Extrafollicular activation of lymph node B cells by antigen-bearing dendritic cells

Science

Volumn 312, Issue 5780, 2006, Pages 1672-1676

  Qi, Hai ^a   Egen, Jackson G ^a   Huang, Alex Y C ^a   Germain, Ronald N ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGENS; CALCIUM; DENDRIMERS; IMAGING TECHNIQUES; IMMUNOLOGY; PROTEINS; SIGNALING;

ANTIGEN ACQUISITION; EXTRAFOLLICULAR ACCUMULATION; IMMUNOGLOBULIN; LYMPHOCYTES;

CELL CULTURE;

B LYMPHOCYTE RECEPTOR; CALCIUM ION; CD19 ANTIGEN; CD68 ANTIGEN; IMMUNOGLOBULIN RECEPTOR; LYSOZYME; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; PRONASE;

ACCUMULATION; ANTIBODY; ANTIGEN; CALCIUM; IMMUNE RESPONSE; MIGRATION;

ANIMAL CELL; ANTIBODY RESPONSE; ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; ANTIGEN SPECIFICITY; ARTICLE; B LYMPHOCYTE; B LYMPHOCYTE ACTIVATION; CALCIUM CELL LEVEL; CALCIUM SIGNALING; CELL INTERACTION; CELL MIGRATION; CONTROLLED STUDY; DENDRITIC CELL; IN VIVO STUDY; LYMPH FOLLICLE; MOUSE; NONHUMAN; PRIORITY JOURNAL; VENULE;

ANIMALS; ANTIGENS; B-LYMPHOCYTES; CALCIUM; CALCIUM SIGNALING; CELL MOVEMENT; CELL SHAPE; COCULTURE TECHNIQUES; DENDRITIC CELLS; ENDOCYTOSIS; LYMPH NODES; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MURAMIDASE; RECEPTORS, ANTIGEN, B-CELL; T-LYMPHOCYTES;

EID: 33745133006     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1125703     Document Type: Article

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31. We are grateful to O. Schwartz at the NIAID Biological Imaging Facility for expert advice on confocal microscopy; I. Ifrim and A. Rinker for research assistance; and R. Casellas, J. Cannons, and P. Schwartzberg for comments on the manuscript. H.Q. and A.Y.C.H. received Cancer Research Institute Postdoctoral Fellowships. H.Q. is particularly in debt to Y. Hong for support, encouragement, and inspiration. This work was supported by funds from the Intramural Program, NIAID, NIH, U.S. Department of Health and Human Services.