메뉴 건너뛰기




Volumn 134, Issue 6, 2008, Pages 1278-1286

Emerging pharmacotherapies for COPD

Author keywords

Antiinflammatory; Bronchodilator; Chemokine; Cytokine; Histone deacetylase; Nuclear factor B; p38 mitogen activated protein kinase; Phosphodiesterase 4; Phosphoinositide 3 kinase

Indexed keywords

ACLIDINIUM BROMIDE; ADZ8309; ANTIINFLAMMATORY AGENT; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; BRONCHODILATING AGENT; CARMOTEROL; CHEMOKINE RECEPTOR ANTAGONIST; CHEMOKINE RECEPTOR CXCR2; CHOLINERGIC RECEPTOR BLOCKING AGENT; CORTICOSTEROID; DOPAMINE 3 RECEPTOR BLOCKING AGENT; GLYCOPYRRONIUM BROMIDE; HISTONE DEACETYLASE 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDACATEROL; INFLIXIMAB; LIPOXYGENASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE P38; MUSCARINIC RECEPTOR BLOCKING AGENT; NICOTINE VACCINE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHODIESTERASE IV; PHOSPHOINOSITIDE 3 KINASE GAMMA; RIMONABANT; THEOPHYLLINE; TIOTROPIUM BROMIDE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; UNINDEXED DRUG; VARENICLINE; VASODILATOR AGENT;

EID: 57349099228     PISSN: 00123692     EISSN: 19313543     Source Type: Journal    
DOI: 10.1378/chest.08-1385     Document Type: Article
Times cited : (101)

References (68)
  • 1
    • 34249742714 scopus 로고    scopus 로고
    • Chronic obstructive pulmonary disease: A growing but neglected epidemic
    • Barnes PJ. Chronic obstructive pulmonary disease: a growing but neglected epidemic. PLoS Med 2007; 4:e112
    • (2007) PLoS Med , vol.4
    • Barnes, P.J.1
  • 2
    • 34548222188 scopus 로고    scopus 로고
    • Global burden of COPD: Risk factors, prevalence, and future trends
    • Mannino DM, Buist AS. Global burden of COPD: risk factors, prevalence, and future trends. Lancet 2007; 370:765-773
    • (2007) Lancet , vol.370 , pp. 765-773
    • Mannino, D.M.1    Buist, A.S.2
  • 3
    • 0141928029 scopus 로고    scopus 로고
    • Chronic obstructive pulmonary disease: Molecular and cellular mechanisms
    • Barnes PJ, Shapiro SD, Pauwels RA. Chronic obstructive pulmonary disease: molecular and cellular mechanisms. Eur Respir J 2003; 22:672-688
    • (2003) Eur Respir J , vol.22 , pp. 672-688
    • Barnes, P.J.1    Shapiro, S.D.2    Pauwels, R.A.3
  • 4
    • 20444480168 scopus 로고    scopus 로고
    • COPD: Current therapeutic interventions and future approaches
    • Barnes PJ, Stockley RA. COPD: current therapeutic interventions and future approaches. Eur Respir J 2005; 25:1084-1106
    • (2005) Eur Respir J , vol.25 , pp. 1084-1106
    • Barnes, P.J.1    Stockley, R.A.2
  • 5
    • 44649112330 scopus 로고    scopus 로고
    • Barnes PJ. Frontrunners in novel pharmacotherapy of COPD. Curr Opin Pharmacol 2008; 8:300-307
    • Barnes PJ. Frontrunners in novel pharmacotherapy of COPD. Curr Opin Pharmacol 2008; 8:300-307
  • 6
    • 33748540402 scopus 로고    scopus 로고
    • Theophylline for COPD
    • Barnes PJ. Theophylline for COPD. Thorax 2006; 61:742-743
    • (2006) Thorax , vol.61 , pp. 742-743
    • Barnes, P.J.1
  • 7
    • 40049104892 scopus 로고    scopus 로고
    • Immunology of asthma and chronic obstructive pulmonary disease
    • Barnes PJ. Immunology of asthma and chronic obstructive pulmonary disease. Nat Immunol Rev 2008; 8:183-192
    • (2008) Nat Immunol Rev , vol.8 , pp. 183-192
    • Barnes, P.J.1
  • 8
    • 36049019384 scopus 로고    scopus 로고
    • Characterisation of phenotypes based on severity of emphysema in chronic obstructive pulmonary disease
    • Makita H, Nasuhara Y, Nagai K, et al. Characterisation of phenotypes based on severity of emphysema in chronic obstructive pulmonary disease. Thorax 2007; 62:932-937
    • (2007) Thorax , vol.62 , pp. 932-937
    • Makita, H.1    Nasuhara, Y.2    Nagai, K.3
  • 9
    • 45849093275 scopus 로고    scopus 로고
    • Small airways: An important but neglected target in the treatment of obstructive airway diseases
    • Sturton G, Persson C, Barnes PJ. Small airways: an important but neglected target in the treatment of obstructive airway diseases. Trends Pharmacol Sci 2008; 29:340-349
    • (2008) Trends Pharmacol Sci , vol.29 , pp. 340-349
    • Sturton, G.1    Persson, C.2    Barnes, P.J.3
  • 10
    • 33847172367 scopus 로고    scopus 로고
    • Salmeterol and fluticasone propionate and survival in chronic obstructive pulmonary disease
    • Calverley PM, Anderson JA, Celli B, et al. Salmeterol and fluticasone propionate and survival in chronic obstructive pulmonary disease. N Engl J Med 2007; 356:775-789
    • (2007) N Engl J Med , vol.356 , pp. 775-789
    • Calverley, P.M.1    Anderson, J.A.2    Celli, B.3
  • 12
    • 34548660457 scopus 로고    scopus 로고
    • Global strategy for the diagnosis, management, and prevention of COPD: 2006 update
    • Rabe KF, Hurd S, Anzueto A, et al. Global strategy for the diagnosis, management, and prevention of COPD: 2006 update. Am J Respir Crit Care Med 2007; 176:532-555
    • (2007) Am J Respir Crit Care Med , vol.176 , pp. 532-555
    • Rabe, K.F.1    Hurd, S.2    Anzueto, A.3
  • 13
    • 33947319650 scopus 로고    scopus 로고
    • 2-adrenoceptor agonists: An emerging therapeutic option for asthma and COPD?
    • 2-adrenoceptor agonists: an emerging therapeutic option for asthma and COPD? Drugs 2007; 67:503-515
    • (2007) Drugs , vol.67 , pp. 503-515
    • Matera, M.G.1    Cazzola, M.2
  • 14
    • 37348999950 scopus 로고    scopus 로고
    • 2- adrenoceptor agonist, on small airways in human and rat precision-cut lung slices
    • 2- adrenoceptor agonist, on small airways in human and rat precision-cut lung slices. J Pharmacol Exp Ther 2008; 324:270-275
    • (2008) J Pharmacol Exp Ther , vol.324 , pp. 270-275
    • Sturton, R.G.1    Nicholson, A.G.2    Trifilieff, A.3
  • 15
    • 44749085093 scopus 로고    scopus 로고
    • A dose-ranging study of indacaterol in obstructive airways disease, with a tiotropium comparison
    • Rennard S, Bantje T, Centanni S, et al. A dose-ranging study of indacaterol in obstructive airways disease, with a tiotropium comparison. Respir Med 2008; 102:1033-1044
    • (2008) Respir Med , vol.102 , pp. 1033-1044
    • Rennard, S.1    Bantje, T.2    Centanni, S.3
  • 16
    • 27144461982 scopus 로고    scopus 로고
    • Glycopyrrolate causes prolonged bronchoprotection and bronchodilatation in patients with asthma
    • Hansel TT, Neighbour H, Erin EM, et al. Glycopyrrolate causes prolonged bronchoprotection and bronchodilatation in patients with asthma. Chest 2005; 128:1974-1979
    • (2005) Chest , vol.128 , pp. 1974-1979
    • Hansel, T.T.1    Neighbour, H.2    Erin, E.M.3
  • 17
    • 44649109092 scopus 로고    scopus 로고
    • Bronchodilator effects of aclidinium bromide, a novel long-acting anticholinergic, in COPD patients: A phase II study [abstract]
    • Joos GF, Schelfhout VJ, Kanniess F, et al. Bronchodilator effects of aclidinium bromide, a novel long-acting anticholinergic, in COPD patients: a phase II study [abstract]. Eur Respir J 2007; 30(suppl):1299
    • (2007) Eur Respir J , vol.30 , Issue.SUPPL. , pp. 1299
    • Joos, G.F.1    Schelfhout, V.J.2    Kanniess, F.3
  • 18
    • 33645116728 scopus 로고    scopus 로고
    • Effects of tiotropium with and without formoterol on airflow obstruction and resting hyperinflation in patients with COPD
    • van Noord JA, Aumann JL, Janssens E, et al. Effects of tiotropium with and without formoterol on airflow obstruction and resting hyperinflation in patients with COPD. Chest 2006; 129:509-517
    • (2006) Chest , vol.129 , pp. 509-517
    • van Noord, J.A.1    Aumann, J.L.2    Janssens, E.3
  • 19
    • 55049140591 scopus 로고    scopus 로고
    • Cahill K, Stead LF, Lancaster T. Nicotine receptor partial agonists for smoking cessation. Cochrane Database Syst Rev (database online). Issue 1, 2007
    • Cahill K, Stead LF, Lancaster T. Nicotine receptor partial agonists for smoking cessation. Cochrane Database Syst Rev (database online). Issue 1, 2007
  • 20
    • 36749075981 scopus 로고    scopus 로고
    • Cahill K, Ussher M. Cannabinoid type 1 receptor antagonists (rimonabant) for smoking cessation. Cochrane Database Syst Rev (database online). Issue 3, 2007
    • Cahill K, Ussher M. Cannabinoid type 1 receptor antagonists (rimonabant) for smoking cessation. Cochrane Database Syst Rev (database online). Issue 3, 2007
  • 21
    • 33847047118 scopus 로고    scopus 로고
    • Non-nicotinic therapies for smoking cessation
    • Siu EC, Tyndale RF. Non-nicotinic therapies for smoking cessation. Annu Rev Pharmacol Toxicol 2007; 47:541-564
    • (2007) Annu Rev Pharmacol Toxicol , vol.47 , pp. 541-564
    • Siu, E.C.1    Tyndale, R.F.2
  • 22
    • 10644266789 scopus 로고    scopus 로고
    • Mediators of chronic obstructive pulmonary disease
    • Barnes PJ. Mediators of chronic obstructive pulmonary disease. Pharm Rev 2004; 56:515-548
    • (2004) Pharm Rev , vol.56 , pp. 515-548
    • Barnes, P.J.1
  • 23
    • 55849148482 scopus 로고    scopus 로고
    • Cytokine networks in asthma and chronic obstructive pulmonary disease
    • Barnes PJ. Cytokine networks in asthma and chronic obstructive pulmonary disease. J Clin Invest 2008; 118:3546-3556
    • (2008) J Clin Invest , vol.118 , pp. 3546-3556
    • Barnes, P.J.1
  • 24
    • 39549095380 scopus 로고    scopus 로고
    • Leukotriene B4 receptor antagonists as therapeutics for inflammatory disease: Preclinical and clinical developments
    • Hicks A, Monkarsh SP, Hoffman AF, et al. Leukotriene B4 receptor antagonists as therapeutics for inflammatory disease: preclinical and clinical developments. Expert Opin Investig Drugs 2007; 16:1909-1920
    • (2007) Expert Opin Investig Drugs , vol.16 , pp. 1909-1920
    • Hicks, A.1    Monkarsh, S.P.2    Hoffman, A.F.3
  • 25
    • 34247607712 scopus 로고    scopus 로고
    • The safety and efficacy of infliximab in moderate-to-severe chronic obstructive pulmonary disease
    • Rennard SI, Fogarty C, Kelsen S, et al. The safety and efficacy of infliximab in moderate-to-severe chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2007; 175:926-934
    • (2007) Am J Respir Crit Care Med , vol.175 , pp. 926-934
    • Rennard, S.I.1    Fogarty, C.2    Kelsen, S.3
  • 26
    • 33749438560 scopus 로고    scopus 로고
    • The effects of a monoclonal antibody directed against tumor necrosis factor-α in asthma
    • Erin EM, Leaker BR, Nicholson GC, et al. The effects of a monoclonal antibody directed against tumor necrosis factor-α in asthma. Am J Respir Crit Care Med 2006; 174:753-762
    • (2006) Am J Respir Crit Care Med , vol.174 , pp. 753-762
    • Erin, E.M.1    Leaker, B.R.2    Nicholson, G.C.3
  • 27
    • 34247604963 scopus 로고    scopus 로고
    • Unexpected failure of anti-tumor necrosis factor therapy in chronic obstructive pulmonary disease
    • Barnes PJ. Unexpected failure of anti-tumor necrosis factor therapy in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2007; 175:866-867
    • (2007) Am J Respir Crit Care Med , vol.175 , pp. 866-867
    • Barnes, P.J.1
  • 28
    • 33750102235 scopus 로고    scopus 로고
    • Tocilizumab: Blockade of interleukin-6 signaling pathway as a therapeutic strategy for inflammatory disorders
    • Paul-Pletzer K. Tocilizumab: blockade of interleukin-6 signaling pathway as a therapeutic strategy for inflammatory disorders. Drugs Today (Barc) 2006; 42:559-576
    • (2006) Drugs Today (Barc) , vol.42 , pp. 559-576
    • Paul-Pletzer, K.1
  • 29
    • 33748580720 scopus 로고    scopus 로고
    • Chemokine receptors as therapeutic targets in chronic obstructive pulmonary disease
    • Donnelly LE, Barnes PJ. Chemokine receptors as therapeutic targets in chronic obstructive pulmonary disease. Trends Pharmacol Sci 2006; 27:546-553
    • (2006) Trends Pharmacol Sci , vol.27 , pp. 546-553
    • Donnelly, L.E.1    Barnes, P.J.2
  • 30
    • 4544275759 scopus 로고    scopus 로고
    • Efficacy and safety of a monoclonal antibody recognizing interleukin-8 in COPD: A pilot study
    • Mahler DA, Huang S, Tabrizi M, et al. Efficacy and safety of a monoclonal antibody recognizing interleukin-8 in COPD: a pilot study. Chest 2004; 126:926-934
    • (2004) Chest , vol.126 , pp. 926-934
    • Mahler, D.A.1    Huang, S.2    Tabrizi, M.3
  • 31
    • 44649111386 scopus 로고    scopus 로고
    • Inhibition of LPS-induced neutrophilic inflammation in healthy volunteers [abstract]
    • O'Connor BJ, Leaker BR, Barnes PJ, et al. Inhibition of LPS-induced neutrophilic inflammation in healthy volunteers [abstract]. Eur Respir J 2007; 30(suppl):1294
    • (2007) Eur Respir J , vol.30 , Issue.SUPPL. , pp. 1294
    • O'Connor, B.J.1    Leaker, B.R.2    Barnes, P.J.3
  • 32
    • 38349077242 scopus 로고    scopus 로고
    • CXCR3 and CCR5 chemokines in the induced sputum from patients with COPD
    • Costa C, Rufino R, Traves SL, et al. CXCR3 and CCR5 chemokines in the induced sputum from patients with COPD. Chest 2008; 133:26-33
    • (2008) Chest , vol.133 , pp. 26-33
    • Costa, C.1    Rufino, R.2    Traves, S.L.3
  • 33
    • 37549027570 scopus 로고    scopus 로고
    • Transforming growth factor-β activation in the lung: Focus on fibrosis and reactive oxygen species
    • Koli K, Myllarniemi M, Keski-Oja J, et al. Transforming growth factor-β activation in the lung: focus on fibrosis and reactive oxygen species. Antioxid Redox Signal 2008; 10:333-342
    • (2008) Antioxid Redox Signal , vol.10 , pp. 333-342
    • Koli, K.1    Myllarniemi, M.2    Keski-Oja, J.3
  • 34
    • 39849096188 scopus 로고    scopus 로고
    • Gene expression profiling in patients with chronic obstructive pulmonary disease and lung cancer
    • Wang IM, Stepaniants S, Boie Y, et al. Gene expression profiling in patients with chronic obstructive pulmonary disease and lung cancer. Am J Respir Crit Care Med 2008; 177:402-411
    • (2008) Am J Respir Crit Care Med , vol.177 , pp. 402-411
    • Wang, I.M.1    Stepaniants, S.2    Boie, Y.3
  • 35
    • 33751173229 scopus 로고    scopus 로고
    • Effect of transforming growth factor-β receptor I kinase inhibitor 2,4-disubstituted pteridine (SD-208) in chronic allergic airway inflammation and remodeling
    • Leung SY, Niimi A, Noble A, et al. Effect of transforming growth factor-β receptor I kinase inhibitor 2,4-disubstituted pteridine (SD-208) in chronic allergic airway inflammation and remodeling. J Pharmacol Exp Ther 2006; 319:586-594
    • (2006) J Pharmacol Exp Ther , vol.319 , pp. 586-594
    • Leung, S.Y.1    Niimi, A.2    Noble, A.3
  • 36
    • 34447520043 scopus 로고    scopus 로고
    • Matrix metalloproteinase inhibitors as therapy for inflammatory and vascular diseases
    • Hu J, Van Den Steen PE, Sang QX, et al. Matrix metalloproteinase inhibitors as therapy for inflammatory and vascular diseases. Nat Rev Drug Discov 2007; 6:480-498
    • (2007) Nat Rev Drug Discov , vol.6 , pp. 480-498
    • Hu, J.1    Van Den Steen, P.E.2    Sang, Q.X.3
  • 37
    • 34547815598 scopus 로고    scopus 로고
    • Effect of an MMP-9/ MMP-12 inhibitor on smoke-induced emphysema and airway remodelling in guinea pigs
    • Churg A, Wang R, Wang X, et al. Effect of an MMP-9/ MMP-12 inhibitor on smoke-induced emphysema and airway remodelling in guinea pigs. Thorax 2007; 62:706-713
    • (2007) Thorax , vol.62 , pp. 706-713
    • Churg, A.1    Wang, R.2    Wang, X.3
  • 38
    • 33644811309 scopus 로고    scopus 로고
    • Phosphodiesterase inhibitors in airways disease
    • Chung KF. Phosphodiesterase inhibitors in airways disease. Eur J Pharmacol 2006; 533:110-117
    • (2006) Eur J Pharmacol , vol.533 , pp. 110-117
    • Chung, K.F.1
  • 39
    • 25444476938 scopus 로고    scopus 로고
    • Roflumilast fully prevents emphysema in mice chronically exposed to cigarette smoke
    • Martorana PA, Beume R, Lucattelli M, et al. Roflumilast fully prevents emphysema in mice chronically exposed to cigarette smoke. Am J Respir Crit Care Med 2005; 172:848-853
    • (2005) Am J Respir Crit Care Med , vol.172 , pp. 848-853
    • Martorana, P.A.1    Beume, R.2    Lucattelli, M.3
  • 40
    • 36749063803 scopus 로고    scopus 로고
    • Reduction in sputum neutrophil and eosinophil numbers by the PDE4 inhibitor roflumilast in patients with COPD
    • Grootendorst DC, Gauw SA, Verhoosel RM, et al. Reduction in sputum neutrophil and eosinophil numbers by the PDE4 inhibitor roflumilast in patients with COPD. Thorax 2007; 62:1081-1087
    • (2007) Thorax , vol.62 , pp. 1081-1087
    • Grootendorst, D.C.1    Gauw, S.A.2    Verhoosel, R.M.3
  • 41
    • 23744451716 scopus 로고    scopus 로고
    • Roflumilast: An oral anti-inflammatory treatment for chronic obstructive pulmonary disease; a randomised controlled trial
    • Rabe KF, Bateman ED, O'Donnell D, et al. Roflumilast: an oral anti-inflammatory treatment for chronic obstructive pulmonary disease; a randomised controlled trial. Lancet 2005; 366:563-571
    • (2005) Lancet , vol.366 , pp. 563-571
    • Rabe, K.F.1    Bateman, E.D.2    O'Donnell, D.3
  • 42
    • 34447310046 scopus 로고    scopus 로고
    • Effect of 1-year treatment with roflumilast in severe chronic obstructive pulmonary disease
    • Calverley PM, Sanchez-Toril F, McIvor A, et al. Effect of 1-year treatment with roflumilast in severe chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2007; 176:154-161
    • (2007) Am J Respir Crit Care Med , vol.176 , pp. 154-161
    • Calverley, P.M.1    Sanchez-Toril, F.2    McIvor, A.3
  • 43
    • 34247139844 scopus 로고    scopus 로고
    • Differential expression and function of phosphodiesterase 4 (PDE4) subtypes in human primary CD4+ T cells: Predominant role of PDE4D
    • Peter D, Jin SL, Conti M, et al. Differential expression and function of phosphodiesterase 4 (PDE4) subtypes in human primary CD4+ T cells: predominant role of PDE4D. J Immunol 2007; 178:4820-4831
    • (2007) J Immunol , vol.178 , pp. 4820-4831
    • Peter, D.1    Jin, S.L.2    Conti, M.3
  • 44
    • 9444228283 scopus 로고    scopus 로고
    • Discovery of BRL 50481, a selective inhibitor of phosphodiesterase 7: In vitro studies in human monocytes, lung macrophages and CD8+ T-lymphocytes
    • Smith SJ, Cieslinski LB, Newton R, et al. Discovery of BRL 50481, a selective inhibitor of phosphodiesterase 7: in vitro studies in human monocytes, lung macrophages and CD8+ T-lymphocytes. Mol Pharmacol 2004; 66:1679-1689
    • (2004) Mol Pharmacol , vol.66 , pp. 1679-1689
    • Smith, S.J.1    Cieslinski, L.B.2    Newton, R.3
  • 45
    • 27644589238 scopus 로고    scopus 로고
    • Phosphodiesterase-4: Selective and dual-specificity inhibitors for the therapy of chronic obstructive pulmonary disease
    • Giembycz MA. Phosphodiesterase-4: selective and dual-specificity inhibitors for the therapy of chronic obstructive pulmonary disease. Proc Am Thorac Soc 2005; 2:326-333
    • (2005) Proc Am Thorac Soc , vol.2 , pp. 326-333
    • Giembycz, M.A.1
  • 46
    • 33745153836 scopus 로고    scopus 로고
    • IκB kinase-2-independent and -dependent inflammation in airway disease models: Relevance of IKK-2 inhibition to the clinic
    • Birrell MA, Wong S, Hardaker EL, et al. IκB kinase-2-independent and -dependent inflammation in airway disease models: relevance of IKK-2 inhibition to the clinic. Mol Pharmacol 2006; 69:1791-1800
    • (2006) Mol Pharmacol , vol.69 , pp. 1791-1800
    • Birrell, M.A.1    Wong, S.2    Hardaker, E.L.3
  • 47
    • 38449118061 scopus 로고    scopus 로고
    • The role of IκB kinase 2, but not activation of NF-κB, in the release of CXCR3 ligands from IFN-γ-stimulated human bronchial epithelial cells
    • Tudhope SJ, Catley MC, Fenwick PS, et al. The role of IκB kinase 2, but not activation of NF-κB, in the release of CXCR3 ligands from IFN-γ-stimulated human bronchial epithelial cells. J Immunol 2007; 179:6237-6245
    • (2007) J Immunol , vol.179 , pp. 6237-6245
    • Tudhope, S.J.1    Catley, M.C.2    Fenwick, P.S.3
  • 48
    • 44649153952 scopus 로고    scopus 로고
    • Increased activation of p38 MAPK in COPD
    • Renda T, Baraldo S, Pelaia G, et al. Increased activation of p38 MAPK in COPD. Eur Respir J 2008; 31:62-69
    • (2008) Eur Respir J , vol.31 , pp. 62-69
    • Renda, T.1    Baraldo, S.2    Pelaia, G.3
  • 49
    • 33750086376 scopus 로고    scopus 로고
    • Inhibitory effect of p38 mitogen-activated protein kinase inhibitors on cytokine release from human macrophages
    • Smith SJ, Fenwick PS, Nicholson AG, et al. Inhibitory effect of p38 mitogen-activated protein kinase inhibitors on cytokine release from human macrophages. Br J Pharmacol 2006; 149:393-404
    • (2006) Br J Pharmacol , vol.149 , pp. 393-404
    • Smith, S.J.1    Fenwick, P.S.2    Nicholson, A.G.3
  • 50
    • 40849119969 scopus 로고    scopus 로고
    • p38a selective MAP kinase inhibitor, SD-282, reduces inflammation in a sub-chronic model of tobacco smoke-induced airway inflammation
    • Medicherla S, Fitzgerald M, Spicer D, et al. p38a selective MAP kinase inhibitor, SD-282, reduces inflammation in a sub-chronic model of tobacco smoke-induced airway inflammation. J Pharmacol Exp Ther 2007; 324:921-929
    • (2007) J Pharmacol Exp Ther , vol.324 , pp. 921-929
    • Medicherla, S.1    Fitzgerald, M.2    Spicer, D.3
  • 51
    • 37349096435 scopus 로고    scopus 로고
    • Different mitogen-activated protein kinase-dependent cytokine responses in cells of the monocyte lineage
    • Tudhope SJ, Finney-Hayward TK, Nicholson AG, et al. Different mitogen-activated protein kinase-dependent cytokine responses in cells of the monocyte lineage. J Pharmacol Exp Ther 2008; 324:306-312
    • (2008) J Pharmacol Exp Ther , vol.324 , pp. 306-312
    • Tudhope, S.J.1    Finney-Hayward, T.K.2    Nicholson, A.G.3
  • 52
    • 34447095246 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase signalling in lung disease: Leucocytes and beyond
    • Medina-Tato DA, Ward SG, Watson ML. Phosphoinositide 3-kinase signalling in lung disease: leucocytes and beyond. Immunology 2007; 121:448-461
    • (2007) Immunology , vol.121 , pp. 448-461
    • Medina-Tato, D.A.1    Ward, S.G.2    Watson, M.L.3
  • 53
    • 0037350266 scopus 로고    scopus 로고
    • Therapeutic potential of phosphoinositide 3-kinase inhibitors
    • Ward S, Sotsios Y, Dowden J, et al. Therapeutic potential of phosphoinositide 3-kinase inhibitors. Chem Biol 2003; 10:207-213
    • (2003) Chem Biol , vol.10 , pp. 207-213
    • Ward, S.1    Sotsios, Y.2    Dowden, J.3
  • 54
    • 33644748138 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor γ agonists as therapy for chronic airway inflammation
    • Belvisi MG, Hele DJ, Birrell MA. Peroxisome proliferator-activated receptor γ agonists as therapy for chronic airway inflammation. Eur J Pharmacol 2006; 533:101-109
    • (2006) Eur J Pharmacol , vol.533 , pp. 101-109
    • Belvisi, M.G.1    Hele, D.J.2    Birrell, M.A.3
  • 55
    • 34547562005 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor expression is reduced in skeletal muscle in COPD
    • Remels AH, Schrauwen P, Broekhuizen R, et al. Peroxisome proliferator-activated receptor expression is reduced in skeletal muscle in COPD. Eur Respir J 2007; 30:245-252
    • (2007) Eur Respir J , vol.30 , pp. 245-252
    • Remels, A.H.1    Schrauwen, P.2    Broekhuizen, R.3
  • 56
    • 84866446105 scopus 로고    scopus 로고
    • Yang IA, Fong KM, Sim EH, et al. Inhaled corticosteroids for stable chronic obstructive pulmonary disease. Cochrane Database Syst Rev (database online). Issue 2, 2007
    • Yang IA, Fong KM, Sim EH, et al. Inhaled corticosteroids for stable chronic obstructive pulmonary disease. Cochrane Database Syst Rev (database online). Issue 2, 2007
  • 57
    • 47049130249 scopus 로고    scopus 로고
    • Methodological issues in therapeutic trials of COPD
    • Suissa S, Ernst P, Vandemheen KL, et al. Methodological issues in therapeutic trials of COPD. Eur Respir J 2008; 31:927-933
    • (2008) Eur Respir J , vol.31 , pp. 927-933
    • Suissa, S.1    Ernst, P.2    Vandemheen, K.L.3
  • 58
    • 33144482007 scopus 로고    scopus 로고
    • Reduced histone deacetylase in COPD: Clinical implications
    • Barnes PJ. Reduced histone deacetylase in COPD: clinical implications. Chest 2006; 129:151-155
    • (2006) Chest , vol.129 , pp. 151-155
    • Barnes, P.J.1
  • 59
    • 31344446119 scopus 로고    scopus 로고
    • Histone deacetylase 2-mediated deacetylation of the glucocorticoid receptor enables NF-κB suppression
    • Ito K, Yamamura S, Essilfie-Quaye S, et al. Histone deacetylase 2-mediated deacetylation of the glucocorticoid receptor enables NF-κB suppression. J Exp Med 2006; 203:7-13
    • (2006) J Exp Med , vol.203 , pp. 7-13
    • Ito, K.1    Yamamura, S.2    Essilfie-Quaye, S.3
  • 60
    • 4544379912 scopus 로고    scopus 로고
    • Theophylline restores histone deacetylase activity and steroid responses in COPD macrophages
    • Cosio BG, Tsaprouni L, Ito K, et al. Theophylline restores histone deacetylase activity and steroid responses in COPD macrophages. J Exp Med 2004; 200:689-695
    • (2004) J Exp Med , vol.200 , pp. 689-695
    • Cosio, B.G.1    Tsaprouni, L.2    Ito, K.3
  • 61
    • 44649174528 scopus 로고    scopus 로고
    • Oral or inhaled corticosteroid combination therapy with low dose theophylline reverses corticosteroid insensitivity in a smoking mouse model [abstract]
    • Fox JC, Spicer D, Ito K, et al. Oral or inhaled corticosteroid combination therapy with low dose theophylline reverses corticosteroid insensitivity in a smoking mouse model [abstract]. Proc Am Thorac Soc 2007; 2:A637
    • (2007) Proc Am Thorac Soc , vol.2
    • Fox, J.C.1    Spicer, D.2    Ito, K.3
  • 62
    • 33744832661 scopus 로고    scopus 로고
    • Oxidative stress in asthma and COPD: Antioxidants as a therapeutic strategy
    • Kirkham P, Rahman I. Oxidative stress in asthma and COPD: antioxidants as a therapeutic strategy. Pharmacol Ther 2006; 111:476-494
    • (2006) Pharmacol Ther , vol.111 , pp. 476-494
    • Kirkham, P.1    Rahman, I.2
  • 63
    • 35948989596 scopus 로고    scopus 로고
    • EM-703, a non-antibacterial erythromycin derivative, restores HDAC2 activation diminished by hypoxia and oxidative stress [abstract]
    • Charron C, Sumakuza T, Oomura S, et al. EM-703, a non-antibacterial erythromycin derivative, restores HDAC2 activation diminished by hypoxia and oxidative stress [abstract]. Proc Am Thorac Soc 2007; 175:A640
    • (2007) Proc Am Thorac Soc , vol.175
    • Charron, C.1    Sumakuza, T.2    Oomura, S.3
  • 64
    • 38549150175 scopus 로고    scopus 로고
    • Retinoic acid-induced alveolar regeneration: Critical differences in strain sensitivity
    • Stinchcombe SV, Maden M. Retinoic acid-induced alveolar regeneration: critical differences in strain sensitivity. Am J Respir Cell Mol Biol 2008; 38:185-191
    • (2008) Am J Respir Cell Mol Biol , vol.38 , pp. 185-191
    • Stinchcombe, S.V.1    Maden, M.2
  • 65
    • 33751241164 scopus 로고    scopus 로고
    • Feasibility of retinoids for the treatment of emphysema study
    • Roth MD, Connett JE, D'Armiento JM, et al. Feasibility of retinoids for the treatment of emphysema study. Chest 2006; 130:1334-1345
    • (2006) Chest , vol.130 , pp. 1334-1345
    • Roth, M.D.1    Connett, J.E.2    D'Armiento, J.M.3
  • 66
    • 34248363665 scopus 로고    scopus 로고
    • A pure population of lung alveolar epithelial type II cells derived from human embryonic stem cells
    • Wang D, Haviland DL, Burns AR, et al. A pure population of lung alveolar epithelial type II cells derived from human embryonic stem cells. Proc Natl Acad Sci U S A 2007; 104:4449-4454
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 4449-4454
    • Wang, D.1    Haviland, D.L.2    Burns, A.R.3
  • 67
    • 34447530953 scopus 로고    scopus 로고
    • Stem cells for lung disease
    • Loebinger MR, Janes SM. Stem cells for lung disease. Chest 2007; 132:279-285
    • (2007) Chest , vol.132 , pp. 279-285
    • Loebinger, M.R.1    Janes, S.M.2
  • 68
    • 34250155299 scopus 로고    scopus 로고
    • Densitometry for assessment of effect of lung volume reduction surgery for emphysema
    • Stolk J, Versteegh MI, Montenij LJ, et al. Densitometry for assessment of effect of lung volume reduction surgery for emphysema. Eur Respir J 2007; 29:1138-1143
    • (2007) Eur Respir J , vol.29 , pp. 1138-1143
    • Stolk, J.1    Versteegh, M.I.2    Montenij, L.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.