Potentiation of vincristine toxicity by itraconazole in children with lymphoid malignancies

Acta Paediatrica, International Journal of Paediatrics

Volumn 90, Issue 10, 2001, Pages 1204-1207

  Kamaluddin, M ^a   McNally, P ^a   Breatnach, F ^a   O'Marcaigh, A ^a   Webb, D ^a   O'Dell, E ^a   Scanlon, P ^a   Butler, K ^a   O'Meara, A ^a  

^a OUR LADY S CHILDREN S HOSPITAL   (Ireland)

Author keywords

ALL; Children; Itraconazole; Neurotoxicity; Vincristine

Indexed keywords

ASPARAGINASE; DAUNORUBICIN; ITRACONAZOLE; NIFEDIPINE; PREDNISOLONE; VINCRISTINE;

ACUTE LYMPHOBLASTIC LEUKEMIA; ANTIFUNGAL ACTIVITY; ARTICLE; BACKACHE; CHILD; CLINICAL ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; DEPRESSION; DISEASE COURSE; DRUG POTENTIATION; DRUG WITHDRAWAL; GAIT DISORDER; HODGKIN DISEASE; HUMAN; HYPERTENSION; HYPOREFLEXIA; INFECTION PREVENTION; IRRITABILITY; MUSCLE CRAMP; MUSCLE WEAKNESS; NEUROTOXICITY; PRIORITY JOURNAL; PTOSIS; SEIZURE; TREATMENT OUTCOME;

ADOLESCENT; ANTIFUNGAL AGENTS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CHILD; CHILD, PRESCHOOL; DRUG SYNERGISM; DRUG THERAPY, COMBINATION; HUMANS; ITRACONAZOLE; LEUKEMIA, LYMPHOCYTIC, ACUTE; LYMPHOMA, T-CELL; NEUROTOXICITY SYNDROMES; VINCRISTINE;

EID: 17944376229     PISSN: 08035253     EISSN: None     Source Type: Journal    
DOI: 10.1080/080352501317061675     Document Type: Article

References (16)

1. Fluconazole: An update of its pharmacodynamic and pharmacokinetic properties and therapeutic use in major superficial and systemic mycoses in immunocomprised patients
2. A randomised controlled trial of itraconazole versus fluconazole for the prevention of fungal infections in patients with haematological malignancies
3. Itraconazole oral solution as antifungal prophylaxis in children undergoing stem cell transplantation or intensive chemotherapy for haematological disorders
4. Radioimmunoassay of vinblastine and vincristine
5. Aggravation of vincristine induced neurotoxicity by itraconazole in the treatment of adult ALL
6. Severe vincristine toxicity in combination with itraconazole
7. Vincristine toxicity in five children with acute lymphoblastic leukemia
8. Itraconazole: A review of its pharmacodynamic and pharmacokinetic properties and therapeutic use in superficial and systemic mycoses
9. Adverse events associated with itraconazole in 189 patients on chronic therapy
10. The comparative clinical pharmacology and pharmacokinetics of vindesine, vincristine and vinblastine in human patients with cancer
11. Syndrome of recurrent increased secretion of antidiuretic hormone following multiple doses of vincristine
12. Mechanism of action of antifungal drugs with special reference to the imidazole derivatives
13. Pharmacokinetic drug interactions of vinca alkaloids: Summary of case reports
14. Pharmacokinetics of vincristine in cancer patients treated with nifedipine
15. P-glycoprotein mediated transport of itraconazole across the blood brain barrier