메뉴 건너뛰기




Volumn 18, Issue 4, 2006, Pages 476-482

Imaging the choreography of lymphocyte trafficking and the immune response

Author keywords

[No Author keywords available]

Indexed keywords

FINGOLIMOD; IMMUNOSUPPRESSIVE AGENT; SEW 2871; SPHINGOSINE 1 PHOSPHATE RECEPTOR; UNCLASSIFIED DRUG;

EID: 33745405518     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.coi.2006.05.013     Document Type: Review
Times cited : (52)

References (33)
  • 1
    • 0036831870 scopus 로고    scopus 로고
    • Two-photon tissue imaging: seeing the immune system in a fresh light
    • Cahalan M.D., Parker I., Wei S.H., and Miller M.J. Two-photon tissue imaging: seeing the immune system in a fresh light. Nat Rev Immunol 2 (2002) 872-880
    • (2002) Nat Rev Immunol , vol.2 , pp. 872-880
    • Cahalan, M.D.1    Parker, I.2    Wei, S.H.3    Miller, M.J.4
  • 2
    • 0037036142 scopus 로고    scopus 로고
    • Two-photon imaging of lymphocyte motility and antigen response in intact lymph node
    • Miller M.J., Wei S.H., Parker I., and Cahalan M.D. Two-photon imaging of lymphocyte motility and antigen response in intact lymph node. Science 296 (2002) 1869-1873
    • (2002) Science , vol.296 , pp. 1869-1873
    • Miller, M.J.1    Wei, S.H.2    Parker, I.3    Cahalan, M.D.4
  • 3
    • 0037418183 scopus 로고    scopus 로고
    • Autonomous T cell trafficking examined in vivo with intravital two-photon microscopy
    • Miller M.J., Wei S.H., Cahalan M.D., and Parker I. Autonomous T cell trafficking examined in vivo with intravital two-photon microscopy. Proc Natl Acad Sci USA 100 (2003) 2604-2609
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 2604-2609
    • Miller, M.J.1    Wei, S.H.2    Cahalan, M.D.3    Parker, I.4
  • 4
    • 0742323358 scopus 로고    scopus 로고
    • T cell repertoire scanning is promoted by dynamic dendritic cell behavior and random T cell motility in the lymph node
    • Miller M.J., Hejazi A.S., Wei S.H., Cahalan M.D., and Parker I. T cell repertoire scanning is promoted by dynamic dendritic cell behavior and random T cell motility in the lymph node. Proc Natl Acad Sci USA 101 (2004) 998-1003
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 998-1003
    • Miller, M.J.1    Hejazi, A.S.2    Wei, S.H.3    Cahalan, M.D.4    Parker, I.5
  • 6
    • 0037501371 scopus 로고    scopus 로고
    • + T cell priming by dendritic cells in intact lymph nodes
    • + T cell priming by dendritic cells in intact lymph nodes. Nat Immunol 4 (2003) 579-585
    • (2003) Nat Immunol , vol.4 , pp. 579-585
    • Bousso, P.1    Robey, E.2
  • 7
    • 0347717903 scopus 로고    scopus 로고
    • T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases
    • Mempel T.R., Henrickson S.E., and Von Andrian U.H. T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases. Nature 427 (2004) 154-159
    • (2004) Nature , vol.427 , pp. 154-159
    • Mempel, T.R.1    Henrickson, S.E.2    Von Andrian, U.H.3
  • 8
    • 16544383331 scopus 로고    scopus 로고
    • Distinct T cell dynamics in lymph nodes during the induction of tolerance and immunity
    • Hugues S., Fetler L., Bonifaz L., Helft J., Amblard F., and Amigorena S. Distinct T cell dynamics in lymph nodes during the induction of tolerance and immunity. Nat Immunol 5 (2004) 1235-1242
    • (2004) Nat Immunol , vol.5 , pp. 1235-1242
    • Hugues, S.1    Fetler, L.2    Bonifaz, L.3    Helft, J.4    Amblard, F.5    Amigorena, S.6
  • 10
    • 21844450539 scopus 로고    scopus 로고
    • Antigen-engaged B cells undergo chemotaxis toward the T zone and form motile conjugates with helper T cells
    • This study used 2-photon microscopy of intact lymph nodes to define the kinetics and micro-anatomical requirements for antigen-specific B cell-T cell interactions. Antigen-engaged B cells within 100 μm of the follicle edge were observed to migrate along relatively straight paths to the edge of the follicular boundary in a CCR7 chemokine receptor-determined fashion. A gradient of CCL21 extending into the follicle over the same range of 100 μm was detected. The antigen-engaged B cells formed long-lasting and highly motile conjugates with antigen-specific helper T cells. These findings provide the first indication of lymphocyte chemotaxis in vivo, and define the complex cellular dynamics of T cell-dependent antibody responses.
    • Okada T., Miller M.J., Parker I., Krummel M.F., Neighbors M., Hartley S.B., O'Garra A., Cahalan M.D., and Cyster J.G. Antigen-engaged B cells undergo chemotaxis toward the T zone and form motile conjugates with helper T cells. PLoS Biol 3 (2005) e150. This study used 2-photon microscopy of intact lymph nodes to define the kinetics and micro-anatomical requirements for antigen-specific B cell-T cell interactions. Antigen-engaged B cells within 100 μm of the follicle edge were observed to migrate along relatively straight paths to the edge of the follicular boundary in a CCR7 chemokine receptor-determined fashion. A gradient of CCL21 extending into the follicle over the same range of 100 μm was detected. The antigen-engaged B cells formed long-lasting and highly motile conjugates with antigen-specific helper T cells. These findings provide the first indication of lymphocyte chemotaxis in vivo, and define the complex cellular dynamics of T cell-dependent antibody responses.
    • (2005) PLoS Biol , vol.3
    • Okada, T.1    Miller, M.J.2    Parker, I.3    Krummel, M.F.4    Neighbors, M.5    Hartley, S.B.6    O'Garra, A.7    Cahalan, M.D.8    Cyster, J.G.9
  • 12
    • 0037036140 scopus 로고    scopus 로고
    • Dynamics of thymocyte-stromal cell interactions visualized by two-photon microscopy
    • Bousso P., Bhakta N.R., Lewis R.S., and Robey E. Dynamics of thymocyte-stromal cell interactions visualized by two-photon microscopy. Science 296 (2002) 1876-1880
    • (2002) Science , vol.296 , pp. 1876-1880
    • Bousso, P.1    Bhakta, N.R.2    Lewis, R.S.3    Robey, E.4
  • 13
    • 13944266418 scopus 로고    scopus 로고
    • Calcium oscillations regulate thymocyte motility during positive selection in the three-dimensional thymic environment
    • This study combined calcium imaging with cell tracking in a thymus slice preparation to demonstrate that a rise in cytosolic calcium level is sufficient to cause motility arrest and prolonged interaction with stromal cells during positive selection.
    • Bhakta N.R., Oh D.Y., and Lewis R.S. Calcium oscillations regulate thymocyte motility during positive selection in the three-dimensional thymic environment. Nat Immunol 6 (2005) 143-151. This study combined calcium imaging with cell tracking in a thymus slice preparation to demonstrate that a rise in cytosolic calcium level is sufficient to cause motility arrest and prolonged interaction with stromal cells during positive selection.
    • (2005) Nat Immunol , vol.6 , pp. 143-151
    • Bhakta, N.R.1    Oh, D.Y.2    Lewis, R.S.3
  • 14
    • 0141455869 scopus 로고    scopus 로고
    • Visualizing thymocyte motility using 2-photon microscopy
    • Robey E.A., and Bousso P. Visualizing thymocyte motility using 2-photon microscopy. Immunol Rev 195 (2003) 51-57
    • (2003) Immunol Rev , vol.195 , pp. 51-57
    • Robey, E.A.1    Bousso, P.2
  • 15
    • 14244259515 scopus 로고    scopus 로고
    • Directed migration of positively selected thymocytes visualized in real time
    • This study demonstrated directional migration of a subset of thymocytes from the cortex into the medulla during positive selection in the thymus.
    • Witt C.M., Raychaudhuri S., Schaefer B., Chakraborty A.K., and Robey E.A. Directed migration of positively selected thymocytes visualized in real time. PLoS Biol 3 (2005) e1062-e1069. This study demonstrated directional migration of a subset of thymocytes from the cortex into the medulla during positive selection in the thymus.
    • (2005) PLoS Biol , vol.3
    • Witt, C.M.1    Raychaudhuri, S.2    Schaefer, B.3    Chakraborty, A.K.4    Robey, E.A.5
  • 17
    • 10944269369 scopus 로고    scopus 로고
    • Two-photon analysis of calcium signals in T lymphocytes of intact lamina propria from human intestine
    • Tutsch E., Griesemer D., Schwarz A., Stallmach A., and Hoth M. Two-photon analysis of calcium signals in T lymphocytes of intact lamina propria from human intestine. Eur J Immunol 34 (2004) 3477-3484
    • (2004) Eur J Immunol , vol.34 , pp. 3477-3484
    • Tutsch, E.1    Griesemer, D.2    Schwarz, A.3    Stallmach, A.4    Hoth, M.5
  • 18
    • 1542267742 scopus 로고    scopus 로고
    • Direct impact of T cells on neurons revealed by two-photon microscopy in living brain tissue
    • Nitsch R., Pohl E.E., Smorodchenko A., Infante-Duarte C., Aktas O., and Zipp F. Direct impact of T cells on neurons revealed by two-photon microscopy in living brain tissue. J Neurosci 24 (2004) 2458-2464
    • (2004) J Neurosci , vol.24 , pp. 2458-2464
    • Nitsch, R.1    Pohl, E.E.2    Smorodchenko, A.3    Infante-Duarte, C.4    Aktas, O.5    Zipp, F.6
  • 19
    • 24944582967 scopus 로고    scopus 로고
    • Functional connectivity between immune cells mediated by tunneling nanotubules
    • Watkins S.C., and Salter R.D. Functional connectivity between immune cells mediated by tunneling nanotubules. Immunity 23 (2005) 309-318
    • (2005) Immunity , vol.23 , pp. 309-318
    • Watkins, S.C.1    Salter, R.D.2
  • 20
    • 0041695164 scopus 로고    scopus 로고
    • Continuous T cell receptor signaling required for synapse maintenance and full effector potential
    • Huppa J.B., Gleimer M., Sumen C., and Davis M.M. Continuous T cell receptor signaling required for synapse maintenance and full effector potential. Nat Immunol 4 (2003) 749-755
    • (2003) Nat Immunol , vol.4 , pp. 749-755
    • Huppa, J.B.1    Gleimer, M.2    Sumen, C.3    Davis, M.M.4
  • 21
    • 0031884839 scopus 로고    scopus 로고
    • The duration of antigenic stimulation determines the fate of naive and effector T cells
    • Iezzi G., Karjalainen K., and Lanzavecchia A. The duration of antigenic stimulation determines the fate of naive and effector T cells. Immunity 8 (1998) 89-95
    • (1998) Immunity , vol.8 , pp. 89-95
    • Iezzi, G.1    Karjalainen, K.2    Lanzavecchia, A.3
  • 22
    • 0033666324 scopus 로고    scopus 로고
    • Antigen presentation in extracellular matrix: interactions of T cells with dendritic cells are dynamic, short lived, and sequential
    • Gunzer M., Schafer A., Borgmann S., Grabbe S., Zanker K.S., Brocker E.B., Kampgen E., and Friedl P. Antigen presentation in extracellular matrix: interactions of T cells with dendritic cells are dynamic, short lived, and sequential. Immunity 13 (2000) 323-332
    • (2000) Immunity , vol.13 , pp. 323-332
    • Gunzer, M.1    Schafer, A.2    Borgmann, S.3    Grabbe, S.4    Zanker, K.S.5    Brocker, E.B.6    Kampgen, E.7    Friedl, P.8
  • 23
    • 27744502556 scopus 로고    scopus 로고
    • CD4 T cells integrate signals delivered during successive DC encounters in vivo
    • This study pits anti-male-specific T cells versus male or female DC, transferred at two different time points, to show that a second wave of antigen-bearing DCs entering the lymph node results in stable T-DC conjugates and modulates subsequent T cell cytokine production.
    • Celli S., Garcia Z., and Bousso P. CD4 T cells integrate signals delivered during successive DC encounters in vivo. J Exp Med 202 (2005) 1271-1278. This study pits anti-male-specific T cells versus male or female DC, transferred at two different time points, to show that a second wave of antigen-bearing DCs entering the lymph node results in stable T-DC conjugates and modulates subsequent T cell cytokine production.
    • (2005) J Exp Med , vol.202 , pp. 1271-1278
    • Celli, S.1    Garcia, Z.2    Bousso, P.3
  • 25
    • 0141566612 scopus 로고    scopus 로고
    • A stochastic view of lymphocyte motility and trafficking within the lymph node
    • Wei S.H., Parker I., Miller M.J., and Cahalan M.D. A stochastic view of lymphocyte motility and trafficking within the lymph node. Immunol Rev 195 (2003) 136-159
    • (2003) Immunol Rev , vol.195 , pp. 136-159
    • Wei, S.H.1    Parker, I.2    Miller, M.J.3    Cahalan, M.D.4
  • 27
    • 17644365138 scopus 로고    scopus 로고
    • Chemokines, sphingosine-1-phosphate, and cell migration in secondary lymphoid organs
    • Cyster J.G. Chemokines, sphingosine-1-phosphate, and cell migration in secondary lymphoid organs. Annu Rev Immunol 23 (2005) 127-159
    • (2005) Annu Rev Immunol , vol.23 , pp. 127-159
    • Cyster, J.G.1
  • 28
    • 21844457949 scopus 로고    scopus 로고
    • Sphingosine 1-phosphate and its receptors: an autocrine and paracrine network
    • Rosen H., and Goetzl E.J. Sphingosine 1-phosphate and its receptors: an autocrine and paracrine network. Nat Rev Immunol 5 (2005) 560-570
    • (2005) Nat Rev Immunol , vol.5 , pp. 560-570
    • Rosen, H.1    Goetzl, E.J.2
  • 29
    • 30044441314 scopus 로고    scopus 로고
    • Sphingosine 1-phosphate type 1 receptor agonism inhibits transendothelial migration of medullary T cells to lymphatic sinuses
    • 1 receptors on lymphocytes. Instead, a novel mechanism is proposed whereby these agents regulate barrier function by acting on receptors on endothelial cells.
    • 1 receptors on lymphocytes. Instead, a novel mechanism is proposed whereby these agents regulate barrier function by acting on receptors on endothelial cells.
    • (2005) Nat Immunol , vol.6 , pp. 1228-1235
    • Wei, S.H.1    Rosen, H.2    Matheu, M.P.3    Sanna, M.G.4    Wang, S.K.5    Jo, E.6    Wong, C.H.7    Parker, I.8    Cahalan, M.D.9
  • 31
    • 22344453196 scopus 로고    scopus 로고
    • Live imaging of effector cell trafficking and autoantigen recognition within the unfolding autoimmune encephalomyelitis lesion
    • Kawakami N., Nagerl U.V., Odoardi F., Bonhoeffer T., Wekerle H., and Flugel A. Live imaging of effector cell trafficking and autoantigen recognition within the unfolding autoimmune encephalomyelitis lesion. J Exp Med 201 (2005) 1805-1814
    • (2005) J Exp Med , vol.201 , pp. 1805-1814
    • Kawakami, N.1    Nagerl, U.V.2    Odoardi, F.3    Bonhoeffer, T.4    Wekerle, H.5    Flugel, A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.