Theophylline for COPD

Thorax

Volumn 61, Issue 9, 2006, Pages 742-744

  Barnes, Peter J ^a  

^a NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; BRONCHODILATING AGENT; CHOLINERGIC RECEPTOR BLOCKING AGENT; HISTONE DEACETYLASE; NITRATE; STEROID; THEOPHYLLINE;

ANTIINFLAMMATORY ACTIVITY; CHRONIC OBSTRUCTIVE LUNG DISEASE; DIURESIS; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG INHIBITION; DRUG MECHANISM; EDITORIAL; HEADACHE; HUMAN; NAUSEA; OXIDATIVE STRESS; PRIORITY JOURNAL; VOMITING;

ANTI-INFLAMMATORY AGENTS; BRONCHODILATOR AGENTS; HISTONE DEACETYLASES; HUMANS; OXIDATIVE STRESS; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; THEOPHYLLINE;

EID: 33748540402     PISSN: 00406376     EISSN: None     Source Type: Journal    
DOI: 10.1136/thx.2006.061002     Document Type: Editorial

References (14)

1. Barnes PJ. Theophylline in chronic obstructive pulmonary disease: new horizons. Proc Am Thorac Soc 2005;2:334-9.
2. Hirano T, Yamagata T, Gohda M, et al. Inhibition of reactive nitrogen species production in COPD airways: comparison between inhaled corticosteroid and oral theophylline. Thorax 2006;61:761-6.
3. Kirsten DK, Wegner RE, Jorres RA, et al. Effects of theophylline withdrawal in severe chronic obstructive pulmonary disease. Chest 1993;104:1101-7.
4. Culpitt SV, de Matos C, Russell RE, et al. Effect of theophylline on induced sputum inflammatory indices and neutrophil chemotaxis in COPD. Am J Respir Crit Care Med 2002;165:1371-6.
5. Kobayashi M, Nasuhara Y, Betsuyaku T, et al. Effect of low-dose theophylline on airway inflammation in COPD. Respirology 2004;9:249-54.
6. Barnes PJ. Theophylline: new perspectives on an old drug. Am J Respir Crit Care Med 2003;167:813-8.
7. Barnes PJ, Adcock IM, Ito K. Histone acetylation and deacelylation: importance in inflammatory lung diseases. Eur Respir J 2005;25:552-63.
8. Ito K, Ito M, Elliott WM, et al. Decreased histone deacetylase activity in chronic obstructive pulmonary disease. N Engl J Med 2005;352:1967-76.
9. Ito K, Lim S, Caramori G, et al. A molecular mechanism of action of theophylline: induction of histone deacetylase activity to decrease inflammatory gene expression. Proc Natl Acad Sci USA 2002;99:8921-6.
10. Cosio BG, Tsaprouni L, Ito K, et al. Theophylline restores histone deacetylase activity and steroid responses in COPD macrophages. J Exp Med 2004;200:689-95.
11. Ito K, Yamamura S, Essilfie-Quaye S, et al. Histone deacetylase 2-mediated deacetylation of the glucocorticold receptor enables NF-κB suppression. J Exp Med 2006;203:7-13.
12. Barnes PJ, Ito K, Adcock IM. A mechanism of corticosteroid resistance in COPD: inactivation of histone deacetylase. Lancet 2004;363:731-3.
13. Ito K, Tomita T, Barnes PJ, et al. Oxidative stress reduces histone deacetylase (HDAC)2 activity and enhances IL-8 gene expression: role of tyrosine nitration. Biochem Biophys Res Commun 2004;315:240-5.
14. Ichinose M, Sugiura H, Yamagata S, et al. Increase in reactive nitrogen species production in chronic obstructive pulmonary disease airways. Am J Respir Crit Care Med 2000;160:701-6.