihydrofolate reductase expression in human B-lineage versus T-lineage leukemic lymphoblasts: mechanisms for lineage differences in methotrexate polyglutamylationandcytotoxicity. Mol Pharmacol, 1997; 52: 155-63.
    • (1997) Mol Pharmacol , vol.52 , pp. 155-163
    • Galpin, A.J.1    Schuetz, J.D.2    Masson, E.3
  • 22
    • 0028037401 scopus 로고
    • Quantitative analysis of folylpolyglutamate synthetase gene expression in tumor tissues by the polymerase chain reaction: Marked variation of expression among leukemia patients
    • Lenz, H. J., Danenberg, K., Schnieders, B., et al. Quantitative analysis of folylpolyglutamate synthetase gene expression in tumor tissues by the polymerase chain reaction: marked variation of expression among leukemia patients. Oncol Res, 1994; 6: 329-35.
    • (1994) Oncol Res , vol.6 , pp. 329-335
    • Lenz, H.J.1    Danenberg, K.2    Schnieders, B.3
  • 23
    • 0033104709 scopus 로고    scopus 로고
    • Role of folylpolyglutamate synthetase and folylpolyglutamate hydrolase in methotrexate accumulation and polyglutamylation in childhood leukemia
    • Rots, M. G., Pieters, R., Peters, G. J., et al. Role of folylpolyglutamate synthetase and folylpolyglutamate hydrolase in methotrexate accumulation and polyglutamylation in childhood leukemia. Blood, 1999; 93: 1677-83.
    • (1999) Blood , vol.93 , pp. 1677-1683
    • Rots, M.G.1    Pieters, R.2    Peters, G.J.3
  • 24
    • 0036452431 scopus 로고    scopus 로고
    • A mathematical model of in vivo methotrexate accumulation in acute lymphoblastic leukemia
    • Panetta, J. C., Yanishevski, Y., Pui, C. H., et al. A mathematical model of in vivo methotrexate accumulation in acute lymphoblastic leukemia. Cancer Chemother Pharmacol, 2002; 50: 419-28.
    • (2002) Cancer Chemother Pharmacol , vol.50 , pp. 419-428
    • Panetta, J.C.1    Yanishevski, Y.2    Pui, C.H.3
  • 25
    • 0030997685 scopus 로고    scopus 로고
    • Gamma-glutamyl hydrolase from human sarcoma HT-1080 cells: Characterization and inhibition by glutamine antagonists
    • Waltham, M.C., Li, W.W., Gritsman, H., et al.Gamma-glutamyl hydrolase from human sarcoma HT-1080 cells: characterization and inhibition by glutamine antagonists. Mol Pharmacol, 1997; 51: 825-32.
    • (1997) Mol Pharmacol , vol.51 , pp. 825-832
    • Waltham, M.C.1    Li, W.W.2    Gritsman, H.3
  • 26
    • 0035360869 scopus 로고    scopus 로고
    • Effects of overexpression of gamma-glutamyl hydrolase on methotrexate metabolism and resistance
    • Cole, P. D., Kamen, B. A., Gorlick, R., et al. Effects of overexpression of gamma-glutamyl hydrolase on methotrexate metabolism and resistance. Cancer Res, 2001; 61: 4599-604.
    • (2001) Cancer Res , vol.61 , pp. 4599-4604
    • Cole, P.D.1    Kamen, B.A.2    Gorlick, R.3
  • 27
    • 0035992440 scopus 로고    scopus 로고
    • Methotrexate intracellular disposition in acute lymphoblastic leukemia: A mathematical model of gamma-glutamyl hydrolase activity
    • Panetta, J. C., Wall, A., Pui, C. H., et al.Methotrexate intracellular disposition in acute lymphoblastic leukemia: a mathematical model of gamma-glutamyl hydrolase activity. Clin Cancer Res, 2002; 8: 2423-9.
    • (2002) Clin Cancer Res , vol.8 , pp. 2423-2429
    • Panetta, J.C.1    Wall, A.2    Pui, C.H.3
  • 28
    • 0026658557 scopus 로고
    • Accumulation of high levels of methotrexate polyglutamates in lymphoblasts from children with hyperdiploid (greater than 50 chromosomes) B-lineage acute lymphoblastic leukemia: A Pediatric Oncology Group study
    • Whitehead, V. M., Vuchich, M. J., Lauer, S. J., et al. Accumulation of high levels of methotrexate polyglutamates in lymphoblasts from children with hyperdiploid (greater than 50 chromosomes) B-lineage acute lymphoblastic leukemia: a Pediatric Oncology Group study. Blood, 1992; 80: 1316-23.
    • (1992) Blood , vol.80 , pp. 1316-1323
    • Whitehead, V.M.1    Vuchich, M.J.2    Lauer, S.J.3
  • 29
    • 0027317529 scopus 로고
    • Decreased polyglutamylation of methotrexate in acute lymphoblastic leukemia blasts in adults compared to children with this disease
    • Goker, E., Lin, J. T., Trippett, T., et al. Decreased polyglutamylation of methotrexate in acute lymphoblastic leukemia blasts in adults compared to children with this disease. Leukemia, 1993; 7: 1000-4.
    • (1993) Leukemia , vol.7 , pp. 1000-1004
    • Goker, E.1    Lin, J.T.2    Trippett, T.3
  • 30
    • 0030034467 scopus 로고    scopus 로고
    • Accumulation of methotrexate polyglutamates in lymphoblasts is a determinant of antileukemic effects in vivo. A rationale for high-dose methotrexate
    • Masson, E., Relling, M. V., Synold, T. W., et al. Accumulation of methotrexate polyglutamates in lymphoblasts is a determinant of antileukemic effects in vivo. A rationale for high-dose methotrexate. J Clin Invest, 1996; 97: 73-80.
    • (1996) J Clin Invest , vol.97 , pp. 73-80
    • Masson, E.1    Relling, M.V.2    Synold, T.W.3
  • 31
    • 0037103310 scopus 로고    scopus 로고
    • Denovo purine synthesis inhibition and antileukemic effects of mercaptopurine alone or in combination with methotrexate in vivo
    • Dervieux, T., Brenner, T. L., Hon, Y. Y., et al.Denovo purine synthesis inhibition and antileukemic effects of mercaptopurine alone or in combination with methotrexate in vivo. Blood, 2002; 100: 1240-7.
    • (2002) Blood , vol.100 , pp. 1240-1247
    • Dervieux, T.1    Brenner, T.L.2    Hon, Y.Y.3
  • 32
    • 0023924833 scopus 로고
    • High dose methotrexate therapy: Insecure rationale?
    • Kamen, B. A. & Winick, N. J. High dose methotrexate therapy: insecure rationale? Biochem Pharmacol, 1988; 37: 2713-15.
    • (1988) Biochem Pharmacol , vol.37 , pp. 2713-2715
    • Kamen, B.A.1    Winick, N.J.2
  • 33
    • 0344333442 scopus 로고    scopus 로고
    • Intermediatedose intravenous methotrexate with intravenous mercaptopurine is superior to repetitive low-dose oral methotrexate with intravenous mercaptopurine for children with lower-risk B-lineage acute lymphoblastic leukemia: A Pediatric Oncology group phase III trial
    • Mahoney, D. H., Jr., Shuster, J., Nitschke, R., et al. Intermediatedose intravenous methotrexate with intravenous mercaptopurine is superior to repetitive low-dose oral methotrexate with intravenous mercaptopurine for children with lower-risk B-lineage acute lymphoblastic leukemia: a Pediatric Oncology group phase III trial. J Clin Oncol, 1998; 16: 246-54.
    • (1998) J Clin Oncol , vol.16 , pp. 246-254
    • Mahoney, D.H.1    Shuster, J.2    Nitschke, R.3
  • 34
    • 0022591568 scopus 로고
    • Clinical pharmacodynamics of high-dose methotrexate in acute lymphocytic leukemia. Identification of a relation between concentration and effect
    • Evans, W. E., Crom, W. R., Abromowitch, M., et al. Clinical pharmacodynamics of high-dose methotrexate in acute lymphocytic leukemia. Identification of a relation between concentration and effect. NEngl J Med, 1986; 314: 471-7.
    • (1986) NEngl J Med , vol.314 , pp. 471-477
    • Evans, W.E.1    Crom, W.R.2    Abromowitch, M.3
  • 35
    • 0025313905 scopus 로고
    • MTX clearance is more important for intermediate-risk ALL [letter; comment]
    • Evans, W. E., Schell, M. J., & Pui, C.-H. MTX clearance is more important for intermediate-risk ALL [letter; comment]. J Clin Oncol, 1990; 8: 1115-16.
    • (1990) J Clin Oncol , vol.8 , pp. 1115-1116
    • Evans, W.E.1    Schell, M.J.2    Pui, C.-H.3
  • 36
    • 0028365137 scopus 로고
    • Intensive intravenous methotrexate and mercaptopurine treatment of higher-risk non-T, non-B acute lymphocytic leukemia: A Pediatric Oncology Group study
    • Camitta, B., Mahoney, D., Leventhal, B., et al. Intensive intravenous methotrexate and mercaptopurine treatment of higher-risk non-T, non-B acute lymphocytic leukemia: a Pediatric Oncology Group study. J Clin Oncol, 1994; 12: 1383-9.
    • (1994) J Clin Oncol , vol.12 , pp. 1383-1389
    • Camitta, B.1    Mahoney, D.2    Leventhal, B.3
  • 37
    • 0025719791 scopus 로고
    • Low-dose versus high-dose methotrexate during remission induction in childhood acute lymphoblastic leukemia (protocol 81-01 update)
    • Niemeyer, C. M., Gelber, R. D., Tarbell, N. J., et al. Low-dose versus high-dose methotrexate during remission induction in childhood acute lymphoblastic leukemia (protocol 81-01 update). Blood, 1991; 78: 2514-19.
    • (1991) Blood , vol.78 , pp. 2514-2519
    • Niemeyer, C.M.1    Gelber, R.D.2    Tarbell, N.J.3
  • 38
    • 0028860142 scopus 로고
    • Risk of relapse in childhood acute lymphoblastic leukemia is related to RBC methotrexate and mercaptopurine metabolites during maintenance chemotherapy. Nordic Society for Pediatric Hematology and Oncology
    • Schmiegelow, K., Schroder, H., Gustafsson, G., et al. Risk of relapse in childhood acute lymphoblastic leukemia is related to RBC methotrexate and mercaptopurine metabolites during maintenance chemotherapy. Nordic Society for Pediatric Hematology and Oncology. J Clin Oncol, 1995; 13: 345-51.
    • (1995) J Clin Oncol , vol.13 , pp. 345-351
    • Schmiegelow, K.1    Schroder, H.2    Gustafsson, G.3
  • 39
    • 0025741478 scopus 로고
    • The influence of serum methotrexate concentrations and drug dosage on outcome in childhood acute lymphoblastic leukaemia
    • Pearson, A. D. J., Amineddine, H. A., Yule, M., et al. The influence of serum methotrexate concentrations and drug dosage on outcome in childhood acute lymphoblastic leukaemia. Br J Cancer, 1991; 64: 169-73.
    • (1991) Br J Cancer , vol.64 , pp. 169-173
    • Pearson, A.D.J.1    Amineddine, H.A.2    Yule, M.3
  • 40
    • 0032545976 scopus 로고    scopus 로고
    • Conventional compared with individualized chemotherapy for childhood acute lymphoblastic leukemia
    • Evans, W. E., Relling, M. V., Rodman, J. H., et al. Conventional compared with individualized chemotherapy for childhood acute lymphoblastic leukemia. N Engl J Med, 1998; 338: 499-505.
    • (1998) N Engl J Med , vol.338 , pp. 499-505
    • Evans, W.E.1    Relling, M.V.2    Rodman, J.H.3
  • 41
    • 0001865992 scopus 로고
    • Methotrexate
    • W. E. Evans, J. J. Schentag, & W. J. Jusko, eds., 3rd edn., Vancouver, Canada: Applied Therapeutics, Inc
    • Crom, W. R. & Evans, W. E. Methotrexate. In W. E. Evans, J. J. Schentag, & W. J. Jusko, eds., Applied Pharmacokinetics, 3rd edn. (Vancouver, Canada: Applied Therapeutics, Inc, 1992).
    • (1992) Applied Pharmacokinetics
    • Crom, W.R.1    Evans, W.E.2
  • 42
    • 0027980646 scopus 로고
    • Patient characteristics associated with high-risk methotrexate concentrations and toxicity
    • Relling, M. V., Fairclough, D., Ayers, D., et al. Patient characteristics associated with high-risk methotrexate concentrations and toxicity. J Clin Oncol, 1994; 12: 1667-72.
    • (1994) J Clin Oncol , vol.12 , pp. 1667-1672
    • Relling, M.V.1    Fairclough, D.2    Ayers, D.3
  • 43
    • 0017745663 scopus 로고
    • Use of plasma pharmacokinetics to predict and prevent methotrexate toxicity
    • Stoller, R. G., Hande, K. R., Jacobs, S. A., et al. Use of plasma pharmacokinetics to predict and prevent methotrexate toxicity. NEngl J Med, 1977; 297: 630-4.
    • (1977) NEngl J Med , vol.297 , pp. 630-634
    • Stoller, R.G.1    Hande, K.R.2    Jacobs, S.A.3
  • 44
    • 0020554087 scopus 로고
    • Thepharmacologyand clinical use of methotrexate
    • Jolivet, J., Cowan, K. H., Curt, G. A., et al.Thepharmacologyand clinical use of methotrexate. NEngl J Med, 1983;309: 1094-104.
    • (1983) NEngl J Med , vol.309 , pp. 1094-1104
    • Jolivet, J.1    Cowan, K.H.2    Curt, G.A.3
  • 45
    • 0033621556 scopus 로고    scopus 로고
    • Individualized methotrexate dosing in children with relapsed acute lymphoblastic leukemia
    • Wall, A. M., Gajjar, A., Link, A., et al. Individualized methotrexate dosing in children with relapsed acute lymphoblastic leukemia. Leukemia, 2000; 14: 221-5.
    • (2000) Leukemia , vol.14 , pp. 221-225
    • Wall, A.M.1    Gajjar, A.2    Link, A.3
  • 46
    • 0023200576 scopus 로고
    • Pharmacokinetics and toxicity of methotrexate in children with Downsyndrome and acute lymphocytic leukemia
    • Garre, M. L., Relling, M. V., Kalwinsky, D., et al. Pharmacokinetics and toxicity of methotrexate in children with Downsyndrome and acute lymphocytic leukemia. J Pediatr, 1987; 111: 606-12.
    • (1987) J Pediatr , vol.111 , pp. 606-612
    • Garre, M.L.1    Relling, M.V.2    Kalwinsky, D.3
  • 47
    • 0023187384 scopus 로고
    • Downsyndromeand leukemia: Unusual clinical aspects and unexpected methotrexate sensitivity
    • Peeters, M.&Poon, A. Downsyndromeand leukemia: unusual clinical aspects and unexpected methotrexate sensitivity. Eur J Pediatr, 1987; 146: 416-22.
    • (1987) Eur J Pediatr , vol.146 , pp. 416-422
    • Peeters, M.1    Poon, A.2
  • 49
    • 0027385417 scopus 로고
    • Differences in purine metabolism in patients with Down's syndrome
    • Peeters, M. A., Megarbane, A., Cattaneo, F., et al. Differences in purine metabolism in patients with Down's syndrome. J Intellect Disabil Res, 1993; 37: 491-505.
    • (1993) J Intellect Disabil Res , vol.37 , pp. 491-505
    • Peeters, M.A.1    Megarbane, A.2    Cattaneo, F.3
  • 50
    • 0022376063 scopus 로고
    • Cystathionine beta synthase: Gene dosage effect in trisomy 21
    • Chadefaux, B., Rethore, M. O., Raoul, O., et al. Cystathionine beta synthase: gene dosage effect in trisomy 21. Biochem Biophys Res Commun, 1985; 128: 40-4.
    • (1985) Biochem Biophys Res Commun , vol.128 , pp. 40-44
    • Chadefaux, B.1    Rethore, M.O.2    Raoul, O.3
  • 51
    • 0026101046 scopus 로고
    • Homocysteine and the methotrexate toxicity in trisomy 21[letter]
    • Lejeune, J., Peeters, M., Rethore, M. O., et al. Homocysteine and the methotrexate toxicity in trisomy 21[letter]. Cancer Chemother Pharmacol, 1991; 27: 331-2.
    • (1991) Cancer Chemother Pharmacol , vol.27 , pp. 331-332
    • Lejeune, J.1    Peeters, M.2    Rethore, M.O.3
  • 52
    • 0029122937 scopus 로고
    • Functional analysis and DNA polymorphism of the tandemly repeated sequences in the 5_-terminal regulatory region of the human gene for thymidylate synthase
    • Horie, N., Aiba, H., Oguro, K., et al. Functional analysis and DNA polymorphism of the tandemly repeated sequences in the 5_-terminal regulatory region of the human gene for thymidylate synthase. Cell Struct Funct, 1995; 20: 191-7.
    • (1995) Cell Struct Funct , vol.20 , pp. 191-197
    • Horie, N.1    Aiba, H.2    Oguro, K.3
  • 53
    • 0035868667 scopus 로고    scopus 로고
    • Polymorphisms of the repeated sequences in the enhancer region of the thymidylate synthase gene promotermaypredict downstaging after preoperative chemoradiation in rectal cancer
    • Villafranca, E., Okruzhnov, Y., Dominguez, M. A., et al. Polymorphisms of the repeated sequences in the enhancer region of the thymidylate synthase gene promotermaypredict downstaging after preoperative chemoradiation in rectal cancer. J Clin Oncol, 2001; 19: 1779-86.
    • (2001) J Clin Oncol , vol.19 , pp. 1779-1786
    • Villafranca, E.1    Okruzhnov, Y.2    Dominguez, M.A.3
  • 54
    • 0035430487 scopus 로고    scopus 로고
    • Polymorphism in the thymidylate synthase promoter enhancer region in colorectal cancer
    • Marsh, S., McKay, J. A., Cassidy, J., et al. Polymorphism in the thymidylate synthase promoter enhancer region in colorectal cancer. Int J Oncol, 2001; 19: 383-6.
    • (2001) Int J Oncol , vol.19 , pp. 383-386
    • Marsh, S.1    McKay, J.A.2    Cassidy, J.3
  • 55
    • 0035750549 scopus 로고    scopus 로고
    • Thymidylate synthase gene polymorphism determines response and toxicity of 5-FU chemotherapy
    • Pullarkat, S. T., Stoehlmacher, J., Ghaderi, V., et al. Thymidylate synthase gene polymorphism determines response and toxicity of 5-FU chemotherapy. Pharmacogenomics J, 2001; 1: 65-70.
    • (2001) Pharmacogenomics J , vol.1 , pp. 65-70
    • Pullarkat, S.T.1    Stoehlmacher, J.2    Ghaderi, V.3
  • 56
    • 20444419044 scopus 로고    scopus 로고
    • Pharmacogenetics of outcome in children with acute lymphoblastic leukemia
    • Rocha, C., Cheng, C., Liu, W., et al. Pharmacogenetics of outcome in children with acute lymphoblastic leukemia. Blood, 2005; 105: 4752-8.
    • (2005) Blood , vol.105 , pp. 4752-4758
    • Rocha, C.1    Cheng, C.2    Liu, W.3
  • 57
    • 0037161062 scopus 로고    scopus 로고
    • Polymorphism of the thymidylate synthase gene and outcome of acute lymphoblastic leukaemia
    • Krajinovic, M., Costea, I., & Chiasson, S. Polymorphism of the thymidylate synthase gene and outcome of acute lymphoblastic leukaemia. Lancet, 2002; 359: 1033-4.
    • (2002) Lancet , vol.359 , pp. 1033-1034
    • Krajinovic, M.1    Costea, I.2    Chiasson, S.3
  • 58
    • 0035412398 scopus 로고    scopus 로고
    • Pharmacogenetics of methotrexate: Toxicity among marrow transplantation patients varies with the methylenetetrahydrofolate reductase C677T polymorphism
    • Ulrich, C. M., Yasui, Y., Storb, R., et al. Pharmacogenetics of methotrexate: toxicity among marrow transplantation patients varies with the methylenetetrahydrofolate reductase C677T polymorphism. Blood, 2001; 98: 231-4.
    • (2001) Blood , vol.98 , pp. 231-234
    • Ulrich, C.M.1    Yasui, Y.2    Storb, R.3
  • 59
    • 0033805360 scopus 로고    scopus 로고
    • A polymorphism (80G->A) in the reduced folate carrier gene and its associations with folate status and homocysteinemia
    • Chango, A., Emery-Fillon, N., de Courcy, G. P., et al. A polymorphism (80G->A) in the reduced folate carrier gene and its associations with folate status and homocysteinemia. Mol Genet Metab, 2000; 70: 310-5.
    • (2000) Mol Genet Metab , vol.70 , pp. 310-315
    • Chango, A.1    Emery-Fillon, N.2    de Courcy, G.P.3
  • 60
    • 0037110469 scopus 로고    scopus 로고
    • Polymorphism G80A in the reduced folate carrier gene and its relationship to methotrexate plasma levels and outcome of childhood acute lymphoblastic leukemia
    • Laverdiere, C., Chiasson, S., Costea, I., et al. Polymorphism G80A in the reduced folate carrier gene and its relationship to methotrexate plasma levels and outcome of childhood acute lymphoblastic leukemia. Blood, 2002; 100: 3832-4.
    • (2002) Blood , vol.100 , pp. 3832-3834
    • Laverdiere, C.1    Chiasson, S.2    Costea, I.3
  • 61
    • 0028833315 scopus 로고
    • Reversal of methylmercaptopurine ribonucleoside cytotoxicity by purine ribonucleosides and adenine
    • Stet, E. H., De Abreu, R. A., Bokkerink, J. P., et al. Reversal of methylmercaptopurine ribonucleoside cytotoxicity by purine ribonucleosides and adenine. Biochem Pharmacol, 1995; 49: 49-56.
    • (1995) Biochem Pharmacol , vol.49 , pp. 49-56
    • Stet, E.H.1    De Abreu, R.A.2    Bokkerink, J.P.3
  • 62
    • 0029073930 scopus 로고
    • Methylation of mercaptopurine, thioguanine, and their nucleotide metabolites by heterologously expressed human thiopurine S-methyltransferase
    • Krynetski, E. Y., Krynetskaia, N. F., Yanishevski, Y., et al.Methylation of mercaptopurine, thioguanine, and their nucleotide metabolites by heterologously expressed human thiopurine S-methyltransferase. Mol Pharmacol, 1995; 47: 1141-7.
    • (1995) Mol Pharmacol , vol.47 , pp. 1141-1147
    • Krynetski, E.Y.1    Krynetskaia, N.F.2    Yanishevski, Y.3
  • 63
    • 0029736709 scopus 로고    scopus 로고
    • Genetic polymorphism of thiopurine S-methyltransferase: Clinical importance and molecular mechanisms
    • Krynetski, E. Y., Tai, H. L., Yates, C. R., et al. Genetic polymorphism of thiopurine S-methyltransferase: clinical importance and molecular mechanisms. Pharmacogenetics, 1996; 6: 279-90.
    • (1996) Pharmacogenetics , vol.6 , pp. 279-290
    • Krynetski, E.Y.1    Tai, H.L.2    Yates, C.R.3
  • 64
    • 0028000052 scopus 로고
    • Purine substrates for human thiopurine methyltransferase
    • Deininger, M., Szumlanski, C. L., Otterness, D. M., et al. Purine substrates for human thiopurine methyltransferase. Biochem Pharmacol, 1994; 48: 2135-8.
    • (1994) Biochem Pharmacol , vol.48 , pp. 2135-2138
    • Deininger, M.1    Szumlanski, C.L.2    Otterness, D.M.3
  • 65
    • 0014501287 scopus 로고
    • Inhibition of phosphoribosyl pyrophosphate amidotransferase for Ehrlich ascites tumor cells by thiopurine nucleotides
    • Tay, B. S., Lilley, R., McMurray, A. W., et al. Inhibition of phosphoribosyl pyrophosphate amidotransferase for Ehrlich ascites tumor cells by thiopurine nucleotides. Biochem Pharmacol, 1969; 18: 936-8.
    • (1969) Biochem Pharmacol , vol.18 , pp. 936-938
    • Tay, B.S.1    Lilley, R.2    McMurray, A.W.3
  • 66
    • 0035423158 scopus 로고    scopus 로고
    • Differing contribution of thiopurine methyltransferase to mercaptopurine versus thioguanine effects in human leukemic cells
    • Dervieux, T., Blanco, J. G., Krynetski, E. Y., et al. Differing contribution of thiopurine methyltransferase to mercaptopurine versus thioguanine effects in human leukemic cells. Cancer Res, 2001; 61: 5810-16.
    • (2001) Cancer Res , vol.61 , pp. 5810-5816
    • Dervieux, T.1    Blanco, J.G.2    Krynetski, E.Y.3
  • 67
    • 0018822866 scopus 로고
    • Mercaptopurine pharmacogenetics: Monogenic inheritance of erythrocyte thiopurine methyltransferase activity
    • Weinshilboum, R. M. & Sladek, S. L. Mercaptopurine pharmacogenetics: monogenic inheritance of erythrocyte thiopurine methyltransferase activity. Am J Hum Genet, 1980; 32: 651-62.
    • (1980) Am J Hum Genet , vol.32 , pp. 651-662
    • Weinshilboum, R.M.1    Sladek, S.L.2
  • 68
    • 0027603194 scopus 로고
    • Factors affecting HPRT mutant frequency in T-lymphocytes of smokers and nonsmokers
    • Jones, I. M., Moore, D. H., Thomas, C. B., et al. Factors affecting HPRT mutant frequency in T-lymphocytes of smokers and nonsmokers. Cancer Epidemiol Biomarkers Prev, 1993; 2: 249-60.
    • (1993) Cancer Epidemiol Biomarkers Prev , vol.2 , pp. 249-260
    • Jones, I.M.1    Moore, D.H.2    Thomas, C.B.3
  • 69
    • 0027449391 scopus 로고
    • Therapyrelated acute myelogenous leukemia associated with 11q23 chromosomal abnormalities and topoisomerase II inhibitors: Report of four additional cases and brief commentary
    • Bredeson, C. N., Barnett, M. J., Horsman, D. E., et al. Therapyrelated acute myelogenous leukemia associated with 11q23 chromosomal abnormalities and topoisomerase II inhibitors: report of four additional cases and brief commentary. Leuk Lymphoma, 1993; 11: 141-5.
    • (1993) Leuk Lymphoma , vol.11 , pp. 141-145
    • Bredeson, C.N.1    Barnett, M.J.2    Horsman, D.E.3
  • 70
    • 0025790142 scopus 로고
    • Pharmacogenetics of human erythrocyte thiopurine methyltransferase activity in a French population
    • Tinel, M., Berson, A., Pessayre, D., et al. Pharmacogenetics of human erythrocyte thiopurine methyltransferase activity in a French population. Br J Clin Pharmacol, 1991; 32: 729-34.
    • (1991) Br J Clin Pharmacol , vol.32 , pp. 729-734
    • Tinel, M.1    Berson, A.2    Pessayre, D.3
  • 71
    • 0026543630 scopus 로고
    • Interethnic difference in thiopurine methyltransferase activity
    • Klemetsdal, B., Tollefsen, E., Loennechen, T., et al. Interethnic difference in thiopurine methyltransferase activity. Clin Pharmacol Ther, 1992; 51: 24-31.
    • (1992) Clin Pharmacol Ther , vol.51 , pp. 24-31
    • Klemetsdal, B.1    Tollefsen, E.2    Loennechen, T.3
  • 72
    • 0026907122 scopus 로고
    • Human liver thiopurine methyltransferase pharmacogenetics: Biochemical properties, liver-erythrocyte correlation and presence of isozymes
    • Szumlanski, C. L., Honchel, R., Scott, M. C., et al. Human liver thiopurine methyltransferase pharmacogenetics: biochemical properties, liver-erythrocyte correlation and presence of isozymes. Pharmacogenetics, 1992; 2: 148-59.
    • (1992) Pharmacogenetics , vol.2 , pp. 148-159
    • Szumlanski, C.L.1    Honchel, R.2    Scott, M.C.3
  • 73
    • 0023178112 scopus 로고
    • Human lymphocyte thiopurine methyltransferasepharmacogenetics:Effect of phenotype on 6-mercaptopurine-induced inhibition of mitogen stimulation
    • Loon, J. A. Van & Weinshilboum, R. M. Human lymphocyte thiopurine methyltransferasepharmacogenetics:effect of phenotype on 6-mercaptopurine-induced inhibition of mitogen stimulation. J Pharmacol Exp Ther, 1987; 242: 21-6.
    • (1987) J Pharmacol Exp Ther , vol.242 , pp. 21-26
    • Loon Van, J.A.1    Weinshilboum, R.M.2
  • 74
    • 0028930908 scopus 로고
    • Polymorphic thiopurine methyltransferase in erythrocytes is indicative of activity in leukemic blasts from children with acute lymphoblastic leukemia
    • McLeod, H. L., Relling, M. V., Liu, Q., et al. Polymorphic thiopurine methyltransferase in erythrocytes is indicative of activity in leukemic blasts from children with acute lymphoblastic leukemia. Blood, 1995; 85: 1897-902.
    • (1995) Blood , vol.85 , pp. 1897-1902
    • McLeod, H.L.1    Relling, M.V.2    Liu, Q.3
  • 75
    • 0030048791 scopus 로고    scopus 로고
    • Thiopurine methyltransferase pharmacogenetics:Humangene cloning and characterization of acommonpolymorphism
    • Szumlanski, C., Otterness, D., Her, C., et al. Thiopurine methyltransferase pharmacogenetics:humangene cloning and characterization of acommonpolymorphism. DNACell Biol, 1996; 15: 17-30.
    • (1996) DNACell Biol , vol.15 , pp. 17-30
    • Szumlanski, C.1    Otterness, D.2    Her, C.3
  • 76
    • 0028861745 scopus 로고
    • A single point mutation leading to loss of catalytic activity in human thiopurine S-methyltransferase
    • Krynetski, E. Y., Schuetz, J. D., Galpin, A. J., et al. A single point mutation leading to loss of catalytic activity in human thiopurine S-methyltransferase. Proc Natl Acad SciUS A, 1995; 92: 949-53.
    • (1995) Proc Natl Acad SciUS A , vol.92 , pp. 949-953
    • Krynetski, E.Y.1    Schuetz, J.D.2    Galpin, A.J.3
  • 77
    • 0028913757 scopus 로고
    • Thiopurine methyltransferase pharmacogenetics. Cloning of human liver cDNA anda processed pseudogeneonhumanchromosome18q21.1
    • Lee, D., Szumlanski, C., Houtman, J., et al. Thiopurine methyltransferase pharmacogenetics. Cloning of human liver cDNA anda processed pseudogeneonhumanchromosome18q21.1. Drug Metab Dispos, 1995; 23: 398-405.
    • (1995) Drug Metab Dispos , vol.23 , pp. 398-405
    • Lee, D.1    Szumlanski, C.2    Houtman, J.3
  • 78
    • 0029919807 scopus 로고    scopus 로고
    • Thiopurine S-methyltransferase deficiency: Two nucleotide transitions define the most prevalent mutant allele associated with loss of catalytic activity in Caucasians
    • Tai, H. L., Krynetski, E. Y., Yates, C. R., et al. Thiopurine S-methyltransferase deficiency: two nucleotide transitions define the most prevalent mutant allele associated with loss of catalytic activity in Caucasians. Am J Hum Genet, 1996; 58: 694-702.
    • (1996) Am J Hum Genet , vol.58 , pp. 694-702
    • Tai, H.L.1    Krynetski, E.Y.2    Yates, C.R.3
  • 79
    • 0030934850 scopus 로고    scopus 로고
    • Molecular diagnosis of thiopurine S-methyltransferase deficiency: Genetic basis for azathioprine and mercaptopurine intolerance
    • Yates, C. R., Krynetski, E. Y., Loennechen, T., et al. Molecular diagnosis of thiopurine S-methyltransferase deficiency: genetic basis for azathioprine and mercaptopurine intolerance. Ann Intern Med, 1997; 126: 608-14.
    • (1997) Ann Intern Med , vol.126 , pp. 608-614
    • Yates, C.R.1    Krynetski, E.Y.2    Loennechen, T.3
  • 80
    • 0024451147 scopus 로고
    • Pharmacogenetics of acute azathioprine toxicity: Relationship to thiopurine methyltransferase genetic polymorphism
    • Lennard, L., Loon, J. A. Van, & Weinshilboum, R. M. Pharmacogenetics of acute azathioprine toxicity: relationship to thiopurine methyltransferase genetic polymorphism. Clin Pharmacol Ther, 1989; 46: 149-54.
    • (1989) Clin Pharmacol Ther , vol.46 , pp. 149-154
    • Lennard, L.1    Loon Van, J.A.2    Weinshilboum, R.M.3
  • 81
    • 0023119219 scopus 로고
    • Thiopurine pharmacogenetics in leukemia: Correlation of erythrocyte thiopurine methyltransferase activity and 6-thioguanine nucleotide concentrations
    • Lennard, L., Loon, J. A. van, Lilleyman, J. S., et al. Thiopurine pharmacogenetics in leukemia: correlation of erythrocyte thiopurine methyltransferase activity and 6-thioguanine nucleotide concentrations. Clin Pharmacol Ther, 1987; 41: 18-25.
    • (1987) Clin Pharmacol Ther , vol.41 , pp. 18-25
    • Lennard, L.1    Loon van, J.A.2    Lilleyman, J.S.3
  • 82
    • 0029126712 scopus 로고
    • Azathioprine toxicity, 6-mercaptopurine accumulation and the "poor" 6-thiopurine methylator phenotype [letter]
    • Escousse, A., Rifle, G., Sgro, C., et al. Azathioprine toxicity, 6-mercaptopurine accumulation and the "poor" 6-thiopurine methylator phenotype [letter]. Eur J Clin Pharmacol, 1995; 48: 309-10.
    • (1995) Eur J Clin Pharmacol , vol.48 , pp. 309-310
    • Escousse, A.1    Rifle, G.2    Sgro, C.3
  • 83
    • 0027401302 scopus 로고
    • Azathioprine-induced myelosuppression in thiopurine methyltransferase deficient heart transplant recipient
    • Schutz, E., Gummert, J., Mohr, F., et al. Azathioprine-induced myelosuppression in thiopurine methyltransferase deficient heart transplant recipient. Lancet, 1993; 341: 436.
    • (1993) Lancet , vol.341 , pp. 436
    • Schutz, E.1    Gummert, J.2    Mohr, F.3
  • 84
    • 0020512528 scopus 로고
    • Childhood leukaemia: A relationship between intracellular 6-mercaptopurine metabolites and neutropenia
    • Lennard, L., Rees, C. A., Lilleyman, J. S., et al. Childhood leukaemia: a relationship between intracellular 6-mercaptopurine metabolites and neutropenia. Br J Clin Pharmacol, 1983; 16: 359-63.
    • (1983) Br J Clin Pharmacol , vol.16 , pp. 359-363
    • Lennard, L.1    Rees, C.A.2    Lilleyman, J.S.3
  • 85
    • 0025837127 scopus 로고
    • Altered mercaptopurine metabolism, toxic effects, and dosage requirement in a Cambridge Books Online (c) Cambridge University Press, 2009 Pharmacokinetic, pharmacodynamic, and pharmacogenetic considerations 407 thiopurine methyltransferase-deficient child with acute lymphocytic leukemia
    • Evans, W. E., Horner, M., Chu, Y. Q., et al. Altered mercaptopurine metabolism, toxic effects, and dosage requirement in a Cambridge Books Online (c) Cambridge University Press, 2009 Pharmacokinetic, pharmacodynamic, and pharmacogenetic considerations 407 thiopurine methyltransferase-deficient child with acute lymphocytic leukemia. J Pediatr, 1991; 119: 985-9.
    • (1991) J Pediatr , vol.119 , pp. 985-989
    • Evans, W.E.1    Horner, M.2    Chu, Y.Q.3
  • 86
    • 0027524983 scopus 로고
    • Congenital thiopurine methyltransferase deficiency and 6-mercaptopurine toxicity during treatment for acute lymphoblastic leukaemia
    • Lennard, L., Gibson, B. E., Nicole, T., et al. Congenital thiopurine methyltransferase deficiency and 6-mercaptopurine toxicity during treatment for acute lymphoblastic leukaemia. Arch Dis Child, 1993; 69: 577-9.
    • (1993) Arch Dis Child , vol.69 , pp. 577-579
    • Lennard, L.1    Gibson, B.E.2    Nicole, T.3
  • 87
    • 0033486029 scopus 로고    scopus 로고
    • Mercaptopurine therapy intolerance and heterozygosity at the thiopurine S-methyltransferase gene locus
    • Relling, M. V., Hancock, M. L., Rivera, G. K., et al. Mercaptopurine therapy intolerance and heterozygosity at the thiopurine S-methyltransferase gene locus. J Natl Cancer Inst, 1999; 91: 2001-8.
    • (1999) J Natl Cancer Inst , vol.91 , pp. 2001-2008
    • Relling, M.V.1    Hancock, M.L.2    Rivera, G.K.3
  • 88
    • 0035871560 scopus 로고    scopus 로고
    • Preponderance of thiopurine S-methyltransferase deficiency and heterozygosity amongpatients intolerant tomercaptopurine or azathioprine
    • Evans, W. E., Hon, Y. Y., Bomgaars, L., et al. Preponderance of thiopurine S-methyltransferase deficiency and heterozygosity amongpatients intolerant tomercaptopurine or azathioprine. J Clin Oncol, 2001; 19: 2293-301.
    • (2001) J Clin Oncol , vol.19 , pp. 2293-2301
    • Evans, W.E.1    Hon, Y.Y.2    Bomgaars, L.3
  • 89
    • 0033568538 scopus 로고    scopus 로고
    • Possible carcinogenic effect of 6-mercaptopurine on bone marrow stem cells
    • Thomsen, J., Schroder, H., Kristinsson, J., et al. Possible carcinogenic effect of 6-mercaptopurine on bone marrow stem cells. Cancer, 1999; 86: 1080-6.
    • (1999) Cancer , vol.86 , pp. 1080-1086
    • Thomsen, J.1    Schroder, H.2    Kristinsson, J.3
  • 90
    • 0033519986 scopus 로고    scopus 로고
    • Highincidenceof secondary brain tumours after radiotherapy and antimetabolites
    • Relling, M.V., Rubnitz, J. E., Rivera, G.K., et al.Highincidenceof secondary brain tumours after radiotherapy and antimetabolites. Lancet, 1999; 354: 34-9.
    • (1999) Lancet , vol.354 , pp. 34-39
    • Relling, M.V.1    Rubnitz, J.E.2    Rivera, G.K.3
  • 91
    • 0031884608 scopus 로고    scopus 로고
    • Etoposide and antimetabolite pharmacology in patients who develop secondary acute myeloid leukemia
    • Relling, M. V., Yanishevski, Y., Nemec, J., et al. Etoposide and antimetabolite pharmacology in patients who develop secondary acute myeloid leukemia. Leukemia, 1998; 12: 346-52.
    • (1998) Leukemia , vol.12 , pp. 346-352
    • Relling, M.V.1    Yanishevski, Y.2    Nemec, J.3
  • 92
    • 0022354811 scopus 로고
    • Skin cancer in renal transplant recipients is associated with increased concentrations of 6-thioguanine nucleotide in red blood cells
    • Lennard, L., Thomas, S., Harrington, C. I., et al. Skin cancer in renal transplant recipients is associated with increased concentrations of 6-thioguanine nucleotide in red blood cells. Br J Dermatol, 1985; 113: 723-9.
    • (1985) Br J Dermatol , vol.113 , pp. 723-729
    • Lennard, L.1    Thomas, S.2    Harrington, C.I.3
  • 93
    • 0033747215 scopus 로고    scopus 로고
    • Thioguanine substitution alters DNA cleavage mediated by topoisomerase II
    • Krynetskaia, N. F., Cai, X., Nitiss, J. L., et al. Thioguanine substitution alters DNA cleavage mediated by topoisomerase II. FASEB J, 2000; 14: 2339-44.
    • (2000) FASEB J , vol.14 , pp. 2339-2344
    • Krynetskaia, N.F.1    Cai, X.2    Nitiss, J.L.3
  • 94
    • 20144365645 scopus 로고    scopus 로고
    • Thiopurine methyltransferase (TPMT) genotype and early treatment response to mercaptopurine in childhood acute lymphoblastic leukemia
    • Stanulla, M., Schaeffeler, E., Flohr, T., et al. Thiopurine methyltransferase (TPMT) genotype and early treatment response to mercaptopurine in childhood acute lymphoblastic leukemia. JAMA, 2005; 293: 1485-9.
    • (2005) JAMA , vol.293 , pp. 1485-1489
    • Stanulla, M.1    Schaeffeler, E.2    Flohr, T.3
  • 95
    • 0025331198 scopus 로고
    • Genetic variation in response to 6-mercaptopurine for childhood acute lymphoblastic leukaemia
    • Lennard, L., Lilleyman, J. S., Loon, J. van, et al. Genetic variation in response to 6-mercaptopurine for childhood acute lymphoblastic leukaemia. Lancet, 1990; 336: 225-9.
    • (1990) Lancet , vol.336 , pp. 225-229
    • Lennard, L.1    Lilleyman van, J.S.2    Loon, J.3
  • 96
    • 0033135738 scopus 로고    scopus 로고
    • Prognostic importance of 6-mercaptopurine dose intensity in acute lymphoblastic leukemia
    • Relling, M. V., Hancock, M. L., Boyett, J. M., et al. Prognostic importance of 6-mercaptopurine dose intensity in acute lymphoblastic leukemia. Blood, 1999; 93: 2817-23.
    • (1999) Blood , vol.93 , pp. 2817-2823
    • Relling, M.V.1    Hancock, M.L.2    Boyett, J.M.3
  • 97
    • 0027298618 scopus 로고
    • Variable mercaptopurine metabolism in children with leukaemia: A problem of non-compliance?
    • Davies, H. A., Lennard, L., & Lilleyman, J. S. Variable mercaptopurine metabolism in children with leukaemia: a problem of non-compliance? Br Med J, 1993; 306: 1239-40.
    • (1993) Br Med J , vol.306 , pp. 1239-1240
    • Davies, H.A.1    Lennard, L.2    Lilleyman, J.S.3
  • 98
    • 0015831459 scopus 로고
    • Treatment of central nervous system leukemia with intrathecal cytosine arabinoside
    • Band, P. R., Holland, J. F., Bernard, J., et al. Treatment of central nervous system leukemia with intrathecal cytosine arabinoside. Cancer, 1973; 32: 744-8.
    • (1973) Cancer , vol.32 , pp. 744-748
    • Band, P.R.1    Holland, J.F.2    Bernard, J.3
  • 99
    • 0015343539 scopus 로고
    • Kinetic and template studies with 1-_-Darabinofuranosylcytosine-5_-triphosphate and mammalian deoxyribonucleic and polymerase
    • Momparler, R. L. Kinetic and template studies with 1-_-Darabinofuranosylcytosine-5_-triphosphate and mammalian deoxyribonucleic and polymerase. Mol Pharmacol, 1972; 8: 362-70.
    • (1972) Mol Pharmacol , vol.8 , pp. 362-370
    • Momparler, R.L.1
  • 100
    • 0019131198 scopus 로고
    • Correlation of cytotoxicity with incorporation of ara-C into DNA
    • 8900
    • Kufe, D.W., Major, P.P., Egan, E. M., et al.Correlation of cytotoxicity with incorporation of ara-C into DNA. J Biol Chem, 1980; 255: 8997-900.
    • (1980) J Biol Chem , vol.255 , pp. 8997
    • Kufe, D.W.1    Major, P.P.2    Egan, E.M.3
  • 101
    • 0019788167 scopus 로고
    • Correlation of thymidine-enhanced incorporation of ara-C in deoxyribonucleic acid with increased cell kill
    • Major, P. P., Sargent, L., Egan, E. M., et al. Correlation of thymidine-enhanced incorporation of ara-C in deoxyribonucleic acid with increased cell kill. Biochem Pharmacol, 1981; 30: 2221-4.
    • (1981) Biochem Pharmacol , vol.30 , pp. 2221-2224
    • Major, P.P.1    Sargent, L.2    Egan, E.M.3
  • 102
    • 1842410098 scopus 로고
    • Lethality ofhuman myeloblasts correlates with the incorporation of arabinofuranosylcytosine into DNA
    • Major, P.P., Egan, E.M., Beardsley, G.P., et al. Lethality ofhuman myeloblasts correlates with the incorporation of arabinofuranosylcytosine into DNA. Proc Natl Acad Sci U S A, 1981; 78: 3235-9.
    • (1981) Proc Natl Acad Sci U S A , vol.78 , pp. 3235-3239
    • Major, P.P.1    Egan, E.M.2    Beardsley, G.P.3
  • 103
    • 0014190668 scopus 로고
    • Transport and phosphorylation as factors in the antitumor action of cytosine arabinoside
    • Kessel, D., Hall, T. C., & Wodinsky, I. Transport and phosphorylation as factors in the antitumor action of cytosine arabinoside. Science, 1967; 156: 1240-1.
    • (1967) Science , vol.156 , pp. 1240-1241
    • Kessel, D.1    Hall, T.C.2    Wodinsky, I.3
  • 104
    • 0020072941 scopus 로고
    • Cytosine arabinoside influx and nucleoside transport sites in acute leukemia
    • Wiley, J. S., Jones, S.P., Sawyer, W. H., et al.Cytosine arabinoside influx and nucleoside transport sites in acute leukemia. J Clin Invest, 1982; 69: 479-89.
    • (1982) J Clin Invest , vol.69 , pp. 479-489
    • Wiley, J.S.1    Jones, S.P.2    Sawyer, W.H.3
  • 105
    • 0024594372 scopus 로고
    • Patient-specific dose rate for continuous infusion high-dose cytarabine in relapsed acute myelogenous leukemia
    • Heinemann, V., Estey, E., Keating, M. J., et al. Patient-specific dose rate for continuous infusion high-dose cytarabine in relapsed acute myelogenous leukemia. J Clin Oncol, 1989; 7: 622-8.
    • (1989) J Clin Oncol , vol.7 , pp. 622-628
    • Heinemann, V.1    Estey, E.2    Keating, M.J.3
  • 106
    • 0023273525 scopus 로고
    • Saturation 1-_-D-arabinofuranosylcytosine 5_-triphosphate accumulation in leukemic cells during high-dose 1-_-D-arabinofuranosylcytosine therapy
    • Plunkett, W., Liliemark, J. O., Adams, T. M., et al. Saturation 1-_-D-arabinofuranosylcytosine 5_-triphosphate accumulation in leukemic cells during high-dose 1-_-D-arabinofuranosylcytosine therapy. Cancer Res, 1987; 47: 3005-11.
    • (1987) Cancer Res , vol.47 , pp. 3005-3011
    • Plunkett, W.1    Liliemark, J.O.2    Adams, T.M.3
  • 107
    • 0023150286 scopus 로고
    • In-vitro studies on phosphorylation and dephosphorylation of cytosine arabinoside in human leukemic cells
    • Muus, P., Drenthe-Schonk, A., Haanen, C., et al. In-vitro studies on phosphorylation and dephosphorylation of cytosine arabinoside in human leukemic cells. Leuk Res, 1987; 11: 319-25.
    • (1987) Leuk Res , vol.11 , pp. 319-325
    • Muus, P.1    Drenthe-Schonk, A.2    Haanen, C.3
  • 108
    • 0023115207 scopus 로고
    • Membrane transport influences the rate of accumulation of cytosine arabinoside in human leukemic cells
    • White, J. C., Rathmell, J. P., Capizzi, R. L. Membrane transport influences the rate of accumulation of cytosine arabinoside in human leukemic cells. J Clin Invest, 1987; 79: 380-7.
    • (1987) J Clin Invest , vol.79 , pp. 380-387
    • White, J.C.1    Rathmell, J.P.2    Capizzi, R.L.3
  • 109
    • 0021847172 scopus 로고
    • Pharmacologically directed ara-C therapy for refractory leukemia
    • Plunkett, W., Iacoboni, S., Estey, E., et al. Pharmacologically directed ara-C therapy for refractory leukemia. Semin Oncol, 1985; 12: 20-30.
    • (1985) Semin Oncol , vol.12 , pp. 20-30
    • Plunkett, W.1    Iacoboni, S.2    Estey, E.3
  • 110
    • 0018741351 scopus 로고
    • Correlation between leukemic cell retention of 1-_-D-arabinofuranosylcytosine 5_-triphosphate and response to therapy
    • Rustum, Y. M. & Preisler, H. D. Correlation between leukemic cell retention of 1-_-D-arabinofuranosylcytosine 5_-triphosphate and response to therapy. Cancer Res, 1979; 39: 42-9.
    • (1979) Cancer Res , vol.39 , pp. 42-49
    • Rustum, Y.M.1    Preisler, H.D.2
  • 111
    • 0025219695 scopus 로고
    • Pharmacokinetics of cytosine arabinoside in cerebrospinal fluid and of its metabolite in leukemic cells
    • Bekassy, A. N., Liliemark, J., Garwicz, S., et al. Pharmacokinetics of cytosine arabinoside in cerebrospinal fluid and of its metabolite in leukemic cells. Med Pediatr Oncol, 1990; 18: 136-42.
    • (1990) Med Pediatr Oncol , vol.18 , pp. 136-142
    • Bekassy, A.N.1    Liliemark, J.2    Garwicz, S.3
  • 112
    • 0023589415 scopus 로고
    • Biochemical pharmacology of high dose 1-_-D-arabinofuranosylcytosine in childhood acute leukemia
    • Avramis, V. L., Biener, R., Krailo, M., et al.Biochemical pharmacology of high dose 1-_-D-arabinofuranosylcytosine in childhood acute leukemia. Cancer Res, 1987; 47: 6786-92.
    • (1987) Cancer Res , vol.47 , pp. 6786-6792
    • Avramis, V.L.1    Biener, R.2    Krailo, M.3
  • 113
    • 0029881104 scopus 로고    scopus 로고
    • Intracellular retention of cytosine arabinoside triphosphate in blast cells from children with acute myelogenous and lymphoblastic leukemia
    • Boos, J., Hohenlochter, B., Schulze-Westhoff, P., et al. Intracellular retention of cytosine arabinoside triphosphate in blast cells from children with acute myelogenous and lymphoblastic leukemia. Med Pediatr Oncol, 1996; 26: 397-404.
    • (1996) Med Pediatr Oncol , vol.26 , pp. 397-404
    • Boos, J.1    Hohenlochter, B.2    Schulze-Westhoff, P.3
  • 114
    • 0022584688 scopus 로고
    • Cellular pharmacology and optimal therapeutic concentrations of 1-_-Darabinofuranosylcytosine 5_-triphosphate in leukemic blasts during treatment of refractory leukemia with high-dose 1-_-D-arabinofuranosylcytosine
    • Plunkett, W., Iacoboni, S., & Keating, M. Cellular pharmacology and optimal therapeutic concentrations of 1-_-Darabinofuranosylcytosine 5_-triphosphate in leukemic blasts during treatment of refractory leukemia with high-dose 1-_-D-arabinofuranosylcytosine. Scand J Haematol, 1986; 34: 51-9.
    • (1986) Scand J Haematol , vol.34 , pp. 51-59
    • Plunkett, W.1    Iacoboni, S.2    Keating, M.3
  • 115
    • 0025008675 scopus 로고
    • Cellular ara-CTP pharmacokinetics response and karyotype in newly diagnosed acute myelogenous leukemia
    • Estey, E. H., Keating, M. J., McCredie, K. B., et al. Cellular ara-CTP pharmacokinetics response and karyotype in newly diagnosed acute myelogenous leukemia. Leukemia, 1990; 4: 95-9.
    • (1990) Leukemia , vol.4 , pp. 95-99
    • Estey, E.H.1    Keating, M.J.2    McCredie, K.B.3
  • 116
    • 9044228414 scopus 로고    scopus 로고
    • A randomized study of high-dose cytarabine in induction in acute myeloid leukemia
    • Bishop, J. F., Matthews, J. P., Young, G. A., et al. A randomized study of high-dose cytarabine in induction in acute myeloid leukemia. Blood, 1996; 87: 1710-17.
    • (1996) Blood , vol.87 , pp. 1710-1717
    • Bishop, J.F.1    Matthews, J.P.2    Young, G.A.3
  • 117
    • 0027941369 scopus 로고
    • Intensive postremission chemotherapy in adults with acutemyeloid leukemia
    • Mayer, R. J., Davis, R. B., Schiffer, C. A., et al. Intensive postremission chemotherapy in adults with acutemyeloid leukemia. NEngl J Med, 1994; 331: 896-903.
    • (1994) NEngl J Med , vol.331 , pp. 896-903
    • Mayer, R.J.1    Davis, R.B.2    Schiffer, C.A.3
  • 118
    • 0032409839 scopus 로고    scopus 로고
    • Expression of deoxycytidine kinase (dCK) gene in leukemic cells in childhood: Decreased expression of dCK gene in relapsed leukemia
    • Kakihara, T., Fukuda, T., Tanaka, A., et al. Expression of deoxycytidine kinase (dCK) gene in leukemic cells in childhood: decreased expression of dCK gene in relapsed leukemia. Leuk Lymphoma, 1998; 31: 405-9.
    • (1998) Leuk Lymphoma , vol.31 , pp. 405-409
    • Kakihara, T.1    Fukuda, T.2    Tanaka, A.3
  • 119
    • 0030858503 scopus 로고    scopus 로고
    • Deoxycytidinekinase mRNAexpression in childhood acute lymphoblastic leukemia
    • Stammler, G., Zintl, F., Sauerbrey, A., et al.Deoxycytidinekinase mRNAexpression in childhood acute lymphoblastic leukemia. Anticancer Drugs, 1997; 8: 517-21.
    • (1997) Anticancer Drugs , vol.8 , pp. 517-521
    • Stammler, G.1    Zintl, F.2    Sauerbrey, A.3
  • 120
    • 0023351150 scopus 로고
    • Deoxycytidine kinase and deoxycytidine deaminase values correspond closely to clinical response to cytosine arabinoside remission induction therapy in patients with acute myelogenous leukemia
    • Colly, L. P., Peters, W. G., Richel, D., et al. Deoxycytidine kinase and deoxycytidine deaminase values correspond closely to clinical response to cytosine arabinoside remission induction therapy in patients with acute myelogenous leukemia. Semin Oncol, 1987; 14: 257-61.
    • (1987) Semin Oncol , vol.14 , pp. 257-261
    • Colly, L.P.1    Peters, W.G.2    Richel, D.3
  • 121
    • 0037082484 scopus 로고    scopus 로고
    • Functional role of alternatively spliced deoxycytidine kinase in sensitivity to cytarabine of acute myeloid leukemic cells
    • Veuger, M. J., Heemskerk, M. H., Honders, M. W., et al. Functional role of alternatively spliced deoxycytidine kinase in sensitivity to cytarabine of acute myeloid leukemic cells. Blood, 2002; 99: 1373-80.
    • (2002) Blood , vol.99 , pp. 1373-1380
    • Veuger, M.J.1    Heemskerk, M.H.2    Honders, M.W.3
  • 122
    • 0034663307 scopus 로고    scopus 로고
    • High incidence of alternatively spliced forms of deoxycytidine kinase in patients with resistant acute myeloid leukemia
    • Veuger, M. J., Honders, M.W., Landegent, J. E., et al.High incidence of alternatively spliced forms of deoxycytidine kinase in patients with resistant acute myeloid leukemia. Blood, 2000; 96: 1517-24.
    • (2000) Blood , vol.96 , pp. 1517-1524
    • Veuger, M.J.1    Honders, M.W.2    Landegent, J.E.3
  • 123
    • 0035885953 scopus 로고    scopus 로고
    • Expression of high Km 5_-nucleotidase in leukemic blasts is an independent prognostic factor in adults with acute myeloid leukemia
    • Galmarini, C. M., Graham, K., Thomas, X., et al. Expression of high Km 5_-nucleotidase in leukemic blasts is an independent prognostic factor in adults with acute myeloid leukemia. Blood, 2001; 98: 1922-6.
    • (2001) Blood , vol.98 , pp. 1922-1926
    • Galmarini, C.M.1    Graham, K.2    Thomas, X.3
  • 124
    • 0030923988 scopus 로고    scopus 로고
    • Activity of thymidine kinase and of polymerase alpha as well as activity and gene expression of deoxycytidine deaminase in leukemic blasts are correlated with clinical response in the setting of granulocyte-macrophage colonystimulating factor-based priming before and during TAD-9 induction therapy in acute myeloid leukemia
    • Jahns-Streubel, G., Reuter, C., auf der Landwehr, U., et al. Activity of thymidine kinase and of polymerase alpha as well as activity and gene expression of deoxycytidine deaminase in leukemic blasts are correlated with clinical response in the setting of granulocyte-macrophage colonystimulating factor-based priming before and during TAD-9 induction therapy in acute myeloid leukemia. Blood, 1997; 90: 1968-76.
    • (1997) Blood , vol.90 , pp. 1968-1976
    • Jahns-Streubel, G.1    Reuter, C.2    auf der Landwehr, U.3
  • 125
    • 0037245970 scopus 로고    scopus 로고
    • Afunctional single-nucleotide polymorphism in the human cytidine deaminase gene contributing to ara-C sensitivity
    • Yue, L., Saikawa, Y., Ota, K., et al.Afunctional single-nucleotide polymorphism in the human cytidine deaminase gene contributing to ara-C sensitivity. Pharmacogenetics, 2003; 13: 29-38.
    • (2003) Pharmacogenetics , vol.13 , pp. 29-38
    • Yue, L.1    Saikawa, Y.2    Ota, K.3
  • 126
    • 0015147420 scopus 로고
    • Clinical pharmacology of 1-_-Darabinofuranosyl cytosine
    • Ho, D. H. W. & Frei, E., III. Clinical pharmacology of 1-_-Darabinofuranosyl cytosine. Clin Pharmacol, 1971; 12: 944-54.
    • (1971) Clin Pharmacol , vol.12 , pp. 944-954
    • Ho, D.H.W.1    Frei, E.2
  • 127
    • 0032528447 scopus 로고    scopus 로고
    • Early intensification of intrathecal chemotherapy virtually eliminates central nervous system relapse in children with acute lymphoblastic leukemia
    • Pui, C. H., Mahmoud, H.H., Rivera, G.K., et al. Early intensification of intrathecal chemotherapy virtually eliminates central nervous system relapse in children with acute lymphoblastic leukemia. Blood, 1998; 92: 411-15.
    • (1998) Blood , vol.92 , pp. 411-415
    • Pui, C.H.1    Mahmoud, H.H.2    Rivera, G.K.3
  • 128
    • 0015384314 scopus 로고
    • Down syndrome and acute leukemia: Myeloblastic or lymphoblastic; report of forty-three cases and review of literature
    • Rosner, F. & Lee, S. Down syndrome and acute leukemia: myeloblastic or lymphoblastic; report of forty-three cases and review of literature. Am J Med, 1972; 53: 203-18.
    • (1972) Am J Med , vol.53 , pp. 203-218
    • Rosner, F.1    Lee, S.2
  • 129
    • 0026574340 scopus 로고
    • Down syndrome and leukemia
    • Robison, L. Down syndrome and leukemia. Leukemia, 1992; 6: 5-7.
    • (1992) Leukemia , vol.6 , pp. 5-7
    • Robison, L.1
  • 130
    • 0029939156 scopus 로고    scopus 로고
    • Enhanced metabolism of 1-beta-D-arabinofuranosylcytosine in Down syndrome cells: A contributing factor to the superior event free survival of Down syndrome children with acute myeloid leukemia
    • Taub, J. W., Matherly, L. H., Stout, M. L., et al. Enhanced metabolism of 1-beta-D-arabinofuranosylcytosine in Down syndrome cells: a contributing factor to the superior event free survival of Down syndrome children with acute myeloid leukemia. Blood, 1996; 87: 3395-403.
    • (1996) Blood , vol.87 , pp. 3395-3403
    • Taub, J.W.1    Matherly, L.H.2    Stout, M.L.3
  • 131
    • 0027258566 scopus 로고
    • Favorable treatment outcome in children with acute myeloid leukemia and Down syndrome [letter; comment]
    • Kojima, S., Kato, K., Matsuyama, T., et al. Favorable treatment outcome in children with acute myeloid leukemia and Down syndrome [letter; comment]. Blood, 1993; 81: 3164.
    • (1993) Blood , vol.81 , pp. 3164
    • Kojima, S.1    Kato, K.2    Matsuyama, T.3
  • 132
    • 0026808789 scopus 로고
    • Acute myeloid leukemia (AML) in Down's syndrome is highly responsive to chemotherapy: Experience on Pediatric Oncology Group AML Study 8498 [see comments]
    • Ravindranath, Y., Abella, E., Krischer, J. P., et al. Acute myeloid leukemia (AML) in Down's syndrome is highly responsive to chemotherapy: experience on Pediatric Oncology Group AML Study 8498 [see comments]. Blood, 1992; 80: 2210-14.
    • (1992) Blood , vol.80 , pp. 2210-2214
    • Ravindranath, Y.1    Abella, E.2    Krischer, J.P.3
  • 133
    • 0033566994 scopus 로고    scopus 로고
    • Expression of chromosome 21-localized genes in acute myeloid leukemia: Differences between Down syndrome and non-Down syndrome blast cells and relationship to in vitro sensitivity to cytosine arabinoside and daunorubicin
    • Taub, J.W., Huang, X., Matherly, L. H., et al. Expression of chromosome 21-localized genes in acute myeloid leukemia: differences between Down syndrome and non-Down syndrome blast cells and relationship to in vitro sensitivity to cytosine arabinoside and daunorubicin. Blood, 1999; 94: 1393-400.
    • (1999) Blood , vol.94 , pp. 1393-1400
    • Taub, J.W.1    Huang, X.2    Matherly, L.H.3
  • 134
    • 0029829735 scopus 로고    scopus 로고
    • High prevalence of a mutation in the cystathionine beta-synthase gene
    • Tsai, M. Y., Bignell, M., Schwichtenberg, K., et al. High prevalence of a mutation in the cystathionine beta-synthase gene. Am J Hum Genet, 1996; 59: 1262-7.
    • (1996) Am J Hum Genet , vol.59 , pp. 1262-1267
    • Tsai, M.Y.1    Bignell, M.2    Schwichtenberg, K.3
  • 135
    • 0036850536 scopus 로고    scopus 로고
    • High frequency of the 844ins68 cystathionine-beta-synthase gene variant in Down syndrome children with acute myeloid leukemia
    • Ge, Y., Jensen, T., James, S. J., et al. High frequency of the 844ins68 cystathionine-beta-synthase gene variant in Down syndrome children with acute myeloid leukemia. Leukemia, 2002; 16: 2339-41.
    • (2002) Leukemia , vol.16 , pp. 2339-2341
    • Ge, Y.1    Jensen, T.2    James, S.J.3
  • 136
    • 0030042611 scopus 로고    scopus 로고
    • Chlorodeoxyadenosine and arabinosylcytosine in patients with acute myelogenous leukemia: Pharmacokinetic, pharmacodynamic, and molecular interactions
    • Gandhi, V., Estey, E., Keating, M. J., et al. Chlorodeoxyadenosine and arabinosylcytosine in patients with acute myelogenous leukemia: pharmacokinetic, pharmacodynamic, and molecular interactions. Blood, 1996; 87: 256-64.
    • (1996) Blood , vol.87 , pp. 256-264
    • Gandhi, V.1    Estey, E.2    Keating, M.J.3
  • 137
    • 0029744389 scopus 로고    scopus 로고
    • Clinical and laboratory studies of 2-chlorodeoxyadenosine ± cytosine arabinoside for relapsed or refractory acute myelogenous leukemia in adults
    • Kornblau, S. M., Gandhi, V., Andreeff, H. M., et al. Clinical and laboratory studies of 2-chlorodeoxyadenosine ± cytosine arabinoside for relapsed or refractory acute myelogenous leukemia in adults. Leukemia, 1996; 10: 1563-9.
    • (1996) Leukemia , vol.10 , pp. 1563-1569
    • Kornblau, S.M.1    Gandhi, V.2    Andreeff, H.M.3
  • 138
    • 0037108698 scopus 로고    scopus 로고
    • Interimcomparison of a continuous infusion versus a short daily infusion of cytarabine given in combination with cladribine for pediatric acute myeloid leukemia
    • Crews, K. R., Gandhi, V., Srivastava, D. K., et al. Interimcomparison of a continuous infusion versus a short daily infusion of cytarabine given in combination with cladribine for pediatric acute myeloid leukemia. J Clin Oncol, 2002; 20: 4217-24.
    • (2002) J Clin Oncol , vol.20 , pp. 4217-4224
    • Crews, K.R.1    Gandhi, V.2    Srivastava, D.K.3
  • 139
    • 0020696296 scopus 로고
    • Specificity of systems mediating transport of adenosine, 9-_-Darabinofuranosyl-2-fluoroadenine, and other purine nucleoside analogues in L1210 cells
    • Sirotnak, F. M., Chello, P. L., Dorick, D. M., et al. Specificity of systems mediating transport of adenosine, 9-_-Darabinofuranosyl-2-fluoroadenine, and other purine nucleoside analogues in L1210 cells. Cancer Res, 1983; 43: 104-9.
    • (1983) Cancer Res , vol.43 , pp. 104-109
    • Sirotnak, F.M.1    Chello, P.L.2    Dorick, D.M.3
  • 140
    • 0023854422 scopus 로고
    • Modulation of arabinosylnucleoside metabolismby arabinosylnucleotides inhumanleukemia cells
    • Gandhi, V. & Plunkett, W. Modulation of arabinosylnucleoside metabolismby arabinosylnucleotides inhumanleukemia cells. Cancer Res, 1988; 48: 329-34.
    • (1988) Cancer Res , vol.48 , pp. 329-334
    • Gandhi, V.1    Plunkett, W.2
  • 141
    • 0027450455 scopus 로고
    • Fludarabine potentiates metabolism of cytarabine in patients with acute myelogenous leukemia during therapy
    • Gandhi, V., Estey, E., Keating, M. J., et al. Fludarabine potentiates metabolism of cytarabine in patients with acute myelogenous leukemia during therapy. J Clin Oncol, 1993; 11: 116-24.
    • (1993) J Clin Oncol , vol.11 , pp. 116-124
    • Gandhi, V.1    Estey, E.2    Keating, M.J.3
  • 142
    • 0024436221 scopus 로고
    • Modulation of arabinosylcytosine metabolism by arabinosyl-2-fluoroadenine in lymphocytes from patients with chronic lymphocytic leukemia: Implications for combination therapy
    • Gandhi, V., Nowak, B., Keating, M. B., et al. Modulation of arabinosylcytosine metabolism by arabinosyl-2-fluoroadenine in lymphocytes from patients with chronic lymphocytic leukemia: implications for combination therapy. Blood, 1989; 74: 2070-5.
    • (1989) Blood , vol.74 , pp. 2070-2075
    • Gandhi, V.1    Nowak, B.2    Keating, M.B.3
  • 143
    • 0028228008 scopus 로고
    • Combination of fludarabine and arabinosylcytosine for treatment of chronic lymphocytic leukemia: Clinical efficacy and modulation of arabinosylcytosine pharmacology
    • Gandhi, V., Robertson, L. E., Keating, M. J., et al. Combination of fludarabine and arabinosylcytosine for treatment of chronic lymphocytic leukemia: clinical efficacy and modulation of arabinosylcytosine pharmacology. Cancer Chemother Pharmacol, 1994; 34: 30-6.
    • (1994) Cancer Chemother Pharmacol , vol.34 , pp. 30-36
    • Gandhi, V.1    Robertson, L.E.2    Keating, M.J.3
  • 144
    • 0026444070 scopus 로고
    • Inhibition of fludarabine metabolism by arabinosylcytosine during therapy
    • Kemena, A., Gandhi, V., Shewach, D. S., et al. Inhibition of fludarabine metabolism by arabinosylcytosine during therapy. Cancer Chemother Pharmacol, 1992; 31: 193-9.
    • (1992) Cancer Chemother Pharmacol , vol.31 , pp. 193-199
    • Kemena, A.1    Gandhi, V.2    Shewach, D.S.3
  • 145
    • 0027213870 scopus 로고
    • Fludarabine and arabinosylcytosine therapy of refractory and relapsed acute myelogenous leukemia
    • Estey, E., Plunkett, W., Gandhi, V., et al. Fludarabine and arabinosylcytosine therapy of refractory and relapsed acute myelogenous leukemia. Leuk Lymph, 1993; 9: 343-50.
    • (1993) Leuk Lymph , vol.9 , pp. 343-350
    • Estey, E.1    Plunkett, W.2    Gandhi, V.3
  • 146
    • 0031882415 scopus 로고    scopus 로고
    • Pharmacokinetic and pharmacodynamic studies of fludarabine and cytosine arabinoside administered as loading boluses followed by continuous infusions after a phase I/II study in pediatric patients with relapsed leukemias. The Children's Cancer Group
    • Avramis, V. I., Wiersma, S., Krailo, M.D., et al. Pharmacokinetic and pharmacodynamic studies of fludarabine and cytosine arabinoside administered as loading boluses followed by continuous infusions after a phase I/II study in pediatric patients with relapsed leukemias. The Children's Cancer Group. Clin Cancer Res, 1998; 4: 45-52.
    • (1998) Clin Cancer Res , vol.4 , pp. 45-52
    • Avramis, V.I.1    Wiersma, S.2    Krailo, M.D.3
  • 147
    • 0030762650 scopus 로고    scopus 로고
    • Phase I/II studyof idarubicingivenwithcontinuousinfusionfludarabine followed by continuous infusion cytarabine in children with acute leukemia: A report from the Children's Cancer Group
    • Dinndorf, P. A., Avramis, V. I., Wiersma, S., et al. Phase I/II studyof idarubicingivenwithcontinuousinfusionfludarabine followed by continuous infusion cytarabine in children with acute leukemia: a report from the Children's Cancer Group. J Clin Oncol, 1997; 15: 2780-5.
    • (1997) J Clin Oncol , vol.15 , pp. 2780-2785
    • Dinndorf, P.A.1    Avramis, V.I.2    Wiersma, S.3
  • 148
    • 0030693132 scopus 로고    scopus 로고
    • A phase I/II study of idarubicin (Ida) with continuous infusion fludarabine (F-ara-A) and cytarabine (ara-C) for refractory or recurrent pediatric acutemyeloid leukemia (AML)
    • Leahey, A., Kelly, K., Rorke, L. B., et al. A phase I/II study of idarubicin (Ida) with continuous infusion fludarabine (F-ara-A) and cytarabine (ara-C) for refractory or recurrent pediatric acutemyeloid leukemia (AML). J Pediatr Hematol Oncol, 1997; 19: 304-8.
    • (1997) J Pediatr Hematol Oncol , vol.19 , pp. 304-308
    • Leahey, A.1    Kelly, K.2    Rorke, L.B.3
  • 149
    • 0031812317 scopus 로고    scopus 로고
    • IDA-FLAG (idarubicin, fludarabine, cytarabine, G-CSF), an effective remissioninduction therapy for poor-prognosis AML of childhood prior to allogeneic or autologous bone marrow transplantation: Experiences of a phase II trial
    • Fleischhack, G., Hasan, C., Graf, N., et al. IDA-FLAG (idarubicin, fludarabine, cytarabine, G-CSF), an effective remissioninduction therapy for poor-prognosis AML of childhood prior to allogeneic or autologous bone marrow transplantation: experiences of a phase II trial. Br J Haematol, 1998; 102: 647-55.
    • (1998) Br J Haematol , vol.102 , pp. 647-655
    • Fleischhack, G.1    Hasan, C.2    Graf, N.3
  • 150
    • 0019988094 scopus 로고
    • Experimental evidence of characteristic tissue distribution of adriamycin. TissueDNA concentration as a determinant
    • Terasaki, T., Iga, T., Sugiyama, Y., et al. Experimental evidence of characteristic tissue distribution of adriamycin. TissueDNA concentration as a determinant. J Pharm Pharmacol, 1982; 34: 597-600.
    • (1982) J Pharm Pharmacol , vol.34 , pp. 597-600
    • Terasaki, T.1    Iga, T.2    Sugiyama, Y.3
  • 151
    • 0014879029 scopus 로고
    • Daunomycin metabolism in rat tissue slides
    • Bachur, N. R.&Craddock, J. C. Daunomycin metabolism in rat tissue slides. J Pharmacol Exp Ther, 1971; 175: 331-7.
    • (1971) J Pharmacol Exp Ther , vol.175 , pp. 331-337
    • Bachur, N.R.1    Craddock, J.C.2
  • 152
    • 0015420430 scopus 로고
    • Daunorubucin metabolism in acute nonlymphocytic leukemia
    • Huffman, D. H., Benjamin, R. S., &Bachur, N. R. Daunorubucin metabolism in acute nonlymphocytic leukemia. Clin Pharmacol Ther, 1972; 13: 895-905.
    • (1972) Clin Pharmacol Ther , vol.13 , pp. 895-905
    • Huffman, D.H.1    Benjamin, R.S.2    Bachur, N.R.3
  • 153
    • 0020584963 scopus 로고
    • Time dependency of adriamycin and adriamycinol kinetics
    • Gill, P., Favre, R., Durand, A., et al. Time dependency of adriamycin and adriamycinol kinetics. Cancer Chemother Pharmacol, 1983; 10: 120-4.
    • (1983) Cancer Chemother Pharmacol , vol.10 , pp. 120-124
    • Gill, P.1    Favre, R.2    Durand, A.3
  • 154
    • 0022635202 scopus 로고
    • Toxicity of doxorubicin metabolites tohumanmarrowerythroidandmyeloid progenitors in vitro
    • Dessypris, E. N., Brenner, D. E., & Hande, K. R. Toxicity of doxorubicin metabolites tohumanmarrowerythroidandmyeloid progenitors in vitro. Cancer Treat Rep, 1986; 70: 487-90.
    • (1986) Cancer Treat Rep , vol.70 , pp. 487-490
    • Dessypris, E.N.1    Brenner, D.E.2    Hande, K.R.3
  • 155
    • 0024355564 scopus 로고
    • Comparative activity of anthracycline 13-dihydrometabolitesagainst ratglioblastomacells in culture [abstract]
    • Schott, B. & Robert, J. Comparative activity of anthracycline 13-dihydrometabolitesagainst ratglioblastomacells in culture [abstract]. Biochem Pharmacol, 1989; 38: 4069-74.
    • (1989) Biochem Pharmacol , vol.38 , pp. 4069-4074
    • Schott, B.1    Robert, J.2
  • 156
    • 0013228058 scopus 로고
    • Doxorubicin cardiotoxicity may be caused by its metabolite, doxorubicinol
    • Olson, R. D., Mushlin, P. S., Brenner, D. E., et al. Doxorubicin cardiotoxicity may be caused by its metabolite, doxorubicinol. Proc Natl Acad Sci U S A, 1988; 85: 3585-9.
    • (1988) Proc Natl Acad Sci U S A , vol.85 , pp. 3585-3589
    • Olson, R.D.1    Mushlin, P.S.2    Brenner, D.E.3
  • 157
    • 0036161278 scopus 로고    scopus 로고
    • Peak plasma concentrations of doxorubicin in children with acute lymphoblastic leukemia or non-Hodgkin lymphoma
    • Hempel, G., Flege, S., Wurthwein, G., et al. Peak plasma concentrations of doxorubicin in children with acute lymphoblastic leukemia or non-Hodgkin lymphoma. Cancer Chemother Pharmacol, 2002; 49: 133-41.
    • (2002) Cancer Chemother Pharmacol , vol.49 , pp. 133-141
    • Hempel, G.1    Flege, S.2    Wurthwein, G.3
  • 158
    • 0028017863 scopus 로고
    • Daunorubicin pharmacokinetics and the correlation with P-glycoprotein and response in patients with acute leukaemia
    • Galettis, P., Boutagy, J., & Ma, D. D. F. Daunorubicin pharmacokinetics and the correlation with P-glycoprotein and response in patients with acute leukaemia. Br J Cancer, 1994; 70: 324-9.
    • (1994) Br J Cancer , vol.70 , pp. 324-329
    • Galettis, P.1    Boutagy, J.2    Ma, D.D.F.3
  • 159
    • 0021353428 scopus 로고
    • Relationship between plasma adriamycin levels and the outcome of remission induction therapy for acute nonlymphocytic leukemia
    • Preisler, H. D., Gessner, T., Azarnia, N., et al. Relationship between plasma adriamycin levels and the outcome of remission induction therapy for acute nonlymphocytic leukemia. Cancer Chemother Pharmacol, 1984; 12: 125-30.
    • (1984) Cancer Chemother Pharmacol , vol.12 , pp. 125-130
    • Preisler, H.D.1    Gessner, T.2    Azarnia, N.3
  • 160
    • 0023882676 scopus 로고
    • Cellular pharmacokinetics of daunorubicin: Relationships with the response to treatment in patients with acute myeloid leukemia
    • Kokenberg, E., Sonneveld, P., Sizoo, W., et al. Cellular pharmacokinetics of daunorubicin: relationships with the response to treatment in patients with acute myeloid leukemia. J Clin Oncol, 1988; 6: 802-12.
    • (1988) J Clin Oncol , vol.6 , pp. 802-812
    • Kokenberg, E.1    Sonneveld, P.2    Sizoo, W.3
  • 161
    • 0027305734 scopus 로고
    • Daunorubicin uptake by leukemic cells: Correlations with treatment outcome and mdr1 expression
    • Marie, J. P., Faussat-Suberville, A. M., Zhou, D., et al.Daunorubicin uptake by leukemic cells: correlations with treatment outcome and mdr1 expression. Leukemia, 1993; 7: 825-31.
    • (1993) Leukemia , vol.7 , pp. 825-831
    • Marie, J.P.1    Faussat-Suberville, A.M.2    Zhou, D.3
  • 162
    • 0023280099 scopus 로고
    • Acute arrhythmogenicity of doxorubicin administration
    • Steinberg, J. S., Cohen, A. J., Wasserman, A. G., et al. Acute arrhythmogenicity of doxorubicin administration. Cancer, 1987; 60: 1213-18.
    • (1987) Cancer , vol.60 , pp. 1213-1218
    • Steinberg, J.S.1    Cohen, A.J.2    Wasserman, A.G.3
  • 163
    • 0017108045 scopus 로고
    • Cardiotoxicity of adriamycin and related anthracyclines
    • Lenaz, L. & Page, J. A. Cardiotoxicity of adriamycin and related anthracyclines. Cancer Treat Rev, 1976; 3: 111-20.
    • (1976) Cancer Treat Rev , vol.3 , pp. 111-120
    • Lenaz, L.1    Page, J.A.2
  • 164
    • 0018189958 scopus 로고
    • Overview of cardiac pathology in relation to anthracycline cardiotoxicity
    • Ferrans, V. J. Overview of cardiac pathology in relation to anthracycline cardiotoxicity. Cancer Treat Rep, 1978; 62: 955-61.
    • (1978) Cancer Treat Rep , vol.62 , pp. 955-961
    • Ferrans, V.J.1
  • 165
    • 0017354816 scopus 로고
    • Daunomycin-induced cardiotoxicity in children and adults. An overview of 110 cases
    • Hoff, D. D. Von, Rozencweig, M., Layard, M., et al. Daunomycin-induced cardiotoxicity in children and adults. An overview of 110 cases. Am J Med, 1977; 62: 200-8.
    • (1977) Am J Med , vol.62 , pp. 200-208
    • Hoff Von, D.D.1    Rozencweig, M.2    Layard, M.3
  • 166
    • 0018194325 scopus 로고
    • Clinical spectrumof anthracycline antibiotic cardiotoxicity
    • Bristow, M. R., Billingham, M. E., Mason, J. W., et al. Clinical spectrumof anthracycline antibiotic cardiotoxicity. Cancer Treat Rep, 1978; 62: 873-9.
    • (1978) Cancer Treat Rep , vol.62 , pp. 873-879
    • Bristow, M.R.1    Billingham, M.E.2    Mason, J.W.3
  • 167
    • 0018134347 scopus 로고
    • Doxorubicin cardiotoxicity. Serial endomyocardial biopsies and systolic time intervals
    • Friedman, M. A., Bozdech, M. J., Billingham, M. E., et al. Doxorubicin cardiotoxicity. Serial endomyocardial biopsies and systolic time intervals. J Am Med Assoc, 1978; 40: 1603-6.
    • (1978) J Am Med Assoc , vol.40 , pp. 1603-1606
    • Friedman, M.A.1    Bozdech, M.J.2    Billingham, M.E.3
  • 168
    • 0021948304 scopus 로고
    • Doxorubicininduced congestive heart failure in adults
    • Haq, M. M., Legha, S. S., Choksi, J., et al. Doxorubicininduced congestive heart failure in adults. Cancer, 1985; 56: 1361-5.
    • (1985) Cancer , vol.56 , pp. 1361-1365
    • Haq, M.M.1    Legha, S.S.2    Choksi, J.3
  • 169
    • 0023634395 scopus 로고
    • Congestive heart failure and left ventricular dysfunction complicating doxorubicn therapy
    • Schwartz, R. G., McKenzie, W. B., Alexander, J., et al. Congestive heart failure and left ventricular dysfunction complicating doxorubicn therapy. Am J Med, 1987; 82: 1109-18.
    • (1987) Am J Med , vol.82 , pp. 1109-1118
    • Schwartz, R.G.1    McKenzie, W.B.2    Alexander, J.3
  • 170
    • 0025850827 scopus 로고
    • Cardiac toxicity 4 to 20 years after completing anthracycline therapy
    • Steinherz, L. J., Steinherz, P. G., Tan, C. T. C., et al. Cardiac toxicity 4 to 20 years after completing anthracycline therapy. J Am Med Assoc, 1991; 266: 1672-7.
    • (1991) J Am Med Assoc , vol.266 , pp. 1672-1677
    • Steinherz, L.J.1    Steinherz, P.G.2    Tan, C.T.C.3
  • 171
    • 0026031848 scopus 로고
    • Late cardiac effects of doxorubicin therapy for acute lymphoblastic leukemia in childhood
    • Lipshultz, S. E., Colan, S. D., Gelber, R. D., et al. Late cardiac effects of doxorubicin therapy for acute lymphoblastic leukemia in childhood. NEngl J Med, 1991; 324: 808-15.
    • (1991) NEngl J Med , vol.324 , pp. 808-815
    • Lipshultz, S.E.1    Colan, S.D.2    Gelber, R.D.3
  • 172
    • 0025875158 scopus 로고
    • Functional myocardial impairmentin children treated with anthracyclines for cancer
    • Yeung, S. T., Yoong, C., Spink, J., et al. Functional myocardial impairmentin children treated with anthracyclines for cancer. Lancet, 1991; 337: 816-18.
    • (1991) Lancet , vol.337 , pp. 816-818
    • Yeung, S.T.1    Yoong, C.2    Spink, J.3
  • 173
    • 0026637815 scopus 로고
    • Electrocardiographic changes and arrhythmias after cancer therapy in children and young adults
    • Larsen, R. L., Jakacki, R. I., Vetter, V. L., et al. Electrocardiographic changes and arrhythmias after cancer therapy in children and young adults. Am J Cardiol, 1992; 70: 73-7.
    • (1992) Am J Cardiol , vol.70 , pp. 73-77
    • Larsen, R.L.1    Jakacki, R.I.2    Vetter, V.L.3
  • 174
    • 0016797157 scopus 로고
    • Adriamycin(NSC-123127) cardiomyopathy-an overview with determination of risk factors
    • Minow, R. A., Benjamin, R. S., &Gottlieb, J. A. Adriamycin(NSC-123127) cardiomyopathy-an overview with determination of risk factors. Cancer Chemother Rep, 1975; 6: 195-201.
    • (1975) Cancer Chemother Rep , vol.6 , pp. 195-201
    • Minow, R.A.1    Benjamin, R.S.2    Gottlieb, J.A.3
  • 175
    • 0018637368 scopus 로고
    • Anthracycline cardiomyopathy in children-report oftwocases
    • Mosijczuk, A. D., Ruymann, F. B., Mease, A. D., et al. Anthracycline cardiomyopathy in children-report oftwocases. Cancer, 1979; 44: 1582-7.
    • (1979) Cancer , vol.44 , pp. 1582-1587
    • Mosijczuk, A.D.1    Ruymann, F.B.2    Mease, A.D.3
  • 176
    • 0018072995 scopus 로고
    • Age-related adriamycin cardiotoxicity in children
    • Pratt, C. B., Ransom, J. L., & Evans, W. E. Age-related adriamycin cardiotoxicity in children. Cancer Treat Rep, 1978; 62: 1381-5.
    • (1978) Cancer Treat Rep , vol.62 , pp. 1381-1385
    • Pratt, C.B.1    Ransom, J.L.2    Evans, W.E.3
  • 177
    • 0037087687 scopus 로고    scopus 로고
    • Doxorubicin administrationby continuous infusion is not cardioprotective: The Dana-Farber 91-01 Acute Lymphoblastic Leukemia protocol
    • Lipshultz, S. E., Giantris, A. L., Lipsitz, S. R., et al. Doxorubicin administrationby continuous infusion is not cardioprotective: the Dana-Farber 91-01 Acute Lymphoblastic Leukemia protocol. J Clin Oncol, 2002; 20: 1677-82.
    • (2002) J Clin Oncol , vol.20 , pp. 1677-1682
    • Lipshultz, S.E.1    Giantris, A.L.2    Lipsitz, S.R.3
  • 178
    • 0021950011 scopus 로고
    • Phase I and II clinical and pharmacological study of 4-demethoxydaunorubicin (idarubicin) in adult patients with acute leukemia
    • Daghestani, A. N., Arlin, Z. A., Leyland-Jones, B., et al. Phase I and II clinical and pharmacological study of 4-demethoxydaunorubicin (idarubicin) in adult patients with acute leukemia. Cancer Res, 1985; 45: 1408-12.
    • (1985) Cancer Res , vol.45 , pp. 1408-1412
    • Daghestani, A.N.1    Arlin, Z.A.2    Leyland-Jones, B.3
  • 179
    • 0028920270 scopus 로고
    • Phase I/II clinical and pharmacokinetic evaluation of liposomal daunorubicin
    • Gill, P. S., Espina, B. M., Muggia, F., et al. Phase I/II clinical and pharmacokinetic evaluation of liposomal daunorubicin. J Clin Oncol, 1995; 13: 996-1003.
    • (1995) J Clin Oncol , vol.13 , pp. 996-1003
    • Gill, P.S.1    Espina, B.M.2    Muggia, F.3
  • 180
    • 0029038996 scopus 로고
    • Liposomal doxorubicin: Antitumor activity and unique toxicities during two complementary phase I studies
    • Uziely, B., Jeffers, S., Isacson, R., et al. Liposomal doxorubicin: antitumor activity and unique toxicities during two complementary phase I studies. J Clin Oncol, 1995; 13: 1777-85.
    • (1995) J Clin Oncol , vol.13 , pp. 1777-1785
    • Uziely, B.1    Jeffers, S.2    Isacson, R.3
  • 181
    • 0029067170 scopus 로고
    • Phase II study of ifosfamide, carboplatin, and oral etoposide chemotherapy for extensive-disease small-cell lung cancer: An Eastern Cooperative Oncology Group pilot study
    • Wolff, A. C., Ettinger, D. S., Neuberg, D., et al. Phase II study of ifosfamide, carboplatin, and oral etoposide chemotherapy for extensive-disease small-cell lung cancer: an Eastern Cooperative Oncology Group pilot study. J Clin Oncol, 1995; 13: 1615-22.
    • (1995) J Clin Oncol , vol.13 , pp. 1615-1622
    • Wolff, A.C.1    Ettinger, D.S.2    Neuberg, D.3
  • 182
    • 0025961169 scopus 로고
    • A phase II study of combined methotrexate and teniposide infusions prior to reinduction therapy in relapsed childhood acute lymphoblastic leukemia: A Pediatric Oncology Group study
    • Ochs, J., Rodman, J., Abromowitch, M., et al. A phase II study of combined methotrexate and teniposide infusions prior to reinduction therapy in relapsed childhood acute lymphoblastic leukemia: a Pediatric Oncology Group study. J Clin Oncol, 1991; 9: 139-44.
    • (1991) J Clin Oncol , vol.9 , pp. 139-144
    • Ochs, J.1    Rodman, J.2    Abromowitch, M.3
  • 183
    • 0029768850 scopus 로고    scopus 로고
    • Effectiveness of intensified rotational combination chemotherapy for late hematologic relapse of childhood acute lymphoblastic leukemia
    • Rivera, G. K., Hudson, M. M., Liu, Q., et al. Effectiveness of intensified rotational combination chemotherapy for late hematologic relapse of childhood acute lymphoblastic leukemia. Blood, 1996; 88: 831-7.
    • (1996) Blood , vol.88 , pp. 831-837
    • Rivera, G.K.1    Hudson, M.M.2    Liu, Q.3
  • 184
    • 0030462907 scopus 로고    scopus 로고
    • Etoposide for the treatment of paediatric tumours: What is the best way to give it?
    • Lowis, S. P. & Newell, D. R. Etoposide for the treatment of paediatric tumours: what is the best way to give it? Eur J Cancer, 1996; 32A: 2291-7.
    • (1996) Eur J Cancer , vol.32 A , pp. 2291-2297
    • Lowis, S.P.1    Newell, D.R.2
  • 185
    • 0023235581 scopus 로고
    • The clinical pharmacology of etoposide and teniposide
    • Clark, P. I. & Slevin, M. L. The clinical pharmacology of etoposide and teniposide. Clin Pharmacokinet, 1987; 12: 223-52.
    • (1987) Clin Pharmacokinet , vol.12 , pp. 223-252
    • Clark, P.I.1    Slevin, M.L.2
  • 186
    • 0028009274 scopus 로고
    • O-Demethylation of epipodophyllotoxins is catalyzed by human cytochrome P450 3A4
    • Relling, M. V., Nemec, J., Schuetz, E. G., et al. O-Demethylation of epipodophyllotoxins is catalyzed by human cytochrome P450 3A4. Mol Pharmacol, 1994; 45: 352-8.
    • (1994) Mol Pharmacol , vol.45 , pp. 352-358
    • Relling, M.V.1    Nemec, J.2    Schuetz, E.G.3
  • 187
    • 0026635651 scopus 로고
    • Human cytochrome P450 metabolism of teniposide and etoposide
    • Relling, M. V., Evans, R., Dass, C., et al. Human cytochrome P450 metabolism of teniposide and etoposide. J Pharmacol Exp Ther, 1992; 261: 491-6.
    • (1992) J Pharmacol Exp Ther , vol.261 , pp. 491-496
    • Relling, M.V.1    Evans, R.2    Dass, C.3
  • 188
    • 0027313395 scopus 로고
    • In vivo accumulation of etoposide in peripheral leukemic cells in patients treated for acute myeloblastic leukemia; relation to plasma concentrations and protein binding
    • Liliemark, E. K., Liliemark, J., Pettersson, B., et al. In vivo accumulation of etoposide in peripheral leukemic cells in patients treated for acute myeloblastic leukemia; relation to plasma concentrations and protein binding. Leuk Lymphoma, 1993; 10: 323-8.
    • (1993) Leuk Lymphoma , vol.10 , pp. 323-328
    • Liliemark, E.K.1    Liliemark, J.2    Pettersson, B.3
  • 189
    • 0030040519 scopus 로고    scopus 로고
    • Etoposide achieves potentially cytotoxic concentrations in CSF of children with acute lymphoblastic leukemia
    • Relling, M. V., Mahmoud, H. H., Pui, C.-H., et al. Etoposide achieves potentially cytotoxic concentrations in CSF of children with acute lymphoblastic leukemia. J Clin Oncol, 1996; 14: 399-404.
    • (1996) J Clin Oncol , vol.14 , pp. 399-404
    • Relling, M.V.1    Mahmoud, H.H.2    Pui, C.-H.3
  • 190
    • 0026530878 scopus 로고
    • Intrathecal administration of etoposide in the treatment of malignant meningitis: Feasibility and pharmacokinetic data
    • Gaast, A. van der, Sonneveld, P., Mans, D. R. A., et al. Intrathecal administration of etoposide in the treatment of malignant meningitis: feasibility and pharmacokinetic data. Cancer Chemother Pharmacol, 1992; 29: 335-7.
    • (1992) Cancer Chemother Pharmacol , vol.29 , pp. 335-337
    • Gaast, A.1    van der Sonneveld, P.2    Mans, D.R.A.3
  • 191
    • 0025744506 scopus 로고
    • Pharmacologically based dosing of etoposide: A means of safely increasing dose intensity
    • Ratain, M. J., Mick, R., Schilsky, R. L., et al. Pharmacologically based dosing of etoposide: a means of safely increasing dose intensity. J Clin Oncol, 1991; 9: 1480-6.
    • (1991) J Clin Oncol , vol.9 , pp. 1480-1486
    • Ratain, M.J.1    Mick, R.2    Schilsky, R.L.3
  • 192
    • 0028924457 scopus 로고
    • A population model for the leukopenic effect of etoposide
    • Karlsson, M. O., Port, R. E., Ratain, M. J., et al. A population model for the leukopenic effect of etoposide. Clin Pharmacol Ther, 1995; 57: 325-34.
    • (1995) Clin Pharmacol Ther , vol.57 , pp. 325-334
    • Karlsson, M.O.1    Port, R.E.2    Ratain, M.J.3
  • 193
    • 0028277792 scopus 로고
    • A randomized trial of two etoposide schedules in small-cell lung cancer: The influence of pharmacokineticsonefficacyandtoxicity
    • Clark, P. I., Slevin, M. L., Joel, S. P., et al. A randomized trial of two etoposide schedules in small-cell lung cancer: the influence of pharmacokineticsonefficacyandtoxicity. J Clin Oncol, 1994; 12: 1427-35.
    • (1994) J Clin Oncol , vol.12 , pp. 1427-1435
    • Clark, P.I.1    Slevin, M.L.2    Joel, S.P.3
  • 194
    • 0027987499 scopus 로고
    • Etoposide pharmacokinetics and pharmacodynamics after acute and chronic exposure to cisplatin
    • Relling, M. V., McLeod, H., Bowman, L., et al. Etoposide pharmacokinetics and pharmacodynamics after acute and chronic exposure to cisplatin. Clin Pharmacol Ther, 1994; 56: 503-11.
    • (1994) Clin Pharmacol Ther , vol.56 , pp. 503-511
    • Relling, M.V.1    McLeod, H.2    Bowman, L.3
  • 195
    • 0026095978 scopus 로고
    • Relation of systemic exposure to unbound etoposide and hematologic toxicity
    • Stewart, C. F., Arbuck, S. G., Fleming, R. A., et al.Relation of systemic exposure to unbound etoposide and hematologic toxicity. Clin Pharmacol Ther, 1991; 50: 385-93.
    • (1991) Clin Pharmacol Ther , vol.50 , pp. 385-393
    • Stewart, C.F.1    Arbuck, S.G.2    Fleming, R.A.3
  • 196
    • 0024589605 scopus 로고
    • Adaptive control of etoposide administration: Impact of interpatient pharmacodynamic variability
    • Ratain, M. J., Schilsky, R. L., Choi, K. E., et al. Adaptive control of etoposide administration: impact of interpatient pharmacodynamic variability. Clin Pharmacol Ther, 1989; 45: 226-33.
    • (1989) Clin Pharmacol Ther , vol.45 , pp. 226-233
    • Ratain, M.J.1    Schilsky, R.L.2    Choi, K.E.3
  • 197
    • 0029092171 scopus 로고
    • Pharmacokinetics and pharmacodynamics of 21 day continuous oral etoposide in pediatric solid tumor patients
    • Sonnichsen, D. S., Ribeiro, R. C., Luo, X., et al. Pharmacokinetics and pharmacodynamics of 21 day continuous oral etoposide in pediatric solid tumor patients. Clin Pharmacol Ther, 1995; 58: 99-107.
    • (1995) Clin Pharmacol Ther , vol.58 , pp. 99-107
    • Sonnichsen, D.S.1    Ribeiro, R.C.2    Luo, X.3
  • 198
    • 0026501704 scopus 로고
    • Differences in teniposide disposition and pharmacodynamics in patients with newly diagnosed versus relapsed acute lymphocytic leukemia
    • Evans, W. E., Rodman, J. H., Relling, M. V., et al. Differences in teniposide disposition and pharmacodynamics in patients with newly diagnosed versus relapsed acute lymphocytic leukemia. J Pharmacol Exp Ther, 1992; 260: 71-7.
    • (1992) J Pharmacol Exp Ther , vol.260 , pp. 71-77
    • Evans, W.E.1    Rodman, J.H.2    Relling, M.V.3
  • 199
    • 0026850273 scopus 로고
    • Clinical pharmacology and schedule dependency of the podophyllotoxin derivatives
    • Clark, P. I. Clinical pharmacology and schedule dependency of the podophyllotoxin derivatives. Semin Oncol, 1992; 19: 20-7.
    • (1992) Semin Oncol , vol.19 , pp. 20-27
    • Clark, P.I.1
  • 200
    • 0028063076 scopus 로고
    • Altered etoposide pharmacokinetics and time to engraftment in pediatric patients undergoing autologous bone marrow transplantation
    • Rodman, J. H., Murry, D. J., Madden, T., et al. Altered etoposide pharmacokinetics and time to engraftment in pediatric patients undergoing autologous bone marrow transplantation. J Clin Oncol, 1994; 12: 2390-7.
    • (1994) J Clin Oncol , vol.12 , pp. 2390-2397
    • Rodman, J.H.1    Murry, D.J.2    Madden, T.3
  • 201
    • 0038175325 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of oral etoposide in children with relapsed or refractory acute lymphoblastic leukemia
    • Edick, M. J., Gajjar, A., Mahmoud, H., et al. Pharmacokinetics and pharmacodynamics of oral etoposide in children with relapsed or refractory acute lymphoblastic leukemia. J Clin Oncol, 2003; 21: 1340-6.
    • (2003) J Clin Oncol , vol.21 , pp. 1340-1346
    • Edick, M.J.1    Gajjar, A.2    Mahmoud, H.3
  • 202
    • 0025983733 scopus 로고
    • Somnolence, hypotension, andmetabolic acidosis followinghigh-doseteniposidetreatmentin childrenwithleukemia
    • McLeod, H. L., Baker, D. K., Jr., Pui, C.-H., et al. Somnolence, hypotension, andmetabolic acidosis followinghigh-doseteniposidetreatmentin childrenwithleukemia. Cancer Chemother Pharmacol, 1991; 29: 150-4.
    • (1991) Cancer Chemother Pharmacol , vol.29 , pp. 150-154
    • McLeod, H.L.1    Baker, D.K.2    Pui, C.-H.3
  • 203
    • 0023607601 scopus 로고
    • Clinical pharmacodynamics of continuous infusion teniposide: Systemic exposure as a determinant of response in a Phase I trial
    • Rodman, J. H., Abromowitch, M., Sinkule, J. A., et al. Clinical pharmacodynamics of continuous infusion teniposide: systemic exposure as a determinant of response in a Phase I trial. J Clin Oncol, 1987; 5: 1007-14.
    • (1987) J Clin Oncol , vol.5 , pp. 1007-1014
    • Rodman, J.H.1    Abromowitch, M.2    Sinkule, J.A.3
  • 204
    • 0035281735 scopus 로고    scopus 로고
    • Glutathione S-transferase polymorphisms and outcome of chemotherapy in childhood acute myeloid leukemia
    • Davies, S. M., Robison, L. L., Buckley, J. D., et al. Glutathione S-transferase polymorphisms and outcome of chemotherapy in childhood acute myeloid leukemia. J Clin Oncol, 2001; 19: 1279-87.
    • (2001) J Clin Oncol , vol.19 , pp. 1279-1287
    • Davies, S.M.1    Robison, L.L.2    Buckley, J.D.3
  • 205
    • 0029054495 scopus 로고
    • Pharmacokinetics of all-trans-retinoic acid administered on an intermittent schedule
    • Adamson, P. C., Bailey, J., Pluda, J., et al. Pharmacokinetics of all-trans-retinoic acid administered on an intermittent schedule. J Clin Oncol, 1995; 13: 1238-41.
    • (1995) J Clin Oncol , vol.13 , pp. 1238-1241
    • Adamson, P.C.1    Bailey, J.2    Pluda, J.3
  • 206
    • 0027405942 scopus 로고
    • Time course of induction of metabolism of all-trans-retinoic acid and the up-regulation of cellular retinoic acid-binding protein
    • Adamson, P. C., Boylan, J. F., Balis, F. M., et al. Time course of induction of metabolism of all-trans-retinoic acid and the up-regulation of cellular retinoic acid-binding protein. Cancer Res, 1993; 53: 472-6.
    • (1993) Cancer Res , vol.53 , pp. 472-476
    • Adamson, P.C.1    Boylan, J.F.2    Balis, F.M.3
  • 207
    • 0027462860 scopus 로고
    • Lipid hydroperoxides greatly increase the rate of oxidative catabolism of all-trans-retinoic acid by human cell culture microsomes genetically enriched in specified cytochrome P-450 isoforms
    • Muindi, J. F. & Young, C. W. Lipid hydroperoxides greatly increase the rate of oxidative catabolism of all-trans-retinoic acid by human cell culture microsomes genetically enriched in specified cytochrome P-450 isoforms. Can Res, 1993; 53: 1226-9.
    • (1993) Can Res , vol.53 , pp. 1226-1229
    • Muindi, J.F.1    Young, C.W.2
  • 208
    • 0028922231 scopus 로고
    • Pharmacokinetics of all-trans retinoic acid in pediatric patients with leukemia
    • Takitani, K., Tamai, H., Morinobu, T., et al. Pharmacokinetics of all-trans retinoic acid in pediatric patients with leukemia. Jpn J Cancer Res, 1995; 86: 400-5.
    • (1995) Jpn J Cancer Res , vol.86 , pp. 400-405
    • Takitani, K.1    Tamai, H.2    Morinobu, T.3
  • 209
    • 0030678635 scopus 로고    scopus 로고
    • Phase I trial and pharmacokinetic study of all-trans-retinoic acid administeredonanintermittentscheduleincombinationwith interferon-alpha2a in pediatric patients with refractory cancer
    • Adamson, P. C., Reaman, G., Finklestein, J. Z., et al. Phase I trial and pharmacokinetic study of all-trans-retinoic acid administeredonanintermittentscheduleincombinationwith interferon-alpha2a in pediatric patients with refractory cancer. J Clin Oncol, 1997; 15: 3330-7.
    • (1997) J Clin Oncol , vol.15 , pp. 3330-3337
    • Adamson, P.C.1    Reaman, G.2    Finklestein, J.Z.3
  • 210
    • 0029151010 scopus 로고
    • All-trans retinoic acid pharmacokinetics and bioavailability in acute promyelocytic leukemia: Intracellular concentrations and biologic response relationship
    • Agadir, A., Cornic, M., Lefebvre, P., et al. All-trans retinoic acid pharmacokinetics and bioavailability in acute promyelocytic leukemia: intracellular concentrations and biologic response relationship. J Clin Oncol, 1995; 13: 2517-23.
    • (1995) J Clin Oncol , vol.13 , pp. 2517-2523
    • Agadir, A.1    Cornic, M.2    Lefebvre, P.3
  • 211
    • 0031027323 scopus 로고    scopus 로고
    • Phase I clinical trial of all-trans-retinoic acid with correlation of its pharmacokinetics and pharmacodynamics
    • Conley, B. A., Egorin, M. J., Sridhara, R., et al. Phase I clinical trial of all-trans-retinoic acid with correlation of its pharmacokinetics and pharmacodynamics. Cancer Chemother Pharmacol, 1997; 39: 291-9.
    • (1997) Cancer Chemother Pharmacol , vol.39 , pp. 291-299
    • Conley, B.A.1    Egorin, M.J.2    Sridhara, R.3
  • 212
    • 0017662049 scopus 로고
    • Optimal use of L-asparaginase (NSC-109229) in acute lymphocytic leukemia
    • Jones, B., Holland, J. F., Glidewell, O., et al. Optimal use of L-asparaginase (NSC-109229) in acute lymphocytic leukemia. Med Pediatr Oncol, 1977; 3: 387-400.
    • (1977) Med Pediatr Oncol , vol.3 , pp. 387-400
    • Jones, B.1    Holland, J.F.2    Glidewell, O.3
  • 213
    • 0015074696 scopus 로고
    • L-asparaginase: Clinical, biochemical, pharmacological, and immunological studies
    • Capizzi, R. L., Bertino, J. R., Skeel, R. T., et al. L-asparaginase: clinical, biochemical, pharmacological, and immunological studies. Ann Intern Med, 1971; 74: 893-901.
    • (1971) Ann Intern Med , vol.74 , pp. 893-901
    • Capizzi, R.L.1    Bertino, J.R.2    Skeel, R.T.3
  • 214
    • 0014851427 scopus 로고
    • Biochemical and pharmacological studies with asparaginase in man
    • Ohnuma, T., Holland, J. F., Freeman, A., et al. Biochemical and pharmacological studies with asparaginase in man. Cancer Res, 1970; 30: 2297-305.
    • (1970) Cancer Res , vol.30 , pp. 2297-2305
    • Ohnuma, T.1    Holland, J.F.2    Freeman, A.3
  • 215
    • 0014735839 scopus 로고
    • L-Asparaginase activity in plasma and other biological fluids
    • Schwartz, M.K., Lash, E.D., Oettgen, H.F., et al. L-Asparaginase activity in plasma and other biological fluids. Cancer, 1970; 25: 244-52.
    • (1970) Cancer , vol.25 , pp. 244-252
    • Schwartz, M.K.1    Lash, E.D.2    Oettgen, H.F.3
  • 216
    • 0014787055 scopus 로고
    • Clinical pharmacologic studies of L-asparaginase
    • Ho, D. H., Thetford, B., Carter, C. J., et al. Clinical pharmacologic studies of L-asparaginase. Clin Pharmacol Ther, 1970; 11: 408-17.
    • (1970) Clin Pharmacol Ther , vol.11 , pp. 408-417
    • Ho, D.H.1    Thetford, B.2    Carter, C.J.3
  • 217
    • 0027197614 scopus 로고
    • Comparative pharmacokinetic studies of three asparaginase preparations
    • Asselin, B. L., Whitin, J. C., Coppola, D. J., et al. Comparative pharmacokinetic studies of three asparaginase preparations. J Clin Oncol, 1993; 11: 1780-6.
    • (1993) J Clin Oncol , vol.11 , pp. 1780-1786
    • Asselin, B.L.1    Whitin, J.C.2    Coppola, D.J.3
  • 218
    • 0037085747 scopus 로고    scopus 로고
    • A randomized comparison of native Escherichia coli asparaginase and polyethylene glycol conjugated asparaginase for treatment of children with newly diagnosed standard-risk acute lymphoblastic leukemia: A Children's Cancer Group study
    • Avramis, V. I., Sencer, S., Periclou, A. P., et al. A randomized comparison of native Escherichia coli asparaginase and polyethylene glycol conjugated asparaginase for treatment of children with newly diagnosed standard-risk acute lymphoblastic leukemia: a Children's Cancer Group study. Blood, 2002; 99: 1986-94.
    • (2002) Blood , vol.99 , pp. 1986-1994
    • Avramis, V.I.1    Sencer, S.2    Periclou, A.P.3
  • 219
    • 0035283163 scopus 로고    scopus 로고
    • Improved outcome for children with acute lymphoblastic leukemia: Results of Dana-Farber Consortium Protocol 91-01
    • Silverman, L.B., Gelber, R.D., Dalton, V. K., et al.Improved outcome for children with acute lymphoblastic leukemia: results of Dana-Farber Consortium Protocol 91-01. Blood, 2001; 97: 1211-18.
    • (2001) Blood , vol.97 , pp. 1211-1218
    • Silverman, L.B.1    Gelber, R.D.2    Dalton, V.K.3
  • 221
    • 0017253880 scopus 로고
    • Hypersensitive reactions and antibody formation during L-asparaginase treatment of children and adults with acute leukemia
    • Killander, D., Dohlwitz, A., Engstedt, L., et al. Hypersensitive reactions and antibody formation during L-asparaginase treatment of children and adults with acute leukemia. Cancer, 1976; 37: 220-8.
    • (1976) Cancer , vol.37 , pp. 220-228
    • Killander, D.1    Dohlwitz, A.2    Engstedt, L.3
  • 222
    • 0031681258 scopus 로고    scopus 로고
    • Anti-asparaginase antibodies following E. coli asparaginase therapy in pediatric acute lymphoblastic leukemia
    • Woo, M. H., Hak, L. J., Storm, M. C., et al. Anti-asparaginase antibodies following E. coli asparaginase therapy in pediatric acute lymphoblastic leukemia. Leukemia, 1998; 12: 1527-33.
    • (1998) Leukemia , vol.12 , pp. 1527-1533
    • Woo, M.H.1    Hak, L.J.2    Storm, M.C.3
  • 223
    • 0034284267 scopus 로고    scopus 로고
    • Weekly polyethylene glycol conjugated L-asparaginase compared with biweekly dosing produces superior induction remission rates in childhood relapsed acute lymphoblastic leukemia: A Pediatric Oncology Group Study
    • Abshire, T. C., Pollock, B. H., Billett, A. L., et al. Weekly polyethylene glycol conjugated L-asparaginase compared with biweekly dosing produces superior induction remission rates in childhood relapsed acute lymphoblastic leukemia: a Pediatric Oncology Group Study. Blood, 2000; 96: 1709-15.
    • (2000) Blood , vol.96 , pp. 1709-1715
    • Abshire, T.C.1    Pollock, B.H.2    Billett, A.L.3
  • 224
    • 0028217495 scopus 로고
    • Determination of L-asparagine in biological samples in the presence of Lasparaginase
    • Gentili, D., Zucchetti, M., Conter, V., et al. Determination of L-asparagine in biological samples in the presence of Lasparaginase. J Chromatogr Biomed Appl, 1994; 657: 47-52.
    • (1994) J Chromatogr Biomed Appl , vol.657 , pp. 47-52
    • Gentili, D.1    Zucchetti, M.2    Conter, V.3
  • 225
    • 0034117076 scopus 로고    scopus 로고
    • Hypersensitivity or development of antibodies to asparaginase does not impact treatment outcome of childhood acute lymphoblastic leukemia
    • Woo, M. H., Hak, L. J., Storm, M. C., et al. Hypersensitivity or development of antibodies to asparaginase does not impact treatment outcome of childhood acute lymphoblastic leukemia. J Clin Oncol, 2000; 18: 1525-32.
    • (2000) J Clin Oncol , vol.18 , pp. 1525-1532
    • Woo, M.H.1    Hak, L.J.2    Storm, M.C.3
  • 226
    • 2942677283 scopus 로고    scopus 로고
    • Asparaginase pharmacodynamics differ by formulation among children with newly diagnosed acute lymphoblastic leukemia
    • Hak, L. J., Relling, M. V., Cheng, C., et al. Asparaginase pharmacodynamics differ by formulation among children with newly diagnosed acute lymphoblastic leukemia. Leukemia, 2004; 18: 1072-7.
    • (2004) Leukemia , vol.18 , pp. 1072-1077
    • Hak, L.J.1    Relling, M.V.2    Cheng, C.3
  • 227
    • 0032945308 scopus 로고    scopus 로고
    • Cerebrospinal fluid asparagine concentrations after Escherichia coli asparaginase in children with acute lymphoblastic leukemia
    • Woo, M. H., Hak, L. J., Storm, M. C., et al. Cerebrospinal fluid asparagine concentrations after Escherichia coli asparaginase in children with acute lymphoblastic leukemia. J Clin Oncol, 1999; 17: 1568-73.
    • (1999) J Clin Oncol , vol.17 , pp. 1568-1573
    • Woo, M.H.1    Hak, L.J.2    Storm, M.C.3
  • 228
    • 0031049365 scopus 로고    scopus 로고
    • Dose reduction of asparaginase under pharmacokinetic and pharmacodynamic control during induction therapy in children with acute lymphoblastic leukemia
    • Ahlke, E., Nowak-Gottl, U., Schulze-Westhoff, P., et al. Dose reduction of asparaginase under pharmacokinetic and pharmacodynamic control during induction therapy in children with acute lymphoblastic leukemia. Br J Haematol, 1997; 96: 675-81.
    • (1997) Br J Haematol , vol.96 , pp. 675-681
    • Ahlke, E.1    Nowak-Gottl, U.2    Schulze-Westhoff, P.3
  • 229
    • 0020080462 scopus 로고
    • Scheduledependent synergy and antagonism between high-dose 1-_-D-arabinofuranosylcytosine and asparaginase in the L5178Y murine leukemia
    • Schwartz, S. A., Morgenstern, B., & Capizzi, R. L. Scheduledependent synergy and antagonism between high-dose 1-_-D-arabinofuranosylcytosine and asparaginase in the L5178Y murine leukemia. Cancer Res, 1982; 42: 2191-7.
    • (1982) Cancer Res , vol.42 , pp. 2191-2197
    • Schwartz, S.A.1    Morgenstern, B.2    Capizzi, R.L.3
  • 230
    • 0022007010 scopus 로고
    • Prevention of methotrexate cytotoxicity by asparaginase inhibition of methotrexate polyglutamate formation
    • Jolivet, J., Cole, D. E., Holcenberg, J. S., et al. Prevention of methotrexate cytotoxicity by asparaginase inhibition of methotrexate polyglutamate formation. Cancer Res, 1985; 45: 217-20.
    • (1985) Cancer Res , vol.45 , pp. 217-220
    • Jolivet, J.1    Cole, D.E.2    Holcenberg, J.S.3
  • 231
    • 0023267466 scopus 로고
    • Adult acute lymphoblastic leukaemia: Is cell proliferation related to other clinical and biological features?
    • French, M., Manel, A. M., Magaud, J. P., et al. Adult acute lymphoblastic leukaemia: is cell proliferation related to other clinical and biological features? Br J Haematol, 1987; 65: 419-23.
    • (1987) Br J Haematol , vol.65 , pp. 419-423
    • French, M.1    Manel, A.M.2    Magaud, J.P.3
  • 232
    • 0023144537 scopus 로고
    • L-asparaginaseinduced modulation of methotrexate polyglutamylation in murine leukemia L5178Y1
    • Sur, P., Fernandes, D. J., Kute, T. E., et al. L-asparaginaseinduced modulation of methotrexate polyglutamylation in murine leukemia L5178Y1. Cancer Res, 1987; 47: 1313-18.
    • (1987) Cancer Res , vol.47 , pp. 1313-1318
    • Sur, P.1    Fernandes, D.J.2    Kute, T.E.3
  • 233
    • 0032973925 scopus 로고    scopus 로고
    • Intensive highdose asparaginase consolidation improves survival for pediatric patients with T cell acute lymphoblastic leukemia and advanced stage lymphoblastic lymphoma: A Pediatric Oncology Group study
    • Amylon, M. D., Shuster, J., Pullen, J., et al. Intensive highdose asparaginase consolidation improves survival for pediatric patients with T cell acute lymphoblastic leukemia and advanced stage lymphoblastic lymphoma: a Pediatric Oncology Group study. Leukemia, 1999; 13: 335-42.
    • (1999) Leukemia , vol.13 , pp. 335-342
    • Amylon, M.D.1    Shuster, J.2    Pullen, J.3
  • 234
    • 0028973397 scopus 로고
    • L-asparaginase may potentiate the leukemogenic effect of the epipodophyllotoxins
    • Pui, C. H., Relling, M. V., Behm, F. G., et al. L-asparaginase may potentiate the leukemogenic effect of the epipodophyllotoxins. Leukemia, 1995; 9: 1680-4.
    • (1995) Leukemia , vol.9 , pp. 1680-1684
    • Pui, C.H.1    Relling, M.V.2    Behm, F.G.3
  • 235
    • 0029960017 scopus 로고    scopus 로고
    • High cure rate with a moderately intensive treatment regimen in nonhigh-risk childhood acute lymphoblastic leukemia: Results of protocol ALL VI from the Dutch Childhood Leukemia Study Group
    • Veerman, A. J. P., Hahlen, K., Kamps, W. A., et al. High cure rate with a moderately intensive treatment regimen in nonhigh-risk childhood acute lymphoblastic leukemia: results of protocol ALL VI from the Dutch Childhood Leukemia Study Group. J Clin Oncol, 1996; 14: 911-18.
    • (1996) J Clin Oncol , vol.14 , pp. 911-918
    • Veerman, A.J.P.1    Hahlen, K.2    Kamps, W.A.3
  • 236
    • 0035865159 scopus 로고    scopus 로고
    • Improved response with higher corticosteroid dose in childrenwithacutelymphoblasticleukemia
    • Schwartz, C. L., Thompson, E. B., Gelber, R. D., et al. Improved response with higher corticosteroid dose in childrenwithacutelymphoblasticleukemia. J Clin Oncol, 2001;19: 1040-6.
    • (2001) J Clin Oncol , vol.19 , pp. 1040-1046
    • Schwartz, C.L.1    Thompson, E.B.2    Gelber, R.D.3
  • 237
    • 0029836218 scopus 로고    scopus 로고
    • Comparative cytotoxicity of dexamethasone and prednisolone in childhood acute lymphoblastic leukemia
    • Ito, C., Evans, W. E., McNinch, L., et al. Comparative cytotoxicity of dexamethasone and prednisolone in childhood acute lymphoblastic leukemia. J Clin Oncol, 1996; 14: 2370-6.
    • (1996) J Clin Oncol , vol.14 , pp. 2370-2376
    • Ito, C.1    Evans, W.E.2    McNinch, L.3
  • 238
    • 0029952309 scopus 로고    scopus 로고
    • Comparison of the antileukemic activity in vitro of dexamethasone and prednisolone in childhood acute lymphoblastic leukemia
    • Kaspers, G. J. L., Veerman, A. J. P., Pop-Snijders, C., et al. Comparison of the antileukemic activity in vitro of dexamethasone and prednisolone in childhood acute lymphoblastic leukemia. Med Pediatr Oncol, 1996; 27: 114-21.
    • (1996) Med Pediatr Oncol , vol.27 , pp. 114-121
    • Kaspers, G.J.L.1    Veerman, A.J.P.2    Pop-Snijders, C.3
  • 239
    • 0034525989 scopus 로고    scopus 로고
    • Children's Cancer Group trials in childhood acute lymphoblastic leukemia: 1983-1995
    • Gaynon, P. S., Trigg, M. E., Heerema, N. A., et al. Children's Cancer Group trials in childhood acute lymphoblastic leukemia: 1983-1995. Leukemia, 2000; 14: 2223-33.
    • (2000) Leukemia , vol.14 , pp. 2223-2233
    • Gaynon, P.S.1    Trigg, M.E.2    Heerema, N.A.3
  • 240
    • 0035300619 scopus 로고    scopus 로고
    • Duration of hospitalization as a measure of cost on Children's Cancer Group acute lymphoblastic leukemia studies
    • Gaynon, P. S., Bostrom, B. C., Hutchinson, R. J., et al. Duration of hospitalization as a measure of cost on Children's Cancer Group acute lymphoblastic leukemia studies. J Clin Oncol, 2001; 19: 1916-25.
    • (2001) J Clin Oncol , vol.19 , pp. 1916-1925
    • Gaynon, P.S.1    Bostrom, B.C.2    Hutchinson, R.J.3
  • 241
    • 0025739294 scopus 로고
    • Lower incidence of meningeal leukemia when prednisone is replaced by dexamethasone in the treatment of acute lymphocytic leukemia
    • Jones, B., Freeman, A. I., Shuster, J. J., et al. Lower incidence of meningeal leukemia when prednisone is replaced by dexamethasone in the treatment of acute lymphocytic leukemia. Med Pediatr Oncol, 1991; 19: 269-75.
    • (1991) Med Pediatr Oncol , vol.19 , pp. 269-275
    • Jones, B.1    Freeman, A.I.2    Shuster, J.J.3
  • 242
    • 0017686297 scopus 로고
    • Potency and duration of action of glucocorticoids. Effects of hydrocortisone, prednisone and dexamethasone on human pituitary-adrenal function
    • Meikle, A. W. & Tyler, F. H. Potency and duration of action of glucocorticoids. Effects of hydrocortisone, prednisone and dexamethasone on human pituitary-adrenal function. Am J Med, 1977; 63: 200-7.
    • (1977) Am J Med , vol.63 , pp. 200-207
    • Meikle, A.W.1    Tyler, F.H.2
  • 243
    • 0034655211 scopus 로고    scopus 로고
    • Substituting dexamethasone for prednisone complicates remission inductionin childrenwithacutelymphoblasticleukemia
    • Hurwitz, C. A., Silverman, L. B., Schorin, M. A., et al. Substituting dexamethasone for prednisone complicates remission inductionin childrenwithacutelymphoblasticleukemia. Cancer, 2000; 88: 1964-9.
    • (2000) Cancer , vol.88 , pp. 1964-1969
    • Hurwitz, C.A.1    Silverman, L.B.2    Schorin, M.A.3
  • 244
    • 0027513201 scopus 로고
    • Metabolism of prednisone in kidney transplanted patients with necrosis of the femoral head
    • Lausten, G. S., Egfjord, M., & Olgaard, K. Metabolism of prednisone in kidney transplanted patients with necrosis of the femoral head. Pharmacol Toxicol, 1993; 72: 78-83.
    • (1993) Pharmacol Toxicol , vol.72 , pp. 78-83
    • Lausten, G.S.1    Egfjord, M.2    Olgaard, K.3
  • 245
    • 0034666338 scopus 로고    scopus 로고
    • Osteonecrosis as a complication of treating acute lymphoblastic leukemia in children: A report from the Children's Cancer Group
    • Mattano, L. A., Jr., Sather, H.N., Trigg, M.E., et al.Osteonecrosis as a complication of treating acute lymphoblastic leukemia in children: a report from the Children's Cancer Group. J Clin Oncol, 2000; 18: 3262-72.
    • (2000) J Clin Oncol , vol.18 , pp. 3262-3272
    • Mattano, L.A.1    Sather, H.N.2    Trigg, M.E.3
  • 246
    • 0026026319 scopus 로고
    • Point mutation causing a single amino acid substitution in the hormonebinding domain of the glucocorticoid receptor in familial glucocorticoid resistance
    • Hurley, D. M., Accili, D., Stratakis, C. A., et al. Point mutation causing a single amino acid substitution in the hormonebinding domain of the glucocorticoid receptor in familial glucocorticoid resistance. J Clin Invest, 1991; 87: 680-6.
    • (1991) J Clin Invest , vol.87 , pp. 680-686
    • Hurley, D.M.1    Accili, D.2    Stratakis, C.A.3
  • 247
    • 0026615126 scopus 로고
    • An association between a Bc1I restriction fragment length polymorphism of the glucocorticoid receptor locus and hyperinsulinaemia in obese women
    • Weaver, J. U., Hitman, G. A., Kopelman, P. G. An association between a Bc1I restriction fragment length polymorphism of the glucocorticoid receptor locus and hyperinsulinaemia in obese women. J Mol Endocrinol, 1992; 9: 295-300.
    • (1992) J Mol Endocrinol , vol.9 , pp. 295-300
    • Weaver, J.U.1    Hitman, G.A.2    Kopelman, P.G.3
  • 248
    • 0036789254 scopus 로고    scopus 로고
    • A polymorphism in the glucocorticoid receptor gene, which decreases sensitivity to glucocorticoids in vivo, is associated with low insulin and cholesterol levels
    • Rossum, E. F. van, Koper, J. W., Huizenga, N. A., et al. A polymorphism in the glucocorticoid receptor gene, which decreases sensitivity to glucocorticoids in vivo, is associated with low insulin and cholesterol levels. Diabetes, 2002; 51: 3128-34.
    • (2002) Diabetes , vol.51 , pp. 3128-3134
    • Rossum van, E.F.1    Koper, J.W.2    Huizenga, N.A.3
  • 250
    • 0037268987 scopus 로고    scopus 로고
    • Molecular determinants of glucocorticoid sensitivity and resistance in acute lymphoblastic leukemia
    • Tissing, W. J., Meijerink, J. P., Noer, M. L. den, & Pieters, R. Molecular determinants of glucocorticoid sensitivity and resistance in acute lymphoblastic leukemia. Leukemia, 2003; 17: 17-25.
    • (2003) Leukemia , vol.17 , pp. 17-25
    • Tissing, W.J.1    Meijerink, J.P.2    Noer den, M.L.3    Pieters, R.4
  • 251
    • 9144247069 scopus 로고    scopus 로고
    • Effects of prednisone and genetic polymorphisms on etoposide disposition in children with acute lymphoblastic leukemia
    • Kishi, S., Yang, W., Morand, S., et al. Effects of prednisone and genetic polymorphisms on etoposide disposition in children with acute lymphoblastic leukemia. Blood, 2004; 103: 67-72.
    • (2004) Blood , vol.103 , pp. 67-72
    • Kishi, S.1    Yang, W.2    Morand, S.3
  • 252
    • 0033645405 scopus 로고    scopus 로고
    • Polymorphisms within glutathione S-transferase genes and initial response to glucocorticoids in childhood acute lymphoblastic leukaemia
    • Anderer, G., Schrappe, M., Brechlin, A. M., et al. Polymorphisms within glutathione S-transferase genes and initial response to glucocorticoids in childhood acute lymphoblastic leukaemia. Pharmacogenetics, 2000; 10: 715-26.
    • (2000) Pharmacogenetics , vol.10 , pp. 715-726
    • Anderer, G.1    Schrappe, M.2    Brechlin, A.M.3
  • 254
    • 0028907999 scopus 로고
    • Vincristine disposition in children with acute lymphoblastic leukemia
    • de Graaf, S. S., Bloemhof, H., Vendrig, D. E., et al. Vincristine disposition in children with acute lymphoblastic leukemia. Med Pediatr Oncol, 1995; 24: 235-40.
    • (1995) Med Pediatr Oncol , vol.24 , pp. 235-240
    • de Graaf, S.S.1    Bloemhof, H.2    Vendrig, D.E.3
  • 256
    • 0036081539 scopus 로고    scopus 로고
    • Pharmacokinetics of vincristine monotherapy in childhood acute lymphoblastic leukemia
    • Groninger, E., Meeuwsen-De Boar, T., Koopmans, P., et al. Pharmacokinetics of vincristine monotherapy in childhood acute lymphoblastic leukemia. Pediatr Res, 2002; 52: 113-18.
    • (2002) Pediatr Res , vol.52 , pp. 113-118
    • Groninger, E.1    Meeuwsen-De Boar, T.2    Koopmans, P.3
  • 257
    • 0033398416 scopus 로고    scopus 로고
    • CytochromeP450-inducing antiepileptics increase the clearance of vincristine in patients with brain tumors
    • Villikka, K., Kivisto, K.T., Maenpaa, H., et al.CytochromeP450-inducing antiepileptics increase the clearance of vincristine in patients with brain tumors. Clin Pharmacol Ther, 1999; 66: 589-93.
    • (1999) Clin Pharmacol Ther , vol.66 , pp. 589-593
    • Villikka, K.1    Kivisto, K.T.2    Maenpaa, H.3
  • 258
    • 17944376229 scopus 로고    scopus 로고
    • Potentiation of vincristine toxicity by itraconazole in children with lymphoid malignancies
    • Kamaluddin, M., McNally, P., Breatnach, F., et al. Potentiation of vincristine toxicity by itraconazole in children with lymphoid malignancies. Acta Paediatr, 2001; 90: 1204-7.
    • (2001) Acta Paediatr , vol.90 , pp. 1204-1207
    • Kamaluddin, M.1    McNally, P.2    Breatnach, F.3
  • 259
    • 0036219998 scopus 로고    scopus 로고
    • Commonallelic variants of cytochrome P4503A4 and their prevalence in different populations
    • Lamba, J. K., Lin, Y. S., Thummel, K., et al. Commonallelic variants of cytochrome P4503A4 and their prevalence in different populations. Pharmacogenetics, 2002; 12: 121-32.
    • (2002) Pharmacogenetics , vol.12 , pp. 121-132
    • Lamba, J.K.1    Lin, Y.S.2    Thummel, K.3
  • 260
    • 0035071598 scopus 로고    scopus 로고
    • Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression
    • Kuehl, P., Zhang, J., Lin, Y., et al. Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression. Nat Genet, 2001; 27: 383-91.
    • (2001) Nat Genet , vol.27 , pp. 383-391
    • Kuehl, P.1    Zhang, J.2    Lin, Y.3
  • 261
    • 0034724324 scopus 로고    scopus 로고
    • Functional polymorphisms of the human multidrug-resistance gene: Multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo
    • Hoffmeyer, S., Burk, O., Richter, O. von, et al. Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo. Proc Natl Acad Sci U S A, 2000; 97: 3473-8.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 3473-3478
    • Hoffmeyer, S.1    Burk von, O.2    Richter, O.3
  • 263
    • 0028079883 scopus 로고
    • Pharmacokinetics of vincristine in children and adolescents with acute lymphocytic leukemia
    • Crom, W. R., de Graaf, S. S., Synold, T., et al. Pharmacokinetics of vincristine in children and adolescents with acute lymphocytic leukemia. J Pediatr, 1994; 125: 642-9.
    • (1994) J Pediatr , vol.125 , pp. 642-649
    • Crom, W.R.1    de Graaf, S.S.2    Synold, T.3
  • 264
    • 0019429771 scopus 로고
    • Life-threatening neuropathy and hepatotoxicity in infants during induction therapy for acute lymphoblastic leukemia
    • Woods, W. G., O'Leary, M., & Nesbit, M. E. Life-threatening neuropathy and hepatotoxicity in infants during induction therapy for acute lymphoblastic leukemia. J Pediatr, 1981; 98: 642-5.
    • (1981) J Pediatr , vol.98 , pp. 642-645
    • Woods, W.G.1    O'Leary, M.2    Nesbit, M.E.3
  • 265
    • 0021814622 scopus 로고
    • Comparative analysis of treatment programs for childhood acute lymphoblastic leukemia
    • Niemeyer, C. M., Hitchcock-Bryan, S., Sallan, S. E. Comparative analysis of treatment programs for childhood acute lymphoblastic leukemia. Semin Oncol, 1985; 12: 122-30.
    • (1985) Semin Oncol , vol.12 , pp. 122-130
    • Niemeyer, C.M.1    Hitchcock-Bryan, S.2    Sallan, S.E.3
  • 266
    • 0015012308 scopus 로고
    • Drug dosage and remission duration in childhood lymphocytic leukemia
    • Pinkel, D., Hernandez, K., Borella, L., et al. Drug dosage and remission duration in childhood lymphocytic leukemia. Cancer, 1971; 37: 247-56.
    • (1971) Cancer , vol.37 , pp. 247-256
    • Pinkel, D.1    Hernandez, K.2    Borella, L.3
  • 267
    • 0028152851 scopus 로고
    • Chemotherapy in 998 unselected childhood acute lymphoblastic leukemia patients. Results and conclusions of the multicenter trial ALLBFM 86
    • Reiter, A., Schrappe, M., Wolf-Dieter, L., et al. Chemotherapy in 998 unselected childhood acute lymphoblastic leukemia patients. Results and conclusions of the multicenter trial ALLBFM 86. Blood, 1994; 84: 3122-33.
    • (1994) Blood , vol.84 , pp. 3122-3133
    • Reiter, A.1    Schrappe, M.2    Wolf-Dieter, L.3
  • 268
    • 0028847796 scopus 로고
    • Ifosfamide: Should the honeymoon be over?
    • Kamen, B. A., Frenkel, E., & Colvin, O. M. Ifosfamide: should the honeymoon be over? J Clin Oncol, 1995; 13: 307-9.
    • (1995) J Clin Oncol , vol.13 , pp. 307-309
    • Kamen, B.A.1    Frenkel, E.2    Colvin, O.M.3
  • 269
    • 0030658755 scopus 로고    scopus 로고
    • Cyclophosphamide and ifosfamide metabolites in the cerebrospinal fluid of children
    • Yule, S. M., Price, L., Pearson, A. D., et al. Cyclophosphamide and ifosfamide metabolites in the cerebrospinal fluid of children. Clin Cancer Res, 1997; 3: 1985-92.
    • (1997) Clin Cancer Res , vol.3 , pp. 1985-1992
    • Yule, S.M.1    Price, L.2    Pearson, A.D.3
  • 270
    • 0026748897 scopus 로고
    • Cyclophosphamide pharmacokinetics: Correlation with cardiac toxicity and tumor response
    • Ayash, L. J., Wright, J. E., Tretyakov, O., et al.Cyclophosphamide pharmacokinetics: correlation with cardiac toxicity and tumor response. J Clin Oncol, 1992; 10: 995-1000.
    • (1992) J Clin Oncol , vol.10 , pp. 995-1000
    • Ayash, L.J.1    Wright, J.E.2    Tretyakov, O.3
  • 271
    • 0033951849 scopus 로고    scopus 로고
    • Role ofhumanlivermicrosomal CYP3A4 and CYP2B6 in catalyzing N-dechloroethylation of cyclophosphamide and ifosfamide
    • Huang, Z., Roy, P., &Waxman, D. J. Role ofhumanlivermicrosomal CYP3A4 and CYP2B6 in catalyzing N-dechloroethylation of cyclophosphamide and ifosfamide. Biochem Pharmacol, 2000; 59: 961-72.
    • (2000) Biochem Pharmacol , vol.59 , pp. 961-972
    • Huang, Z.1    Roy, P.2    Waxman, D.J.3
  • 272
    • 0034948077 scopus 로고    scopus 로고
    • Extensive genetic polymorphism in the human CYP2B6 gene with impact on expression and function inhumanliver
    • Lang, T., Klein, K., Fischer, J., et al. Extensive genetic polymorphism in the human CYP2B6 gene with impact on expression and function inhumanliver. Pharmacogenetics, 2001; 11: 399-415.
    • (2001) Pharmacogenetics , vol.11 , pp. 399-415
    • Lang, T.1    Klein, K.2    Fischer, J.3
  • 273
    • 0034667365 scopus 로고    scopus 로고
    • Association between survival after treatment for breast cancer and glutathione S-transferase P1Ile105Valpolymorphism
    • Sweeney, C., McClure, G. Y., Fares, M. Y., et al. Association between survival after treatment for breast cancer and glutathione S-transferase P1Ile105Valpolymorphism. Cancer Res, 2000; 60: 5621-4.
    • (2000) Cancer Res , vol.60 , pp. 5621-5624
    • Sweeney, C.1    McClure, G.Y.2    Fares, M.Y.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.