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Volumn 5, Issue 8, 2008, Pages 857-864

Future treatments for chronic obstructive pulmonary disease and its comorbidities

Author keywords

Antioxidants; Nuclear factor B inhibitors; Peroxisome proliferator activated receptor agonists; Phosphodiesterase 4 inhibitors; Statins

Indexed keywords

ADALIMUMAB; ATLIZUMAB; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; C REACTIVE PROTEIN; CLOFIBRATE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; ERLOTINIB; ETANERCEPT; FENOFIBRATE; FLUTICASONE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INFLIXIMAB; INTERLEUKIN 6; IRBESARTAN; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR AGONIST; PHOSPHODIESTERASE IV INHIBITOR; ROFLUMILAST; ROSIGLITAZONE; SALMETEROL; THEOPHYLLINE; TIOTROPIUM BROMIDE; TUMOR NECROSIS FACTOR ALPHA;

EID: 57349120676     PISSN: 15463222     EISSN: None     Source Type: Journal    
DOI: 10.1513/pats.200807-069TH     Document Type: Conference Paper
Times cited : (74)

References (108)
  • 1
    • 4444280869 scopus 로고    scopus 로고
    • Prospects for new drugs for chronic obstructive pulmonary disease
    • Barnes PJ, Hansel TT. Prospects for new drugs for chronic obstructive pulmonary disease. Lancet 2004;364:985-996.
    • (2004) Lancet , vol.364 , pp. 985-996
    • Barnes, P.J.1    Hansel, T.T.2
  • 2
    • 44649112330 scopus 로고    scopus 로고
    • Barnes PJ. Frontrunners in novel pharmacotherapy of COPD. Curr Opin. Pharmacol 2008;8:300-307.
    • Barnes PJ. Frontrunners in novel pharmacotherapy of COPD. Curr Opin. Pharmacol 2008;8:300-307.
  • 3
    • 57349099228 scopus 로고    scopus 로고
    • Emerging pharmacotherapies for COPD
    • In press
    • Barnes PJ. Emerging pharmacotherapies for COPD. Chest (In press)
    • Chest
    • Barnes, P.J.1
  • 5
    • 33744994082 scopus 로고    scopus 로고
    • Reduction of morbidity and mortality by statins, angiotensin-converting enzyme inhibitors, and angiotensin receptor blockers in patients with chronic obstructive pulmonary disease
    • Mancini GB, Etminan M, Zhang B, Levesque LE, FitzGerald JM, Brophy JM. Reduction of morbidity and mortality by statins, angiotensin-converting enzyme inhibitors, and angiotensin receptor blockers in patients with chronic obstructive pulmonary disease. J Am Coll Cardiol 2006;47:2554-2560.
    • (2006) J Am Coll Cardiol , vol.47 , pp. 2554-2560
    • Mancini, G.B.1    Etminan, M.2    Zhang, B.3    Levesque, L.E.4    FitzGerald, J.M.5    Brophy, J.M.6
  • 6
    • 33846931592 scopus 로고    scopus 로고
    • Statin use is associated with reduced mortality in chronic obstructive pulmonary disease
    • Soyseth V, Brekke PH, Smith P, Omland T. Statin use is associated with reduced mortality in chronic obstructive pulmonary disease. Eur Respir J 2006;29:279-283.
    • (2006) Eur Respir J , vol.29 , pp. 279-283
    • Soyseth, V.1    Brekke, P.H.2    Smith, P.3    Omland, T.4
  • 9
    • 33747079023 scopus 로고    scopus 로고
    • Potential therapeutic role for statins in respiratory disease
    • Hothersall E, McSharry C, Thomson NC. Potential therapeutic role for statins in respiratory disease. Thorax 2006;61:729-734.
    • (2006) Thorax , vol.61 , pp. 729-734
    • Hothersall, E.1    McSharry, C.2    Thomson, N.C.3
  • 14
    • 0041346077 scopus 로고    scopus 로고
    • Alveolar macrophages from subjects with chronic obstructive pulmonary disease are deficient in their ability to phagocytose apoptotic airway epithelial cells
    • Hodge S, Hodge G, Scicchitano R, Reynolds PN, Holmes M. Alveolar macrophages from subjects with chronic obstructive pulmonary disease are deficient in their ability to phagocytose apoptotic airway epithelial cells. Immunol Cell Biol 2003;81:289-296.
    • (2003) Immunol Cell Biol , vol.81 , pp. 289-296
    • Hodge, S.1    Hodge, G.2    Scicchitano, R.3    Reynolds, P.N.4    Holmes, M.5
  • 15
    • 45549102525 scopus 로고    scopus 로고
    • Simvastatin inhibits IL-17 secretion by targeting multiple IL-17-regulatory cytokines and by inhibiting the expression of IL-17 transcription factor RORC in CD41 lymphocytes
    • Zhang X, Jin J, Peng X, Ramgolam VS, Markovic-Plese S. Simvastatin inhibits IL-17 secretion by targeting multiple IL-17-regulatory cytokines and by inhibiting the expression of IL-17 transcription factor RORC in CD41 lymphocytes. J Immunol 2008;180:6988-6996.
    • (2008) J Immunol , vol.180 , pp. 6988-6996
    • Zhang, X.1    Jin, J.2    Peng, X.3    Ramgolam, V.S.4    Markovic-Plese, S.5
  • 16
    • 40049104892 scopus 로고    scopus 로고
    • Immunology of asthma and chronic obstructive pulmonary disease
    • Barnes PJ. Immunology of asthma and chronic obstructive pulmonary disease. Nat Rev Immunol 2008;8:183-192.
    • (2008) Nat Rev Immunol , vol.8 , pp. 183-192
    • Barnes, P.J.1
  • 17
    • 49349115994 scopus 로고    scopus 로고
    • Statins may reduce episodes of exacerbation and the requirement for intubation in patients with COPD: Evidence from a retrospective cohort study
    • Blamoun AI, Batty GN, Debari VA, Rashid AO, Sheikh M, Khan MA. Statins may reduce episodes of exacerbation and the requirement for intubation in patients with COPD: evidence from a retrospective cohort study. Int J Clin Pract 2008;62:1373-1378.
    • (2008) Int J Clin Pract , vol.62 , pp. 1373-1378
    • Blamoun, A.I.1    Batty, G.N.2    Debari, V.A.3    Rashid, A.O.4    Sheikh, M.5    Khan, M.A.6
  • 18
    • 36949033817 scopus 로고    scopus 로고
    • Emerging indications for statins: A pluripotent family of agents with several potential applications
    • Paraskevas KI, Tzovaras AA, Briana DD, Mikhailidis DP. Emerging indications for statins: a pluripotent family of agents with several potential applications. Curr Pharm Des 2007;13:3622-3636.
    • (2007) Curr Pharm Des , vol.13 , pp. 3622-3636
    • Paraskevas, K.I.1    Tzovaras, A.A.2    Briana, D.D.3    Mikhailidis, D.P.4
  • 19
    • 33845538684 scopus 로고    scopus 로고
    • Angiotensin II and inflammation: The effect of angiotensin-converting enzyme inhibition and angiotensin II receptor blockade
    • Dandona P, Dhindsa S, Ghanim H, Chaudhuri A. Angiotensin II and inflammation: the effect of angiotensin-converting enzyme inhibition and angiotensin II receptor blockade. J Hum Hypertens 2007;21:20-27.
    • (2007) J Hum Hypertens , vol.21 , pp. 20-27
    • Dandona, P.1    Dhindsa, S.2    Ghanim, H.3    Chaudhuri, A.4
  • 24
    • 36049034344 scopus 로고    scopus 로고
    • Anti-inflammatory actions of PPAR ligands: New insights on cellular and molecular mechanisms
    • Straus DS, Glass CK. Anti-inflammatory actions of PPAR ligands: new insights on cellular and molecular mechanisms. Trends Immunol 2007;28:551-558.
    • (2007) Trends Immunol , vol.28 , pp. 551-558
    • Straus, D.S.1    Glass, C.K.2
  • 27
    • 70349254621 scopus 로고    scopus 로고
    • The antifibrogenic potential of PPARgamma ligands in pulmonary fibrosis
    • Sime PJ. The antifibrogenic potential of PPARgamma ligands in pulmonary fibrosis. J Investig Med 2008;56:534-538.
    • (2008) J Investig Med , vol.56 , pp. 534-538
    • Sime, P.J.1
  • 30
    • 33144482007 scopus 로고    scopus 로고
    • Reduced histone deacetylase in COPD: Clinical implications
    • Barnes PJ. Reduced histone deacetylase in COPD: clinical implications. Chest 2006;129:151-155.
    • (2006) Chest , vol.129 , pp. 151-155
    • Barnes, P.J.1
  • 32
    • 4644230621 scopus 로고    scopus 로고
    • Effects of fluticasone on systemic markers of inflammation in chronic obstructive pulmonary disease
    • Sin DD, Lacy P, York E, Man SF. Effects of fluticasone on systemic markers of inflammation in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2004;170:760-765.
    • (2004) Am J Respir Crit Care Med , vol.170 , pp. 760-765
    • Sin, D.D.1    Lacy, P.2    York, E.3    Man, S.F.4
  • 37
    • 36049046128 scopus 로고    scopus 로고
    • Effect of salmeterol/fluticasone propionate on airway inflammation in COPD: A randomised controlled trial
    • Bourbeau J, Christodoulopoulos P, Maltais F, Yamauchi Y, Olivenstein R, Hamid Q. Effect of salmeterol/fluticasone propionate on airway inflammation in COPD: a randomised controlled trial. Thorax 2007;62:938-943.
    • (2007) Thorax , vol.62 , pp. 938-943
    • Bourbeau, J.1    Christodoulopoulos, P.2    Maltais, F.3    Yamauchi, Y.4    Olivenstein, R.5    Hamid, Q.6
  • 39
    • 42049097879 scopus 로고    scopus 로고
    • Role of beta-adrenoceptor signaling in skeletal muscle: Implications for muscle wasting and disease
    • Lynch GS, Ryall JG. Role of beta-adrenoceptor signaling in skeletal muscle: implications for muscle wasting and disease. Physiol Rev 2008;88:729-767.
    • (2008) Physiol Rev , vol.88 , pp. 729-767
    • Lynch, G.S.1    Ryall, J.G.2
  • 41
    • 34249983499 scopus 로고    scopus 로고
    • Recent progress in understanding the non-neuronal cholinergic system in humans
    • Grando SA, Kawashima K, Kirkpatrick CJ, Wessler I. Recent progress in understanding the non-neuronal cholinergic system in humans. Life Sci 2007;80:2181-2185.
    • (2007) Life Sci , vol.80 , pp. 2181-2185
    • Grando, S.A.1    Kawashima, K.2    Kirkpatrick, C.J.3    Wessler, I.4
  • 43
    • 33645973265 scopus 로고    scopus 로고
    • Chronic effects of mechanical force on airways
    • Tschumperlin DJ, Drazen JM. Chronic effects of mechanical force on airways. Annu Rev Physiol 2006;68:563-583..
    • (2006) Annu Rev Physiol , vol.68 , pp. 563-583
    • Tschumperlin, D.J.1    Drazen, J.M.2
  • 44
    • 24644452840 scopus 로고    scopus 로고
    • Does mechanical injury of the peripheral airways play a role in the genesis of COPD in smokers?
    • Milic-Emili J. Does mechanical injury of the peripheral airways play a role in the genesis of COPD in smokers? COPD 2004;1:85-92.
    • (2004) COPD , vol.1 , pp. 85-92
    • Milic-Emili, J.1
  • 46
    • 0023923899 scopus 로고
    • Aminophylline and the respiratory muscles: An alternative view
    • Moxham J. Aminophylline and the respiratory muscles: an alternative view. Clin Chest Med 1988;2:325-336.
    • (1988) Clin Chest Med , vol.2 , pp. 325-336
    • Moxham, J.1
  • 49
    • 52949120563 scopus 로고    scopus 로고
    • Effect of infliximab on local and systemic inflammation in chronic obstructive pulmonary disease: A pilot study
    • Dentener MA, Creutzberg EC, Pennings HJ, Rijkers GT, Mercken E, Wouters EF. Effect of infliximab on local and systemic inflammation in chronic obstructive pulmonary disease: a pilot study. Respiration 2008;76:275-282.
    • (2008) Respiration , vol.76 , pp. 275-282
    • Dentener, M.A.1    Creutzberg, E.C.2    Pennings, H.J.3    Rijkers, G.T.4    Mercken, E.5    Wouters, E.F.6
  • 50
    • 34247604963 scopus 로고    scopus 로고
    • Unexpected failure of anti-tumor necrosis factor therapy in chronic obstructive pulmonary disease
    • Barnes PJ. Unexpected failure of anti-tumor necrosis factor therapy in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2007;175:866-867.
    • (2007) Am J Respir Crit Care Med , vol.175 , pp. 866-867
    • Barnes, P.J.1
  • 51
    • 0034018102 scopus 로고    scopus 로고
    • Relation of sputum inflammatory markers to symptoms and lung function changes in COPD exacerbations
    • Bhowmik A, Seemungal TA, Sapsford RJ, Wedzicha JA. Relation of sputum inflammatory markers to symptoms and lung function changes in COPD exacerbations. Thorax 2000;55:114-120.
    • (2000) Thorax , vol.55 , pp. 114-120
    • Bhowmik, A.1    Seemungal, T.A.2    Sapsford, R.J.3    Wedzicha, J.A.4
  • 53
    • 33750102235 scopus 로고    scopus 로고
    • Tocilizumab: Blockade of interleukin-6 signaling pathway as a therapeutic strategy for inflammatory disorders
    • Paul-Pletzer K. Tocilizumab: blockade of interleukin-6 signaling pathway as a therapeutic strategy for inflammatory disorders. Drugs Today (Barc.) 2006;42:559-576.
    • (2006) Drugs Today (Barc.) , vol.42 , pp. 559-576
    • Paul-Pletzer, K.1
  • 55
    • 45949086220 scopus 로고    scopus 로고
    • de Torres JP, Pinto-Plata V, Casanova C, Mullerova H, Cordoba-Lanus E, Muros dF, Aguirre-Jaime A, Celli BR. C-reactive protein levels and survival in patients with moderate to very severe COPD. Chest 2008;133:1336-1343.
    • de Torres JP, Pinto-Plata V, Casanova C, Mullerova H, Cordoba-Lanus E, Muros dF, Aguirre-Jaime A, Celli BR. C-reactive protein levels and survival in patients with moderate to very severe COPD. Chest 2008;133:1336-1343.
  • 56
    • 33748420343 scopus 로고    scopus 로고
    • C-reactive protein and cardiovascular disease: Weighing the evidence
    • Lowe GD, Pepys MB. C-reactive protein and cardiovascular disease: weighing the evidence. Curr Atheroscler Rep 2006;8:421-428.
    • (2006) Curr Atheroscler Rep , vol.8 , pp. 421-428
    • Lowe, G.D.1    Pepys, M.B.2
  • 59
    • 0037097803 scopus 로고    scopus 로고
    • Protection from Streptococcus pneumoniae infection by C-reactive protein and natural antibody requires complement but not Fc gamma receptors
    • Mold C, Rodic-Polic B, Du Clos TW. Protection from Streptococcus pneumoniae infection by C-reactive protein and natural antibody requires complement but not Fc gamma receptors. J Immunol 2002;168:6375-6381.
    • (2002) J Immunol , vol.168 , pp. 6375-6381
    • Mold, C.1    Rodic-Polic, B.2    Du Clos, T.W.3
  • 62
    • 23744451716 scopus 로고    scopus 로고
    • Roflumilast - an oral anti-inflammatory treatment for chronic obstructive pulmonary disease: A randomised controlled trial
    • Rabe KF, Bateman ED, O'Donnell D, Witte S, Bredenbroker D, Bethke TD. Roflumilast - an oral anti-inflammatory treatment for chronic obstructive pulmonary disease: a randomised controlled trial. Lancet 2005;366:563-571.
    • (2005) Lancet , vol.366 , pp. 563-571
    • Rabe, K.F.1    Bateman, E.D.2    O'Donnell, D.3    Witte, S.4    Bredenbroker, D.5    Bethke, T.D.6
  • 63
    • 34547868158 scopus 로고    scopus 로고
    • Rolipram, a phosphodiesterase 4 inhibitor, prevented cancellous and cortical bone loss by inhibiting endosteal bone resorption and maintaining the elevated periosteal bone formation in adult ovariectomized rats
    • Yao W, Tian XY, Chen J, Setterberg RB, Lundy MW, Chmielzwski P, Froman CA, Jee WS. Rolipram, a phosphodiesterase 4 inhibitor, prevented cancellous and cortical bone loss by inhibiting endosteal bone resorption and maintaining the elevated periosteal bone formation in adult ovariectomized rats. J Musculoskelet Neuronal Interact 2007;7:119-130.
    • (2007) J Musculoskelet Neuronal Interact , vol.7 , pp. 119-130
    • Yao, W.1    Tian, X.Y.2    Chen, J.3    Setterberg, R.B.4    Lundy, M.W.5    Chmielzwski, P.6    Froman, C.A.7    Jee, W.S.8
  • 66
    • 2942662046 scopus 로고    scopus 로고
    • NF-κB activation and iNOS upregulation in skeletal muscle of patients with COPD and low body weight
    • Agusti A, Morla M, Sauleda J, Saus C, Busquets X. NF-κB activation and iNOS upregulation in skeletal muscle of patients with COPD and low body weight. Thorax 2004;59:483-487.
    • (2004) Thorax , vol.59 , pp. 483-487
    • Agusti, A.1    Morla, M.2    Sauleda, J.3    Saus, C.4    Busquets, X.5
  • 67
    • 52549133171 scopus 로고    scopus 로고
    • Nuclear factor-κB signaling in skeletal muscle atrophy
    • Li H, Malhotra S, Kumar A. Nuclear factor-κB signaling in skeletal muscle atrophy. J Mol Med 2008;86:1113-1126.
    • (2008) J Mol Med , vol.86 , pp. 1113-1126
    • Li, H.1    Malhotra, S.2    Kumar, A.3
  • 71
    • 0345073628 scopus 로고    scopus 로고
    • Increased leukotriene B4 and 8-isoprostane in exhaled breath condensate of patients with exacerbations of COPD
    • Biernacki WA, Kharitonov SA, Barnes PJ. Increased leukotriene B4 and 8-isoprostane in exhaled breath condensate of patients with exacerbations of COPD. Thorax 2003;58:294-298.
    • (2003) Thorax , vol.58 , pp. 294-298
    • Biernacki, W.A.1    Kharitonov, S.A.2    Barnes, P.J.3
  • 72
    • 14044269009 scopus 로고    scopus 로고
    • The role of oxidative stress in chronic obstructive pulmonary disease
    • Bowler RP, Barnes PJ, Crapo JD. The role of oxidative stress in chronic obstructive pulmonary disease. COPD 2004;2:255-277.
    • (2004) COPD , vol.2 , pp. 255-277
    • Bowler, R.P.1    Barnes, P.J.2    Crapo, J.D.3
  • 73
    • 58249099942 scopus 로고    scopus 로고
    • COPD as a disease of accelerated lung aging
    • In press
    • Ito K, Barnes PJ. COPD as a disease of accelerated lung aging. Chest (In press).
    • Chest
    • Ito, K.1    Barnes, P.J.2
  • 77
    • 33748052967 scopus 로고    scopus 로고
    • Nrf2-Keap1 regulation of cellular defense mechanisms against electrophiles and reactive oxygen species
    • Kobayashi M, Yamamoto M. Nrf2-Keap1 regulation of cellular defense mechanisms against electrophiles and reactive oxygen species. Adv Enzyme Regul 2006;46:113-140.
    • (2006) Adv Enzyme Regul , vol.46 , pp. 113-140
    • Kobayashi, M.1    Yamamoto, M.2
  • 78
    • 33750052885 scopus 로고    scopus 로고
    • DJ-1, a cancer- and Parkinson's disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2
    • Clements CM, McNally RS, Conti BJ, Mak TW, Ting JP. DJ-1, a cancer- and Parkinson's disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2. Proc Natl Acad Sci USA 2006;103:15091-15096.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 15091-15096
    • Clements, C.M.1    McNally, R.S.2    Conti, B.J.3    Mak, T.W.4    Ting, J.P.5
  • 84
    • 0842308109 scopus 로고    scopus 로고
    • Oxidative stress reduces histone deacetylase (HDAC)2 activity and enhances IL-8 gene expression: Role of tyrosine nitration
    • Ito K, Tomita T, Barnes PJ, Adcock IM. Oxidative stress reduces histone deacetylase (HDAC)2 activity and enhances IL-8 gene expression: role of tyrosine nitration. Biochem Biophys Res Commun 2004;315:240-245.
    • (2004) Biochem Biophys Res Commun , vol.315 , pp. 240-245
    • Ito, K.1    Tomita, T.2    Barnes, P.J.3    Adcock, I.M.4
  • 85
    • 57349158300 scopus 로고    scopus 로고
    • Oxidative stress-induced PI3-kinase activation reduces HDAC activity and is inhibited by theophylline
    • Failla M, To Y, Ito M, Adcock IM, Barnes PJ, Ito K. Oxidative stress-induced PI3-kinase activation reduces HDAC activity and is inhibited by theophylline. Proc Am Thorac Soc 2007;2:A45.
    • (2007) Proc Am Thorac Soc , vol.2
    • Failla, M.1    To, Y.2    Ito, M.3    Adcock, I.M.4    Barnes, P.J.5    Ito, K.6
  • 86
    • 33748540402 scopus 로고    scopus 로고
    • Theophylline for COPD
    • Barnes PJ. Theophylline for COPD. Thorax 2006;61:742-743.
    • (2006) Thorax , vol.61 , pp. 742-743
    • Barnes, P.J.1
  • 87
    • 33744477341 scopus 로고    scopus 로고
    • How corticosteroids control inflammation
    • Barnes PJ. How corticosteroids control inflammation. Br J Pharmacol 2006;148:245-254.
    • (2006) Br J Pharmacol , vol.148 , pp. 245-254
    • Barnes, P.J.1
  • 91
    • 40949123149 scopus 로고    scopus 로고
    • Activation of innate immunity system during aging: NF-κB signaling is the molecular culprit of inflamm-aging
    • Salminen A, Huuskonen J, Ojala J, Kauppinen A, Kaarniranta K, Suuronen T. Activation of innate immunity system during aging: NF-κB signaling is the molecular culprit of inflamm-aging. Ageing Res Rev 2008;7:83-105.
    • (2008) Ageing Res Rev , vol.7 , pp. 83-105
    • Salminen, A.1    Huuskonen, J.2    Ojala, J.3    Kauppinen, A.4    Kaarniranta, K.5    Suuronen, T.6
  • 92
    • 33749841717 scopus 로고    scopus 로고
    • Alveolar cell senescence in patients with pulmonary emphysema
    • Tsuji T, Aoshiba K, Nagai A. Alveolar cell senescence in patients with pulmonary emphysema. Am J Respir Crit Care Med 2006;174:886-893.
    • (2006) Am J Respir Crit Care Med , vol.174 , pp. 886-893
    • Tsuji, T.1    Aoshiba, K.2    Nagai, A.3
  • 97
    • 36249016246 scopus 로고    scopus 로고
    • A therapeutic role for sirtuins in diseases of aging?
    • Westphal CH, Dipp MA, Guarente L. A therapeutic role for sirtuins in diseases of aging? Trends Biochem Sci 2007;32:555-560.
    • (2007) Trends Biochem Sci , vol.32 , pp. 555-560
    • Westphal, C.H.1    Dipp, M.A.2    Guarente, L.3
  • 99
    • 42649146208 scopus 로고    scopus 로고
    • SIRT1, an antiinflammatory and antiaging protein, is decreased in lungs of patients with chronic obstructive pulmonary disease
    • Rajendrasozhan S, Yang SR, Kinnula VL, Rahman I. SIRT1, an antiinflammatory and antiaging protein, is decreased in lungs of patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2008;177:861-870.
    • (2008) Am J Respir Crit Care Med , vol.177 , pp. 861-870
    • Rajendrasozhan, S.1    Yang, S.R.2    Kinnula, V.L.3    Rahman, I.4
  • 102
    • 33846687101 scopus 로고    scopus 로고
    • Molecular signaling and genetic pathways of senescence: Its role in tumorigenesis and aging
    • Zhang H. Molecular signaling and genetic pathways of senescence: its role in tumorigenesis and aging. J Cell Physiol 2007;210:567-574.
    • (2007) J Cell Physiol , vol.210 , pp. 567-574
    • Zhang, H.1
  • 103
    • 34248141100 scopus 로고    scopus 로고
    • A cytokine-mediated link between innate immunity, inflammation, and cancer
    • Lin WW, Karin M. A cytokine-mediated link between innate immunity, inflammation, and cancer. J Clin Invest 2007;117:1175-1183.
    • (2007) J Clin Invest , vol.117 , pp. 1175-1183
    • Lin, W.W.1    Karin, M.2
  • 105
    • 40249109853 scopus 로고    scopus 로고
    • The IkappaB kinase - a bridge between inflammation and cancer
    • Karin M. The IkappaB kinase - a bridge between inflammation and cancer. Cell Res 2008;18:334-342.
    • (2008) Cell Res , vol.18 , pp. 334-342
    • Karin, M.1
  • 106
    • 31544462308 scopus 로고    scopus 로고
    • Expression of epidermal growth factors and their receptors in the bronchial epithelium of subjects with chronic obstructive pulmonary disease
    • de Boer WI, Hau CM, van Schadewijk A, Stolk J, van Krieken JH, Hiemstra PS. Expression of epidermal growth factors and their receptors in the bronchial epithelium of subjects with chronic obstructive pulmonary disease. Am J Clin Pathol 2006;125:184-192.
    • (2006) Am J Clin Pathol , vol.125 , pp. 184-192
    • de Boer, W.I.1    Hau, C.M.2    van Schadewijk, A.3    Stolk, J.4    van Krieken, J.H.5    Hiemstra, P.S.6
  • 107
    • 33646242760 scopus 로고    scopus 로고
    • Clinical experience with erlotinib in non-small-cell lung cancer
    • Felip E, Rosell R. Clinical experience with erlotinib in non-small-cell lung cancer. Drugs Today (Barc.) 2006;42:147-156.
    • (2006) Drugs Today (Barc.) , vol.42 , pp. 147-156
    • Felip, E.1    Rosell, R.2
  • 108
    • 8544250584 scopus 로고    scopus 로고
    • Roles of epidermal growth factor receptor activation in epithelial cell repair and mucin production in airway epithelium
    • Burgel PR, Nadel JA. Roles of epidermal growth factor receptor activation in epithelial cell repair and mucin production in airway epithelium. Thorax 2004;59:992-996.
    • (2004) Thorax , vol.59 , pp. 992-996
    • Burgel, P.R.1    Nadel, J.A.2


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