-
1
-
-
0023654283
-
The ATP-dependent interaction of eukaryotic initiation factors with mRNA
-
Abramson, R. D., T. E. Dever, T. G. Lawson, B. K. Ray, R. E. Thach, and W. C. Merrick. 1987. The ATP-dependent interaction of eukaryotic initiation factors with mRNA. J. Biol. Chem. 262:3826-3832.
-
(1987)
J. Biol. Chem.
, vol.262
, pp. 3826-3832
-
-
Abramson, R.D.1
Dever, T.E.2
Lawson, T.G.3
Ray, B.K.4
Thach, R.E.5
Merrick, W.C.6
-
2
-
-
0033828440
-
Eukaryote-specific domains in translation initiation factors: Implications for translation regulation and evolution of the translation system
-
Aravind, L., and E. V. Koonin. 2000. Eukaryote-specific domains in translation initiation factors: implications for translation regulation and evolution of the translation system. Genome Res. 10:1172-1184.
-
(2000)
Genome Res.
, vol.10
, pp. 1172-1184
-
-
Aravind, L.1
Koonin, E.V.2
-
3
-
-
0032193771
-
Differential transcriptional regulation of CD161 and a novel gene, 197/15a, by IL-2, IL-15, and IL-12 in NK and T cells
-
Azzoni, L., O. Zatsepina, B. Abede, I. M. Bennett, P. Kanakaraj, and B. Perussia. 1998. Differential transcriptional regulation of CD161 and a novel gene, 197/15a, by IL-2, IL-15, and IL-12 in NK and T cells. J. Immunology 161:3493-3500.
-
(1998)
J. Immunology
, vol.161
, pp. 3493-3500
-
-
Azzoni, L.1
Zatsepina, O.2
Abede, B.3
Bennett, I.M.4
Kanakaraj, P.5
Perussia, B.6
-
4
-
-
18144432729
-
The transformation suppressor protein Pdcd4 shuttles between nucleus and cytoplasm and binds RNA
-
Bohm, M., K. Sawicka, J. P. Siebrasse, A. Brehmer-Fastnacht, R. Peters, and K. H. Klempnauer. 2003. The transformation suppressor protein Pdcd4 shuttles between nucleus and cytoplasm and binds RNA. Oncogene 22:4905-4910.
-
(2003)
Oncogene
, vol.22
, pp. 4905-4910
-
-
Bohm, M.1
Sawicka, K.2
Siebrasse, J.P.3
Brehmer-Fastnacht, A.4
Peters, R.5
Klempnauer, K.H.6
-
5
-
-
0030598885
-
A signaling pathway to translational control
-
Brown, E. J., and S. L. Schreiber. 1996. A signaling pathway to translational control. Cell 86:517-520.
-
(1996)
Cell
, vol.86
, pp. 517-520
-
-
Brown, E.J.1
Schreiber, S.L.2
-
6
-
-
0034700086
-
Crystal structure of yeast initiation factor 4A, a DEAD-box RNA helicase
-
Caruthers, J. M., E. R. Johnson, and D. B. McKay. 2000. Crystal structure of yeast initiation factor 4A, a DEAD-box RNA helicase. Proc. Natl. Acad. Sci. USA 97:13080-13085.
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 13080-13085
-
-
Caruthers, J.M.1
Johnson, E.R.2
McKay, D.B.3
-
7
-
-
85047699977
-
Identification of genes regulated by dexamethasone in multiple myeloma cells using oligonucleotide arrays
-
Chauhan, D., D. Auclair, E. K. Robinson, T. Hideshima, G. Li, K. Podar, D. Gupta, P. Richardson, R. L. Schlossman, N. Krett, L. B. Chen, N. C. Munshi, and K. C. Anderson. 2002. Identification of genes regulated by dexamethasone in multiple myeloma cells using oligonucleotide arrays. Oncogene 21:1346-1358.
-
(2002)
Oncogene
, vol.21
, pp. 1346-1358
-
-
Chauhan, D.1
Auclair, D.2
Robinson, E.K.3
Hideshima, T.4
Li, G.5
Podar, K.6
Gupta, D.7
Richardson, P.8
Schlossman, R.L.9
Krett, N.10
Chen, L.B.11
Munshi, N.C.12
Anderson, K.C.13
-
8
-
-
0042524204
-
Loss of PDCD4 expression in human lung cancer correlates with tumour progression and prognosis
-
Chen, Y. H., T. Knosel, G. Kristiansen, A. Pietas, M. E. Garber, S. Matsuhashi, I. Ozaki, and I. Petersen. 2003. Loss of PDCD4 expression in human lung cancer correlates with tumour progression and prognosis. J. Pathol. 200:640-646.
-
(2003)
J. Pathol.
, vol.200
, pp. 640-646
-
-
Chen, Y.H.1
Knosel, T.2
Kristiansen, G.3
Pietas, A.4
Garber, M.E.5
Matsuhashi, S.6
Ozaki, I.7
Petersen, I.8
-
9
-
-
0033598712
-
Differentially expressed protein Pdcd4 inhibits tumor promoter-induced neoplastic transformation
-
Cmarik, J. L., H. Min, G. Hegamyer, S. Zhan, M. Kulesz-Martin, H. Yoshinaga, S. Matsuhashi, and N. H. Colburn. 1999. Differentially expressed protein Pdcd4 inhibits tumor promoter-induced neoplastic transformation. Proc. Natl. Acad. Sci. USA 96:14037-14042.
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 14037-14042
-
-
Cmarik, J.L.1
Min, H.2
Hegamyer, G.3
Zhan, S.4
Kulesz-Martin, M.5
Yoshinaga, H.6
Matsuhashi, S.7
Colburn, N.H.8
-
10
-
-
0033044355
-
eIF4E expression in tumors: Its possible role in progression of malignancies
-
De Benedetti, A., and A. L. Harris. 1999. eIF4E expression in tumors: its possible role in progression of malignancies. Int. J. Biochem. Cell. Biol. 31:59-72.
-
(1999)
Int. J. Biochem. Cell. Biol.
, vol.31
, pp. 59-72
-
-
De Benedetti, A.1
Harris, A.L.2
-
11
-
-
0031869508
-
Translational activation of uncapped mRNAs by the central part of human eIF4G is 5′ end-dependent
-
De Gregorio, E., T. Preiss, and M. W. Hentze. 1998. Translational activation of uncapped mRNAs by the central part of human eIF4G is 5′ end-dependent. RNA 4:828-836.
-
(1998)
RNA
, vol.4
, pp. 828-836
-
-
De Gregorio, E.1
Preiss, T.2
Hentze, M.W.3
-
12
-
-
0028905444
-
Transformation reversion induced in JB6 RT101 cells by AP-1 inhibitors
-
Dong, Z., V. Lavrovsky, and N. H. Colburn. 1995. Transformation reversion induced in JB6 RT101 cells by AP-1 inhibitors. Carcinogenesis 16:749-756.
-
(1995)
Carcinogenesis
, vol.16
, pp. 749-756
-
-
Dong, Z.1
Lavrovsky, V.2
Colburn, N.H.3
-
13
-
-
0029061281
-
Progressive elevation of AP-1 activity during preneoplastic-to-neoplastic progression as modeled in mouse JB6 cell variants
-
Dong, Z., R. G. Watts, Y. Sun, S.-N. Zhan, and N. Colburn. 1995. Progressive elevation of AP-1 activity during preneoplastic-to-neoplastic progression as modeled in mouse JB6 cell variants. Int. J. Oncol. 7:359-364.
-
(1995)
Int. J. Oncol.
, vol.7
, pp. 359-364
-
-
Dong, Z.1
Watts, R.G.2
Sun, Y.3
Zhan, S.-N.4
Colburn, N.5
-
14
-
-
0036384266
-
DUG is a novel homologue of translation initiation factor 4G that binds eIF4A
-
Goke, A., R. Goke, A. Knolle, H. Trusheim, H. Schmidt, A. Wilmen, R. Carmody, B. Goke, and Y. H. Chen. 2002. DUG is a novel homologue of translation initiation factor 4G that binds eIF4A. Biochem. Biophys. Res. Commun. 297:78-82.
-
(2002)
Biochem. Biophys. Res. Commun.
, vol.297
, pp. 78-82
-
-
Goke, A.1
Goke, R.2
Knolle, A.3
Trusheim, H.4
Schmidt, H.5
Wilmen, A.6
Carmody, R.7
Goke, B.8
Chen, Y.H.9
-
15
-
-
0028438188
-
Regulation of protein synthesis by mRNA structure
-
Gray, N. K., and M. W. Hentze. 1994. Regulation of protein synthesis by mRNA structure. Mol. Biol. Rep. 19:195-200.
-
(1994)
Mol. Biol. Rep.
, vol.19
, pp. 195-200
-
-
Gray, N.K.1
Hentze, M.W.2
-
16
-
-
0034190272
-
Activator protein 1 (AP-1)- and nuclear factor KB (NF-κB) -dependent transcriptional events in carcinogenesis
-
Hsu, T. C., M. R. Young, J. Cmarik, and N. H. Colburn. 2000. Activator protein 1 (AP-1)- and nuclear factor KB (NF-κB)-dependent transcriptional events in carcinogenesis. Free Radic. Biol. Med. 28:1338-1348.
-
(2000)
Free Radic. Biol. Med.
, vol.28
, pp. 1338-1348
-
-
Hsu, T.C.1
Young, M.R.2
Cmarik, J.3
Colburn, N.H.4
-
17
-
-
0031039645
-
A new translational regulator with homology to eukaryotic translation initiation factor 4G
-
Imataka, H., H. S. Olsen, and N. Sonenberg. 1997. A new translational regulator with homology to eukaryotic translation initiation factor 4G. EMBO J. 16:817-825.
-
(1997)
EMBO J.
, vol.16
, pp. 817-825
-
-
Imataka, H.1
Olsen, H.S.2
Sonenberg, N.3
-
18
-
-
0030666625
-
Human eukaryotic translation initiation factor 4G (eIF4G) possesses two separate and independent binding sites for eIF4A
-
Imataka, H., and N. Sonenberg. 1997. Human eukaryotic translation initiation factor 4G (eIF4G) possesses two separate and independent binding sites for eIF4A. Mol. Cell. Biol. 17:6940-6947.
-
(1997)
Mol. Cell. Biol.
, vol.17
, pp. 6940-6947
-
-
Imataka, H.1
Sonenberg, N.2
-
19
-
-
0018233480
-
How do eucaryotic ribosomes select initiation regions in messenger RNA?
-
Kozak, M. 1978. How do eucaryotic ribosomes select initiation regions in messenger RNA? Cell 15:1109-1123.
-
(1978)
Cell
, vol.15
, pp. 1109-1123
-
-
Kozak, M.1
-
20
-
-
0024414469
-
Circumstances and mechanisms of inhibition of translation by secondary structure in eucaryotic mRNAs
-
Kozak, M. 1989. Circumstances and mechanisms of inhibition of translation by secondary structure in eucaryotic mRNAs. Mol. Cell. Biol. 9:5134-5142.
-
(1989)
Mol. Cell. Biol.
, vol.9
, pp. 5134-5142
-
-
Kozak, M.1
-
21
-
-
0026151096
-
Effects of long 5′ leader sequences on initiation by eukaryotic ribosomes in vitro
-
Kozak, M. 1991. Effects of long 5′ leader sequences on initiation by eukaryotic ribosomes in vitro. Gene Expr. 1:117-125.
-
(1991)
Gene Expr.
, vol.1
, pp. 117-125
-
-
Kozak, M.1
-
22
-
-
18144441468
-
Sequence of the genes TIF1 and TIF2 from Saccharomyces cerevisiae coding for a translation initiation factor
-
Linder, P., and P. P. Slonimski. 1988. Sequence of the genes TIF1 and TIF2 from Saccharomyces cerevisiae coding for a translation initiation factor. Nucleic Acids Res. 16:10359.
-
(1988)
Nucleic Acids Res.
, vol.16
, pp. 10359
-
-
Linder, P.1
Slonimski, P.P.2
-
23
-
-
0033852315
-
Physical association of eukaryotic initiation factor 4G (eIF4G) with eIF4A strongly enhances binding of eIF4G to the internal ribosomal entry site of encephalomyocarditis virus and is required for internal initiation of translation
-
Lomakin, I. B., C. U. Hellen, and T. V. Pestova. 2000. Physical association of eukaryotic initiation factor 4G (eIF4G) with eIF4A strongly enhances binding of eIF4G to the internal ribosomal entry site of encephalomyocarditis virus and is required for internal initiation of translation. Mol. Cell. Biol. 20:6019-6029.
-
(2000)
Mol. Cell. Biol.
, vol.20
, pp. 6019-6029
-
-
Lomakin, I.B.1
Hellen, C.U.2
Pestova, T.V.3
-
24
-
-
0033957406
-
Eukaryotic translation initiation factor 4E (eIF4E) binding site and the middle one-third of eIF4GI constitute the core domain for cap-dependent translation, and the C-terminal one-third functions as a modulatory region
-
Morino, S., H. Imataka, Y. V. Svitkin, T. V. Pestova, and N. Sonenberg. 2000. Eukaryotic translation initiation factor 4E (eIF4E) binding site and the middle one-third of eIF4GI constitute the core domain for cap-dependent translation, and the C-terminal one-third functions as a modulatory region. Mol. Cell. Biol. 20:468-477.
-
(2000)
Mol. Cell. Biol.
, vol.20
, pp. 468-477
-
-
Morino, S.1
Imataka, H.2
Svitkin, Y.V.3
Pestova, T.V.4
Sonenberg, N.5
-
25
-
-
0024039480
-
The mouse protein synthesis initiation factor 4A gene family includes two related functional genes which are differentially expressed
-
Nielsen, P. J., and H. Trachsel. 1988. The mouse protein synthesis initiation factor 4A gene family includes two related functional genes which are differentially expressed. EMBO J. 7:2097-2105.
-
(1988)
EMBO J.
, vol.7
, pp. 2097-2105
-
-
Nielsen, P.J.1
Trachsel, H.2
-
26
-
-
0032712599
-
Secondary structure in the 5′-leader or 3′-untranslated region reduces protein yield but does not affect the functional interaction between the 5′-cap and the poly(A) tail
-
Niepel, M., L. Ling, and D. R. Gallie. 1999. Secondary structure in the 5′-leader or 3′-untranslated region reduces protein yield but does not affect the functional interaction between the 5′-cap and the poly(A) tail. FEBS Lett. 26:79-84.
-
(1999)
FEBS Lett.
, vol.26
, pp. 79-84
-
-
Niepel, M.1
Ling, L.2
Gallie, D.R.3
-
27
-
-
0030296790
-
Molecular cloning of the genes suppressed in RVC lymphoma cells by topoisomerase inhibitors
-
Onishi, Y., and H. Kizaki. 1996. Molecular cloning of the genes suppressed in RVC lymphoma cells by topoisomerase inhibitors. Biochem. Biophys. Res. Commun. 228:7-13.
-
(1996)
Biochem. Biophys. Res. Commun.
, vol.228
, pp. 7-13
-
-
Onishi, Y.1
Kizaki, H.2
-
28
-
-
0027494565
-
The HRIGRXXR region of the DEAD box RNA helicase eukaryotic translation initiation factor 4A is required for RNA binding and ATP hydrolysis
-
Pause, A., N. Methot, and N. Sonenberg. 1993. The HRIGRXXR region of the DEAD box RNA helicase eukaryotic translation initiation factor 4A is required for RNA binding and ATP hydrolysis. Mol. Cell. Biol. 13:6789-6798.
-
(1993)
Mol. Cell. Biol.
, vol.13
, pp. 6789-6798
-
-
Pause, A.1
Methot, N.2
Sonenberg, N.3
-
29
-
-
0028197298
-
Dominant negative mutants of mammalian translation initiation factor eIF-4A define a critical role for eIF-4F in cap-dependent and cap-independent initiation of translation
-
Pause, A., N. Methot, Y. Svitkin, W. C. Merrick, and N. Sonenberg. 1994. Dominant negative mutants of mammalian translation initiation factor eIF-4A define a critical role for eIF-4F in cap-dependent and cap-independent initiation of translation. EMBO J. 13:1205-1215.
-
(1994)
EMBO J.
, vol.13
, pp. 1205-1215
-
-
Pause, A.1
Methot, N.2
Svitkin, Y.3
Merrick, W.C.4
Sonenberg, N.5
-
30
-
-
0026680746
-
Mutational analysis of a DEAD box RNA helicase: The mammalian translation initiation factor eIF-4A
-
Pause, A., and N. Sonenberg. 1992. Mutational analysis of a DEAD box RNA helicase: the mammalian translation initiation factor eIF-4A. EMBO J. 11:2643-2654.
-
(1992)
EMBO J.
, vol.11
, pp. 2643-2654
-
-
Pause, A.1
Sonenberg, N.2
-
31
-
-
0029956389
-
Canonical eukaryotic initiation factors determine initiation of translation by internal ribosomal entry
-
Pestova, T. V., C. U. Hellen, and I. N. Shatsky. 1996. Canonical eukaryotic initiation factors determine initiation of translation by internal ribosomal entry. Mol. Cell. Biol. 16:6859-6869.
-
(1996)
Mol. Cell. Biol.
, vol.16
, pp. 6859-6869
-
-
Pestova, T.V.1
Hellen, C.U.2
Shatsky, I.N.3
-
32
-
-
0037112055
-
The roles of individual eukaryotic translation initiation factors in ribosomal scanning and initiation codon selection
-
Pestova, T. V., and V. G. Kolupaeva. 2002. The roles of individual eukaryotic translation initiation factors in ribosomal scanning and initiation codon selection. Genes. Dev. 16:2906-2922.
-
(2002)
Genes. Dev.
, vol.16
, pp. 2906-2922
-
-
Pestova, T.V.1
Kolupaeva, V.G.2
-
33
-
-
0034284394
-
Novel eIF4G domain homologues linking mRNA translation with nonsense-mediated mRNA decay
-
Ponting, C. P. 2000. Novel eIF4G domain homologues linking mRNA translation with nonsense-mediated mRNA decay. Trends Biochem. Sci. 25:423-426.
-
(2000)
Trends Biochem. Sci.
, vol.25
, pp. 423-426
-
-
Ponting, C.P.1
-
34
-
-
0028114771
-
Translation: Turned on by insulin
-
Proud, C. G. 1994. Translation: turned on by insulin. Nature 371:747-748.
-
(1994)
Nature
, vol.371
, pp. 747-748
-
-
Proud, C.G.1
-
35
-
-
0032571398
-
Purification and characterization of a new eukaryotic protein translation factor. Eukaryotic initiation factor 4H
-
Richter-Cook, N. J., T. E. Dever, J. O. Hensold, and W. C. Merrick. 1998. Purification and characterization of a new eukaryotic protein translation factor. Eukaryotic initiation factor 4H. J. Biol. Chem. 273:7579-7587.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 7579-7587
-
-
Richter-Cook, N.J.1
Dever, T.E.2
Hensold, J.O.3
Merrick, W.C.4
-
37
-
-
0035903136
-
Modulation of the helicase activity of eIF4A by eIF4B, eIF4H, and eIF4F
-
Rogers, G. W., Jr., N. J. Richter, W. F. Lima, and W. C. Merrick. 2001. Modulation of the helicase activity of eIF4A by eIF4B, eIF4H, and eIF4F. J. Biol. Chem. 276:30914-30922.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 30914-30922
-
-
Rogers Jr., G.W.1
Richter, N.J.2
Lima, W.F.3
Merrick, W.C.4
-
38
-
-
0025176473
-
Bidirectional RNA helicase activity of eucaryotic translation initiation factors 4A and 4F
-
Rozen, F., I. Edery, K. Meerovitch, T. E. Dever, W. C. Merrick, and N. Sonenberg. 1990. Bidirectional RNA helicase activity of eucaryotic translation initiation factors 4A and 4F. Mol. Cell. Biol. 10:1134-1144.
-
(1990)
Mol. Cell. Biol.
, vol.10
, pp. 1134-1144
-
-
Rozen, F.1
Edery, I.2
Meerovitch, K.3
Dever, T.E.4
Merrick, W.C.5
Sonenberg, N.6
-
39
-
-
0029595270
-
Isolation of a novel mouse gene MA-3 that is induced upon programmed cell death
-
Shibahara, K., M. Asano, Y. Ishida, T. Aoki, T. Koike, and T. Honjo. 1995. Isolation of a novel mouse gene MA-3 that is induced upon programmed cell death. Gene 166:297-301.
-
(1995)
Gene
, vol.166
, pp. 297-301
-
-
Shibahara, K.1
Asano, M.2
Ishida, Y.3
Aoki, T.4
Koike, T.5
Honjo, T.6
-
40
-
-
0035032444
-
The requirement for eukaryotic initiation factor 4A (eIF4A) in translation is in direct proportion to the degree of mRNA 5′ secondary structure
-
Svitkin, Y. V., A. Pause, A. Haghighat, S. Pyronnet, G. Witherell, G. J. Belsham, and N. Sonenberg. 2001. The requirement for eukaryotic initiation factor 4A (eIF4A) in translation is in direct proportion to the degree of mRNA 5′ secondary structure. RNA 7:382-394.
-
(2001)
RNA
, vol.7
, pp. 382-394
-
-
Svitkin, Y.V.1
Pause, A.2
Haghighat, A.3
Pyronnet, S.4
Witherell, G.5
Belsham, G.J.6
Sonenberg, N.7
-
41
-
-
85047696004
-
Translation initiation and its deregulation during tumorigenesis
-
Watkins, S. J., and C. J. Norbury. 2002. Translation initiation and its deregulation during tumorigenesis. Br. J. Cancer 86:1023-1027.
-
(2002)
Br. J. Cancer
, vol.86
, pp. 1023-1027
-
-
Watkins, S.J.1
Norbury, C.J.2
-
42
-
-
0037216626
-
The transformation suppressor Pdcd4 is a novel eukaryotic translation initiation factor 4A binding protein that inhibits translation
-
Yang, H. S., A. P. Jansen, A. A. Komar, X. Zheng, W. C. Merrick, S. Costes, S. J. Lockett, N. Sonenberg, and N. H. Colburn. 2003. The transformation suppressor Pdcd4 is a novel eukaryotic translation initiation factor 4A binding protein that inhibits translation. Mol. Cell. Biol. 23:26-37.
-
(2003)
Mol. Cell. Biol.
, vol.23
, pp. 26-37
-
-
Yang, H.S.1
Jansen, A.P.2
Komar, A.A.3
Zheng, X.4
Merrick, W.C.5
Costes, S.6
Lockett, S.J.7
Sonenberg, N.8
Colburn, N.H.9
-
43
-
-
0035825611
-
A novel transformation suppressor, Pdcd4, inhibits AP-1 transactivation but not NF-κB or ODC transactivation
-
Yang, H. S., A. P. Jansen, R. Nair, K. Shibahara, A. K. Verma, J. L. Cmarik, and N. H. Colburn. 2001. A novel transformation suppressor, Pdcd4, inhibits AP-1 transactivation but not NF-κB or ODC transactivation. Oncogene 20:669-676.
-
(2001)
Oncogene
, vol.20
, pp. 669-676
-
-
Yang, H.S.1
Jansen, A.P.2
Nair, R.3
Shibahara, K.4
Verma, A.K.5
Cmarik, J.L.6
Colburn, N.H.7
-
44
-
-
0038209450
-
Pdcd4 suppresses tumor phenotype in JB6 cells by inhibiting AP-1 transactivation
-
Yang, H. S., J. L. Knues, C. Stark, and N. H. Colburn. 2003. Pdcd4 suppresses tumor phenotype in JB6 cells by inhibiting AP-1 transactivation. Oncogene 22:3712-3720.
-
(2003)
Oncogene
, vol.22
, pp. 3712-3720
-
-
Yang, H.S.1
Knues, J.L.2
Stark, C.3
Colburn, N.H.4
-
45
-
-
0034925982
-
Human dihydrolipoamide dehydrogenase gene transcription is mediated by cAMP-response element-like site and TACGAC direct repeat
-
Yang, H. S., J. I. Morris, Q. Wang, L. G. Korotchkina, M. Kwon, and M. S. Patel. 2001. Human dihydrolipoamide dehydrogenase gene transcription is mediated by cAMP-response element-like site and TACGAC direct repeat. Int. J. Biochem. Cell. Biol. 33:902-913.
-
(2001)
Int. J. Biochem. Cell. Biol.
, vol.33
, pp. 902-913
-
-
Yang, H.S.1
Morris, J.I.2
Wang, Q.3
Korotchkina, L.G.4
Kwon, M.5
Patel, M.S.6
|