Human hepatocyte nuclear factor 4 isoforms are encoded by distinct and differentially expressed genes

Molecular and Cellular Biology

Volumn 16, Issue 3, 1996, Pages 925-931

  Drewes, Thorsten ^a   Senkel, Sabine ^a   Holewa, Beatrix ^a   Ryffel, Gerhart U ^a  

^a UNIVERSITY HOSPITAL ESSEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

NUCLEAR FACTOR;

ARTICLE; BINDING SITE; DNA BINDING; GENE EXPRESSION REGULATION; GENE ISOLATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PURIFICATION; TRANSCRIPTION REGULATION;

EID: 0030042979     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.16.3.925     Document Type: Article

References (28)

1. Avraham, K. B., V. R. Prezioso, W. S. Chen, E. Lai, F. M. Sladek, W. Zhong, J. E. Darnell, N. A. Jenkins, and N. G. Copeland. 1992. Murine chromosomal location of four hepatocyte-enriched transcription factors: HNF-3 alpha, HNF-3 beta, HNF-3 gamma, and HNF-4. Genomics 13:264-268.
2. Chartier, F. L., J. P. Bossu, V. Laudet, J. C. Fruchart, and B. Laine. 1994. Cloning and sequencing of cDNAs encoding the human hepatocyte nuclear factor 4 indicate the presence of two isoforms in human liver. Gene 147: 269-272.
3. Chen, W. S., K. Manova, D. C. Weinstein, S. A. Duncan, A. S. Plump, V. R. Prezioso, R. F. Bachvarova, and J. E. Darnell. 1994. Disruption of the HNF-4 gene, expressed in visceral endoderm, leads to cell death in embryonic ectoderm and impaired gastrulation of mouse embryos. Genes Dev. 8:2466-2477
4. Clairmont, A., T. Ebert, H. Weber, C. Zoidl, P. Eickelmann, W. A. Schulz, H. Sies, and G. U. Ryffel. 1994. Lowered amounts of the tissue-specific transcription factor LFB1 (HNF1) correlate with decreased levels of glutathione S-transferase alpha messenger RNA in human renal cell carcinoma. Cancer Res. 54:1319-1323.
5. Costa, R. H., D. R. Grayson, and J. E. Darnell, Jr. 1989. Multiple hepatocyte-enriched nuclear factors function in the regulation of transthyretin and α1-antitrypsin genes. Mol. Cell. Biol. 9:1415-1425
6. Deschatrette, J., E. E. Moore, M. Dubois, and M. C. Weiss. 1980. Dedifferentiated variants of a rat hepatoma: reversion analysis Cell 19:1043-1051.
7. Drewes, T., A. Clairmont, L. Klein-Hitpaß, and G. U. Ryffel. 1994 Estrogen-inducible derivatives of hepatocyte nuclear factor-4, hepatocyte nuclear factor-3 and liver factor B1 are differently affected by pure and partial antiestrogens. Eur. J. Biochem 225:441-448.
8. Hata, S., T. Inoue, K. Kosuga, T. Nakashima, T. Tsukamoto, and T. Osumi. 1995. Identification of two splice isoforms of mRNA for mouse hepatocyte nuclear factor 4 (HNF-4). Biochim. Biophys. Acta 1260:55-61.
9. Holewa, B., E. Pogge von Strandmann, D. Zapp, P. Lorenz, and G. U. Ryffel. Mech. Dev., in press.
10. Holewa, B., D. Zapp, T. Drewes, L. Klein-Hitpass, and G. U. Ryffel. Unpublished data.
11. Kastner, P., A. Krust, B. Turcotte, U. Stropp, L. Tora, H. Gronemeyer, and P. Chambon. 1990. Two distinct estrogen-regulated promoters generate transcripts encoding the two functionally different human progesterone receptor forms A and B. EMBO J. 9:1603-1614.
12. Kuo, C. J., P. B. Conley, L. Chen, F. M. Sladek, J. E. Darnell, Jr., and G. R. Crabtree. 1992. A transcriptional hierarchy involved in mammalian cell-type specification. Nature (London) 355:457-461.
13. Lai, E., and J. E. Darnell. 1991. Transcriptional control in hepatocytes: a window on development. Trends Biochem. Sci 16:427-430
14. Miquerol, L., S. Lopez, N. Cartier, M. Tulliez, M. Raymondjean, and A. Kahn. 1994. Expression of the L-type pyruvate kinase gene and the hepatocyte nuclear factor 4 transcription factor in exocrine and endocrine pancreas. J. Biol Chem 269:8944-8951.
15. Nordeen, S. K. 1988 Luciferase reporter gene vectors for analysis of promoters and enhancers. BioTechmques 6:454-457
16. Schorpp, M., W. Kugler, u. Wagner, and G. U. Ryffel. 1988. Hepatocyte-specific promoter element HP1 of the Xenopus albumin gene interacts with transcriptional factors of mammalian hepatocytes. J. Mol. Biol. 202:307-320.
17. Sel, S., T. Ebert, G. U. Ryffel, and T. Drewes. Submitted for publication
18. Sladek, F. M. 1994. Hepatocyte nuclear factor 4 (HNF-4), p. 207-230. In F. Tronche and M. Yaniv (ed.), Liver specific gene expression. R. G. Landes Co., Austin, Tex.
19. Sladek, F. M., and J. E. Darnell. 1992. Mechanisms of liver-specific gene expression. Curr. Opin. Genet. Dev. 2:256-259
20. Sladek, F. M., W. M. Zhong, E. Lai, and J. E. Darnell. 1990. Liver-enriched transcription factor HNF-4 is a novel member of the steroid hormone receptor superfamily. Genes Dev. 4:2353-2365-
21. Sucov, H. M., and R. M. Evans. 1995. Retinoic acid and retinoic acid receptors in development. Mol. Neurobiol. 10:169-184.
22. Taraviras, S., A. P. Monaghan, G. Schütz, and G. Kelsey. 1994. Characterization of the mouse HNF-4 gene and its expression during embryogenesis. Mech Dev. 48:67-79.
23. Tian, J. M., and U. Schibler. 1991. Tissue-specific expression of the gene encoding hepatocyte nuclear factor 1 may involve hepatocyte nuclear factor 4. Genes Dev 5:2225-2234.
24. Tronche, F., and M. Yaniv. 1992. HNF1, a homeoprotein member of the hepatic transcription regulatory network. Bioessays 14:579-587.
25. Xanthopoulos, K. G., and J. Mirkovitch. 1993. Gene regulation in rodent hepatocytes during development, differentiation and disease. Eur. J. Biochem. 216:353-360.
26. Zapp, D., S. Bartkowski, B. Holewa, C. Zoidl, L. Klein-Hitpaß, and G. U. Ryffel. 1993. Elements and factors involved in tissue-specific and embryonic expression of the liver transcription factor LFB1 in Xenopus laevis. Mol Cell. Biol. 13:5416-6426.
27. Zhong, W., J. Mirkovitch, and J. E. Darnell, Jr. 1994. Tissue-specific regulation of mouse hepatocyte nuclear factor 4 expression. Mol. Cell. Biol. 14:7276-7284.
28. Zhong, W. M., F. M. Stadek, and J. E. Darnell. 1993. The expression pattern of a Drosophila homolog to the mouse transcription factor HNF-4 suggests a determinative role in gut formation. EMBO J. 12:537-544.