메뉴 건너뛰기




Volumn 8, Issue 10, 2008, Pages 764-775

Form follows function: Lymphoid tissue microarchitecture in antimicrobial immune defence

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CCR7; CHEMOKINE RECEPTOR CXCR5; EPITHELIAL DERIVED NEUTROPHIL ACTIVATING FACTOR 78; INTERCELLULAR ADHESION MOLECULE 1; INTERCELLULAR ADHESION MOLECULE 3; INTERFERON; INTERLEUKIN 7; LYMPHOTOXIN BETA; MACROPHAGE INFLAMMATORY PROTEIN 3BETA; SCLEROPROTEIN; SECONDARY LYMPHOID TISSUE CHEMOKINE; SPHINGOSINE 1 PHOSPHATE; VASCULAR CELL ADHESION MOLECULE 1; VASCULOTROPIN;

EID: 52949090785     PISSN: 14741733     EISSN: None     Source Type: Journal    
DOI: 10.1038/nri2414     Document Type: Review
Times cited : (217)

References (115)
  • 1
    • 0008446030 scopus 로고
    • The tall office building artistically considered
    • online
    • Sullivan, L. H. The tall office building artistically considered. Lippincott's Magazine [online] http://ecow.engr.wisc.edu/cgi-bin/get/cee/ 340/bank/interestin/formfollowsfunctionsullivan-189.pdf (1896).
    • (1896) Lippincott's Magazine
    • Sullivan, L.H.1
  • 2
    • 33745370610 scopus 로고    scopus 로고
    • Evidence that a significant number of naive T cells enter non-lymphoid organs as part of a normal migratory pathway
    • Cose, S., Brammer, C., Khanna, K. M., Masopust, D. & Lefrancois, L. Evidence that a significant number of naive T cells enter non-lymphoid organs as part of a normal migratory pathway. Eur. J. Immunol. 36, 1423-1433 (2006).
    • (2006) Eur. J. Immunol , vol.36 , pp. 1423-1433
    • Cose, S.1    Brammer, C.2    Khanna, K.M.3    Masopust, D.4    Lefrancois, L.5
  • 3
    • 0141796315 scopus 로고    scopus 로고
    • Bone marrow as a priming site for T-cell responses to blood-borne antigen
    • Feuerer, M. et al. Bone marrow as a priming site for T-cell responses to blood-borne antigen. Nature Med. 9, 1151-1157 (2003).
    • (2003) Nature Med , vol.9 , pp. 1151-1157
    • Feuerer, M.1
  • 4
    • 27144535376 scopus 로고    scopus 로고
    • Activation of bone marrow-resident memory T cells by circulating, antigen-bearing dendritic cells
    • Cavanagh, L. L. et al. Activation of bone marrow-resident memory T cells by circulating, antigen-bearing dendritic cells. Nature Immunol. 6, 1029-1037 (2005).
    • (2005) Nature Immunol , vol.6 , pp. 1029-1037
    • Cavanagh, L.L.1
  • 5
    • 0032787091 scopus 로고    scopus 로고
    • Control of early viral and bacterial distribution and disease by natural antibodies
    • Ochsenbein, A. F. et al. Control of early viral and bacterial distribution and disease by natural antibodies. Science 286, 2156-2159 (1999).
    • (1999) Science , vol.286 , pp. 2156-2159
    • Ochsenbein, A.F.1
  • 6
    • 35948935059 scopus 로고    scopus 로고
    • Subcapsular sinus macrophages in lymph nodes clear lymph-borne viruses and present them to antiviral B cells
    • + macrophages that line the SCS of lymph nodes as essential for the capture of viruses and the initiation of antiviral B-cell responses
    • + macrophages that line the SCS of lymph nodes as essential for the capture of viruses and the initiation of antiviral B-cell responses.
    • (2007) Nature , vol.450 , pp. 110-114
    • Junt, T.1
  • 7
    • 33846886363 scopus 로고    scopus 로고
    • Control of coronavirus infection through plasmacytoid dendritic-cell-derived type I interferon
    • Cervantes-Barragan, L. et al. Control of coronavirus infection through plasmacytoid dendritic-cell-derived type I interferon. Blood 109, 1131-1137 (2007).
    • (2007) Blood , vol.109 , pp. 1131-1137
    • Cervantes-Barragan, L.1
  • 8
    • 0037036114 scopus 로고    scopus 로고
    • Dynamic imaging of T cell-dendritic cell interactions in lymph nodes
    • Stoll, S., Delon, J., Brotz, T. M. & Germain, R. N. Dynamic imaging of T cell-dendritic cell interactions in lymph nodes. Science 296, 1873-1876 (2002).
    • (2002) Science , vol.296 , pp. 1873-1876
    • Stoll, S.1    Delon, J.2    Brotz, T.M.3    Germain, R.N.4
  • 9
    • 0347717903 scopus 로고    scopus 로고
    • T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases
    • Mempel, T. R., Henrickson, S. E. & von Andrian, U. H. T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases. Nature 427, 154-159 (2004).
    • (2004) Nature , vol.427 , pp. 154-159
    • Mempel, T.R.1    Henrickson, S.E.2    von Andrian, U.H.3
  • 10
    • 0038655228 scopus 로고    scopus 로고
    • Cytokine control of memory T-cell development and survival
    • Schluns, K. S. & Lefrancois, L. Cytokine control of memory T-cell development and survival. Nature Rev. Immunol. 3, 269-279 (2003).
    • (2003) Nature Rev. Immunol , vol.3 , pp. 269-279
    • Schluns, K.S.1    Lefrancois, L.2
  • 11
    • 0030906253 scopus 로고    scopus 로고
    • -/-) mutant mice. J. Exp. Med. 185, 2157-2170 (1997). This study shows that lymph nodes are crucial for the induction of antiviral immune responses. In the absence of lymph nodes, cytopathic virus infection resulted in death of the animals, whereas infection with a non-cytopathic virus led to viral persistence.
    • -/-) mutant mice. J. Exp. Med. 185, 2157-2170 (1997). This study shows that lymph nodes are crucial for the induction of antiviral immune responses. In the absence of lymph nodes, cytopathic virus infection resulted in death of the animals, whereas infection with a non-cytopathic virus led to viral persistence.
  • 12
    • 33747401325 scopus 로고    scopus 로고
    • Expression of lymphotoxin β governs immunity at two distinct levels
    • Junt, T. et al. Expression of lymphotoxin β governs immunity at two distinct levels. Eur. J. Immunol. 36, 2061-2075 (2006).
    • (2006) Eur. J. Immunol , vol.36 , pp. 2061-2075
    • Junt, T.1
  • 13
    • 0037320017 scopus 로고    scopus 로고
    • +-T-cell expansion and trafficking following central nervous system infection
    • +-T-cell expansion and trafficking following central nervous system infection. J. Virol. 77, 2775-2778 (2003).
    • (2003) J. Virol , vol.77 , pp. 2775-2778
    • Marten, N.W.1    Stohlman, S.A.2    Zhou, J.3    Bergmann, C.C.4
  • 14
    • 0037018098 scopus 로고    scopus 로고
    • Estimating the precursor frequency of naive antigen-specific CD8 T cells
    • Blattman, J. N. et al. Estimating the precursor frequency of naive antigen-specific CD8 T cells. J. Exp. Med. 195, 657-664 (2002).
    • (2002) J. Exp. Med , vol.195 , pp. 657-664
    • Blattman, J.N.1
  • 15
    • 34548038390 scopus 로고    scopus 로고
    • + T cell frequency varies for different epitopes and predicts repertoire diversity and response magnitude
    • + T cell frequency varies for different epitopes and predicts repertoire diversity and response magnitude. Immunity 27, 203-213 (2007).
    • (2007) Immunity , vol.27 , pp. 203-213
    • Moon, J.J.1
  • 16
    • 38349177550 scopus 로고    scopus 로고
    • + T cells.
    • + T cells.
  • 18
    • 38849143079 scopus 로고    scopus 로고
    • Key role for clumping factor B in Staphylococcus aureus nasal colonization of humans
    • Wertheim, H. F. et al. Key role for clumping factor B in Staphylococcus aureus nasal colonization of humans. PLoS Med. 5, e17 (2008).
    • (2008) PLoS Med , vol.5
    • Wertheim, H.F.1
  • 19
    • 34548834163 scopus 로고    scopus 로고
    • From induced to programmed lymphoid tissues: The long road to preempt pathogens
    • Eberl, G. From induced to programmed lymphoid tissues: the long road to preempt pathogens. Trends Immunol. 28, 423-428 (2007).
    • (2007) Trends Immunol , vol.28 , pp. 423-428
    • Eberl, G.1
  • 20
    • 28044432553 scopus 로고    scopus 로고
    • Innate control of adaptive immunity via remodeling of lymph node feed arteriole
    • Soderberg, K. A. et al. Innate control of adaptive immunity via remodeling of lymph node feed arteriole. Proc. Natl Acad. Sci. USA 102, 16315-16320 (2005).
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 16315-16320
    • Soderberg, K.A.1
  • 21
    • 32244443955 scopus 로고    scopus 로고
    • B cell-driven lymphangiogenesis in inflamed lymph nodes enhances dendritic cell mobilization
    • Angeli, V. et al. B cell-driven lymphangiogenesis in inflamed lymph nodes enhances dendritic cell mobilization. Immunity 24, 203-215 (2006).
    • (2006) Immunity , vol.24 , pp. 203-215
    • Angeli, V.1
  • 22
    • 36248956701 scopus 로고    scopus 로고
    • Finding a way out: Lymphocyte egress from lymphoid organs
    • Schwab, S. R. & Cyster, J. G. Finding a way out: lymphocyte egress from lymphoid organs. Nature Immunol. 8, 1295-1301 (2007).
    • (2007) Nature Immunol , vol.8 , pp. 1295-1301
    • Schwab, S.R.1    Cyster, J.G.2
  • 23
    • 38949137056 scopus 로고    scopus 로고
    • Making friends in out-of-the-way places: How cells of the immune system get together and how they conduct their business as revealed by intravital imaging
    • Germain, R. N. et al. Making friends in out-of-the-way places: how cells of the immune system get together and how they conduct their business as revealed by intravital imaging. Immunol. Rev. 221, 163-181 (2008).
    • (2008) Immunol. Rev , vol.221 , pp. 163-181
    • Germain, R.N.1
  • 24
    • 12444297666 scopus 로고    scopus 로고
    • The conduit system transports soluble antigens from the afferent lymph to resident dendritic cells in the T cell area of the lymph node
    • This study describes antigen sampling by lymph-node-resident DCs from within the FRC-conduit system
    • Sixt, M. et al. The conduit system transports soluble antigens from the afferent lymph to resident dendritic cells in the T cell area of the lymph node. Immunity 22, 19-29 (2005). This study describes antigen sampling by lymph-node-resident DCs from within the FRC-conduit system.
    • (2005) Immunity , vol.22 , pp. 19-29
    • Sixt, M.1
  • 25
    • 0034693949 scopus 로고    scopus 로고
    • Lymph-borne chemokines and other low molecular weight molecules reach high endothelial venules via specialized conduits while a functional barrier limits access to the lymphocyte microenvironments in lymph node cortex
    • Gretz, J. E., Norbury, C. C., Anderson, A. O., Proudfoot, A. E. & Shaw, S. Lymph-borne chemokines and other low molecular weight molecules reach high endothelial venules via specialized conduits while a functional barrier limits access to the lymphocyte microenvironments in lymph node cortex. J. Exp. Med. 192, 1425-1440 (2000).
    • (2000) J. Exp. Med , vol.192 , pp. 1425-1440
    • Gretz, J.E.1    Norbury, C.C.2    Anderson, A.O.3    Proudfoot, A.E.4    Shaw, S.5
  • 26
    • 0000568115 scopus 로고
    • Mouse-pox; infectious ectromelia of mice; a review
    • Fenner, F. Mouse-pox; infectious ectromelia of mice; a review. J. Immunol. 63, 341-373 (1949).
    • (1949) J. Immunol , vol.63 , pp. 341-373
    • Fenner, F.1
  • 27
    • 0036754302 scopus 로고    scopus 로고
    • Blood dendritic cells interact with splenic marginal zone B cells to initiate T-independent immune responses
    • Balazs, M., Martin, F., Zhou, T. & Kearney, J. Blood dendritic cells interact with splenic marginal zone B cells to initiate T-independent immune responses. Immunity 17, 341-352 (2002).
    • (2002) Immunity , vol.17 , pp. 341-352
    • Balazs, M.1    Martin, F.2    Zhou, T.3    Kearney, J.4
  • 28
    • 0033987138 scopus 로고    scopus 로고
    • Induction of optimal anti-viral neutralizing B cell responses by dendritic cells requires transport and release of virus particles in secondary lymphoid organs
    • Ludewig, B. et al. Induction of optimal anti-viral neutralizing B cell responses by dendritic cells requires transport and release of virus particles in secondary lymphoid organs. Eur. J. Immunol. 30, 185-196 (2000).
    • (2000) Eur. J. Immunol , vol.30 , pp. 185-196
    • Ludewig, B.1
  • 29
    • 0042847262 scopus 로고    scopus 로고
    • Macrophages of the splenic marginal zone are essential for trapping of blood-borne particulate antigen but dispensable for induction of specific T cell responses
    • Aichele, P. et al. Macrophages of the splenic marginal zone are essential for trapping of blood-borne particulate antigen but dispensable for induction of specific T cell responses. J. Immunol. 171, 1148-1155 (2003).
    • (2003) J. Immunol , vol.171 , pp. 1148-1155
    • Aichele, P.1
  • 30
    • 0027233926 scopus 로고
    • Binding of Candida albicans yeast cells to mouse popliteal lymph node tissue is mediated by macrophages
    • Han, Y., van Rooijen, N. & Cutler, J. E. Binding of Candida albicans yeast cells to mouse popliteal lymph node tissue is mediated by macrophages. Infect. Immun. 61, 3244-3249 (1993).
    • (1993) Infect. Immun , vol.61 , pp. 3244-3249
    • Han, Y.1    van Rooijen, N.2    Cutler, J.E.3
  • 31
    • 0029962824 scopus 로고    scopus 로고
    • Humoral immune responses against particulate bacterial antigens are dependent on marginal metallophilic macrophages in the spleen
    • Buiting, A. M., De Rover, Z., Kraal, G. & van Rooijen, N. Humoral immune responses against particulate bacterial antigens are dependent on marginal metallophilic macrophages in the spleen. Scand. J. Immunol. 43, 398-405 (1996).
    • (1996) Scand. J. Immunol , vol.43 , pp. 398-405
    • Buiting, A.M.1    De Rover, Z.2    Kraal, G.3    van Rooijen, N.4
  • 32
    • 0033856794 scopus 로고    scopus 로고
    • Follicular dendritic cells and dissemination of Creutzfeldt-Jakob disease
    • Manuelidis, L. et al. Follicular dendritic cells and dissemination of Creutzfeldt-Jakob disease. J. Virol. 74, 8614-8622 (2000).
    • (2000) J. Virol , vol.74 , pp. 8614-8622
    • Manuelidis, L.1
  • 33
    • 0031889474 scopus 로고    scopus 로고
    • Dendritic cells, but not macrophages, produce IL-12 immediately following Leishmania donovani infection
    • Gorak, P. M., Engwerda, C. R. & Kaye, P. M. Dendritic cells, but not macrophages, produce IL-12 immediately following Leishmania donovani infection. Eur. J. Immunol. 28, 687-695 (1998).
    • (1998) Eur. J. Immunol , vol.28 , pp. 687-695
    • Gorak, P.M.1    Engwerda, C.R.2    Kaye, P.M.3
  • 34
    • 0030699401 scopus 로고    scopus 로고
    • Crucial role of marginal zone macrophages and marginal zone metallophils in the clearance of lymphocytic choriomeningitis virus infection
    • Seiler, P. et al. Crucial role of marginal zone macrophages and marginal zone metallophils in the clearance of lymphocytic choriomeningitis virus infection. Eur. J. Immunol. 27, 2626-2633 (1997).
    • (1997) Eur. J. Immunol , vol.27 , pp. 2626-2633
    • Seiler, P.1
  • 35
  • 36
    • 0034508025 scopus 로고    scopus 로고
    • Natural antibodies and complement link innate and acquired immunity
    • Ochsenbein, A. F. & Zinkernagel, R. M. Natural antibodies and complement link innate and acquired immunity. Immunol. Today 21, 624-630 (2000).
    • (2000) Immunol. Today , vol.21 , pp. 624-630
    • Ochsenbein, A.F.1    Zinkernagel, R.M.2
  • 37
    • 34548044827 scopus 로고    scopus 로고
    • Subcapsular encounter and complement-dependent transport of immune complexes by lymph node B cells
    • Phan, T. G., Grigorova, I., Okada, T. & Cyster, J. G. Subcapsular encounter and complement-dependent transport of immune complexes by lymph node B cells. Nature Immunol. 8, 992-1000 (2007).
    • (2007) Nature Immunol , vol.8 , pp. 992-1000
    • Phan, T.G.1    Grigorova, I.2    Okada, T.3    Cyster, J.G.4
  • 38
    • 0037108432 scopus 로고    scopus 로고
    • Marginal zone macrophages express a murine homologue of DC-SIGN that captures blood-borne antigens in vivo
    • Geijtenbeek, T. B. et al. Marginal zone macrophages express a murine homologue of DC-SIGN that captures blood-borne antigens in vivo. Blood 100, 2908-2916 (2002).
    • (2002) Blood , vol.100 , pp. 2908-2916
    • Geijtenbeek, T.B.1
  • 39
    • 9144229622 scopus 로고    scopus 로고
    • The C-type lectin SIGN-R1 mediates uptake of the capsular polysaccharide of Streptococcus pneumoniae in the marginal zone of mouse spleen
    • Kang, Y. S. et al. The C-type lectin SIGN-R1 mediates uptake of the capsular polysaccharide of Streptococcus pneumoniae in the marginal zone of mouse spleen. Proc. Natl Acad. Sci. USA. 101, 215-220 (2004).
    • (2004) Proc. Natl Acad. Sci. USA , vol.101 , pp. 215-220
    • Kang, Y.S.1
  • 41
    • 29144509535 scopus 로고    scopus 로고
    • Defective microarchitecture of the spleen marginal zone and impaired response to a thymus-independent type 2 antigen in mice lacking scavenger receptors MARCO and SR-A
    • Chen, Y. et al. Defective microarchitecture of the spleen marginal zone and impaired response to a thymus-independent type 2 antigen in mice lacking scavenger receptors MARCO and SR-A. J. Immunol. 175, 8173-8180 (2005).
    • (2005) J. Immunol , vol.175 , pp. 8173-8180
    • Chen, Y.1
  • 42
    • 33745133006 scopus 로고    scopus 로고
    • Extrafollicular activation of lymph node B cells by antigen-bearing dendritic cells
    • Qi, H., Egen, J. G., Huang, A. Y. & Germain, R. N. Extrafollicular activation of lymph node B cells by antigen-bearing dendritic cells. Science 312, 1672-1676 (2006).
    • (2006) Science , vol.312 , pp. 1672-1676
    • Qi, H.1    Egen, J.G.2    Huang, A.Y.3    Germain, R.N.4
  • 43
    • 0036167984 scopus 로고    scopus 로고
    • Role of an intact splenic microarchitecture in early lymphocytic choriomeningitis virus production
    • Muller, S. et al. Role of an intact splenic microarchitecture in early lymphocytic choriomeningitis virus production. J. Virol. 76, 2375-2383 (2002).
    • (2002) J. Virol , vol.76 , pp. 2375-2383
    • Muller, S.1
  • 44
    • 0032969658 scopus 로고    scopus 로고
    • Splenic marginal metallophilic macrophages and marginal zone macrophages are the major interferon-α/ β producers in mice upon intravenous challenge with herpes simplex virus
    • Eloranta, M. L. & Alm, G. V. Splenic marginal metallophilic macrophages and marginal zone macrophages are the major interferon-α/ β producers in mice upon intravenous challenge with herpes simplex virus. Scand. J. Immunol. 49, 391-394 (1999).
    • (1999) Scand. J. Immunol , vol.49 , pp. 391-394
    • Eloranta, M.L.1    Alm, G.V.2
  • 45
    • 18644375874 scopus 로고    scopus 로고
    • + T cells by exogenous cell-associated antigens
    • + T cells by exogenous cell-associated antigens. Immunity 17, 211-220 (2002).
    • (2002) Immunity , vol.17 , pp. 211-220
    • Jung, S.1
  • 46
    • 23044446577 scopus 로고    scopus 로고
    • - DTR/GFP mice after in vivo depletion of dendritic cells
    • - DTR/GFP mice after in vivo depletion of dendritic cells. Clin. Exp. Immunol. 141, 398-404 (2005).
    • (2005) Clin. Exp. Immunol , vol.141 , pp. 398-404
    • Probst, H.C.1
  • 47
    • 47049100427 scopus 로고    scopus 로고
    • Nanoparticles target distinct dendritic cell populations according to their size
    • Manolova, V. et al. Nanoparticles target distinct dendritic cell populations according to their size. Eur. J. Immunol. 38, 1404-1413 (2008).
    • (2008) Eur. J. Immunol , vol.38 , pp. 1404-1413
    • Manolova, V.1
  • 48
    • 1542618118 scopus 로고    scopus 로고
    • Induction of protective IgA by intestinal dendritic cells carrying commensal bacteria
    • Macpherson, A. J. & Uhr, T. Induction of protective IgA by intestinal dendritic cells carrying commensal bacteria. Science 303, 1662-1665 (2004).
    • (2004) Science , vol.303 , pp. 1662-1665
    • Macpherson, A.J.1    Uhr, T.2
  • 49
    • 0037769037 scopus 로고    scopus 로고
    • Distinct dendritic cell populations sequentially present antigen to CD4 T cells and stimulate different aspects of cell-mediated immunity
    • Itano, A. A. et al. Distinct dendritic cell populations sequentially present antigen to CD4 T cells and stimulate different aspects of cell-mediated immunity. Immunity 19, 47-57 (2003).
    • (2003) Immunity , vol.19 , pp. 47-57
    • Itano, A.A.1
  • 50
    • 4644284542 scopus 로고    scopus 로고
    • Lymph node fibroblastic reticular cells construct the stromal reticulum via contact with lymphocytes
    • Katakai, T., Hara, T., Sugai, M., Gonda, H. & Shimizu, A. Lymph node fibroblastic reticular cells construct the stromal reticulum via contact with lymphocytes. J. Exp. Med. 200, 783-795 (2004).
    • (2004) J. Exp. Med , vol.200 , pp. 783-795
    • Katakai, T.1    Hara, T.2    Sugai, M.3    Gonda, H.4    Shimizu, A.5
  • 51
    • 0026722290 scopus 로고
    • Characterization and cloning of a novel glycoprotein expressed by stromal cells in T-dependent areas of peripheral lymphoid tissues
    • Farr, A. G. et al. Characterization and cloning of a novel glycoprotein expressed by stromal cells in T-dependent areas of peripheral lymphoid tissues. J. Exp. Med. 176, 1477-1482 (1992).
    • (1992) J. Exp. Med , vol.176 , pp. 1477-1482
    • Farr, A.G.1
  • 52
    • 4344651077 scopus 로고    scopus 로고
    • A novel reticular stromal structure in lymph node cortex: An immuno-platform for interactions among dendritic cells, T cells and B cells
    • Katakai, T. et al. A novel reticular stromal structure in lymph node cortex: an immuno-platform for interactions among dendritic cells, T cells and B cells. Int. Immunol. 16, 1133-1142 (2004).
    • (2004) Int. Immunol , vol.16 , pp. 1133-1142
    • Katakai, T.1
  • 53
    • 0030944142 scopus 로고    scopus 로고
    • Cords, channels, corridors and conduits: Critical architectural elements facilitating cell interactions in the lymph node cortex
    • Gretz, J. E., Anderson, A. O. & Shaw, S. Cords, channels, corridors and conduits: critical architectural elements facilitating cell interactions in the lymph node cortex. Immunol. Rev. 156, 11-24 (1997).
    • (1997) Immunol. Rev , vol.156 , pp. 11-24
    • Gretz, J.E.1    Anderson, A.O.2    Shaw, S.3
  • 54
    • 0042624814 scopus 로고    scopus 로고
    • Nolte, M. A. et al. A conduit system distributes chemokines and small blood-borne molecules through the splenic white pulp. J. Exp. Med. 198, 505-512 (2003). This study reveals that the conduit system in the spleen has an important role in the distribution of both blood-borne and locally produced molecules, and provides a framework for directing lymphocyte migration and the organization of the white pulp of the spleen.
    • Nolte, M. A. et al. A conduit system distributes chemokines and small blood-borne molecules through the splenic white pulp. J. Exp. Med. 198, 505-512 (2003). This study reveals that the conduit system in the spleen has an important role in the distribution of both blood-borne and locally produced molecules, and provides a framework for directing lymphocyte migration and the organization of the white pulp of the spleen.
  • 55
    • 0035158575 scopus 로고    scopus 로고
    • Inflammatory chemokine transport and presentation in HEV: A remote control mechanism for monocyte recruitment to lymph nodes in inflamed tissues
    • Palframan, R. T. et al. Inflammatory chemokine transport and presentation in HEV: a remote control mechanism for monocyte recruitment to lymph nodes in inflamed tissues. J. Exp. Med. 194, 1361-1373 (2001).
    • (2001) J. Exp. Med , vol.194 , pp. 1361-1373
    • Palframan, R.T.1
  • 56
    • 0042922810 scopus 로고    scopus 로고
    • Regulation of dendritic cell migration to the draining lymph node: Impact on T lymphocyte traffic and priming
    • MartIn-Fontecha, A. et al. Regulation of dendritic cell migration to the draining lymph node: impact on T lymphocyte traffic and priming. J. Exp. Med. 198, 615-621 (2003).
    • (2003) J. Exp. Med , vol.198 , pp. 615-621
    • MartIn-Fontecha, A.1
  • 57
    • 20244377997 scopus 로고    scopus 로고
    • CCL19 and CCL21 induce a potent proinflammatory differentiation program in licensed dendritic cells
    • Marsland, B. J. et al. CCL19 and CCL21 induce a potent proinflammatory differentiation program in licensed dendritic cells. Immunity 22, 493-505 (2005).
    • (2005) Immunity , vol.22 , pp. 493-505
    • Marsland, B.J.1
  • 58
    • 33746924370 scopus 로고    scopus 로고
    • Regulation of lymph node vascular growth by dendritic cells
    • Webster, B. et al. Regulation of lymph node vascular growth by dendritic cells. J. Exp. Med. 203, 1903-1913 (2006).
    • (2006) J. Exp. Med , vol.203 , pp. 1903-1913
    • Webster, B.1
  • 59
    • 0033748035 scopus 로고    scopus 로고
    • Coexpression of the chemokines ELC and SLC by T zone stromal cells and deletion of the ELC gene in the plt/plt mouse
    • Luther, S. A., Tang, H. L., Hyman, P. L., Farr, A. G. & Cyster, J. G. Coexpression of the chemokines ELC and SLC by T zone stromal cells and deletion of the ELC gene in the plt/plt mouse. Proc. Natl Acad. Sci. USA 97, 12694-12699 (2000).
    • (2000) Proc. Natl Acad. Sci. USA , vol.97 , pp. 12694-12699
    • Luther, S.A.1    Tang, H.L.2    Hyman, P.L.3    Farr, A.G.4    Cyster, J.G.5
  • 60
    • 0031712324 scopus 로고    scopus 로고
    • Rapid and coordinated switch in chemokine receptor expression during dendritic cell maturation
    • Sallusto, F. et al. Rapid and coordinated switch in chemokine receptor expression during dendritic cell maturation. Eur. J. Immunol. 28, 2760-2769 (1998).
    • (1998) Eur. J. Immunol , vol.28 , pp. 2760-2769
    • Sallusto, F.1
  • 61
    • 42649086026 scopus 로고    scopus 로고
    • CCR7 and its ligands: Balancing immunity and tolerance
    • Forster, R., Davalos-Misslitz, A. C. & Rot, A. CCR7 and its ligands: balancing immunity and tolerance. Nature Rev. Immunol. 8, 362-371 (2008).
    • (2008) Nature Rev. Immunol , vol.8 , pp. 362-371
    • Forster, R.1    Davalos-Misslitz, A.C.2    Rot, A.3
  • 62
    • 34548780292 scopus 로고    scopus 로고
    • Lymph node chemokines promote sustained T lymphocyte motility without triggering stable integrin adhesiveness in the absence of shear forces
    • Woolf, E. et al. Lymph node chemokines promote sustained T lymphocyte motility without triggering stable integrin adhesiveness in the absence of shear forces. Nature Immunol. 8, 1076-1085 (2007).
    • (2007) Nature Immunol , vol.8 , pp. 1076-1085
    • Woolf, E.1
  • 63
    • 0035821218 scopus 로고    scopus 로고
    • The CCR7 ligand elc (CCL19) is transcytosed in high endothelial venules and mediates T cell recruitment
    • Baekkevold, E. S. et al. The CCR7 ligand elc (CCL19) is transcytosed in high endothelial venules and mediates T cell recruitment. J. Exp. Med. 193, 1105-1112 (2001).
    • (2001) J. Exp. Med , vol.193 , pp. 1105-1112
    • Baekkevold, E.S.1
  • 64
    • 35548975191 scopus 로고    scopus 로고
    • Fibroblastic reticular cells in lymph nodes regulate the homeostasis of naive T cells
    • This study reveals that access of T cells to IL-7-producing FRCs in lymph nodes is crucial for T-cell homeostasis
    • Link, A. et al. Fibroblastic reticular cells in lymph nodes regulate the homeostasis of naive T cells. Nature Immunol. 8, 1255-1265 (2007). This study reveals that access of T cells to IL-7-producing FRCs in lymph nodes is crucial for T-cell homeostasis.
    • (2007) Nature Immunol , vol.8 , pp. 1255-1265
    • Link, A.1
  • 65
    • 33645866471 scopus 로고    scopus 로고
    • + T cell-dendritic cell interaction
    • + T cell-dendritic cell interaction. Nature 440, 890-895 (2006).
    • (2006) Nature , vol.440 , pp. 890-895
    • Castellino, F.1
  • 66
    • 33845455093 scopus 로고    scopus 로고
    • Stromal cell networks regulate lymphocyte entry, migration, and territoriality in lymph nodes
    • This study shows that T cells are in continuous intimate contact with FRCs as they migrate through the T-cell zone and that FRCs delimit the borders of the T-cell zone
    • Bajenoff, M. et al. Stromal cell networks regulate lymphocyte entry, migration, and territoriality in lymph nodes. Immunity 25, 989-1001 (2006). This study shows that T cells are in continuous intimate contact with FRCs as they migrate through the T-cell zone and that FRCs delimit the borders of the T-cell zone.
    • (2006) Immunity , vol.25 , pp. 989-1001
    • Bajenoff, M.1
  • 67
    • 33846546257 scopus 로고    scopus 로고
    • Peripheral antigen display by lymph node stroma promotes T cell tolerance to intestinal self
    • This study reveals that peripheral tolerance can not only be mediated by DCs in SLOs that have taken up antigen in peripheral tissues but also by stromal cells in the lymph node, which synthesize and present peripheral tissue antigens directly to T cells
    • Lee, J. W. et al. Peripheral antigen display by lymph node stroma promotes T cell tolerance to intestinal self. Nature Immunol. 8, 181-190 (2007). This study reveals that peripheral tolerance can not only be mediated by DCs in SLOs that have taken up antigen in peripheral tissues but also by stromal cells in the lymph node, which synthesize and present peripheral tissue antigens directly to T cells.
    • (2007) Nature Immunol , vol.8 , pp. 181-190
    • Lee, J.W.1
  • 68
    • 34247645487 scopus 로고    scopus 로고
    • Antigen presentation by nonhemopoietic cells amplifies clonal expansion of effector CD8 T cells in a pathogen-specific manner
    • Thomas, S., Kolumam, G. A. & Murali-Krishna, K. Antigen presentation by nonhemopoietic cells amplifies clonal expansion of effector CD8 T cells in a pathogen-specific manner. J. Immunol. 178, 5802-5811 (2007).
    • (2007) J. Immunol , vol.178 , pp. 5802-5811
    • Thomas, S.1    Kolumam, G.A.2    Murali-Krishna, K.3
  • 69
    • 38449121250 scopus 로고    scopus 로고
    • The antiproliferative effect of mesenchymal stem cells is a fundamental property shared by all stromal cells
    • Jones, S., Horwood, N., Cope, A. & Dazzi, F. The antiproliferative effect of mesenchymal stem cells is a fundamental property shared by all stromal cells. J. Immunol. 179, 2824-2831 (2007).
    • (2007) J. Immunol , vol.179 , pp. 2824-2831
    • Jones, S.1    Horwood, N.2    Cope, A.3    Dazzi, F.4
  • 70
    • 34848852256 scopus 로고    scopus 로고
    • Viral targeting of fibroblastic reticular cells contributes to immunosuppression and persistence during chronic infection
    • Mueller, S. N. et al. Viral targeting of fibroblastic reticular cells contributes to immunosuppression and persistence during chronic infection. Proc. Natl Acad. Sci. USA 104, 15430-15435 (2007).
    • (2007) Proc. Natl Acad. Sci. USA , vol.104 , pp. 15430-15435
    • Mueller, S.N.1
  • 71
    • 10344239885 scopus 로고    scopus 로고
    • + progenitor cells.
    • + progenitor cells.
  • 72
    • 39449094869 scopus 로고    scopus 로고
    • T cell sensing of antigen dose governs interactive behavior with dendritic cells and sets a threshold for T cell activation
    • Henrickson, S. E. et al. T cell sensing of antigen dose governs interactive behavior with dendritic cells and sets a threshold for T cell activation. Nature Immunol. 9, 282-291 (2008).
    • (2008) Nature Immunol , vol.9 , pp. 282-291
    • Henrickson, S.E.1
  • 74
    • 0141678822 scopus 로고    scopus 로고
    • Dissecting the role of lymphotoxin in lymphoid organs by conditional targeting
    • Tumanov, A. V. et al. Dissecting the role of lymphotoxin in lymphoid organs by conditional targeting. Immunol. Rev. 195, 106-116 (2003).
    • (2003) Immunol. Rev , vol.195 , pp. 106-116
    • Tumanov, A.V.1
  • 75
    • 0030582773 scopus 로고    scopus 로고
    • A putative chemokine receptor, BLR1, directs B cell migration to defined lymphoid organs and specific anatomic compartments of the spleen
    • Forster, R. et al. A putative chemokine receptor, BLR1, directs B cell migration to defined lymphoid organs and specific anatomic compartments of the spleen. Cell 87, 1037-1047 (1996).
    • (1996) Cell , vol.87 , pp. 1037-1047
    • Forster, R.1
  • 76
    • 28244485491 scopus 로고    scopus 로고
    • CXCR5-dependent seeding of follicular niches by B and Th cells augments antiviral B cell responses
    • Junt, T. et al. CXCR5-dependent seeding of follicular niches by B and Th cells augments antiviral B cell responses. J. Immunol. 175, 7109-7116 (2005).
    • (2005) J. Immunol , vol.175 , pp. 7109-7116
    • Junt, T.1
  • 77
    • 0033214348 scopus 로고    scopus 로고
    • CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs
    • Forster, R. et al. CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs. Cell 99, 23-33 (1999).
    • (1999) Cell , vol.99 , pp. 23-33
    • Forster, R.1
  • 78
    • 0037097506 scopus 로고    scopus 로고
    • Antiviral immune responses in the absence of organized lymphoid T cell zones in plt/plt mice
    • Junt, T. et al. Antiviral immune responses in the absence of organized lymphoid T cell zones in plt/plt mice. J. Immunol. 168, 6032-6040 (2002).
    • (2002) J. Immunol , vol.168 , pp. 6032-6040
    • Junt, T.1
  • 79
    • 9144257931 scopus 로고    scopus 로고
    • Impact of CCR7 on priming and distribution of antiviral effector and memory CTL
    • Junt, T. et al. Impact of CCR7 on priming and distribution of antiviral effector and memory CTL. J. Immunol. 173, 6684-6693 (2004).
    • (2004) J. Immunol , vol.173 , pp. 6684-6693
    • Junt, T.1
  • 80
    • 33846547204 scopus 로고    scopus 로고
    • Dendritic cell-independent B cell activation during acute virus infection: A role for early CCR7-driven B-T helper cell collaboration
    • Scandella, E. et al. Dendritic cell-independent B cell activation during acute virus infection: a role for early CCR7-driven B-T helper cell collaboration. J. Immunol. 178, 1468-1476 (2007).
    • (2007) J. Immunol , vol.178 , pp. 1468-1476
    • Scandella, E.1
  • 81
    • 0035862332 scopus 로고    scopus 로고
    • Mice lacking expression of the chemokines CCL21-ser and CCL19 (plt mice) demonstrate delayed but enhanced T cell immune responses
    • Mori, S. et al. Mice lacking expression of the chemokines CCL21-ser and CCL19 (plt mice) demonstrate delayed but enhanced T cell immune responses. J. Exp. Med. 193, 207-218 (2001).
    • (2001) J. Exp. Med , vol.193 , pp. 207-218
    • Mori, S.1
  • 82
    • 18644382218 scopus 로고    scopus 로고
    • Differential requirements for the chemokine receptor CCR7 in T cell activation during Listeria monocytogenes infection
    • Kursar, M. et al. Differential requirements for the chemokine receptor CCR7 in T cell activation during Listeria monocytogenes infection. J. Exp. Med. 201, 1447-1457 (2005).
    • (2005) J. Exp. Med , vol.201 , pp. 1447-1457
    • Kursar, M.1
  • 83
    • 38949191290 scopus 로고    scopus 로고
    • Decoding the dynamics of T cell-dendritic cell interactions in vivo
    • Celli, S., Garcia, Z., Beuneu, H. & Bousso, P. Decoding the dynamics of T cell-dendritic cell interactions in vivo. Immunol. Rev. 221, 182-187 (2008).
    • (2008) Immunol. Rev , vol.221 , pp. 182-187
    • Celli, S.1    Garcia, Z.2    Beuneu, H.3    Bousso, P.4
  • 84
    • 35148819683 scopus 로고    scopus 로고
    • + T-cell exit from the white pulp to the red pulp of the spleen through bridging channels.
    • + T-cell exit from the white pulp to the red pulp of the spleen through bridging channels.
  • 85
    • 34247149876 scopus 로고    scopus 로고
    • The humoral immune response is initiated in lymph nodes by B cells that acquire soluble antigen directly in the follicles
    • Pape, K. A., Catron, D. M., Itano, A. A. & Jenkins, M. K. The humoral immune response is initiated in lymph nodes by B cells that acquire soluble antigen directly in the follicles. Immunity 26, 491-502 (2007).
    • (2007) Immunity , vol.26 , pp. 491-502
    • Pape, K.A.1    Catron, D.M.2    Itano, A.A.3    Jenkins, M.K.4
  • 86
    • 38949135155 scopus 로고    scopus 로고
    • The microanatomy of T-cell responses
    • Lammermann, T. & Sixt, M. The microanatomy of T-cell responses. Immunol. Rev. 221, 26-43 (2008).
    • (2008) Immunol. Rev , vol.221 , pp. 26-43
    • Lammermann, T.1    Sixt, M.2
  • 87
    • 32244448982 scopus 로고    scopus 로고
    • Quantitative imaging of Plasmodium transmission from mosquito to mammal
    • Amino, R. et al. Quantitative imaging of Plasmodium transmission from mosquito to mammal. Nature Med. 12, 220-224 (2006).
    • (2006) Nature Med , vol.12 , pp. 220-224
    • Amino, R.1
  • 88
    • 0141654300 scopus 로고    scopus 로고
    • + dendritic cells but not by Langerhans cells
    • + dendritic cells but not by Langerhans cells. Science 301, 1925-1928 (2003).
    • (2003) Science , vol.301 , pp. 1925-1928
    • Allan, R.S.1
  • 89
    • 33645796485 scopus 로고    scopus 로고
    • Specific remodeling of splenic architecture by cytomegalovirus
    • Benedict, C. A. et al. Specific remodeling of splenic architecture by cytomegalovirus. PLoS Pathog. 2, e16 (2006).
    • (2006) PLoS Pathog , vol.2
    • Benedict, C.A.1
  • 90
    • 34547782880 scopus 로고    scopus 로고
    • Regulation of homeostatic chemokine expression and cell trafficking during immune responses
    • This paper shows that viral infection can lead to the downregulation of constitutive chemokine expression, thereby precipitating a transient period of immunosuppression
    • Mueller, S. N. et al. Regulation of homeostatic chemokine expression and cell trafficking during immune responses. Science 317, 670-674 (2007). This paper shows that viral infection can lead to the downregulation of constitutive chemokine expression, thereby precipitating a transient period of immunosuppression.
    • (2007) Science , vol.317 , pp. 670-674
    • Mueller, S.N.1
  • 91
    • 44049100259 scopus 로고    scopus 로고
    • Restoration of lymphoid organ integrity through the interaction of lymphoid tissue-inducer cells with stroma of the T cell zone
    • This study shows that the interaction between LTi cells and mesenchymal organizer cells can be reactivated following the infection-associated immunopathological destruction of SLO microenvironments
    • Scandella, E. et al. Restoration of lymphoid organ integrity through the interaction of lymphoid tissue-inducer cells with stroma of the T cell zone. Nature Immunol. 9, 667-675 (2008). This study shows that the interaction between LTi cells and mesenchymal organizer cells can be reactivated following the infection-associated immunopathological destruction of SLO microenvironments.
    • (2008) Nature Immunol , vol.9 , pp. 667-675
    • Scandella, E.1
  • 92
    • 0025787430 scopus 로고
    • Virus-triggered acquired immunodeficiency by cytotoxic T-cell-dependent destruction of antigen-presenting cells and lymph follicle structure
    • Odermatt, B., Eppler, M., Leist, T. P., Hengartner, H. & Zinkernagel, R. M. Virus-triggered acquired immunodeficiency by cytotoxic T-cell-dependent destruction of antigen-presenting cells and lymph follicle structure. Proc. Natl Acad. Sci. USA 88, 8252-8256 (1991).
    • (1991) Proc. Natl Acad. Sci. USA , vol.88 , pp. 8252-8256
    • Odermatt, B.1    Eppler, M.2    Leist, T.P.3    Hengartner, H.4    Zinkernagel, R.M.5
  • 93
    • 0842343142 scopus 로고    scopus 로고
    • Lymphoid follicle destruction and immunosuppression after repeated CpG oligodeoxynucleotide administration
    • Heikenwalder, M. et al. Lymphoid follicle destruction and immunosuppression after repeated CpG oligodeoxynucleotide administration. Nature Med. 10, 187-192 (2004).
    • (2004) Nature Med , vol.10 , pp. 187-192
    • Heikenwalder, M.1
  • 94
    • 33846194007 scopus 로고    scopus 로고
    • Chemokines CCL19 and CCL21 promote activation-induced cell death of antigen-responding T cells
    • Yasuda, T. et al. Chemokines CCL19 and CCL21 promote activation-induced cell death of antigen-responding T cells. Blood 109, 449-456 (2007).
    • (2007) Blood , vol.109 , pp. 449-456
    • Yasuda, T.1
  • 95
    • 37849033437 scopus 로고    scopus 로고
    • Pham, T. H., Okada, T., Matloubian, M., Lo, C. G. & Cyster, J. G. S1P1 receptor signaling overrides retention mediated by Gαi-coupled receptors to promote T cell egress. Immunity 28, 122-133 (2008).
    • Pham, T. H., Okada, T., Matloubian, M., Lo, C. G. & Cyster, J. G. S1P1 receptor signaling overrides retention mediated by Gαi-coupled receptors to promote T cell egress. Immunity 28, 122-133 (2008).
  • 96
    • 0347382593 scopus 로고    scopus 로고
    • Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells
    • Kaech, S. M. et al. Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells. Nature Immunol. 4, 1191-1198 (2003).
    • (2003) Nature Immunol , vol.4 , pp. 1191-1198
    • Kaech, S.M.1
  • 97
    • 39649100240 scopus 로고    scopus 로고
    • + T cells to HIV-1 infection: A novel model of HIV-1 latency
    • + T cells to HIV-1 infection: a novel model of HIV-1 latency. Blood 110, 4161-4164 (2007).
    • (2007) Blood , vol.110 , pp. 4161-4164
    • Saleh, S.1
  • 98
    • 0036906535 scopus 로고    scopus 로고
    • Defective CCR7 expression on dendritic cells contributes to the development of visceral leishmaniasis
    • Ato, M., Stager, S., Engwerda, C. R. & Kaye, P. M. Defective CCR7 expression on dendritic cells contributes to the development of visceral leishmaniasis. Nature Immunol. 3, 1185-1191 (2002).
    • (2002) Nature Immunol , vol.3 , pp. 1185-1191
    • Ato, M.1    Stager, S.2    Engwerda, C.R.3    Kaye, P.M.4
  • 99
    • 0023851366 scopus 로고
    • Pathogenesis of murine cytomegalovirus infection: Identification of infected cells in the spleen during acute and latent infections
    • Mercer, J. A., Wiley, C. A. & Spector, D. H. Pathogenesis of murine cytomegalovirus infection: identification of infected cells in the spleen during acute and latent infections. J. Virol. 62, 987-997 (1988).
    • (1988) J. Virol , vol.62 , pp. 987-997
    • Mercer, J.A.1    Wiley, C.A.2    Spector, D.H.3
  • 100
    • 0034686436 scopus 로고    scopus 로고
    • Fibroblasts as host cells in latent leishmaniosis
    • Bogdan, C. et al. Fibroblasts as host cells in latent leishmaniosis. J. Exp. Med. 191, 2121-2130 (2000).
    • (2000) J. Exp. Med , vol.191 , pp. 2121-2130
    • Bogdan, C.1
  • 101
    • 0024357510 scopus 로고
    • Mechanisms of splenic control of murine malaria: Cellular reactions of the spleen in lethal (strain 17XL) Plasmodium yoelii malaria in BALB/c mice, and the consequences of pre-infective splenectomy
    • Weiss, L. Mechanisms of splenic control of murine malaria: cellular reactions of the spleen in lethal (strain 17XL) Plasmodium yoelii malaria in BALB/c mice, and the consequences of pre-infective splenectomy. Am. J. Trop. Med. Hyg. 41, 144-160 (1989).
    • (1989) Am. J. Trop. Med. Hyg , vol.41 , pp. 144-160
    • Weiss, L.1
  • 102
    • 2942625911 scopus 로고    scopus 로고
    • Interactions between commensal intestinal bacteria and the immune system
    • Macpherson, A. J. & Harris, N. L. Interactions between commensal intestinal bacteria and the immune system. Nature Rev. Immunol. 4, 478-485 (2004).
    • (2004) Nature Rev. Immunol , vol.4 , pp. 478-485
    • Macpherson, A.J.1    Harris, N.L.2
  • 103
    • 33645068450 scopus 로고    scopus 로고
    • Mesenteric lymph nodes at the center of immune anatomy
    • Macpherson, A. J. & Smith, K. Mesenteric lymph nodes at the center of immune anatomy. J. Exp. Med. 203, 497-500 (2006).
    • (2006) J. Exp. Med , vol.203 , pp. 497-500
    • Macpherson, A.J.1    Smith, K.2
  • 104
    • 0035858127 scopus 로고    scopus 로고
    • Neonatal and early life vaccinology
    • Siegrist, C. A. Neonatal and early life vaccinology. Vaccine 19, 3331-3346 (2001).
    • (2001) Vaccine , vol.19 , pp. 3331-3346
    • Siegrist, C.A.1
  • 105
    • 22144490199 scopus 로고    scopus 로고
    • An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system
    • This study shows that during colonization of germ-free animals with the ubiquitous gut microorganism B. fragilis, a bacterial cell-wall polysaccharide is sufficient to direct the cellular and morphological maturation of the immune system
    • Mazmanian, S. K., Liu, C. H., Tzianabos, A. O. & Kasper, D. L. An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system. Cell 122, 107-118 (2005). This study shows that during colonization of germ-free animals with the ubiquitous gut microorganism B. fragilis, a bacterial cell-wall polysaccharide is sufficient to direct the cellular and morphological maturation of the immune system.
    • (2005) Cell , vol.122 , pp. 107-118
    • Mazmanian, S.K.1    Liu, C.H.2    Tzianabos, A.O.3    Kasper, D.L.4
  • 106
    • 0035803465 scopus 로고    scopus 로고
    • Splenic T zone development is B cell dependent
    • Ngo, V. N., Cornall, R. J. & Cyster, J. G. Splenic T zone development is B cell dependent. J. Exp. Med. 194, 1649-1660 (2001).
    • (2001) J. Exp. Med , vol.194 , pp. 1649-1660
    • Ngo, V.N.1    Cornall, R.J.2    Cyster, J.G.3
  • 107
    • 0032728216 scopus 로고    scopus 로고
    • BCA-1 is highly expressed in Helicobacter pylori-induced mucosa-associated lymphoid tissue and gastric lymphoma
    • Mazzucchelli, L. et al. BCA-1 is highly expressed in Helicobacter pylori-induced mucosa-associated lymphoid tissue and gastric lymphoma. J. Clin. Invest. 104, R49-R54 (1999).
    • (1999) J. Clin. Invest , vol.104
    • Mazzucchelli, L.1
  • 108
    • 14044261259 scopus 로고    scopus 로고
    • In situ diversification of the antibody repertoire in chronic Lyme arthritis synovium
    • Ghosh, S., Steere, A. C., Stollar, B. D. & Huber, B. T. In situ diversification of the antibody repertoire in chronic Lyme arthritis synovium. J. Immunol. 174, 2860-2869 (2005).
    • (2005) J. Immunol , vol.174 , pp. 2860-2869
    • Ghosh, S.1    Steere, A.C.2    Stollar, B.D.3    Huber, B.T.4
  • 109
    • 47249139528 scopus 로고    scopus 로고
    • Inhibition of the lymphotoxin pathway as a therapy for autoimmune disease
    • Browning, J. L. Inhibition of the lymphotoxin pathway as a therapy for autoimmune disease. Immunol. Rev. 223, 202-220 (2008).
    • (2008) Immunol. Rev , vol.223 , pp. 202-220
    • Browning, J.L.1
  • 110
    • 44949101393 scopus 로고    scopus 로고
    • How antigen quantity and quality determine T-cell decisions in lymphoid tissue
    • Zheng, H. et al. How antigen quantity and quality determine T-cell decisions in lymphoid tissue. Mol. Cell Biol. 28, 4040-4051 (2008).
    • (2008) Mol. Cell Biol , vol.28 , pp. 4040-4051
    • Zheng, H.1
  • 111
    • 0030975532 scopus 로고    scopus 로고
    • Antigen localisation regulates immune responses in a dose- and time-dependent fashion: A geographical view of immune reactivity
    • Zinkernagel, R. M. et al. Antigen localisation regulates immune responses in a dose- and time-dependent fashion: a geographical view of immune reactivity. Immunol. Rev. 156, 199-209 (1997).
    • (1997) Immunol. Rev , vol.156 , pp. 199-209
    • Zinkernagel, R.M.1
  • 112
    • 0037978900 scopus 로고    scopus 로고
    • Organogenesis of lymphoid tissues
    • Mebius, R. E. Organogenesis of lymphoid tissues. Nature Rev. Immunol. 3, 292-303 (2003).
    • (2003) Nature Rev. Immunol , vol.3 , pp. 292-303
    • Mebius, R.E.1
  • 113
    • 33645106845 scopus 로고    scopus 로고
    • Lymphoid organ development: From ontogeny to neogenesis
    • Drayton, D. L., Liao, S., Mounzer, R. H. & Ruddle, N. H. Lymphoid organ development: from ontogeny to neogenesis. Nature Immunol. 7, 344-353 (2006).
    • (2006) Nature Immunol , vol.7 , pp. 344-353
    • Drayton, D.L.1    Liao, S.2    Mounzer, R.H.3    Ruddle, N.H.4
  • 114
    • 0036753679 scopus 로고    scopus 로고
    • 1 integrin activation by CXCR5. Immunity 17, 363-373 (2002).
    • 1 integrin activation by CXCR5. Immunity 17, 363-373 (2002).
  • 115
    • 18644366772 scopus 로고    scopus 로고
    • Distinct role of surface lymphotoxin expressed by B cells in the organization of secondary lymphoid tissues
    • Tumanov, A. et al. Distinct role of surface lymphotoxin expressed by B cells in the organization of secondary lymphoid tissues. Immunity 17, 239-250 (2002).
    • (2002) Immunity , vol.17 , pp. 239-250
    • Tumanov, A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.