B cell ligand discrimination through a spreading and contraction response

Science

Volumn 312, Issue 5774, 2006, Pages 738-741

  Fleire, S J ^a   Goldman, J P ^b,c   Carrasco, Y R ^a   Weber, M ^a   Bray, D ^c   Batista, F D ^a  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^b UNIVERSITY OF KENT   (United Kingdom)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MEMBRANES; BROWNIAN MOVEMENT; CELL CULTURE; IMMUNOLOGY;

AFFINITY DISCRIMINATION; B CELLS; IMMUNOGLOBULIN RECEPTORS; LIGAND DISCRIMINATION; MEMBRANE-BOUND LIGANDS;

ANTIGENS;

ANTIGEN; B LYMPHOCYTE RECEPTOR; CELL SURFACE RECEPTOR; IMMUNOGLOBULIN RECEPTOR; LIGAND;

ANTIGEN; BROWNIAN MOTION; CELL ORGANELLE; DISCRIMINANT ANALYSIS; LIGAND; SIMULATION;

ACTIN POLYMERIZATION; ANIMAL CELL; ANTIGEN RECOGNITION; ARTICLE; B LYMPHOCYTE; B LYMPHOCYTE ACTIVATION; BINDING AFFINITY; CELL MEMBRANE; CELL SPREADING; CONTROLLED STUDY; DIFFUSION; IMMUNE RESPONSE; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ACTINS; ALGORITHMS; ANIMALS; ANTIBODY AFFINITY; ANTIGEN PRESENTATION; ANTIGENS, SURFACE; B-LYMPHOCYTES; CELL SHAPE; COMPUTER SIMULATION; FLOW CYTOMETRY; LIGANDS; LIPID BILAYERS; LYMPHOCYTE ACTIVATION; MICE; MICE, TRANSGENIC; MICROSCOPY, FLUORESCENCE; MODELS, IMMUNOLOGICAL; MURAMIDASE; RECEPTORS, ANTIGEN, B-CELL; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION; STOCHASTIC PROCESSES; T-LYMPHOCYTES;

ANIMALIA;

EID: 33646454106     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1123940     Document Type: Article

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26. We thank P. Bates and his group, J. Lewis, K. Lipkow, V. Silva-Vargas, and C. Reis e Sousa for critical reading of this manuscript. We also thank the Electron Microscopy Unit at the London Research Institute. This work was funded by National Institute of General Medical Sciences grant G64713 (D.B.), Cancer Research UK, and the European Molecular Biology Organization Young Investigator Program (F.D.B.).